schliessen

Filtern

 

Bibliotheken

Oxalate-curcumin-based probe for micro- and macroimaging of reactive oxygen species in Alzheimer's disease

Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that has a progression that is closely associated with oxidative stress. It has long been speculated that the reactive oxygen species (ROS) level in AD brains is much higher than that in healthy brains. However, evidence from liv... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America 21 November 2017, Vol.114(47), pp.12384-12389
Main Author: Yang, Jian
Other Authors: Zhang, Xueli , Yuan, Peng , Yang, Jing , Xu, Yungen , Grutzendler, Jaime , Shao, Yihan , Moore, Anna , Ran, Chongzhao
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1091-6490 ; PMID: 29109280 Version:1 ; DOI: 10.1073/pnas.1706248114
Link: http://pubmed.gov/29109280
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: medline29109280
title: Oxalate-curcumin-based probe for micro- and macroimaging of reactive oxygen species in Alzheimer's disease
format: Article
creator:
  • Yang, Jian
  • Zhang, Xueli
  • Yuan, Peng
  • Yang, Jing
  • Xu, Yungen
  • Grutzendler, Jaime
  • Shao, Yihan
  • Moore, Anna
  • Ran, Chongzhao
subjects:
  • Alzheimer’s Disease
  • Curcumin
  • Fluorescence Imaging
  • Oxalate
  • Reactive Oxygen Species
  • Alzheimer Disease -- Diagnosis
  • Molecular Imaging -- Methods
  • Molecular Probes -- Chemistry
  • Reactive Oxygen Species -- Chemistry
ispartof: Proceedings of the National Academy of Sciences of the United States of America, 21 November 2017, Vol.114(47), pp.12384-12389
description: Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that has a progression that is closely associated with oxidative stress. It has long been speculated that the reactive oxygen species (ROS) level in AD brains is much higher than that in healthy brains. However, evidence from living beings is scarce. Inspired by the "chemistry of glow stick," we designed a near-IR fluorescence (NIRF) imaging probe, termed CRANAD-61, for sensing ROS to provide evidence at micro- and macrolevels. In CRANAD-61, an oxalate moiety was utilized to react with ROS and to consequentially produce wavelength shifting. Our in vitro data showed that CRANAD-61 was highly sensitive and rapidly responsive to various ROS. On reacting with ROS, its excitation and emission wavelengths significantly shifted to short wavelengths, and this shifting could be harnessed for dual-color two-photon imaging and transformative NIRF imaging. In this report, we showed that CRANAD-61 could be used to identify "active"...
language: eng
source:
identifier: E-ISSN: 1091-6490 ; PMID: 29109280 Version:1 ; DOI: 10.1073/pnas.1706248114
fulltext: fulltext
issn:
  • 10916490
  • 1091-6490
url: Link


