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Chitosan-based liposomal thermogels for the controlled delivery of pingyangmycin: design, optimization and in vitro and in vivo studies

Pingyangmycin (PYM) has been applied clinically for many years to treat vascular malformations (VM) in China. The major limitation of PYM injections is quick diffusion from the injection site, which increases side effects, especially the possibility of pulmonary injury. In this paper, chitosan/glyce... Full description

Journal Title: Drug delivery November 2018, Vol.25(1), pp.690-702
Main Author: Zhang, Ling
Other Authors: Chen, Fen , Zheng, Jiatong , Wang, Hongwei , Qin, Xingjun , Pan, Weisan
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1521-0464 ; PMID: 29484910 Version:1 ; DOI: 10.1080/10717544.2018.1444684
Link: http://pubmed.gov/29484910
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recordid: medline29484910
title: Chitosan-based liposomal thermogels for the controlled delivery of pingyangmycin: design, optimization and in vitro and in vivo studies
format: Article
creator:
  • Zhang, Ling
  • Chen, Fen
  • Zheng, Jiatong
  • Wang, Hongwei
  • Qin, Xingjun
  • Pan, Weisan
subjects:
  • Box-Behnken
  • Pingyangmycin
  • Chitosan
  • Liposomal Thermogels
  • Optimization
  • Bleomycin -- Analogs & Derivatives
  • Chitosan -- Chemistry
  • Delayed-Action Preparations -- Administration & Dosage
  • Liposomes -- Chemistry
ispartof: Drug delivery, November 2018, Vol.25(1), pp.690-702
description: Pingyangmycin (PYM) has been applied clinically for many years to treat vascular malformations (VM) in China. The major limitation of PYM injections is quick diffusion from the injection site, which increases side effects, especially the possibility of pulmonary injury. In this paper, chitosan/glycerophosphate disodium (CS/GP) thermogels containing liposomes for sustained and localized PYM delivery were prepared and optimized by a three-level three-factorial Box-Behnken experimental design to evaluate the effects of different variables (the PYM concentration, CS amount and GP content), on the selected responses (cumulative percentage PYM released in 1 day, 9 days and the rate constant k). The results revealed that the optimized PYM liposomal thermogels had a controlled PYM release for 14 days in vitro, which confirmed the validity of optimization. In vitro morphological observation, cell cycle and apoptosis analysis showed an effective anti-proliferation action of PYM liposomal thermogels...
language: eng
source:
identifier: E-ISSN: 1521-0464 ; PMID: 29484910 Version:1 ; DOI: 10.1080/10717544.2018.1444684
fulltext: fulltext
issn:
  • 15210464
  • 1521-0464
url: Link


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titleChitosan-based liposomal thermogels for the controlled delivery of pingyangmycin: design, optimization and in vitro and in vivo studies
creatorZhang, Ling ; Chen, Fen ; Zheng, Jiatong ; Wang, Hongwei ; Qin, Xingjun ; Pan, Weisan
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subjectBox-Behnken ; Pingyangmycin ; Chitosan ; Liposomal Thermogels ; Optimization ; Bleomycin -- Analogs & Derivatives ; Chitosan -- Chemistry ; Delayed-Action Preparations -- Administration & Dosage ; Liposomes -- Chemistry
descriptionPingyangmycin (PYM) has been applied clinically for many years to treat vascular malformations (VM) in China. The major limitation of PYM injections is quick diffusion from the injection site, which increases side effects, especially the possibility of pulmonary injury. In this paper, chitosan/glycerophosphate disodium (CS/GP) thermogels containing liposomes for sustained and localized PYM delivery were prepared and optimized by a three-level three-factorial Box-Behnken experimental design to evaluate the effects of different variables (the PYM concentration, CS amount and GP content), on the selected responses (cumulative percentage PYM released in 1 day, 9 days and the rate constant k). The results revealed that the optimized PYM liposomal thermogels had a controlled PYM release for 14 days in vitro, which confirmed the validity of optimization. In vitro morphological observation, cell cycle and apoptosis analysis showed an effective anti-proliferation action of PYM liposomal thermogels...
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abstractPingyangmycin (PYM) has been applied clinically for many years to treat vascular malformations (VM) in China. The major limitation of PYM injections is quick diffusion from the injection site, which increases side effects, especially the possibility of pulmonary injury. In this paper, chitosan/glycerophosphate disodium (CS/GP) thermogels containing liposomes for sustained and localized PYM delivery were prepared and optimized by a three-level three-factorial Box-Behnken experimental design to evaluate the effects of different variables (the PYM concentration, CS amount and GP content), on the selected responses (cumulative percentage PYM released in 1 day, 9 days and the rate constant k). The results revealed that the optimized PYM liposomal thermogels had a controlled PYM release for 14 days in vitro, which confirmed the validity of optimization. In vitro morphological observation, cell cycle and apoptosis analysis showed an effective anti-proliferation action of PYM liposomal thermogels...
doi10.1080/10717544.2018.1444684
pmid29484910
date2018-11