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The Bordetella Bps Polysaccharide Is Required for Biofilm Formation and Enhances Survival in the Lower Respiratory Tract of Swine

is pervasive in swine populations and plays multiple roles in respiratory disease. Additionally, is capable of establishing long-term or chronic infections in swine. Bacterial biofilms are increasingly recognized as important contributors to chronic bacterial infections. Recently the polysaccharide... Full description

Journal Title: Infection and immunity August 2017, Vol.85(8)
Main Author: Nicholson, Tracy L
Other Authors: Brockmeier, Susan L , Sukumar, Neelima , Paharik, Alexandra E , Lister, Jessica L , Horswill, Alexander R , Kehrli, Marcus E , Loving, Crystal L , Shore, Sarah M , Deora, Rajendar
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1098-5522 ; PMID: 28559403 Version:1 ; DOI: 10.1128/IAI.00261-17
Link: http://pubmed.gov/28559403
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recordid: medline28559403
title: The Bordetella Bps Polysaccharide Is Required for Biofilm Formation and Enhances Survival in the Lower Respiratory Tract of Swine
format: Article
creator:
  • Nicholson, Tracy L
  • Brockmeier, Susan L
  • Sukumar, Neelima
  • Paharik, Alexandra E
  • Lister, Jessica L
  • Horswill, Alexander R
  • Kehrli, Marcus E
  • Loving, Crystal L
  • Shore, Sarah M
  • Deora, Rajendar
subjects:
  • Bordetella
  • Biofilms
  • Biofilms -- Growth & Development
  • Bordetella Infections -- Microbiology
  • Bordetella Bronchiseptica -- Pathogenicity
  • Polysaccharides, Bacterial -- Metabolism
  • Trachea -- Microbiology
ispartof: Infection and immunity, August 2017, Vol.85(8)
description: is pervasive in swine populations and plays multiple roles in respiratory disease. Additionally, is capable of establishing long-term or chronic infections in swine. Bacterial biofilms are increasingly recognized as important contributors to chronic bacterial infections. Recently the polysaccharide locus has been demonstrated to serve a critical role in the development of mature biofilms formed by the sequenced laboratory strain of We hypothesized that swine isolates would also have the ability to form mature biofilms and the locus would serve a key role in this process. A mutant containing an in-frame deletion of the structural genes was constructed in a wild-type swine isolate and found to be negative for poly-N-acetylglucosamine (PNAG)-like material by immunoblot assay. Further, the locus was found to be required for the development and maintenance of the three-dimensional structures under continuous-flow conditions. To investigate the contribution of the locus to the pathogenesis...
language: eng
source:
identifier: E-ISSN: 1098-5522 ; PMID: 28559403 Version:1 ; DOI: 10.1128/IAI.00261-17
fulltext: fulltext
issn:
  • 10985522
  • 1098-5522
url: Link


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titleThe Bordetella Bps Polysaccharide Is Required for Biofilm Formation and Enhances Survival in the Lower Respiratory Tract of Swine
creatorNicholson, Tracy L ; Brockmeier, Susan L ; Sukumar, Neelima ; Paharik, Alexandra E ; Lister, Jessica L ; Horswill, Alexander R ; Kehrli, Marcus E ; Loving, Crystal L ; Shore, Sarah M ; Deora, Rajendar
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subjectBordetella ; Biofilms ; Biofilms -- Growth & Development ; Bordetella Infections -- Microbiology ; Bordetella Bronchiseptica -- Pathogenicity ; Polysaccharides, Bacterial -- Metabolism ; Trachea -- Microbiology
descriptionis pervasive in swine populations and plays multiple roles in respiratory disease. Additionally, is capable of establishing long-term or chronic infections in swine. Bacterial biofilms are increasingly recognized as important contributors to chronic bacterial infections. Recently the polysaccharide locus has been demonstrated to serve a critical role in the development of mature biofilms formed by the sequenced laboratory strain of We hypothesized that swine isolates would also have the ability to form mature biofilms and the locus would serve a key role in this process. A mutant containing an in-frame deletion of the structural genes was constructed in a wild-type swine isolate and found to be negative for poly-N-acetylglucosamine (PNAG)-like material by immunoblot assay. Further, the locus was found to be required for the development and maintenance of the three-dimensional structures under continuous-flow conditions. To investigate the contribution of the locus to the pathogenesis...
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titleThe Bordetella Bps Polysaccharide Is Required for Biofilm Formation and Enhances Survival in the Lower Respiratory Tract of Swine
descriptionis pervasive in swine populations and plays multiple roles in respiratory disease. Additionally, is capable of establishing long-term or chronic infections in swine. Bacterial biofilms are increasingly recognized as important contributors to chronic bacterial infections. Recently the polysaccharide locus has been demonstrated to serve a critical role in the development of mature biofilms formed by the sequenced laboratory strain of We hypothesized that swine isolates would also have the ability to form mature biofilms and the locus would serve a key role in this process. A mutant containing an in-frame deletion of the structural genes was constructed in a wild-type swine isolate and found to be negative for poly-N-acetylglucosamine (PNAG)-like material by immunoblot assay. Further, the locus was found to be required for the development and maintenance of the three-dimensional structures under continuous-flow conditions. To investigate the contribution of the locus to the pathogenesis...
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abstractis pervasive in swine populations and plays multiple roles in respiratory disease. Additionally, is capable of establishing long-term or chronic infections in swine. Bacterial biofilms are increasingly recognized as important contributors to chronic bacterial infections. Recently the polysaccharide locus has been demonstrated to serve a critical role in the development of mature biofilms formed by the sequenced laboratory strain of We hypothesized that swine isolates would also have the ability to form mature biofilms and the locus would serve a key role in this process. A mutant containing an in-frame deletion of the structural genes was constructed in a wild-type swine isolate and found to be negative for poly-N-acetylglucosamine (PNAG)-like material by immunoblot assay. Further, the locus was found to be required for the development and maintenance of the three-dimensional structures under continuous-flow conditions. To investigate the contribution of the locus to the pathogenesis...
doi10.1128/IAI.00261-17
pmid28559403
date2017-08