@attributes
ID667539123
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid29109280
sourceidmedline
recordidTN_medline29109280
sourceformatXML
sourcesystemPC
pqid1961637835
galeid534318035
display
typearticle
titleOxalate-curcumin-based probe for micro- and macroimaging of reactive oxygen species in Alzheimer's disease
creatorYang, Jian ; Zhang, Xueli ; Yuan, Peng ; Yang, Jing ; Xu, Yungen ; Grutzendler, Jaime ; Shao, Yihan ; Moore, Anna ; Ran, Chongzhao
ispartofProceedings of the National Academy of Sciences of the United States of America, 21 November 2017, Vol.114(47), pp.12384-12389
identifier
subjectAlzheimer’s Disease ; Curcumin ; Fluorescence Imaging ; Oxalate ; Reactive Oxygen Species ; Alzheimer Disease -- Diagnosis ; Molecular Imaging -- Methods ; Molecular Probes -- Chemistry ; Reactive Oxygen Species -- Chemistry
descriptionAlzheimer's disease (AD) is an irreversible neurodegenerative disorder that has a progression that is closely associated with oxidative stress. It has long been speculated that the reactive oxygen species (ROS) level in AD brains is much higher than that in healthy brains. However, evidence from living beings is scarce. Inspired by the "chemistry of glow stick," we designed a near-IR fluorescence (NIRF) imaging probe, termed CRANAD-61, for sensing ROS to provide evidence at micro- and macrolevels. In CRANAD-61, an oxalate moiety was utilized to react with ROS and to consequentially produce wavelength shifting. Our in vitro data showed that CRANAD-61 was highly sensitive and rapidly responsive to various ROS. On reacting with ROS, its excitation and emission wavelengths significantly shifted to short wavelengths, and this shifting could be harnessed for dual-color two-photon imaging and transformative NIRF imaging. In this report, we showed that CRANAD-61 could be used to identify "active"...
languageeng
source
version5
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://pubmed.gov/29109280$$EView_this_record_in_MEDLINE/PubMed
openurlfulltext$$Topenurlfull_article
addlink$$Uhttp://exlibris-pub.s3.amazonaws.com/aboutMedline.html$$EView_the_MEDLINE/PubMed_Copyright_Statement
search
creatorcontrib
0Yang, Jian
1Zhang, Xueli
2Yuan, Peng
3Yang, Jing
4Xu, Yungen
5Grutzendler, Jaime
6Shao, Yihan
7Moore, Anna
8Ran, Chongzhao
titleOxalate-curcumin-based probe for micro- and macroimaging of reactive oxygen species in Alzheimer's disease
descriptionAlzheimer's disease (AD) is an irreversible neurodegenerative disorder that has a progression that is closely associated with oxidative stress. It has long been speculated that the reactive oxygen species (ROS) level in AD brains is much higher than that in healthy brains. However, evidence from living beings is scarce. Inspired by the "chemistry of glow stick," we designed a near-IR fluorescence (NIRF) imaging probe, termed CRANAD-61, for sensing ROS to provide evidence at micro- and macrolevels. In CRANAD-61, an oxalate moiety was utilized to react with ROS and to consequentially produce wavelength shifting. Our in vitro data showed that CRANAD-61 was highly sensitive and rapidly responsive to various ROS. On reacting with ROS, its excitation and emission wavelengths significantly shifted to short wavelengths, and this shifting could be harnessed for dual-color two-photon imaging and transformative NIRF imaging. In this report, we showed that CRANAD-61 could be used to identify "active"...
subject
0Alzheimer’s Disease
1Curcumin
2Fluorescence Imaging
3Oxalate
4Reactive Oxygen Species
5Alzheimer Disease -- Diagnosis
6Molecular Imaging -- Methods
7Molecular Probes -- Chemistry
8Reactive Oxygen Species -- Chemistry
general
029109280
1English
2MEDLINE/PubMed (U.S. National Library of Medicine)
310.1073/pnas.1706248114
4MEDLINE/PubMed (NLM)
sourceidmedline
recordidmedline29109280
issn
010916490
11091-6490
rsrctypearticle
creationdate2017
addtitleProceedings of the National Academy of Sciences of the United States of America
searchscope
0medline
1nlm_medline
2MEDLINE
scope
0medline
1nlm_medline
2MEDLINE
lsr41201721
citationpf 12384 vol 114 issue 47
startdate20171121
enddate20171121
lsr30VSR-Enriched:[galeid, pqid]
sort
titleOxalate-curcumin-based probe for micro- and macroimaging of reactive oxygen species in Alzheimer's disease
authorYang, Jian ; Zhang, Xueli ; Yuan, Peng ; Yang, Jing ; Xu, Yungen ; Grutzendler, Jaime ; Shao, Yihan ; Moore, Anna ; Ran, Chongzhao
creationdate20171121
lso0120171121
facets
frbrgroupid1594469356770976095
frbrtype5
newrecords20190701
languageeng
creationdate2017
topic
0Alzheimer’s Disease
1Curcumin
2Fluorescence Imaging
3Oxalate
4Reactive Oxygen Species
5Alzheimer Disease–Diagnosis
6Molecular Imaging–Methods
7Molecular Probes–Chemistry
8Reactive Oxygen Species–Chemistry
collectionMEDLINE/PubMed (NLM)
prefilterarticles
rsrctypearticles
creatorcontrib
0Yang, Jian
1Zhang, Xueli
2Yuan, Peng
3Yang, Jing
4Xu, Yungen
5Grutzendler, Jaime
6Shao, Yihan
7Moore, Anna
8Ran, Chongzhao
jtitleProceedings Of The National Academy Of Sciences Of The United States Of America
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Yang
1Zhang
2Yuan
3Xu
4Grutzendler
5Shao
6Moore
7Ran
aufirst
0Jian
1Xueli
2Peng
3Jing
4Yungen
5Jaime
6Yihan
7Anna
8Chongzhao
au
0Yang, Jian
1Zhang, Xueli
2Yuan, Peng
3Yang, Jing
4Xu, Yungen
5Grutzendler, Jaime
6Shao, Yihan
7Moore, Anna
8Ran, Chongzhao
atitleOxalate-curcumin-based probe for micro- and macroimaging of reactive oxygen species in Alzheimer's disease
jtitleProceedings of the National Academy of Sciences of the United States of America
risdate20171121
volume114
issue47
spage12384
pages12384-12389
issn0027-8424
eissn1091-6490
formatjournal
genrearticle
ristypeJOUR
abstractAlzheimer's disease (AD) is an irreversible neurodegenerative disorder that has a progression that is closely associated with oxidative stress. It has long been speculated that the reactive oxygen species (ROS) level in AD brains is much higher than that in healthy brains. However, evidence from living beings is scarce. Inspired by the "chemistry of glow stick," we designed a near-IR fluorescence (NIRF) imaging probe, termed CRANAD-61, for sensing ROS to provide evidence at micro- and macrolevels. In CRANAD-61, an oxalate moiety was utilized to react with ROS and to consequentially produce wavelength shifting. Our in vitro data showed that CRANAD-61 was highly sensitive and rapidly responsive to various ROS. On reacting with ROS, its excitation and emission wavelengths significantly shifted to short wavelengths, and this shifting could be harnessed for dual-color two-photon imaging and transformative NIRF imaging. In this report, we showed that CRANAD-61 could be used to identify "active"...
doi10.1073/pnas.1706248114
pmid29109280
date2017-11-21