schliessen

Filtern

 

Bibliotheken

DEC2 modulates orexin expression and regulates sleep

Adequate sleep is essential for physical and mental health. We previously identified a missense mutation in the human gene () leading to the familial natural short sleep behavioral trait. DEC2 is a transcription factor regulating the circadian clock in mammals, although its role in sleep regulation... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America 27 March 2018, Vol.115(13), pp.3434-3439
Main Author: Hirano, Arisa
Other Authors: Hsu, Pei-Ken , Zhang, Luoying , Xing, Lijuan , Mcmahon, Thomas , Yamazaki, Maya , Ptáček, Louis J , Fu, Ying-Hui
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1091-6490 ; PMID: 29531056 Version:1 ; DOI: 10.1073/pnas.1801693115
Link: http://pubmed.gov/29531056
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: medline29531056
title: DEC2 modulates orexin expression and regulates sleep
format: Article
creator:
  • Hirano, Arisa
  • Hsu, Pei-Ken
  • Zhang, Luoying
  • Xing, Lijuan
  • Mcmahon, Thomas
  • Yamazaki, Maya
  • Ptáček, Louis J
  • Fu, Ying-Hui
subjects:
  • Behavior
  • Genetics
  • Mouse Model
  • Sleep
  • Gene Expression Regulation
  • Mutation
  • Promoter Regions, Genetic
  • Basic Helix-Loop-Helix Transcription Factors -- Genetics
  • Orexins -- Genetics
  • Sleep -- Physiology
ispartof: Proceedings of the National Academy of Sciences of the United States of America, 27 March 2018, Vol.115(13), pp.3434-3439
description: Adequate sleep is essential for physical and mental health. We previously identified a missense mutation in the human gene () leading to the familial natural short sleep behavioral trait. DEC2 is a transcription factor regulating the circadian clock in mammals, although its role in sleep regulation has been unclear. Here we report that , also known as (), gene expression is increased in the mouse model expressing the mutant h transgene (h). encodes a precursor protein of a neuropeptide producing orexin A and B (hcrt1 and hcrt2), which is enriched in the hypothalamus and regulates maintenance of arousal. In cell culture, DEC2 suppressed () expression through -acting E-box elements. The mutant DEC2 has less repressor activity than WT-DEC2, resulting in increased orexin expression. DEC2-binding affinity for the gene promoter is decreased by the P384R mutation, likely due to weakened interaction with other transcription factors. In vivo, the decreased immobility time of the mutant transgenic...
language: eng
source:
identifier: E-ISSN: 1091-6490 ; PMID: 29531056 Version:1 ; DOI: 10.1073/pnas.1801693115
fulltext: fulltext
issn:
  • 10916490
  • 1091-6490
url: Link


