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Precise Two-Photon Photodynamic Therapy using an Efficient Photosensitizer with Aggregation-Induced Emission Characteristics

Two-photon photodynamic therapy (PDT) is able to offer precise 3D manipulation of treatment volumes, providing a target level that is unattainable with current therapeutic techniques. The advancement of this technique is greatly hampered by the availability of photosensitizers with large two-photon... Full description

Journal Title: Advanced materials (Deerfield Beach Fla.), July 2017, Vol.29(28)
Main Author: Gu, Bobo
Other Authors: Wu, Wenbo , Xu, Gaixia , Feng, Guangxue , Yin, Feng , Chong, Peter Han Joo , Qu, Junle , Yong, Ken-Tye , Liu, Bin
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1521-4095 ; PMID: 28556297 Version:1 ; DOI: 10.1002/adma.201701076
Link: http://pubmed.gov/28556297
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recordid: medline28556297
title: Precise Two-Photon Photodynamic Therapy using an Efficient Photosensitizer with Aggregation-Induced Emission Characteristics
format: Article
creator:
  • Gu, Bobo
  • Wu, Wenbo
  • Xu, Gaixia
  • Feng, Guangxue
  • Yin, Feng
  • Chong, Peter Han Joo
  • Qu, Junle
  • Yong, Ken-Tye
  • Liu, Bin
subjects:
  • Aggregation-Induced Emission
  • Brain-Blood-Vessel Closure
  • Cancer Cells
  • Photodynamic Therapy
  • Two-Photon Excitation
  • Biocompatible Materials -- Chemistry
  • Photosensitizing Agents -- Chemistry
ispartof: Advanced materials (Deerfield Beach, Fla.), July 2017, Vol.29(28)
description: Two-photon photodynamic therapy (PDT) is able to offer precise 3D manipulation of treatment volumes, providing a target level that is unattainable with current therapeutic techniques. The advancement of this technique is greatly hampered by the availability of photosensitizers with large two-photon absorption (TPA) cross section, high reactive-oxygen-species (ROS) generation efficiency, and bright two-photon fluorescence. Here, an effective photosensitizer with aggregation-induced emission (AIE) characteristics is synthesized, characterized, and encapsulated into an amphiphilic block copolymer to form organic dots for two-photon PDT applications. The AIE dots possess large TPA cross section, high ROS generation efficiency, and excellent photostability and biocompatibility, which overcomes the limitations of many conventional two-photon photosensitizers. Outstanding therapeutic performance of the AIE dots in two-photon PDT is demonstrated using in vitro cancer cell ablation and in vivo brain-blood-vessel closure as examples. This shows therapy precision up to 5 µm under two-photon excitation.
language: eng
source:
identifier: E-ISSN: 1521-4095 ; PMID: 28556297 Version:1 ; DOI: 10.1002/adma.201701076
fulltext: fulltext
issn:
  • 15214095
  • 1521-4095
url: Link


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titlePrecise Two-Photon Photodynamic Therapy using an Efficient Photosensitizer with Aggregation-Induced Emission Characteristics
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subjectAggregation-Induced Emission ; Brain-Blood-Vessel Closure ; Cancer Cells ; Photodynamic Therapy ; Two-Photon Excitation ; Biocompatible Materials -- Chemistry ; Photosensitizing Agents -- Chemistry
descriptionTwo-photon photodynamic therapy (PDT) is able to offer precise 3D manipulation of treatment volumes, providing a target level that is unattainable with current therapeutic techniques. The advancement of this technique is greatly hampered by the availability of photosensitizers with large two-photon absorption (TPA) cross section, high reactive-oxygen-species (ROS) generation efficiency, and bright two-photon fluorescence. Here, an effective photosensitizer with aggregation-induced emission (AIE) characteristics is synthesized, characterized, and encapsulated into an amphiphilic block copolymer to form organic dots for two-photon PDT applications. The AIE dots possess large TPA cross section, high ROS generation efficiency, and excellent photostability and biocompatibility, which overcomes the limitations of many conventional two-photon photosensitizers. Outstanding therapeutic performance of the AIE dots in two-photon PDT is demonstrated using in vitro cancer cell ablation and in vivo brain-blood-vessel closure as examples. This shows therapy precision up to 5 µm under two-photon excitation.
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abstractTwo-photon photodynamic therapy (PDT) is able to offer precise 3D manipulation of treatment volumes, providing a target level that is unattainable with current therapeutic techniques. The advancement of this technique is greatly hampered by the availability of photosensitizers with large two-photon absorption (TPA) cross section, high reactive-oxygen-species (ROS) generation efficiency, and bright two-photon fluorescence. Here, an effective photosensitizer with aggregation-induced emission (AIE) characteristics is synthesized, characterized, and encapsulated into an amphiphilic block copolymer to form organic dots for two-photon PDT applications. The AIE dots possess large TPA cross section, high ROS generation efficiency, and excellent photostability and biocompatibility, which overcomes the limitations of many conventional two-photon photosensitizers. Outstanding therapeutic performance of the AIE dots in two-photon PDT is demonstrated using in vitro cancer cell ablation and in vivo brain-blood-vessel closure as examples. This shows therapy precision up to 5 µm under two-photon excitation.
doi10.1002/adma.201701076
pmid28556297
pages1-7
issn09359648
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date2017-07