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Development and characterization of polymer-coated liposomes for vaginal delivery of sildenafil citrate

Vaginal administration of sildenafil citrate has shown recently to develop efficiently the uterine lining with subsequent successful embryo implantation following in vitro fertilization. The aim of the present study was to develop sildenafil-loaded liposomes coated with bioadhesive polymers for enha... Full description

Journal Title: Drug delivery November 2017, Vol.24(1), pp.278-288
Main Author: Refai, Hanan
Other Authors: Hassan, Doaa , Abdelmonem, Rehab
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1521-0464 ; PMID: 28165805 Version:1 ; DOI: 10.1080/10717544.2016.1247925
Link: http://pubmed.gov/28165805
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recordid: medline28165805
title: Development and characterization of polymer-coated liposomes for vaginal delivery of sildenafil citrate
format: Article
creator:
  • Refai, Hanan
  • Hassan, Doaa
  • Abdelmonem, Rehab
subjects:
  • Chitosan
  • Ex Vivo Vaginal Permeation
  • Histopathological Study
  • Polymer-Coated Liposomes
  • Sildenafil Citrate
  • Vaginal Administration
  • Drug Delivery Systems -- Methods
  • Polymers -- Administration & Dosage
  • Sildenafil Citrate -- Administration & Dosage
  • Vagina -- Metabolism
ispartof: Drug delivery, November 2017, Vol.24(1), pp.278-288
description: Vaginal administration of sildenafil citrate has shown recently to develop efficiently the uterine lining with subsequent successful embryo implantation following in vitro fertilization. The aim of the present study was to develop sildenafil-loaded liposomes coated with bioadhesive polymers for enhanced vaginal retention and improved drug permeation. Three liposomal formulae were prepared by thin-film method using different phospholipid:cholesterol ratios. The optimal liposomal formulation was coated with bioadhesive polymers (chitosan and HPMC). A marked increase in liposomal size and zeta potential was observed for all coated liposomal formulations. HPMC-coated liposomes showed the greater bioadhesion and higher entrapment efficiency than chitosan-coated formulae. The in vitro release studies showed prolonged release of sildenafil from coated liposomes as compared to uncoated liposomes and sildenafil solution. Ex vivo permeation study revealed the enhanced permeation of coated relative...
language: eng
source:
identifier: E-ISSN: 1521-0464 ; PMID: 28165805 Version:1 ; DOI: 10.1080/10717544.2016.1247925
fulltext: fulltext
issn:
  • 15210464
  • 1521-0464
url: Link


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titleDevelopment and characterization of polymer-coated liposomes for vaginal delivery of sildenafil citrate
creatorRefai, Hanan ; Hassan, Doaa ; Abdelmonem, Rehab
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subjectChitosan ; Ex Vivo Vaginal Permeation ; Histopathological Study ; Polymer-Coated Liposomes ; Sildenafil Citrate ; Vaginal Administration ; Drug Delivery Systems -- Methods ; Polymers -- Administration & Dosage ; Sildenafil Citrate -- Administration & Dosage ; Vagina -- Metabolism
descriptionVaginal administration of sildenafil citrate has shown recently to develop efficiently the uterine lining with subsequent successful embryo implantation following in vitro fertilization. The aim of the present study was to develop sildenafil-loaded liposomes coated with bioadhesive polymers for enhanced vaginal retention and improved drug permeation. Three liposomal formulae were prepared by thin-film method using different phospholipid:cholesterol ratios. The optimal liposomal formulation was coated with bioadhesive polymers (chitosan and HPMC). A marked increase in liposomal size and zeta potential was observed for all coated liposomal formulations. HPMC-coated liposomes showed the greater bioadhesion and higher entrapment efficiency than chitosan-coated formulae. The in vitro release studies showed prolonged release of sildenafil from coated liposomes as compared to uncoated liposomes and sildenafil solution. Ex vivo permeation study revealed the enhanced permeation of coated relative...
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descriptionVaginal administration of sildenafil citrate has shown recently to develop efficiently the uterine lining with subsequent successful embryo implantation following in vitro fertilization. The aim of the present study was to develop sildenafil-loaded liposomes coated with bioadhesive polymers for enhanced vaginal retention and improved drug permeation. Three liposomal formulae were prepared by thin-film method using different phospholipid:cholesterol ratios. The optimal liposomal formulation was coated with bioadhesive polymers (chitosan and HPMC). A marked increase in liposomal size and zeta potential was observed for all coated liposomal formulations. HPMC-coated liposomes showed the greater bioadhesion and higher entrapment efficiency than chitosan-coated formulae. The in vitro release studies showed prolonged release of sildenafil from coated liposomes as compared to uncoated liposomes and sildenafil solution. Ex vivo permeation study revealed the enhanced permeation of coated relative...
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abstractVaginal administration of sildenafil citrate has shown recently to develop efficiently the uterine lining with subsequent successful embryo implantation following in vitro fertilization. The aim of the present study was to develop sildenafil-loaded liposomes coated with bioadhesive polymers for enhanced vaginal retention and improved drug permeation. Three liposomal formulae were prepared by thin-film method using different phospholipid:cholesterol ratios. The optimal liposomal formulation was coated with bioadhesive polymers (chitosan and HPMC). A marked increase in liposomal size and zeta potential was observed for all coated liposomal formulations. HPMC-coated liposomes showed the greater bioadhesion and higher entrapment efficiency than chitosan-coated formulae. The in vitro release studies showed prolonged release of sildenafil from coated liposomes as compared to uncoated liposomes and sildenafil solution. Ex vivo permeation study revealed the enhanced permeation of coated relative...
doi10.1080/10717544.2016.1247925
pmid28165805
date2017-11