@attributes
ID49526679
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid29531056
sourceidmedline
recordidTN_medline29531056
sourceformatXML
sourcesystemPC
pqid2101331791
galeid535824870
display
typearticle
titleDEC2 modulates orexin expression and regulates sleep
creatorHirano, Arisa ; Hsu, Pei-Ken ; Zhang, Luoying ; Xing, Lijuan ; Mcmahon, Thomas ; Yamazaki, Maya ; Ptáček, Louis J ; Fu, Ying-Hui
ispartofProceedings of the National Academy of Sciences of the United States of America, 27 March 2018, Vol.115(13), pp.3434-3439
identifier
subjectBehavior ; Genetics ; Mouse Model ; Sleep ; Gene Expression Regulation ; Mutation ; Promoter Regions, Genetic ; Basic Helix-Loop-Helix Transcription Factors -- Genetics ; Orexins -- Genetics ; Sleep -- Physiology
descriptionAdequate sleep is essential for physical and mental health. We previously identified a missense mutation in the human gene () leading to the familial natural short sleep behavioral trait. DEC2 is a transcription factor regulating the circadian clock in mammals, although its role in sleep regulation has been unclear. Here we report that , also known as (), gene expression is increased in the mouse model expressing the mutant h transgene (h). encodes a precursor protein of a neuropeptide producing orexin A and B (hcrt1 and hcrt2), which is enriched in the hypothalamus and regulates maintenance of arousal. In cell culture, DEC2 suppressed () expression through -acting E-box elements. The mutant DEC2 has less repressor activity than WT-DEC2, resulting in increased orexin expression. DEC2-binding affinity for the gene promoter is decreased by the P384R mutation, likely due to weakened interaction with other transcription factors. In vivo, the decreased immobility time of the mutant transgenic...
languageeng
source
version5
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://pubmed.gov/29531056$$EView_this_record_in_MEDLINE/PubMed
openurlfulltext$$Topenurlfull_article
addlink$$Uhttp://exlibris-pub.s3.amazonaws.com/aboutMedline.html$$EView_the_MEDLINE/PubMed_Copyright_Statement
search
creatorcontrib
0Hirano, Arisa
1Hsu, Pei-Ken
2Zhang, Luoying
3Xing, Lijuan
4McMahon, Thomas
5Yamazaki, Maya
6Ptáček, Louis J
7Fu, Ying-Hui
titleDEC2 modulates orexin expression and regulates sleep
descriptionAdequate sleep is essential for physical and mental health. We previously identified a missense mutation in the human gene () leading to the familial natural short sleep behavioral trait. DEC2 is a transcription factor regulating the circadian clock in mammals, although its role in sleep regulation has been unclear. Here we report that , also known as (), gene expression is increased in the mouse model expressing the mutant h transgene (h). encodes a precursor protein of a neuropeptide producing orexin A and B (hcrt1 and hcrt2), which is enriched in the hypothalamus and regulates maintenance of arousal. In cell culture, DEC2 suppressed () expression through -acting E-box elements. The mutant DEC2 has less repressor activity than WT-DEC2, resulting in increased orexin expression. DEC2-binding affinity for the gene promoter is decreased by the P384R mutation, likely due to weakened interaction with other transcription factors. In vivo, the decreased immobility time of the mutant transgenic...
subject
0Behavior
1Genetics
2Mouse Model
3Sleep
4Gene Expression Regulation
5Mutation
6Promoter Regions, Genetic
7Basic Helix-Loop-Helix Transcription Factors -- Genetics
8Orexins -- Genetics
9Sleep -- Physiology
general
029531056
1English
2MEDLINE/PubMed (U.S. National Library of Medicine)
310.1073/pnas.1801693115
4MEDLINE/PubMed (NLM)
sourceidmedline
recordidmedline29531056
issn
010916490
11091-6490
rsrctypearticle
creationdate2018
addtitleProceedings of the National Academy of Sciences of the United States of America
searchscope
0medline
1nlm_medline
2MEDLINE
scope
0medline
1nlm_medline
2MEDLINE
lsr41201827
citationpf 3434 vol 115 issue 13
startdate20180327
enddate20180327
lsr30VSR-Enriched:[pqid, galeid]
sort
titleDEC2 modulates orexin expression and regulates sleep
authorHirano, Arisa ; Hsu, Pei-Ken ; Zhang, Luoying ; Xing, Lijuan ; Mcmahon, Thomas ; Yamazaki, Maya ; Ptáček, Louis J ; Fu, Ying-Hui
creationdate20180327
lso0120180327
facets
frbrgroupid6604302705458167632
frbrtype5
newrecords20190701
languageeng
creationdate2018
topic
0Behavior
1Genetics
2Mouse Model
3Sleep
4Gene Expression Regulation
5Mutation
6Promoter Regions, Genetic
7Basic Helix-Loop-Helix Transcription Factors–Genetics
8Orexins–Genetics
9Sleep–Physiology
collectionMEDLINE/PubMed (NLM)
prefilterarticles
rsrctypearticles
creatorcontrib
0Hirano, Arisa
1Hsu, Pei-Ken
2Zhang, Luoying
3Xing, Lijuan
4Mcmahon, Thomas
5Yamazaki, Maya
6Ptáček, Louis J
7Fu, Ying-Hui
jtitleProceedings Of The National Academy Of Sciences Of The United States Of America
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Hirano
1Hsu
2Zhang
3Xing
4Mcmahon
5Yamazaki
6Ptáček
7Fu
aufirst
0Arisa
1Pei-Ken
2Luoying
3Lijuan
4Thomas
5Maya
6Louis J
7Ying-Hui
au
0Hirano, Arisa
1Hsu, Pei-Ken
2Zhang, Luoying
3Xing, Lijuan
4Mcmahon, Thomas
5Yamazaki, Maya
6Ptáček, Louis J
7Fu, Ying-Hui
atitleDEC2 modulates orexin expression and regulates sleep
jtitleProceedings of the National Academy of Sciences of the United States of America
risdate20180327
volume115
issue13
spage3434
pages3434-3439
issn0027-8424
eissn1091-6490
formatjournal
genrearticle
ristypeJOUR
abstractAdequate sleep is essential for physical and mental health. We previously identified a missense mutation in the human gene () leading to the familial natural short sleep behavioral trait. DEC2 is a transcription factor regulating the circadian clock in mammals, although its role in sleep regulation has been unclear. Here we report that , also known as (), gene expression is increased in the mouse model expressing the mutant h transgene (h). encodes a precursor protein of a neuropeptide producing orexin A and B (hcrt1 and hcrt2), which is enriched in the hypothalamus and regulates maintenance of arousal. In cell culture, DEC2 suppressed () expression through -acting E-box elements. The mutant DEC2 has less repressor activity than WT-DEC2, resulting in increased orexin expression. DEC2-binding affinity for the gene promoter is decreased by the P384R mutation, likely due to weakened interaction with other transcription factors. In vivo, the decreased immobility time of the mutant transgenic...
doi10.1073/pnas.1801693115
pmid29531056
date2018-03-27