schliessen

Filtern

 

Bibliotheken

Dietary L-serine modifies free amino acid composition of maternal milk and lowers the body weight of the offspring in mice

The growth of offspring is affected not only by the protein in maternal milk but also by the free amino acids (FAAs) contained in it. L-Serine (L-Ser) is known as an important FAA for the development of the central nervous system and behavioral activity. However, it is not clear whether L-Ser is tra... Full description

Journal Title: The Journal of veterinary medical science 09 February 2018, Vol.80(2), pp.235-241
Main Author: Nagamachi, Satsuki
Other Authors: Nishigawa, Takuma , Takakura, Mayumi , Ikeda, Hiromi , Kodaira, Momoko , Yamaguchi, Takeshi , Chowdhury, Vishwajit Sur , Yasuo, Shinobu , Furuse, Mitsuhiro
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1347-7439 ; PMID: 29269705 Version:1 ; DOI: 10.1292/jvms.17-0577
Link: http://pubmed.gov/29269705
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: medline29269705
title: Dietary L-serine modifies free amino acid composition of maternal milk and lowers the body weight of the offspring in mice
format: Article
creator:
  • Nagamachi, Satsuki
  • Nishigawa, Takuma
  • Takakura, Mayumi
  • Ikeda, Hiromi
  • Kodaira, Momoko
  • Yamaguchi, Takeshi
  • Chowdhury, Vishwajit Sur
  • Yasuo, Shinobu
  • Furuse, Mitsuhiro
subjects:
  • L-Serine
  • Free Amino Acid
  • Growth
  • Maternal Milk
  • Mouse
  • Amino Acids -- Analysis
  • Milk -- Chemistry
  • Serine -- Pharmacology
ispartof: The Journal of veterinary medical science, 09 February 2018, Vol.80(2), pp.235-241
description: The growth of offspring is affected not only by the protein in maternal milk but also by the free amino acids (FAAs) contained in it. L-Serine (L-Ser) is known as an important FAA for the development of the central nervous system and behavioral activity. However, it is not clear whether L-Ser is transported into the pool of FAAs contained in milk and thereby affects the growth of offspring. Using mice, the current study investigated the effects of dietary L-Ser during pregnancy and lactation on milk and plasma FAA composition, as well as on growth, behavior, and plasma FAAs of offspring. Dietary L-Ser did not significantly affect the maternal, anxiety-like, or cognitive behaviors of either the dam or the offspring. The FAA composition notably differed between plasma and milk in dams. In milk, dietary L-Ser increased free L-Ser levels, while glutamic acid, L-alanine, D-alanine and taurine levels were decreased. The body weight of the offspring was lowered by dietary L-Ser. The concentrations of plasma FAAs in 13-day-old offspring (fed only milk) were not altered, but 20-day-old offspring (fed both milk and parental diet) showed higher plasma L-Ser and D-Ser concentrations as a result of the dietary L-Ser treatment. In conclusion, the present study found that dietary L-Ser transported easily from maternal plasma to milk and that dietary L-Ser treatment could change the FAA composition of milk, but that an enhanced level of L-Ser in milk did not enhance the plasma L-Ser level in the offspring.
language: eng
source:
identifier: E-ISSN: 1347-7439 ; PMID: 29269705 Version:1 ; DOI: 10.1292/jvms.17-0577
fulltext: fulltext
issn:
  • 13477439
  • 1347-7439
url: Link


