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Sex- and bone-specific responses in bone structure to exogenous leptin and leptin receptor antagonism in the ovine fetus

Widespread expression of leptin and its receptor in developing cartilage and bone suggests that leptin may regulate bone growth and development in the fetus. Using microcomputed tomography, this study investigated the effects of exogenous leptin and leptin receptor antagonism on aspects of bone stru... Full description

Journal Title: American journal of physiology. Regulatory integrative and comparative physiology, 01 June 2018, Vol.314(6), pp.R781-R790
Main Author: De Blasio, Miles J
Other Authors: Lanham, Stuart A , Blache, Dominique , Oreffo, Richard O C , Fowden, Abigail L , Forhead, Alison J
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1522-1490 ; PMID: 29443548 Version:1 ; DOI: 10.1152/ajpregu.00351.2017
Link: http://pubmed.gov/29443548
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recordid: medline29443548
title: Sex- and bone-specific responses in bone structure to exogenous leptin and leptin receptor antagonism in the ovine fetus
format: Article
creator:
  • De Blasio, Miles J
  • Lanham, Stuart A
  • Blache, Dominique
  • Oreffo, Richard O C
  • Fowden, Abigail L
  • Forhead, Alison J
subjects:
  • Femur
  • Metatarsal
  • Vertebra
  • Bone and Bones -- Drug Effects
  • Fetus -- Drug Effects
  • Leptin -- Pharmacology
  • Receptors, Leptin -- Antagonists & Inhibitors
ispartof: American journal of physiology. Regulatory, integrative and comparative physiology, 01 June 2018, Vol.314(6), pp.R781-R790
description: Widespread expression of leptin and its receptor in developing cartilage and bone suggests that leptin may regulate bone growth and development in the fetus. Using microcomputed tomography, this study investigated the effects of exogenous leptin and leptin receptor antagonism on aspects of bone structure in the sheep fetus during late gestation. From 125 to 130 days of gestation (term ~145 days), chronically catheterized singleton sheep fetuses were infused intravenously for 5 days with either saline (0.9% saline, n = 13), recombinant ovine leptin at two doses (0.6 mg·kg·day LEP1, n = 10 or 1.4 mg·kg·day LEP2, n = 7), or recombinant superactive ovine leptin receptor antagonist (4.6 mg·kg·day SOLA, n = 6). No significant differences in plasma insulin-like growth factor-I, osteocalcin, calcium, inorganic phosphate, or alkaline phosphatase were observed between treatment groups. Total femur midshaft diameter and metatarsal lumen diameter were narrower in male fetuses treated with exogenous...
language: eng
source:
identifier: E-ISSN: 1522-1490 ; PMID: 29443548 Version:1 ; DOI: 10.1152/ajpregu.00351.2017
fulltext: fulltext
issn:
  • 15221490
  • 1522-1490
url: Link


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titleSex- and bone-specific responses in bone structure to exogenous leptin and leptin receptor antagonism in the ovine fetus
creatorDe Blasio, Miles J ; Lanham, Stuart A ; Blache, Dominique ; Oreffo, Richard O C ; Fowden, Abigail L ; Forhead, Alison J
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subjectFemur ; Metatarsal ; Vertebra ; Bone and Bones -- Drug Effects ; Fetus -- Drug Effects ; Leptin -- Pharmacology ; Receptors, Leptin -- Antagonists & Inhibitors
descriptionWidespread expression of leptin and its receptor in developing cartilage and bone suggests that leptin may regulate bone growth and development in the fetus. Using microcomputed tomography, this study investigated the effects of exogenous leptin and leptin receptor antagonism on aspects of bone structure in the sheep fetus during late gestation. From 125 to 130 days of gestation (term ~145 days), chronically catheterized singleton sheep fetuses were infused intravenously for 5 days with either saline (0.9% saline, n = 13), recombinant ovine leptin at two doses (0.6 mg·kg·day LEP1, n = 10 or 1.4 mg·kg·day LEP2, n = 7), or recombinant superactive ovine leptin receptor antagonist (4.6 mg·kg·day SOLA, n = 6). No significant differences in plasma insulin-like growth factor-I, osteocalcin, calcium, inorganic phosphate, or alkaline phosphatase were observed between treatment groups. Total femur midshaft diameter and metatarsal lumen diameter were narrower in male fetuses treated with exogenous...
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descriptionWidespread expression of leptin and its receptor in developing cartilage and bone suggests that leptin may regulate bone growth and development in the fetus. Using microcomputed tomography, this study investigated the effects of exogenous leptin and leptin receptor antagonism on aspects of bone structure in the sheep fetus during late gestation. From 125 to 130 days of gestation (term ~145 days), chronically catheterized singleton sheep fetuses were infused intravenously for 5 days with either saline (0.9% saline, n = 13), recombinant ovine leptin at two doses (0.6 mg·kg·day LEP1, n = 10 or 1.4 mg·kg·day LEP2, n = 7), or recombinant superactive ovine leptin receptor antagonist (4.6 mg·kg·day SOLA, n = 6). No significant differences in plasma insulin-like growth factor-I, osteocalcin, calcium, inorganic phosphate, or alkaline phosphatase were observed between treatment groups. Total femur midshaft diameter and metatarsal lumen diameter were narrower in male fetuses treated with exogenous...
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abstractWidespread expression of leptin and its receptor in developing cartilage and bone suggests that leptin may regulate bone growth and development in the fetus. Using microcomputed tomography, this study investigated the effects of exogenous leptin and leptin receptor antagonism on aspects of bone structure in the sheep fetus during late gestation. From 125 to 130 days of gestation (term ~145 days), chronically catheterized singleton sheep fetuses were infused intravenously for 5 days with either saline (0.9% saline, n = 13), recombinant ovine leptin at two doses (0.6 mg·kg·day LEP1, n = 10 or 1.4 mg·kg·day LEP2, n = 7), or recombinant superactive ovine leptin receptor antagonist (4.6 mg·kg·day SOLA, n = 6). No significant differences in plasma insulin-like growth factor-I, osteocalcin, calcium, inorganic phosphate, or alkaline phosphatase were observed between treatment groups. Total femur midshaft diameter and metatarsal lumen diameter were narrower in male fetuses treated with exogenous...
doi10.1152/ajpregu.00351.2017
pmid29443548
date2018-06-01