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Berberine-induced Inactivation of Signal Transducer and Activator of Transcription 5 Signaling Promotes Male-specific Expression of a Bile Acid Uptake Transporter

Sodium-taurocholate co-transporting polypeptide (Ntcp/NTCP) is the major uptake transporter of bile salts in mouse and human livers. In certain diseases, including endotoxemia, cholestasis, diabetes, and hepatocarcinoma, Ntcp/NTCP expression is markedly reduced, which interferes with enterohepatic c... Full description

Journal Title: The Journal of biological chemistry 17 March 2017, Vol.292(11), pp.4602-4613
Main Author: Bu, Pengli
Other Authors: Le, Yuan , Zhang, Yue , Zhang, Youcai , Cheng, Xingguo
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1083-351X ; PMID: 28154180 Version:1 ; DOI: 10.1074/jbc.M116.757567
Link: http://pubmed.gov/28154180
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recordid: medline28154180
title: Berberine-induced Inactivation of Signal Transducer and Activator of Transcription 5 Signaling Promotes Male-specific Expression of a Bile Acid Uptake Transporter
format: Article
creator:
  • Bu, Pengli
  • Le, Yuan
  • Zhang, Yue
  • Zhang, Youcai
  • Cheng, Xingguo
subjects:
  • Stat Transcription Factor
  • Bile Acid
  • Gene Regulation
  • Transcription Regulation
  • Transporter
  • Berberine -- Pharmacology
  • Liver -- Drug Effects
  • Organic Anion Transporters, Sodium-Dependent -- Metabolism
  • Stat5 Transcription Factor -- Metabolism
  • Signal Transduction -- Drug Effects
  • Symporters -- Metabolism
ispartof: The Journal of biological chemistry, 17 March 2017, Vol.292(11), pp.4602-4613
description: Sodium-taurocholate co-transporting polypeptide (Ntcp/NTCP) is the major uptake transporter of bile salts in mouse and human livers. In certain diseases, including endotoxemia, cholestasis, diabetes, and hepatocarcinoma, Ntcp/NTCP expression is markedly reduced, which interferes with enterohepatic circulation of bile salts, impairing the absorption of lipophilic compounds. Therefore, normal Ntcp/NTCP expression in the liver is physiologically important. Berberine is an herbal medicine used historically to improve liver function and has recently been shown to repress STAT signaling. However, berberine effects on Ntcp/NTCP expression are unknown, prompting use to investigate this possible connection. Our results showed that berberine dose-dependently increased Ntcp expression in male mouse liver and decreased taurocholic acid levels in serum but increased them in the liver. In mouse and human hepatoma cells, berberine induced Ntcp/NTCP mRNA and protein expression and increased cellular uptake...
language: eng
source:
identifier: E-ISSN: 1083-351X ; PMID: 28154180 Version:1 ; DOI: 10.1074/jbc.M116.757567
fulltext: fulltext
issn:
  • 1083351X
  • 1083-351X
url: Link


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titleBerberine-induced Inactivation of Signal Transducer and Activator of Transcription 5 Signaling Promotes Male-specific Expression of a Bile Acid Uptake Transporter
creatorBu, Pengli ; Le, Yuan ; Zhang, Yue ; Zhang, Youcai ; Cheng, Xingguo
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subjectStat Transcription Factor ; Bile Acid ; Gene Regulation ; Transcription Regulation ; Transporter ; Berberine -- Pharmacology ; Liver -- Drug Effects ; Organic Anion Transporters, Sodium-Dependent -- Metabolism ; Stat5 Transcription Factor -- Metabolism ; Signal Transduction -- Drug Effects ; Symporters -- Metabolism
descriptionSodium-taurocholate co-transporting polypeptide (Ntcp/NTCP) is the major uptake transporter of bile salts in mouse and human livers. In certain diseases, including endotoxemia, cholestasis, diabetes, and hepatocarcinoma, Ntcp/NTCP expression is markedly reduced, which interferes with enterohepatic circulation of bile salts, impairing the absorption of lipophilic compounds. Therefore, normal Ntcp/NTCP expression in the liver is physiologically important. Berberine is an herbal medicine used historically to improve liver function and has recently been shown to repress STAT signaling. However, berberine effects on Ntcp/NTCP expression are unknown, prompting use to investigate this possible connection. Our results showed that berberine dose-dependently increased Ntcp expression in male mouse liver and decreased taurocholic acid levels in serum but increased them in the liver. In mouse and human hepatoma cells, berberine induced Ntcp/NTCP mRNA and protein expression and increased cellular uptake...
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descriptionSodium-taurocholate co-transporting polypeptide (Ntcp/NTCP) is the major uptake transporter of bile salts in mouse and human livers. In certain diseases, including endotoxemia, cholestasis, diabetes, and hepatocarcinoma, Ntcp/NTCP expression is markedly reduced, which interferes with enterohepatic circulation of bile salts, impairing the absorption of lipophilic compounds. Therefore, normal Ntcp/NTCP expression in the liver is physiologically important. Berberine is an herbal medicine used historically to improve liver function and has recently been shown to repress STAT signaling. However, berberine effects on Ntcp/NTCP expression are unknown, prompting use to investigate this possible connection. Our results showed that berberine dose-dependently increased Ntcp expression in male mouse liver and decreased taurocholic acid levels in serum but increased them in the liver. In mouse and human hepatoma cells, berberine induced Ntcp/NTCP mRNA and protein expression and increased cellular uptake...
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abstractSodium-taurocholate co-transporting polypeptide (Ntcp/NTCP) is the major uptake transporter of bile salts in mouse and human livers. In certain diseases, including endotoxemia, cholestasis, diabetes, and hepatocarcinoma, Ntcp/NTCP expression is markedly reduced, which interferes with enterohepatic circulation of bile salts, impairing the absorption of lipophilic compounds. Therefore, normal Ntcp/NTCP expression in the liver is physiologically important. Berberine is an herbal medicine used historically to improve liver function and has recently been shown to repress STAT signaling. However, berberine effects on Ntcp/NTCP expression are unknown, prompting use to investigate this possible connection. Our results showed that berberine dose-dependently increased Ntcp expression in male mouse liver and decreased taurocholic acid levels in serum but increased them in the liver. In mouse and human hepatoma cells, berberine induced Ntcp/NTCP mRNA and protein expression and increased cellular uptake...
doi10.1074/jbc.M116.757567
pmid28154180
date2017-03-17