@attributes
ID1273750336
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid29269705
sourceidmedline
recordidTN_medline29269705
sourceformatXML
sourcesystemOther
pqid1979965366
display
typearticle
titleDietary L-serine modifies free amino acid composition of maternal milk and lowers the body weight of the offspring in mice
creatorNagamachi, Satsuki ; Nishigawa, Takuma ; Takakura, Mayumi ; Ikeda, Hiromi ; Kodaira, Momoko ; Yamaguchi, Takeshi ; Chowdhury, Vishwajit Sur ; Yasuo, Shinobu ; Furuse, Mitsuhiro
ispartofThe Journal of veterinary medical science, 09 February 2018, Vol.80(2), pp.235-241
identifier
subjectL-Serine ; Free Amino Acid ; Growth ; Maternal Milk ; Mouse ; Amino Acids -- Analysis ; Milk -- Chemistry ; Serine -- Pharmacology
descriptionThe growth of offspring is affected not only by the protein in maternal milk but also by the free amino acids (FAAs) contained in it. L-Serine (L-Ser) is known as an important FAA for the development of the central nervous system and behavioral activity. However, it is not clear whether L-Ser is transported into the pool of FAAs contained in milk and thereby affects the growth of offspring. Using mice, the current study investigated the effects of dietary L-Ser during pregnancy and lactation on milk and plasma FAA composition, as well as on growth, behavior, and plasma FAAs of offspring. Dietary L-Ser did not significantly affect the maternal, anxiety-like, or cognitive behaviors of either the dam or the offspring. The FAA composition notably differed between plasma and milk in dams. In milk, dietary L-Ser increased free L-Ser levels, while glutamic acid, L-alanine, D-alanine and taurine levels were decreased. The body weight of the offspring was lowered by dietary L-Ser. The concentrations of plasma FAAs in 13-day-old offspring (fed only milk) were not altered, but 20-day-old offspring (fed both milk and parental diet) showed higher plasma L-Ser and D-Ser concentrations as a result of the dietary L-Ser treatment. In conclusion, the present study found that dietary L-Ser transported easily from maternal plasma to milk and that dietary L-Ser treatment could change the FAA composition of milk, but that an enhanced level of L-Ser in milk did not enhance the plasma L-Ser level in the offspring.
languageeng
source
version7
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://pubmed.gov/29269705$$EView_this_record_in_MEDLINE/PubMed
openurlfulltext$$Topenurlfull_article
addlink$$Uhttp://exlibris-pub.s3.amazonaws.com/aboutMedline.html$$EView_the_MEDLINE/PubMed_Copyright_Statement
search
creatorcontrib
0Nagamachi, Satsuki
1Nishigawa, Takuma
2Takakura, Mayumi
3Ikeda, Hiromi
4Kodaira, Momoko
5Yamaguchi, Takeshi
6Chowdhury, Vishwajit Sur
7Yasuo, Shinobu
8Furuse, Mitsuhiro
titleDietary L-serine modifies free amino acid composition of maternal milk and lowers the body weight of the offspring in mice
descriptionThe growth of offspring is affected not only by the protein in maternal milk but also by the free amino acids (FAAs) contained in it. L-Serine (L-Ser) is known as an important FAA for the development of the central nervous system and behavioral activity. However, it is not clear whether L-Ser is transported into the pool of FAAs contained in milk and thereby affects the growth of offspring. Using mice, the current study investigated the effects of dietary L-Ser during pregnancy and lactation on milk and plasma FAA composition, as well as on growth, behavior, and plasma FAAs of offspring. Dietary L-Ser did not significantly affect the maternal, anxiety-like, or cognitive behaviors of either the dam or the offspring. The FAA composition notably differed between plasma and milk in dams. In milk, dietary L-Ser increased free L-Ser levels, while glutamic acid, L-alanine, D-alanine and taurine levels were decreased. The body weight of the offspring was lowered by dietary L-Ser. The concentrations of plasma FAAs in 13-day-old offspring (fed only milk) were not altered, but 20-day-old offspring (fed both milk and parental diet) showed higher plasma L-Ser and D-Ser concentrations as a result of the dietary L-Ser treatment. In conclusion, the present study found that dietary L-Ser transported easily from maternal plasma to milk and that dietary L-Ser treatment could change the FAA composition of milk, but that an enhanced level of L-Ser in milk did not enhance the plasma L-Ser level in the offspring.
