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Essential role of immobilized chemokine CXCL12 in the regulation of the humoral immune response

Chemokines control the migration of a large array of cells by binding to specific receptors on cell surfaces. The biological function of chemokines also depends on interactions between nonreceptor binding domains and proteoglycans, which mediate chemokine immobilization on cellular or extracellular... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America 28 February 2017, Vol.114(9), pp.2319-2324
Main Author: Barinov, Aleksandr
Other Authors: Luo, Lingjie , Gasse, Pamela , Meas-Yedid, Vannary , Donnadieu, Emmanuel , Arenzana-Seisdedos, Fernando , Vieira, Paulo
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1091-6490 ; PMID: 28193885 Version:1 ; DOI: 10.1073/pnas.1611958114
Link: http://pubmed.gov/28193885
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recordid: medline28193885
title: Essential role of immobilized chemokine CXCL12 in the regulation of the humoral immune response
format: Article
creator:
  • Barinov, Aleksandr
  • Luo, Lingjie
  • Gasse, Pamela
  • Meas-Yedid, Vannary
  • Donnadieu, Emmanuel
  • Arenzana-Seisdedos, Fernando
  • Vieira, Paulo
subjects:
  • Cxcl12
  • Germinal Center Reaction
  • Humoral Immune Responses
  • Immunity, Humoral
  • B-Lymphocytes -- Immunology
  • Chemokine Cxcl12 -- Immunology
  • Germinal Center -- Immunology
  • Immobilized Proteins -- Immunology
  • Immunoglobulins -- Genetics
ispartof: Proceedings of the National Academy of Sciences of the United States of America, 28 February 2017, Vol.114(9), pp.2319-2324
description: Chemokines control the migration of a large array of cells by binding to specific receptors on cell surfaces. The biological function of chemokines also depends on interactions between nonreceptor binding domains and proteoglycans, which mediate chemokine immobilization on cellular or extracellular surfaces and formation of fixed gradients. Chemokine gradients regulate synchronous cell motility and integrin-dependent cell adhesion. Of the various chemokines, CXCL12 has a unique structure because its receptor-binding domain is distinct and does not overlap with the immobilization domains. Although CXCL12 is known to be essential for the germinal center (GC) response, the role of its immobilization in biological functions has never been addressed. In this work, we investigated the unexplored paradigm of CXCL12 immobilization during the germinal center reaction, a fundamental process where cellular traffic is crucial for the quality of humoral immune responses. We show that the structure of...
language: eng
source:
identifier: E-ISSN: 1091-6490 ; PMID: 28193885 Version:1 ; DOI: 10.1073/pnas.1611958114
fulltext: fulltext
issn:
  • 10916490
  • 1091-6490
url: Link


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titleEssential role of immobilized chemokine CXCL12 in the regulation of the humoral immune response
creatorBarinov, Aleksandr ; Luo, Lingjie ; Gasse, Pamela ; Meas-Yedid, Vannary ; Donnadieu, Emmanuel ; Arenzana-Seisdedos, Fernando ; Vieira, Paulo
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subjectCxcl12 ; Germinal Center Reaction ; Humoral Immune Responses ; Immunity, Humoral ; B-Lymphocytes -- Immunology ; Chemokine Cxcl12 -- Immunology ; Germinal Center -- Immunology ; Immobilized Proteins -- Immunology ; Immunoglobulins -- Genetics
descriptionChemokines control the migration of a large array of cells by binding to specific receptors on cell surfaces. The biological function of chemokines also depends on interactions between nonreceptor binding domains and proteoglycans, which mediate chemokine immobilization on cellular or extracellular surfaces and formation of fixed gradients. Chemokine gradients regulate synchronous cell motility and integrin-dependent cell adhesion. Of the various chemokines, CXCL12 has a unique structure because its receptor-binding domain is distinct and does not overlap with the immobilization domains. Although CXCL12 is known to be essential for the germinal center (GC) response, the role of its immobilization in biological functions has never been addressed. In this work, we investigated the unexplored paradigm of CXCL12 immobilization during the germinal center reaction, a fundamental process where cellular traffic is crucial for the quality of humoral immune responses. We show that the structure of...
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titleEssential role of immobilized chemokine CXCL12 in the regulation of the humoral immune response
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titleEssential role of immobilized chemokine CXCL12 in the regulation of the humoral immune response
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abstractChemokines control the migration of a large array of cells by binding to specific receptors on cell surfaces. The biological function of chemokines also depends on interactions between nonreceptor binding domains and proteoglycans, which mediate chemokine immobilization on cellular or extracellular surfaces and formation of fixed gradients. Chemokine gradients regulate synchronous cell motility and integrin-dependent cell adhesion. Of the various chemokines, CXCL12 has a unique structure because its receptor-binding domain is distinct and does not overlap with the immobilization domains. Although CXCL12 is known to be essential for the germinal center (GC) response, the role of its immobilization in biological functions has never been addressed. In this work, we investigated the unexplored paradigm of CXCL12 immobilization during the germinal center reaction, a fundamental process where cellular traffic is crucial for the quality of humoral immune responses. We show that the structure of...
doi10.1073/pnas.1611958114
pmid28193885
orcidid0000-0002-4985-7254
date2017-02-28