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Predictive value of peripheral regulatory T cells in non-small cell lung cancer patients undergoing radiotherapy

Studies increasingly focus on the impact of radiotherapy on immunity; however, the role of peripheral cellular immunity prior to radiotherapy in cancer patients remains largely unknown. In this study, we investigated the predictive roles of lymphocyte subsets on tumor progression in non-small cell l... Full description

Journal Title: Oncotarget 27 June 2017, Vol.8(26), pp.43427-43438
Main Author: Liu, Chao
Other Authors: Wu, Shikai , Meng, Xiangying , Liu, Guangxian , Chen, Dongmei , Cong, Yang , Shen, Ge , Sun, Bing , Wang, Wei , Wang, Qian , Gao, Hongjun , Liu, Xiaoqing
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1949-2553 ; PMID: 28624781 Version:1 ; DOI: 10.18632/oncotarget.15238
Link: http://pubmed.gov/28624781
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recordid: medline28624781
title: Predictive value of peripheral regulatory T cells in non-small cell lung cancer patients undergoing radiotherapy
format: Article
creator:
  • Liu, Chao
  • Wu, Shikai
  • Meng, Xiangying
  • Liu, Guangxian
  • Chen, Dongmei
  • Cong, Yang
  • Shen, Ge
  • Sun, Bing
  • Wang, Wei
  • Wang, Qian
  • Gao, Hongjun
  • Liu, Xiaoqing
subjects:
  • T Cells
  • Immunotherapy
  • Lymphocyte Subsets
  • Non-Small Cell Lung Cancer
  • Stereotactic Body Radiation Therapy
  • Carcinoma, Non-Small-Cell Lung -- Immunology
  • Lung Neoplasms -- Immunology
  • T-Lymphocyte Subsets -- Immunology
  • T-Lymphocytes, Regulatory -- Immunology
ispartof: Oncotarget, 27 June 2017, Vol.8(26), pp.43427-43438
description: Studies increasingly focus on the impact of radiotherapy on immunity; however, the role of peripheral cellular immunity prior to radiotherapy in cancer patients remains largely unknown. In this study, we investigated the predictive roles of lymphocyte subsets on tumor progression in non-small cell lung cancer (NSCLC) patients undergoing radiotherapy, and their expression in NSCLC patients at first relapse. We enrolled 70 NSCLC patients and 14 age- and sex-matched healthy donors and tested the lymphocyte subsets in their peripheral blood by flow cytometry. Among them, 40 newly diagnosed patients received radiotherapy and were enrolled to investigate the predictive value of lymphocyte subsets on tumor progression after radiotherapy by uni- and multivariate analyses; 30 patients at first relapse were included to evaluate the differences of lymphocyte subsets between them and first diagnosed patients and healthy volunteers. Increased proportions of regulatory T cells, CD8+ T cells, and CD8+CD28- T cells and decreased CD4+ T cells and CD4/CD8 ratios were observed in NSCLC patients at first relapse compared to newly diagnosed patients. In the 40 first diagnosed patients undergoing radiotherapy, uni- and multivariate analyses showed that increased level of regulatory T cells correlated with poor progression-free survival (hazard ratio = 2.55 and 3.76, P = 0.022 and 0.010, respectively). Peripheral regulatory T cells were increased and independently predict tumor progression in NSCLC patients undergoing radiotherapy, suggesting the promising combination of radiotherapy and immunotherapy.
language: eng
source:
identifier: E-ISSN: 1949-2553 ; PMID: 28624781 Version:1 ; DOI: 10.18632/oncotarget.15238
fulltext: fulltext
issn:
  • 19492553
  • 1949-2553
url: Link