subject
0L-Serine
1Free Amino Acid
2Growth
3Maternal Milk
4Mouse
5Amino Acids -- Analysis
6Milk -- Chemistry
7Serine -- Pharmacology
general
029269705
1English
2MEDLINE/PubMed (U.S. National Library of Medicine)
310.1292/jvms.17-0577
4MEDLINE/PubMed (NLM)
sourceidmedline
recordidmedline29269705
issn
013477439
11347-7439
rsrctypearticle
creationdate2018
addtitleThe Journal of veterinary medical science
searchscope
0medline
1nlm_medline
2MEDLINE
scope
0medline
1nlm_medline
2MEDLINE
lsr4120180209
citationpf 235 vol 80 issue 2
startdate20180209
enddate20180209
lsr30VSR-Enriched:[issn, pqid]
sort
titleDietary L-serine modifies free amino acid composition of maternal milk and lowers the body weight of the offspring in mice
authorNagamachi, Satsuki ; Nishigawa, Takuma ; Takakura, Mayumi ; Ikeda, Hiromi ; Kodaira, Momoko ; Yamaguchi, Takeshi ; Chowdhury, Vishwajit Sur ; Yasuo, Shinobu ; Furuse, Mitsuhiro
creationdate20180209
lso0120180209
facets
frbrgroupid-2343681073777935316
frbrtype5
newrecords20190701
languageeng
creationdate2018
topic
0L-Serine
1Free Amino Acid
2Growth
3Maternal Milk
4Mouse
5Amino Acids–Analysis
6Milk–Chemistry
7Serine–Pharmacology
collectionMEDLINE/PubMed (NLM)
prefilterarticles
rsrctypearticles
creatorcontrib
0Nagamachi, Satsuki
1Nishigawa, Takuma
2Takakura, Mayumi
3Ikeda, Hiromi
4Kodaira, Momoko
5Yamaguchi, Takeshi
6Chowdhury, Vishwajit Sur
7Yasuo, Shinobu
8Furuse, Mitsuhiro
jtitleJournal Of Veterinary Medical Science
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Nagamachi
1Nishigawa
2Takakura
3Ikeda
4Kodaira
5Yamaguchi
6Chowdhury
7Yasuo
8Furuse
aufirst
0Satsuki
1Takuma
2Mayumi
3Hiromi
4Momoko
5Takeshi
6Vishwajit Sur
7Shinobu
8Mitsuhiro
au
0Nagamachi, Satsuki
1Nishigawa, Takuma
2Takakura, Mayumi
3Ikeda, Hiromi
4Kodaira, Momoko
5Yamaguchi, Takeshi
6Chowdhury, Vishwajit Sur
7Yasuo, Shinobu
8Furuse, Mitsuhiro
atitleDietary L-serine modifies free amino acid composition of maternal milk and lowers the body weight of the offspring in mice
jtitleThe Journal of veterinary medical science
risdate20180209
volume80
issue2
spage235
pages235-241
eissn1347-7439
formatjournal
genrearticle
ristypeJOUR
abstractThe growth of offspring is affected not only by the protein in maternal milk but also by the free amino acids (FAAs) contained in it. L-Serine (L-Ser) is known as an important FAA for the development of the central nervous system and behavioral activity. However, it is not clear whether L-Ser is transported into the pool of FAAs contained in milk and thereby affects the growth of offspring. Using mice, the current study investigated the effects of dietary L-Ser during pregnancy and lactation on milk and plasma FAA composition, as well as on growth, behavior, and plasma FAAs of offspring. Dietary L-Ser did not significantly affect the maternal, anxiety-like, or cognitive behaviors of either the dam or the offspring. The FAA composition notably differed between plasma and milk in dams. In milk, dietary L-Ser increased free L-Ser levels, while glutamic acid, L-alanine, D-alanine and taurine levels were decreased. The body weight of the offspring was lowered by dietary L-Ser. The concentrations of plasma FAAs in 13-day-old offspring (fed only milk) were not altered, but 20-day-old offspring (fed both milk and parental diet) showed higher plasma L-Ser and D-Ser concentrations as a result of the dietary L-Ser treatment. In conclusion, the present study found that dietary L-Ser transported easily from maternal plasma to milk and that dietary L-Ser treatment could change the FAA composition of milk, but that an enhanced level of L-Ser in milk did not enhance the plasma L-Ser level in the offspring.
doi10.1292/jvms.17-0577
pmid29269705
issn09167250
oafree_for_read
date2018-02-09