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Graphene Encapsulated Copper Microwires as Highly MRI Compatible Neural Electrodes

Magnetic resonance imaging (MRI) compatible neural electrodes are important for combining high-resolution electrophysiological measurements with more global MRI mapping of brain activity, which is critical for fundamental neuroscience studies, as well as clinical evaluation and monitoring. Copper is... Full description

Journal Title: Nano letters 14 December 2016, Vol.16(12), pp.7731-7738
Main Author: Zhao, Siyuan
Other Authors: Liu, Xiaojun , Xu, Zheng , Ren, Huaying , Deng, Bing , Tang, Miao , Lu, Linlin , Fu, Xuefeng , Peng, Hailin , Liu, Zhongfan , Duan, Xiaojie
Format: Electronic Article Electronic Article
Language: English
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ID: E-ISSN: 1530-6992 ; PMID: 27802387 Version:1
Link: http://pubmed.gov/27802387
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recordid: medline27802387
title: Graphene Encapsulated Copper Microwires as Highly MRI Compatible Neural Electrodes
format: Article
creator:
  • Zhao, Siyuan
  • Liu, Xiaojun
  • Xu, Zheng
  • Ren, Huaying
  • Deng, Bing
  • Tang, Miao
  • Lu, Linlin
  • Fu, Xuefeng
  • Peng, Hailin
  • Liu, Zhongfan
  • Duan, Xiaojie
subjects:
  • Neural Electrodes
  • Anticorrosion
  • Biocompatibility
  • Graphene Biosensing
  • Magnetic Resonance Imaging
ispartof: Nano letters, 14 December 2016, Vol.16(12), pp.7731-7738
description: Magnetic resonance imaging (MRI) compatible neural electrodes are important for combining high-resolution electrophysiological measurements with more global MRI mapping of brain activity, which is critical for fundamental neuroscience studies, as well as clinical evaluation and monitoring. Copper is a favorable material to use in MRI because it has magnetic susceptibility close to water and tissues. However, the cytotoxicity of copper precludes its direct implantation for neural recording. Here, we overcome this limitation by developing a graphene encapsulated copper (G-Cu) microelectrode. The toxicity of copper is largely eliminated, as evidenced by the in vitro cell tests and in vivo histology studies. Local field potentials and single-unit spikes were recorded from rodent brains with the G-Cu microelectrodes. Notably, the G-Cu microelectrodes show no image artifacts in a 7.0 T MRI scanner, indicating minimal magnetic field distortion in their vicinity. This high MRI compatibility of our G-Cu probes would open up new opportunities for fundamental brain activity studies and clinical applications requiring continuous MRI and electrophysiological recordings.
language: eng
source:
identifier: E-ISSN: 1530-6992 ; PMID: 27802387 Version:1
fulltext: no_fulltext
issn:
  • 15306992
  • 1530-6992
url: Link


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titleGraphene Encapsulated Copper Microwires as Highly MRI Compatible Neural Electrodes
creatorZhao, Siyuan ; Liu, Xiaojun ; Xu, Zheng ; Ren, Huaying ; Deng, Bing ; Tang, Miao ; Lu, Linlin ; Fu, Xuefeng ; Peng, Hailin ; Liu, Zhongfan ; Duan, Xiaojie
ispartofNano letters, 14 December 2016, Vol.16(12), pp.7731-7738
identifierE-ISSN: 1530-6992 ; PMID: 27802387 Version:1
subjectNeural Electrodes ; Anticorrosion ; Biocompatibility ; Graphene Biosensing ; Magnetic Resonance Imaging
descriptionMagnetic resonance imaging (MRI) compatible neural electrodes are important for combining high-resolution electrophysiological measurements with more global MRI mapping of brain activity, which is critical for fundamental neuroscience studies, as well as clinical evaluation and monitoring. Copper is a favorable material to use in MRI because it has magnetic susceptibility close to water and tissues. However, the cytotoxicity of copper precludes its direct implantation for neural recording. Here, we overcome this limitation by developing a graphene encapsulated copper (G-Cu) microelectrode. The toxicity of copper is largely eliminated, as evidenced by the in vitro cell tests and in vivo histology studies. Local field potentials and single-unit spikes were recorded from rodent brains with the G-Cu microelectrodes. Notably, the G-Cu microelectrodes show no image artifacts in a 7.0 T MRI scanner, indicating minimal magnetic field distortion in their vicinity. This high MRI compatibility of our G-Cu probes would open up new opportunities for fundamental brain activity studies and clinical applications requiring continuous MRI and electrophysiological recordings.
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titleGraphene Encapsulated Copper Microwires as Highly MRI Compatible Neural Electrodes
authorZhao, Siyuan ; Liu, Xiaojun ; Xu, Zheng ; Ren, Huaying ; Deng, Bing ; Tang, Miao ; Lu, Linlin ; Fu, Xuefeng ; Peng, Hailin ; Liu, Zhongfan ; Duan, Xiaojie
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abstractMagnetic resonance imaging (MRI) compatible neural electrodes are important for combining high-resolution electrophysiological measurements with more global MRI mapping of brain activity, which is critical for fundamental neuroscience studies, as well as clinical evaluation and monitoring. Copper is a favorable material to use in MRI because it has magnetic susceptibility close to water and tissues. However, the cytotoxicity of copper precludes its direct implantation for neural recording. Here, we overcome this limitation by developing a graphene encapsulated copper (G-Cu) microelectrode. The toxicity of copper is largely eliminated, as evidenced by the in vitro cell tests and in vivo histology studies. Local field potentials and single-unit spikes were recorded from rodent brains with the G-Cu microelectrodes. Notably, the G-Cu microelectrodes show no image artifacts in a 7.0 T MRI scanner, indicating minimal magnetic field distortion in their vicinity. This high MRI compatibility of our G-Cu probes would open up new opportunities for fundamental brain activity studies and clinical applications requiring continuous MRI and electrophysiological recordings.
pmid27802387
doi10.1021/acs.nanolett.6b03829
issn15306984
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date2016-12-14