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A DNA-Based Nanocarrier for Efficient Gene Delivery and Combined Cancer Therapy

The efficient delivery of a therapeutic gene into target tissues has remained a major obstacle in realizing a viable gene-based medicine. Herein, we introduce a facile and universal strategy to construct a DNA nanostructure-based codelivery system containing a linear tumor therapeutic gene (p53) and... Full description

Journal Title: Nano letters 13 June 2018, Vol.18(6), pp.3328-3334
Main Author: Liu, Jianbing
Other Authors: Song, Linlin , Liu, Shaoli , Jiang, Qiao , Liu, Qing , Li, Na , Wang, Zhen-Gang , Ding, Baoquan
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1530-6992 ; PMID: 29708760 Version:1 ; DOI: 10.1021/acs.nanolett.7b04812
Link: http://pubmed.gov/29708760
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recordid: medline29708760
title: A DNA-Based Nanocarrier for Efficient Gene Delivery and Combined Cancer Therapy
format: Article
creator:
  • Liu, Jianbing
  • Song, Linlin
  • Liu, Shaoli
  • Jiang, Qiao
  • Liu, Qing
  • Li, Na
  • Wang, Zhen-Gang
  • Ding, Baoquan
subjects:
  • DNA Nanotechnology
  • Self-Assembly
  • Cancer Therapy
  • Drug Delivery
  • Gene Therapy
  • Gene Transfer Techniques
  • Genes, P53
  • Antibiotics, Antineoplastic -- Administration & Dosage
  • DNA -- Chemistry
  • Doxorubicin -- Administration & Dosage
  • Nanostructures -- Chemistry
  • Neoplasms -- Therapy
ispartof: Nano letters, 13 June 2018, Vol.18(6), pp.3328-3334
description: The efficient delivery of a therapeutic gene into target tissues has remained a major obstacle in realizing a viable gene-based medicine. Herein, we introduce a facile and universal strategy to construct a DNA nanostructure-based codelivery system containing a linear tumor therapeutic gene (p53) and a chemotherapeutic drug (doxorubicin, DOX) for combined therapy of multidrug resistant tumor (MCF-7R). This novel codelivery system, which is structurally similar to a kite, is rationally designed to contain multiple functional groups for the targeted delivery and controlled release of the therapeutic cargoes. The self-assembled DNA nanokite achieves efficient gene delivery and exhibits effective inhibition of tumor growth in vitro and in vivo without apparent systemic toxicity. These structurally and chemically well-defined codelivery nanovectors provide a new platform for the development of gene therapeutics for not only cancer but also a wide range of diseases.
language: eng
source:
identifier: E-ISSN: 1530-6992 ; PMID: 29708760 Version:1 ; DOI: 10.1021/acs.nanolett.7b04812
fulltext: no_fulltext
issn:
  • 15306992
  • 1530-6992
url: Link


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titleA DNA-Based Nanocarrier for Efficient Gene Delivery and Combined Cancer Therapy
creatorLiu, Jianbing ; Song, Linlin ; Liu, Shaoli ; Jiang, Qiao ; Liu, Qing ; Li, Na ; Wang, Zhen-Gang ; Ding, Baoquan
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subjectDNA Nanotechnology ; Self-Assembly ; Cancer Therapy ; Drug Delivery ; Gene Therapy ; Gene Transfer Techniques ; Genes, P53 ; Antibiotics, Antineoplastic -- Administration & Dosage ; DNA -- Chemistry ; Doxorubicin -- Administration & Dosage ; Nanostructures -- Chemistry ; Neoplasms -- Therapy
descriptionThe efficient delivery of a therapeutic gene into target tissues has remained a major obstacle in realizing a viable gene-based medicine. Herein, we introduce a facile and universal strategy to construct a DNA nanostructure-based codelivery system containing a linear tumor therapeutic gene (p53) and a chemotherapeutic drug (doxorubicin, DOX) for combined therapy of multidrug resistant tumor (MCF-7R). This novel codelivery system, which is structurally similar to a kite, is rationally designed to contain multiple functional groups for the targeted delivery and controlled release of the therapeutic cargoes. The self-assembled DNA nanokite achieves efficient gene delivery and exhibits effective inhibition of tumor growth in vitro and in vivo without apparent systemic toxicity. These structurally and chemically well-defined codelivery nanovectors provide a new platform for the development of gene therapeutics for not only cancer but also a wide range of diseases.
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titleA DNA-Based Nanocarrier for Efficient Gene Delivery and Combined Cancer Therapy
descriptionThe efficient delivery of a therapeutic gene into target tissues has remained a major obstacle in realizing a viable gene-based medicine. Herein, we introduce a facile and universal strategy to construct a DNA nanostructure-based codelivery system containing a linear tumor therapeutic gene (p53) and a chemotherapeutic drug (doxorubicin, DOX) for combined therapy of multidrug resistant tumor (MCF-7R). This novel codelivery system, which is structurally similar to a kite, is rationally designed to contain multiple functional groups for the targeted delivery and controlled release of the therapeutic cargoes. The self-assembled DNA nanokite achieves efficient gene delivery and exhibits effective inhibition of tumor growth in vitro and in vivo without apparent systemic toxicity. These structurally and chemically well-defined codelivery nanovectors provide a new platform for the development of gene therapeutics for not only cancer but also a wide range of diseases.
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titleA DNA-Based Nanocarrier for Efficient Gene Delivery and Combined Cancer Therapy
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abstractThe efficient delivery of a therapeutic gene into target tissues has remained a major obstacle in realizing a viable gene-based medicine. Herein, we introduce a facile and universal strategy to construct a DNA nanostructure-based codelivery system containing a linear tumor therapeutic gene (p53) and a chemotherapeutic drug (doxorubicin, DOX) for combined therapy of multidrug resistant tumor (MCF-7R). This novel codelivery system, which is structurally similar to a kite, is rationally designed to contain multiple functional groups for the targeted delivery and controlled release of the therapeutic cargoes. The self-assembled DNA nanokite achieves efficient gene delivery and exhibits effective inhibition of tumor growth in vitro and in vivo without apparent systemic toxicity. These structurally and chemically well-defined codelivery nanovectors provide a new platform for the development of gene therapeutics for not only cancer but also a wide range of diseases.
doi10.1021/acs.nanolett.7b04812
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date2018-06-13