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Anti-hyperglycemic activity of Aegle marmelos (L.) corr. is partly mediated by increased insulin secretion, α-amylase inhibition, and retardation of glucose absorption

Aegle marmelos (commonly known as Bael, golden apple) was formerly described to have anti-hyperglycemic activity. The present study aimed to explore the possible effects, in depth, of A. marmelos extracts on carbohydrate absorption, glucose utilization, and α-amylase inhibition and insulin content i... Full description

Journal Title: Journal of pediatric endocrinology & metabolism : JPEM 01 January 2017, Vol.30(1), pp.37-47
Main Author: Ansari, Prawej
Other Authors: Afroz, Nadia , Jalil, Shahnaz , Azad, Sohel Bin , Mustakim, Md Gazi , Anwar, Sabbir , Haque, S M Nazmul , Hossain, Saad Mosharraf , Tony, Ramisha Rifat , Hannan, J M A
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 2191-0251 ; PMID: 28002030 Version:1 ; DOI: 10.1515/jpem-2016-0160
Link: http://pubmed.gov/28002030
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title: Anti-hyperglycemic activity of Aegle marmelos (L.) corr. is partly mediated by increased insulin secretion, α-amylase inhibition, and retardation of glucose absorption
format: Article
creator:
  • Ansari, Prawej
  • Afroz, Nadia
  • Jalil, Shahnaz
  • Azad, Sohel Bin
  • Mustakim, Md Gazi
  • Anwar, Sabbir
  • Haque, S M Nazmul
  • Hossain, Saad Mosharraf
  • Tony, Ramisha Rifat
  • Hannan, J M A
subjects:
  • Aegle -- Chemistry
  • Diabetes Mellitus, Experimental -- Drug Therapy
  • Glucose -- Metabolism
  • Hyperglycemia -- Prevention & Control
  • Hypoglycemic Agents -- Pharmacology
  • Insulin -- Metabolism
  • Plant Extracts -- Pharmacology
  • Alpha-Amylases -- Antagonists & Inhibitors
ispartof: Journal of pediatric endocrinology & metabolism : JPEM, 01 January 2017, Vol.30(1), pp.37-47
description: Aegle marmelos (commonly known as Bael, golden apple) was formerly described to have anti-hyperglycemic activity. The present study aimed to explore the possible effects, in depth, of A. marmelos extracts on carbohydrate absorption, glucose utilization, and α-amylase inhibition and insulin content in pancreases of type 2 diabetic rats. This research begins with fasting blood glucose and oral glucose tolerance test (OGTT) to evaluate the primary anti-hyperglycemic effect in chemically induced type 2 diabetic rats. Furthermore, the plasma insulin concentration and serum glucose level were studied, which include measuring the sucrose content in six different segments of the gastrointestinal (GI) tract of the rats following oral sucrose feeding. An in situ, perfused, intestinal model in rats and glucose-fiber binding assay were conducted to find the effects of A. marmelos extracts on glucose absorption. Extract effects on carbohydrate breakdown, intestinal disaccharidase enzyme activity, and α-amylase inhibition were assessed. Effect on GI motility was evaluated using BaSO4 milk traverse test. Treatment of extracts suppressed blood glucose elevation after oral sucrose (2.5 g/kg) administration and significantly (p
language: eng
source:
identifier: E-ISSN: 2191-0251 ; PMID: 28002030 Version:1 ; DOI: 10.1515/jpem-2016-0160
fulltext: fulltext
issn:
  • 21910251
  • 2191-0251
url: Link


