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MicroRNA-18a inhibits cell growth and induces apoptosis in osteosarcoma by targeting MED27

Osteosarcoma (OS) is a common malignant primary bone tumor and patients with OS are known to have a poor response to chemotherapy. MicroRNAs (miRNAs or miRs) are small non-coding RNA molecules (approximately 22 nucleotides in length) and they have recently become a topic for research as regards thei... Full description

Journal Title: International journal of oncology July 2018, Vol.53(1), pp.329-338
Main Author: Ding, Jing
Other Authors: Sha, Lin , Shen, Pinquan , Huang, Man , Cai, Qixun , Li, Jiyu
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1791-2423 ; PMID: 29693135 Version:1 ; DOI: 10.3892/ijo.2018.4374
Link: http://pubmed.gov/29693135
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recordid: medline29693135
title: MicroRNA-18a inhibits cell growth and induces apoptosis in osteosarcoma by targeting MED27
format: Article
creator:
  • Ding, Jing
  • Sha, Lin
  • Shen, Pinquan
  • Huang, Man
  • Cai, Qixun
  • Li, Jiyu
subjects:
  • Cell Proliferation -- Genetics
  • Mediator Complex -- Genetics
  • Micrornas -- Genetics
  • Osteosarcoma -- Genetics
ispartof: International journal of oncology, July 2018, Vol.53(1), pp.329-338
description: Osteosarcoma (OS) is a common malignant primary bone tumor and patients with OS are known to have a poor response to chemotherapy. MicroRNAs (miRNAs or miRs) are small non-coding RNA molecules (approximately 22 nucleotides in length) and they have recently become a topic for research as regards their role in cancer therapeutics. Previous studies have reported miR‑18a expression in patients with OS is significantly decreased compared with that in normal adjacent tissue. miR‑18a belongs to the miR‑17‑92 cluster encoded by the host gene MIR17HG. However, the detailed role of miR‑18a in OS remains to be determined. In this study, we demonstrated that miR‑18a mimics inhibited MG63 and Saos‑2 cell viability and migration. In addition, flow cytometry assay revealed that miR‑18a induced OS cell apoptosis. Western blot analysis indicated that the expression levels of Bcl‑2 and p‑Akt were downregulated, while the levels of cleaved caspase‑3 and Bax proteins were upregulated by miR‑18a. Moreover,...
language: eng
source:
identifier: E-ISSN: 1791-2423 ; PMID: 29693135 Version:1 ; DOI: 10.3892/ijo.2018.4374
fulltext: fulltext
issn:
  • 17912423
  • 1791-2423
url: Link


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titleMicroRNA-18a inhibits cell growth and induces apoptosis in osteosarcoma by targeting MED27
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subjectCell Proliferation -- Genetics ; Mediator Complex -- Genetics ; Micrornas -- Genetics ; Osteosarcoma -- Genetics
descriptionOsteosarcoma (OS) is a common malignant primary bone tumor and patients with OS are known to have a poor response to chemotherapy. MicroRNAs (miRNAs or miRs) are small non-coding RNA molecules (approximately 22 nucleotides in length) and they have recently become a topic for research as regards their role in cancer therapeutics. Previous studies have reported miR‑18a expression in patients with OS is significantly decreased compared with that in normal adjacent tissue. miR‑18a belongs to the miR‑17‑92 cluster encoded by the host gene MIR17HG. However, the detailed role of miR‑18a in OS remains to be determined. In this study, we demonstrated that miR‑18a mimics inhibited MG63 and Saos‑2 cell viability and migration. In addition, flow cytometry assay revealed that miR‑18a induced OS cell apoptosis. Western blot analysis indicated that the expression levels of Bcl‑2 and p‑Akt were downregulated, while the levels of cleaved caspase‑3 and Bax proteins were upregulated by miR‑18a. Moreover,...
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descriptionOsteosarcoma (OS) is a common malignant primary bone tumor and patients with OS are known to have a poor response to chemotherapy. MicroRNAs (miRNAs or miRs) are small non-coding RNA molecules (approximately 22 nucleotides in length) and they have recently become a topic for research as regards their role in cancer therapeutics. Previous studies have reported miR‑18a expression in patients with OS is significantly decreased compared with that in normal adjacent tissue. miR‑18a belongs to the miR‑17‑92 cluster encoded by the host gene MIR17HG. However, the detailed role of miR‑18a in OS remains to be determined. In this study, we demonstrated that miR‑18a mimics inhibited MG63 and Saos‑2 cell viability and migration. In addition, flow cytometry assay revealed that miR‑18a induced OS cell apoptosis. Western blot analysis indicated that the expression levels of Bcl‑2 and p‑Akt were downregulated, while the levels of cleaved caspase‑3 and Bax proteins were upregulated by miR‑18a. Moreover,...
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abstractOsteosarcoma (OS) is a common malignant primary bone tumor and patients with OS are known to have a poor response to chemotherapy. MicroRNAs (miRNAs or miRs) are small non-coding RNA molecules (approximately 22 nucleotides in length) and they have recently become a topic for research as regards their role in cancer therapeutics. Previous studies have reported miR‑18a expression in patients with OS is significantly decreased compared with that in normal adjacent tissue. miR‑18a belongs to the miR‑17‑92 cluster encoded by the host gene MIR17HG. However, the detailed role of miR‑18a in OS remains to be determined. In this study, we demonstrated that miR‑18a mimics inhibited MG63 and Saos‑2 cell viability and migration. In addition, flow cytometry assay revealed that miR‑18a induced OS cell apoptosis. Western blot analysis indicated that the expression levels of Bcl‑2 and p‑Akt were downregulated, while the levels of cleaved caspase‑3 and Bax proteins were upregulated by miR‑18a. Moreover,...
doi10.3892/ijo.2018.4374
pmid29693135
date2018-07