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Enhancing Photodynamic Therapy through Resonance Energy Transfer Constructed Near-Infrared Photosensitized Nanoparticles

Photodynamic therapy (PDT) is an important cancer treatment modality due to its minimally invasive nature. However, the efficiency of existing PDT drug molecules in the deep-tissue-penetrable near-infrared (NIR) region has been the major hurdle that has hindered further development and clinical usag... Full description

Journal Title: Advanced materials (Deerfield Beach Fla.), July 2017, Vol.29(28)
Main Author: Huang, Ling
Other Authors: Li, Zhanjun , Zhao, Yang , Yang, Jinyi , Yang, Yucheng , Pendharkar, Aarushi Iris , Zhang, Yuanwei , Kelmar, Sharon , Chen, Liyong , Wu, Wenting , Zhao, Jianzhang , Han, Gang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1521-4095 ; PMID: 28586102 Version:1 ; DOI: 10.1002/adma.201604789
Link: http://pubmed.gov/28586102
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recordid: medline28586102
title: Enhancing Photodynamic Therapy through Resonance Energy Transfer Constructed Near-Infrared Photosensitized Nanoparticles
format: Article
creator:
  • Huang, Ling
  • Li, Zhanjun
  • Zhao, Yang
  • Yang, Jinyi
  • Yang, Yucheng
  • Pendharkar, Aarushi Iris
  • Zhang, Yuanwei
  • Kelmar, Sharon
  • Chen, Liyong
  • Wu, Wenting
  • Zhao, Jianzhang
  • Han, Gang
subjects:
  • Bodipy
  • Nanoparticles
  • Near-Infrared Radiation
  • Photodynamic Therapy
  • Resonance Energy Transfer
  • Infrared Rays
  • Nanoparticles -- Chemistry
  • Photosensitizing Agents -- Chemistry
ispartof: Advanced materials (Deerfield Beach, Fla.), July 2017, Vol.29(28)
description: Photodynamic therapy (PDT) is an important cancer treatment modality due to its minimally invasive nature. However, the efficiency of existing PDT drug molecules in the deep-tissue-penetrable near-infrared (NIR) region has been the major hurdle that has hindered further development and clinical usage of PDT. Thus, herein a strategy is presented to utilize a resonance energy transfer (RET) mechanism to construct a novel dyad photosensitizer which is able to dramatically boost NIR photon utility and enhance singlet oxygen generation. In this work, the energy donor moiety (distyryl-BODIPY) is connected to a photosensitizer (i.e., diiodo-distyryl-BODIPY) to form a dyad molecule (RET-BDP). The resulting RET-BDP shows significantly enhanced absorption and singlet oxygen efficiency relative to that of the acceptor moiety of the photosensitizer alone in the NIR range. After being encapsulated with biodegradable copolymer pluronic F-127-folic acid (F-127-FA), RET-BDP molecules can form uniform and small organic nanoparticles that are water soluble and tumor targetable. Used in conjunction with an exceptionally low-power NIR LED light irradiation (10 mW cm ), these nanoparticles show superior tumor-targeted therapeutic PDT effects against cancer cells both in vitro and in vivo relative to unmodified photosensitizers. This study offers a new method to expand the options for designing NIR-absorbing photosensitizers for future clinical cancer treatments.
language: eng
source:
identifier: E-ISSN: 1521-4095 ; PMID: 28586102 Version:1 ; DOI: 10.1002/adma.201604789
fulltext: fulltext
issn:
  • 15214095
  • 1521-4095
url: Link


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titleEnhancing Photodynamic Therapy through Resonance Energy Transfer Constructed Near-Infrared Photosensitized Nanoparticles
creatorHuang, Ling ; Li, Zhanjun ; Zhao, Yang ; Yang, Jinyi ; Yang, Yucheng ; Pendharkar, Aarushi Iris ; Zhang, Yuanwei ; Kelmar, Sharon ; Chen, Liyong ; Wu, Wenting ; Zhao, Jianzhang ; Han, Gang
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subjectBodipy ; Nanoparticles ; Near-Infrared Radiation ; Photodynamic Therapy ; Resonance Energy Transfer ; Infrared Rays ; Nanoparticles -- Chemistry ; Photosensitizing Agents -- Chemistry
descriptionPhotodynamic therapy (PDT) is an important cancer treatment modality due to its minimally invasive nature. However, the efficiency of existing PDT drug molecules in the deep-tissue-penetrable near-infrared (NIR) region has been the major hurdle that has hindered further development and clinical usage of PDT. Thus, herein a strategy is presented to utilize a resonance energy transfer (RET) mechanism to construct a novel dyad photosensitizer which is able to dramatically boost NIR photon utility and enhance singlet oxygen generation. In this work, the energy donor moiety (distyryl-BODIPY) is connected to a photosensitizer (i.e., diiodo-distyryl-BODIPY) to form a dyad molecule (RET-BDP). The resulting RET-BDP shows significantly enhanced absorption and singlet oxygen efficiency relative to that of the acceptor moiety of the photosensitizer alone in the NIR range. After being encapsulated with biodegradable copolymer pluronic F-127-folic acid (F-127-FA), RET-BDP molecules can form uniform and small organic nanoparticles that are water soluble and tumor targetable. Used in conjunction with an exceptionally low-power NIR LED light irradiation (10 mW cm ), these nanoparticles show superior tumor-targeted therapeutic PDT effects against cancer cells both in vitro and in vivo relative to unmodified photosensitizers. This study offers a new method to expand the options for designing NIR-absorbing photosensitizers for future clinical cancer treatments.
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abstractPhotodynamic therapy (PDT) is an important cancer treatment modality due to its minimally invasive nature. However, the efficiency of existing PDT drug molecules in the deep-tissue-penetrable near-infrared (NIR) region has been the major hurdle that has hindered further development and clinical usage of PDT. Thus, herein a strategy is presented to utilize a resonance energy transfer (RET) mechanism to construct a novel dyad photosensitizer which is able to dramatically boost NIR photon utility and enhance singlet oxygen generation. In this work, the energy donor moiety (distyryl-BODIPY) is connected to a photosensitizer (i.e., diiodo-distyryl-BODIPY) to form a dyad molecule (RET-BDP). The resulting RET-BDP shows significantly enhanced absorption and singlet oxygen efficiency relative to that of the acceptor moiety of the photosensitizer alone in the NIR range. After being encapsulated with biodegradable copolymer pluronic F-127-folic acid (F-127-FA), RET-BDP molecules can form uniform and small organic nanoparticles that are water soluble and tumor targetable. Used in conjunction with an exceptionally low-power NIR LED light irradiation (10 mW cm ), these nanoparticles show superior tumor-targeted therapeutic PDT effects against cancer cells both in vitro and in vivo relative to unmodified photosensitizers. This study offers a new method to expand the options for designing NIR-absorbing photosensitizers for future clinical cancer treatments.
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