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Aberrant status and clinicopathologic characteristic associations of 11 target genes in 1,321 Chinese patients with lung adenocarcinoma

The aberrant status of target genes and their associations with clinicopathologic characteristics are still unclear in primary lung adenocarcinoma. The common mutations and translocations of nine target genes were evaluated in 1,247 specimens of surgically-resected primary lung adenocarcinoma. Immun... Full description

Journal Title: Journal of thoracic disease January 2018, Vol.10(1), pp.398-407
Main Author: Zhao, Mengnan
Other Authors: Zhan, Cheng , Li, Ming , Yang, Xiaodong , Yang, Xinyu , Zhang, Yong , Lin, Miao , Xia, Yifeng , Feng, Mingxiang , Wang, Qun
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 2072-1439 ; PMID: 29600072 Version:1 ; DOI: 10.21037/jtd.2017.12.68
Link: http://pubmed.gov/29600072
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recordid: medline29600072
title: Aberrant status and clinicopathologic characteristic associations of 11 target genes in 1,321 Chinese patients with lung adenocarcinoma
format: Article
creator:
  • Zhao, Mengnan
  • Zhan, Cheng
  • Li, Ming
  • Yang, Xiaodong
  • Yang, Xinyu
  • Zhang, Yong
  • Lin, Miao
  • Xia, Yifeng
  • Feng, Mingxiang
  • Wang, Qun
subjects:
  • Lung Adenocarcinoma
  • Epidermal Growth Factor Receptor (Egfr)
  • Human Epidermal Growth Factor Receptor 2 (Her2)
  • Programmed Death-1 (PD-1)/Programmed Death-Ligand 1 (PD-L1)
  • V-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (Kras)
ispartof: Journal of thoracic disease, January 2018, Vol.10(1), pp.398-407
description: The aberrant status of target genes and their associations with clinicopathologic characteristics are still unclear in primary lung adenocarcinoma. The common mutations and translocations of nine target genes were evaluated in 1,247 specimens of surgically-resected primary lung adenocarcinoma. Immunohistochemistry was used to analyze the expressions of programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) in 731 specimens. The frequency of the aberrations and their associations with clinicopathologic characteristics were analyzed. Overall, 952 (76.3%) of 1,247 patients harbored at least one target mutation or translocation: epidermal growth factor receptor () (729, 58.5%), v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog () (83, 6.7%), human epidermal growth factor receptor 2 () (82, 6.6%), anaplastic lymphoma kinase ( (23, 1.8%), phosphoinositide-3-kinase catalytic alpha polypeptide () (20, 1.6%), Ret proto-oncogene (15, 1.2%), ROS proto-oncogene 1 receptor tyrosine kinase () (12, 1.0%), B-raf proto-oncogene () (9, 0.7%), neuroblastoma RAS viral (v-ras) oncogene homolog () (3, 0.2%). Fourteen (1.9%) of 731 patients were PD-1 positive and 95 (13.0%) were PD-L1 positive in tumor cells. In men and smokers, there were more frequent mutations (both P
language: eng
source:
identifier: ISSN: 2072-1439 ; PMID: 29600072 Version:1 ; DOI: 10.21037/jtd.2017.12.68
fulltext: fulltext
issn:
  • 20721439
  • 2072-1439
url: Link


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titleAberrant status and clinicopathologic characteristic associations of 11 target genes in 1,321 Chinese patients with lung adenocarcinoma
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subjectLung Adenocarcinoma ; Epidermal Growth Factor Receptor (Egfr) ; Human Epidermal Growth Factor Receptor 2 (Her2) ; Programmed Death-1 (PD-1)/Programmed Death-Ligand 1 (PD-L1) ; V-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (Kras)
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titleAberrant status and clinicopathologic characteristic associations of 11 target genes in 1,321 Chinese patients with lung adenocarcinoma
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abstractThe aberrant status of target genes and their associations with clinicopathologic characteristics are still unclear in primary lung adenocarcinoma.
doi10.21037/jtd.2017.12.68
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