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Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons

The present study examined the effects of glutamate on the outgrowth of dendrites and axons in isolated hippocampal pyramidal-like neurons in cell culture. During the first day of culture the survival and outgrowth of these neurons was unaffected by high concentrations (up to 1 nM) of glutamate, qui... Full description

Journal Title: The Journal of neuroscience : the official journal of the Society for Neuroscience June 1988, Vol.8(6), pp.2087-100
Main Author: Mattson, M P
Other Authors: Dou, P , Kater, S B
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0270-6474 ; PMID: 2898515 Version:1
Link: http://pubmed.gov/2898515
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recordid: medline2898515
title: Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons
format: Article
creator:
  • Mattson, M P
  • Dou, P
  • Kater, S B
subjects:
  • Glutamates -- Pharmacology
  • Hippocampus -- Cytology
  • Neurons -- Drug Effects
ispartof: The Journal of neuroscience : the official journal of the Society for Neuroscience, June 1988, Vol.8(6), pp.2087-100
description: The present study examined the effects of glutamate on the outgrowth of dendrites and axons in isolated hippocampal pyramidal-like neurons in cell culture. During the first day of culture the survival and outgrowth of these neurons was unaffected by high concentrations (up to 1 nM) of glutamate, quisqualic acid (QA), kainic acid (KA), and N-methyl-D-aspartic acid. Beginning on day 2 of culture high levels of glutamate, KA and QA were toxic to the majority of pyramidal neurons, while subtoxic levels of these agents caused a well-defined, dose-dependent, sequence of effects on dendritic outgrowth. At increasing concentrations of glutamate, QA, and KA, the following events were observed: (1) dendritic outgrowth rates were reduced, while axonal elongation rates were unaffected; (2) dendritic length was reduced, while axons continued to grow; (3) dendrites regressed dramatically, and axonal outgrowth rate was reduced. These dendrite-specific effects of glutamate were apparently mediated at the...
language: eng
source:
identifier: ISSN: 0270-6474 ; PMID: 2898515 Version:1
fulltext: fulltext
issn:
  • 02706474
  • 0270-6474
url: Link


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titleOutgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons
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identifierISSN: 0270-6474 ; PMID: 2898515 Version:1
subjectGlutamates -- Pharmacology ; Hippocampus -- Cytology ; Neurons -- Drug Effects
descriptionThe present study examined the effects of glutamate on the outgrowth of dendrites and axons in isolated hippocampal pyramidal-like neurons in cell culture. During the first day of culture the survival and outgrowth of these neurons was unaffected by high concentrations (up to 1 nM) of glutamate, quisqualic acid (QA), kainic acid (KA), and N-methyl-D-aspartic acid. Beginning on day 2 of culture high levels of glutamate, KA and QA were toxic to the majority of pyramidal neurons, while subtoxic levels of these agents caused a well-defined, dose-dependent, sequence of effects on dendritic outgrowth. At increasing concentrations of glutamate, QA, and KA, the following events were observed: (1) dendritic outgrowth rates were reduced, while axonal elongation rates were unaffected; (2) dendritic length was reduced, while axons continued to grow; (3) dendrites regressed dramatically, and axonal outgrowth rate was reduced. These dendrite-specific effects of glutamate were apparently mediated at the...
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abstractThe present study examined the effects of glutamate on the outgrowth of dendrites and axons in isolated hippocampal pyramidal-like neurons in cell culture. During the first day of culture the survival and outgrowth of these neurons was unaffected by high concentrations (up to 1 nM) of glutamate, quisqualic acid (QA), kainic acid (KA), and N-methyl-D-aspartic acid. Beginning on day 2 of culture high levels of glutamate, KA and QA were toxic to the majority of pyramidal neurons, while subtoxic levels of these agents caused a well-defined, dose-dependent, sequence of effects on dendritic outgrowth. At increasing concentrations of glutamate, QA, and KA, the following events were observed: (1) dendritic outgrowth rates were reduced, while axonal elongation rates were unaffected; (2) dendritic length was reduced, while axons continued to grow; (3) dendrites regressed dramatically, and axonal outgrowth rate was reduced. These dendrite-specific effects of glutamate were apparently mediated at the...
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