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titlePredictive value of peripheral regulatory T cells in non-small cell lung cancer patients undergoing radiotherapy
creatorLiu, Chao ; Wu, Shikai ; Meng, Xiangying ; Liu, Guangxian ; Chen, Dongmei ; Cong, Yang ; Shen, Ge ; Sun, Bing ; Wang, Wei ; Wang, Qian ; Gao, Hongjun ; Liu, Xiaoqing
ispartofOncotarget, 27 June 2017, Vol.8(26), pp.43427-43438
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subjectT Cells ; Immunotherapy ; Lymphocyte Subsets ; Non-Small Cell Lung Cancer ; Stereotactic Body Radiation Therapy ; Carcinoma, Non-Small-Cell Lung -- Immunology ; Lung Neoplasms -- Immunology ; T-Lymphocyte Subsets -- Immunology ; T-Lymphocytes, Regulatory -- Immunology
descriptionStudies increasingly focus on the impact of radiotherapy on immunity; however, the role of peripheral cellular immunity prior to radiotherapy in cancer patients remains largely unknown. In this study, we investigated the predictive roles of lymphocyte subsets on tumor progression in non-small cell lung cancer (NSCLC) patients undergoing radiotherapy, and their expression in NSCLC patients at first relapse. We enrolled 70 NSCLC patients and 14 age- and sex-matched healthy donors and tested the lymphocyte subsets in their peripheral blood by flow cytometry. Among them, 40 newly diagnosed patients received radiotherapy and were enrolled to investigate the predictive value of lymphocyte subsets on tumor progression after radiotherapy by uni- and multivariate analyses; 30 patients at first relapse were included to evaluate the differences of lymphocyte subsets between them and first diagnosed patients and healthy volunteers. Increased proportions of regulatory T cells, CD8+ T cells, and CD8+CD28- T cells and decreased CD4+ T cells and CD4/CD8 ratios were observed in NSCLC patients at first relapse compared to newly diagnosed patients. In the 40 first diagnosed patients undergoing radiotherapy, uni- and multivariate analyses showed that increased level of regulatory T cells correlated with poor progression-free survival (hazard ratio = 2.55 and 3.76, P = 0.022 and 0.010, respectively). Peripheral regulatory T cells were increased and independently predict tumor progression in NSCLC patients undergoing radiotherapy, suggesting the promising combination of radiotherapy and immunotherapy.
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0Studies increasingly focus on the impact of radiotherapy on immunity; however, the role of peripheral cellular immunity prior to radiotherapy in cancer patients remains largely unknown. In this study, we investigated the predictive roles of lymphocyte subsets on tumor progression in non-small cell lung cancer (NSCLC) patients undergoing radiotherapy, and their expression in NSCLC patients at first relapse.
1We enrolled 70 NSCLC patients and 14 age- and sex-matched healthy donors and tested the lymphocyte subsets in their peripheral blood by flow cytometry. Among them, 40 newly diagnosed patients received radiotherapy and were enrolled to investigate the predictive value of lymphocyte subsets on tumor progression after radiotherapy by uni- and multivariate analyses; 30 patients at first relapse were included to evaluate the differences of lymphocyte subsets between them and first diagnosed patients and healthy volunteers.
2Increased proportions of regulatory T cells, CD8+ T cells, and CD8+CD28- T cells and decreased CD4+ T cells and CD4/CD8 ratios were observed in NSCLC patients at first relapse compared to newly diagnosed patients. In the 40 first diagnosed patients undergoing radiotherapy, uni- and multivariate analyses showed that increased level of regulatory T cells correlated with poor progression-free survival (hazard ratio = 2.55 and 3.76, P = 0.022 and 0.010, respectively).
3Peripheral regulatory T cells were increased and independently predict tumor progression in NSCLC patients undergoing radiotherapy, suggesting the promising combination of radiotherapy and immunotherapy.
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abstractStudies increasingly focus on the impact of radiotherapy on immunity; however, the role of peripheral cellular immunity prior to radiotherapy in cancer patients remains largely unknown. In this study, we investigated the predictive roles of lymphocyte subsets on tumor progression in non-small cell lung cancer (NSCLC) patients undergoing radiotherapy, and their expression in NSCLC patients at first relapse.
doi10.18632/oncotarget.15238
pmid28624781
date2017-06-27