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Reduced SCD1 activity alters markers of fatty acid reesterification, glyceroneogenesis, and lipolysis in murine white adipose tissue and 3T3-L1 adipocytes

White adipose tissue (WAT) has a critical role in lipid handling. Previous work demonstrated that SCD1 is an important regulator of WAT fatty acid (FA) composition; however, its influence on the various interconnected pathways influencing WAT lipid handling remains unclear. Our objective was to inve... Full description

Journal Title: American journal of physiology. Cell physiology 01 September 2017, Vol.313(3), pp.C295-C304
Main Author: Dragos, Steven M
Other Authors: Bergeron, Karl F , Desmarais, Frédérik , Suitor, Katherine , Wright, David C , Mounier, Catherine , Mutch, David M
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1522-1563 ; PMID: 28659287 Version:1 ; DOI: 10.1152/ajpcell.00097.2017
Link: http://pubmed.gov/28659287
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recordid: medline28659287
title: Reduced SCD1 activity alters markers of fatty acid reesterification, glyceroneogenesis, and lipolysis in murine white adipose tissue and 3T3-L1 adipocytes
format: Article
creator:
  • Dragos, Steven M
  • Bergeron, Karl F
  • Desmarais, Frédérik
  • Suitor, Katherine
  • Wright, David C
  • Mounier, Catherine
  • Mutch, David M
subjects:
  • Scd1 Inhibitor
  • Scd1−/− Mice
  • Adipocytes
  • Epididymal Adipose Tissue
  • Inguinal Adipose Tissue
  • Adipose Tissue, White -- Physiology
  • Fatty Acids -- Metabolism
  • Glycerophosphates -- Biosynthesis
  • Lipid Metabolism -- Physiology
  • Lipolysis -- Physiology
  • Stearoyl-Coa Desaturase -- Metabolism
ispartof: American journal of physiology. Cell physiology, 01 September 2017, Vol.313(3), pp.C295-C304
description: White adipose tissue (WAT) has a critical role in lipid handling. Previous work demonstrated that SCD1 is an important regulator of WAT fatty acid (FA) composition; however, its influence on the various interconnected pathways influencing WAT lipid handling remains unclear. Our objective was to investigate the role of SCD1 on WAT lipid handling using knockout (KO) mice and SCD1-inhibited 3T3-L1 adipocytes by measuring gene, protein, and metabolite markers related to FA reesterification, glyceroneogenesis, and lipolysis. Triacylglycerol (TAG) content was higher in inguinal WAT (iWAT) from KO mice compared with wild-type, but significantly lower in epididymal WAT (eWAT). The SCD1 desaturation index was decreased in both WAT depots in KO mice. FA reesterification, as measured with a NEFA:glycerol ratio, was reduced in both WAT depots in KO mice, as well as SCD1-inhibited 3T3-L1 adipocytes. , , and gene expression was reduced in both WAT depots of KO mice, while and gene expression showed...
language: eng
source:
identifier: E-ISSN: 1522-1563 ; PMID: 28659287 Version:1 ; DOI: 10.1152/ajpcell.00097.2017
fulltext: fulltext
issn:
  • 15221563
  • 1522-1563
url: Link


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titleReduced SCD1 activity alters markers of fatty acid reesterification, glyceroneogenesis, and lipolysis in murine white adipose tissue and 3T3-L1 adipocytes
creatorDragos, Steven M ; Bergeron, Karl F ; Desmarais, Frédérik ; Suitor, Katherine ; Wright, David C ; Mounier, Catherine ; Mutch, David M
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subjectScd1 Inhibitor ; Scd1−/− Mice ; Adipocytes ; Epididymal Adipose Tissue ; Inguinal Adipose Tissue ; Adipose Tissue, White -- Physiology ; Fatty Acids -- Metabolism ; Glycerophosphates -- Biosynthesis ; Lipid Metabolism -- Physiology ; Lipolysis -- Physiology ; Stearoyl-Coa Desaturase -- Metabolism
descriptionWhite adipose tissue (WAT) has a critical role in lipid handling. Previous work demonstrated that SCD1 is an important regulator of WAT fatty acid (FA) composition; however, its influence on the various interconnected pathways influencing WAT lipid handling remains unclear. Our objective was to investigate the role of SCD1 on WAT lipid handling using knockout (KO) mice and SCD1-inhibited 3T3-L1 adipocytes by measuring gene, protein, and metabolite markers related to FA reesterification, glyceroneogenesis, and lipolysis. Triacylglycerol (TAG) content was higher in inguinal WAT (iWAT) from KO mice compared with wild-type, but significantly lower in epididymal WAT (eWAT). The SCD1 desaturation index was decreased in both WAT depots in KO mice. FA reesterification, as measured with a NEFA:glycerol ratio, was reduced in both WAT depots in KO mice, as well as SCD1-inhibited 3T3-L1 adipocytes. , , and gene expression was reduced in both WAT depots of KO mice, while and gene expression showed...
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titleReduced SCD1 activity alters markers of fatty acid reesterification, glyceroneogenesis, and lipolysis in murine white adipose tissue and 3T3-L1 adipocytes
descriptionWhite adipose tissue (WAT) has a critical role in lipid handling. Previous work demonstrated that SCD1 is an important regulator of WAT fatty acid (FA) composition; however, its influence on the various interconnected pathways influencing WAT lipid handling remains unclear. Our objective was to investigate the role of SCD1 on WAT lipid handling using knockout (KO) mice and SCD1-inhibited 3T3-L1 adipocytes by measuring gene, protein, and metabolite markers related to FA reesterification, glyceroneogenesis, and lipolysis. Triacylglycerol (TAG) content was higher in inguinal WAT (iWAT) from KO mice compared with wild-type, but significantly lower in epididymal WAT (eWAT). The SCD1 desaturation index was decreased in both WAT depots in KO mice. FA reesterification, as measured with a NEFA:glycerol ratio, was reduced in both WAT depots in KO mice, as well as SCD1-inhibited 3T3-L1 adipocytes. , , and gene expression was reduced in both WAT depots of KO mice, while and gene expression showed...
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abstractWhite adipose tissue (WAT) has a critical role in lipid handling. Previous work demonstrated that SCD1 is an important regulator of WAT fatty acid (FA) composition; however, its influence on the various interconnected pathways influencing WAT lipid handling remains unclear. Our objective was to investigate the role of SCD1 on WAT lipid handling using knockout (KO) mice and SCD1-inhibited 3T3-L1 adipocytes by measuring gene, protein, and metabolite markers related to FA reesterification, glyceroneogenesis, and lipolysis. Triacylglycerol (TAG) content was higher in inguinal WAT (iWAT) from KO mice compared with wild-type, but significantly lower in epididymal WAT (eWAT). The SCD1 desaturation index was decreased in both WAT depots in KO mice. FA reesterification, as measured with a NEFA:glycerol ratio, was reduced in both WAT depots in KO mice, as well as SCD1-inhibited 3T3-L1 adipocytes. , , and gene expression was reduced in both WAT depots of KO mice, while and gene expression showed...
doi10.1152/ajpcell.00097.2017
pmid28659287
orcidid0000-0002-7215-9104
date2017-09-01