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Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice

It is increasingly recognized that sleep disturbances and Alzheimer's disease (AD) share a bidirectional relationship. AD patients exhibit sleep problems and alterations in the regulation of circadian rhythms; conversely, poor quality of sleep increases the risk of development of AD. The aim of the... Full description

Journal Title: Brain behavior, and immunity, August 2017, Vol.64, pp.140-151
Main Author: Kincheski, Grasielle C
Other Authors: Valentim, Isabela S , Clarke, Julia R , Cozachenco, Danielle , Castelo-Branco, Morgana T L , Ramos-Lobo, Angela M , Rumjanek, Vivian M B D , Donato, José , De Felice, Fernanda G , Ferreira, Sergio T
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1090-2139 ; PMID: 28412140 Version:1 ; DOI: 10.1016/j.bbi.2017.04.007
Link: http://pubmed.gov/28412140
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recordid: medline28412140
title: Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice
format: Article
creator:
  • Kincheski, Grasielle C
  • Valentim, Isabela S
  • Clarke, Julia R
  • Cozachenco, Danielle
  • Castelo-Branco, Morgana T L
  • Ramos-Lobo, Angela M
  • Rumjanek, Vivian M B D
  • Donato, José
  • De Felice, Fernanda G
  • Ferreira, Sergio T
subjects:
  • Alzheimer’s Disease
  • Amyloid-Β Oligomers
  • Chronic Sleep Restriction
  • Cytokines
  • Hippocampus
  • Il-1β
  • Il-6
  • Inflammation
  • Psd-95
  • Sleep
  • Synaptic Proteins
  • Synaptophysin
  • Tnf-Α
  • Amyloid Beta-Peptides -- Administration & Dosage
  • Cognitive Dysfunction
ispartof: Brain, behavior, and immunity, August 2017, Vol.64, pp.140-151
description: It is increasingly recognized that sleep disturbances and Alzheimer's disease (AD) share a bidirectional relationship. AD patients exhibit sleep problems and alterations in the regulation of circadian rhythms; conversely, poor quality of sleep increases the risk of development of AD. The aim of the current study was to determine whether chronic sleep restriction potentiates the brain impact of amyloid-β oligomers (AβOs), toxins that build up in AD brains and are thought to underlie synapse damage and memory impairment. We further investigated whether alterations in levels of pro-inflammatory mediators could play a role in memory impairment in sleep-restricted mice. We found that a single intracerebroventricular (i.c.v.) infusion of AβOs disturbed sleep pattern in mice. Conversely, chronically sleep-restricted mice exhibited higher brain expression of pro-inflammatory mediators, reductions in levels of pre- and post-synaptic marker proteins, and exhibited increased susceptibility to the...
language: eng
source:
identifier: E-ISSN: 1090-2139 ; PMID: 28412140 Version:1 ; DOI: 10.1016/j.bbi.2017.04.007
fulltext: fulltext
issn:
  • 10902139
  • 1090-2139
url: Link


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titleChronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice
creatorKincheski, Grasielle C ; Valentim, Isabela S ; Clarke, Julia R ; Cozachenco, Danielle ; Castelo-Branco, Morgana T L ; Ramos-Lobo, Angela M ; Rumjanek, Vivian M B D ; Donato, José ; De Felice, Fernanda G ; Ferreira, Sergio T
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subjectAlzheimer’s Disease ; Amyloid-Β Oligomers ; Chronic Sleep Restriction ; Cytokines ; Hippocampus ; Il-1β ; Il-6 ; Inflammation ; Psd-95 ; Sleep ; Synaptic Proteins ; Synaptophysin ; Tnf-Α ; Amyloid Beta-Peptides -- Administration & Dosage ; Cognitive Dysfunction
descriptionIt is increasingly recognized that sleep disturbances and Alzheimer's disease (AD) share a bidirectional relationship. AD patients exhibit sleep problems and alterations in the regulation of circadian rhythms; conversely, poor quality of sleep increases the risk of development of AD. The aim of the current study was to determine whether chronic sleep restriction potentiates the brain impact of amyloid-β oligomers (AβOs), toxins that build up in AD brains and are thought to underlie synapse damage and memory impairment. We further investigated whether alterations in levels of pro-inflammatory mediators could play a role in memory impairment in sleep-restricted mice. We found that a single intracerebroventricular (i.c.v.) infusion of AβOs disturbed sleep pattern in mice. Conversely, chronically sleep-restricted mice exhibited higher brain expression of pro-inflammatory mediators, reductions in levels of pre- and post-synaptic marker proteins, and exhibited increased susceptibility to the...
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titleChronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice
descriptionIt is increasingly recognized that sleep disturbances and Alzheimer's disease (AD) share a bidirectional relationship. AD patients exhibit sleep problems and alterations in the regulation of circadian rhythms; conversely, poor quality of sleep increases the risk of development of AD. The aim of the current study was to determine whether chronic sleep restriction potentiates the brain impact of amyloid-β oligomers (AβOs), toxins that build up in AD brains and are thought to underlie synapse damage and memory impairment. We further investigated whether alterations in levels of pro-inflammatory mediators could play a role in memory impairment in sleep-restricted mice. We found that a single intracerebroventricular (i.c.v.) infusion of AβOs disturbed sleep pattern in mice. Conversely, chronically sleep-restricted mice exhibited higher brain expression of pro-inflammatory mediators, reductions in levels of pre- and post-synaptic marker proteins, and exhibited increased susceptibility to the...
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abstractIt is increasingly recognized that sleep disturbances and Alzheimer's disease (AD) share a bidirectional relationship. AD patients exhibit sleep problems and alterations in the regulation of circadian rhythms; conversely, poor quality of sleep increases the risk of development of AD. The aim of the current study was to determine whether chronic sleep restriction potentiates the brain impact of amyloid-β oligomers (AβOs), toxins that build up in AD brains and are thought to underlie synapse damage and memory impairment. We further investigated whether alterations in levels of pro-inflammatory mediators could play a role in memory impairment in sleep-restricted mice. We found that a single intracerebroventricular (i.c.v.) infusion of AβOs disturbed sleep pattern in mice. Conversely, chronically sleep-restricted mice exhibited higher brain expression of pro-inflammatory mediators, reductions in levels of pre- and post-synaptic marker proteins, and exhibited increased susceptibility to the...
doi10.1016/j.bbi.2017.04.007
pmid28412140
date2017-08