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titleAnti-hyperglycemic activity of Aegle marmelos (L.) corr. is partly mediated by increased insulin secretion, α-amylase inhibition, and retardation of glucose absorption
creatorAnsari, Prawej ; Afroz, Nadia ; Jalil, Shahnaz ; Azad, Sohel Bin ; Mustakim, Md Gazi ; Anwar, Sabbir ; Haque, S M Nazmul ; Hossain, Saad Mosharraf ; Tony, Ramisha Rifat ; Hannan, J M A
ispartofJournal of pediatric endocrinology & metabolism : JPEM, 01 January 2017, Vol.30(1), pp.37-47
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subjectAegle -- Chemistry ; Diabetes Mellitus, Experimental -- Drug Therapy ; Glucose -- Metabolism ; Hyperglycemia -- Prevention & Control ; Hypoglycemic Agents -- Pharmacology ; Insulin -- Metabolism ; Plant Extracts -- Pharmacology ; Alpha-Amylases -- Antagonists & Inhibitors
descriptionAegle marmelos (commonly known as Bael, golden apple) was formerly described to have anti-hyperglycemic activity. The present study aimed to explore the possible effects, in depth, of A. marmelos extracts on carbohydrate absorption, glucose utilization, and α-amylase inhibition and insulin content in pancreases of type 2 diabetic rats. This research begins with fasting blood glucose and oral glucose tolerance test (OGTT) to evaluate the primary anti-hyperglycemic effect in chemically induced type 2 diabetic rats. Furthermore, the plasma insulin concentration and serum glucose level were studied, which include measuring the sucrose content in six different segments of the gastrointestinal (GI) tract of the rats following oral sucrose feeding. An in situ, perfused, intestinal model in rats and glucose-fiber binding assay were conducted to find the effects of A. marmelos extracts on glucose absorption. Extract effects on carbohydrate breakdown, intestinal disaccharidase enzyme activity, and α-amylase inhibition were assessed. Effect on GI motility was evaluated using BaSO4 milk traverse test. Treatment of extracts suppressed blood glucose elevation after oral sucrose (2.5 g/kg) administration and significantly (p<0.05) improved oral glucose tolerance in type 2 diabetic rats. Aegle marmelos extracts showed remarkable (p<0.05) changes in plasma insulin secretion at 30 min and 60 min, respectively. A noticeable reduction in glucose absorption was observed in the in situ perfused rat intestinal model at two different doses (250 and 500 mg/kg). The extract was also found to inhibit the action of both α-amylase and intestinal disaccharidase enzyme, and this study was affirmed again by the sucrose malabsorption test, where sucrose digestion was inhibited throughout the length of the GI tract. During this chronic study, body mass of rats became normal and their polydipsic and polyphagic conditions were ameliorated also. The findings demonstrate that anti-hyperglycemic activity of A. marmelos is mediated by the inhibition of carbohydrate digestion and absorption, and improvement of insulin action to uptake glucose in peripheral tissue. Additional study is required to correlate A. marmelos extracts' specific mechanism of glucose-fiber binding capacity and glucose transporters.
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1Afroz, Nadia
2Jalil, Shahnaz
3Azad, Sohel Bin
4Mustakim, Md Gazi
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6Haque, S M Nazmul
7Hossain, Saad Mosharraf
8Tony, Ramisha Rifat
9Hannan, J M A
titleAnti-hyperglycemic activity of Aegle marmelos (L.) corr. is partly mediated by increased insulin secretion, α-amylase inhibition, and retardation of glucose absorption
description
0Aegle marmelos (commonly known as Bael, golden apple) was formerly described to have anti-hyperglycemic activity. The present study aimed to explore the possible effects, in depth, of A. marmelos extracts on carbohydrate absorption, glucose utilization, and α-amylase inhibition and insulin content in pancreases of type 2 diabetic rats.
1This research begins with fasting blood glucose and oral glucose tolerance test (OGTT) to evaluate the primary anti-hyperglycemic effect in chemically induced type 2 diabetic rats. Furthermore, the plasma insulin concentration and serum glucose level were studied, which include measuring the sucrose content in six different segments of the gastrointestinal (GI) tract of the rats following oral sucrose feeding. An in situ, perfused, intestinal model in rats and glucose-fiber binding assay were conducted to find the effects of A. marmelos extracts on glucose absorption. Extract effects on carbohydrate breakdown, intestinal disaccharidase enzyme activity, and α-amylase inhibition were assessed. Effect on GI motility was evaluated using BaSO4 milk traverse test.
2Treatment of extracts suppressed blood glucose elevation after oral sucrose (2.5 g/kg) administration and significantly (p<0.05) improved oral glucose tolerance in type 2 diabetic rats. Aegle marmelos extracts showed remarkable (p<0.05) changes in plasma insulin secretion at 30 min and 60 min, respectively. A noticeable reduction in glucose absorption was observed in the in situ perfused rat intestinal model at two different doses (250 and 500 mg/kg). The extract was also found to inhibit the action of both α-amylase and intestinal disaccharidase enzyme, and this study was affirmed again by the sucrose malabsorption test, where sucrose digestion was inhibited throughout the length of the GI tract. During this chronic study, body mass of rats became normal and their polydipsic and polyphagic conditions were ameliorated also.
3The findings demonstrate that anti-hyperglycemic activity of A. marmelos is mediated by the inhibition of carbohydrate digestion and absorption, and improvement of insulin action to uptake glucose in peripheral tissue. Additional study is required to correlate A. marmelos extracts' specific mechanism of glucose-fiber binding capacity and glucose transporters.
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0Aegle -- Chemistry
1Diabetes Mellitus, Experimental -- Drug Therapy
2Glucose -- Metabolism
3Hyperglycemia -- Prevention & Control
4Hypoglycemic Agents -- Pharmacology
5Insulin -- Metabolism
6Plant Extracts -- Pharmacology
7Alpha-Amylases -- Antagonists & Inhibitors
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titleAnti-hyperglycemic activity of Aegle marmelos (L.) corr. is partly mediated by increased insulin secretion, α-amylase inhibition, and retardation of glucose absorption
authorAnsari, Prawej ; Afroz, Nadia ; Jalil, Shahnaz ; Azad, Sohel Bin ; Mustakim, Md Gazi ; Anwar, Sabbir ; Haque, S M Nazmul ; Hossain, Saad Mosharraf ; Tony, Ramisha Rifat ; Hannan, J M A
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7Alpha-Amylases–Antagonists & Inhibitors
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abstractAegle marmelos (commonly known as Bael, golden apple) was formerly described to have anti-hyperglycemic activity. The present study aimed to explore the possible effects, in depth, of A. marmelos extracts on carbohydrate absorption, glucose utilization, and α-amylase inhibition and insulin content in pancreases of type 2 diabetic rats.
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