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Enhanced production of Lovastatin by filamentous fungi through solid state fermentation

Lovastatin is a natural competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme-A (HMG-CoA) reductase and inhibits specifically rate limiting step in cholesterol biosynthesis. Further, lovastatin in comparison with synthetic drugs has no well-reported side effects. Four pure isolated filamento... Full description

Journal Title: Pakistan journal of pharmaceutical sciences July 2018, Vol.31(4(Supplementary)), pp.1583-1589
Main Author: Kamal, Shagufta
Other Authors: Akhter, Naheed , Khan, Samreen Gul , Kiran, Shumaila , Farooq, Tahir , Akram, Muhammad , Shah, Syed Muhammad Ali , Tahir, Imtiaz Mahmood , Akhlaq, Muhammad , Said, Fahad , Zaheer, Jawad
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1011-601X ; PMID: 30058552 Version:1
Link: http://pubmed.gov/30058552
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recordid: medline30058552
title: Enhanced production of Lovastatin by filamentous fungi through solid state fermentation
format: Article
creator:
  • Kamal, Shagufta
  • Akhter, Naheed
  • Khan, Samreen Gul
  • Kiran, Shumaila
  • Farooq, Tahir
  • Akram, Muhammad
  • Shah, Syed Muhammad Ali
  • Tahir, Imtiaz Mahmood
  • Akhlaq, Muhammad
  • Said, Fahad
  • Zaheer, Jawad
subjects:
  • Fermentation -- Physiology
  • Fungi -- Metabolism
  • Hydroxymethylglutaryl-Coa Reductase Inhibitors -- Metabolism
  • Lovastatin -- Metabolism
ispartof: Pakistan journal of pharmaceutical sciences, July 2018, Vol.31(4(Supplementary)), pp.1583-1589
description: Lovastatin is a natural competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme-A (HMG-CoA) reductase and inhibits specifically rate limiting step in cholesterol biosynthesis. Further, lovastatin in comparison with synthetic drugs has no well-reported side effects. Four pure isolated filamentous fungal strains including Aspergillus niger IBL, Aspergillus terreus FFCBP-1053, Aspergillus flavus PML and Aspergillus nidulans FFCBP-014 have been cultured by solid state fermentation (SSF) using rice straw as substrate for the synthesis of lovastatin. After selecting Aspergillus terreus FFCBP-1053 as the best producer of lovastatin, various selected physical parameters including pH, temperature, inoculums size and moisture content were optimized through response surface methodology (RSM) under center composite design (CCD) for lovastatin hyper production. Maximum lovastatin production of 2070±91.5 was predicted by the quadratic model in the medium having moisture content 70% and pH 4.5 at 35°C which was verified experimentally to be 2140±93.25µg/g DW of FM (microgram/gram dry weight of fermentation medium), significantly (P0.05) measured by spectrophotometer at 245 nm against standard. It was determined that optimized conditions for the hyper-production of lovastatin from fungal sources have a significant effect.
language: eng
source:
identifier: ISSN: 1011-601X ; PMID: 30058552 Version:1
fulltext: fulltext
issn:
  • 1011601X
  • 1011-601X
url: Link


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titleEnhanced production of Lovastatin by filamentous fungi through solid state fermentation
creatorKamal, Shagufta ; Akhter, Naheed ; Khan, Samreen Gul ; Kiran, Shumaila ; Farooq, Tahir ; Akram, Muhammad ; Shah, Syed Muhammad Ali ; Tahir, Imtiaz Mahmood ; Akhlaq, Muhammad ; Said, Fahad ; Zaheer, Jawad
ispartofPakistan journal of pharmaceutical sciences, July 2018, Vol.31(4(Supplementary)), pp.1583-1589
identifierISSN: 1011-601X ; PMID: 30058552 Version:1
subjectFermentation -- Physiology ; Fungi -- Metabolism ; Hydroxymethylglutaryl-Coa Reductase Inhibitors -- Metabolism ; Lovastatin -- Metabolism
descriptionLovastatin is a natural competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme-A (HMG-CoA) reductase and inhibits specifically rate limiting step in cholesterol biosynthesis. Further, lovastatin in comparison with synthetic drugs has no well-reported side effects. Four pure isolated filamentous fungal strains including Aspergillus niger IBL, Aspergillus terreus FFCBP-1053, Aspergillus flavus PML and Aspergillus nidulans FFCBP-014 have been cultured by solid state fermentation (SSF) using rice straw as substrate for the synthesis of lovastatin. After selecting Aspergillus terreus FFCBP-1053 as the best producer of lovastatin, various selected physical parameters including pH, temperature, inoculums size and moisture content were optimized through response surface methodology (RSM) under center composite design (CCD) for lovastatin hyper production. Maximum lovastatin production of 2070±91.5 was predicted by the quadratic model in the medium having moisture content 70% and pH 4.5 at 35°C which was verified experimentally to be 2140±93.25µg/g DW of FM (microgram/gram dry weight of fermentation medium), significantly (P0.05) measured by spectrophotometer at 245 nm against standard. It was determined that optimized conditions for the hyper-production of lovastatin from fungal sources have a significant effect.
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titleEnhanced production of Lovastatin by filamentous fungi through solid state fermentation
descriptionLovastatin is a natural competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme-A (HMG-CoA) reductase and inhibits specifically rate limiting step in cholesterol biosynthesis. Further, lovastatin in comparison with synthetic drugs has no well-reported side effects. Four pure isolated filamentous fungal strains including Aspergillus niger IBL, Aspergillus terreus FFCBP-1053, Aspergillus flavus PML and Aspergillus nidulans FFCBP-014 have been cultured by solid state fermentation (SSF) using rice straw as substrate for the synthesis of lovastatin. After selecting Aspergillus terreus FFCBP-1053 as the best producer of lovastatin, various selected physical parameters including pH, temperature, inoculums size and moisture content were optimized through response surface methodology (RSM) under center composite design (CCD) for lovastatin hyper production. Maximum lovastatin production of 2070±91.5 was predicted by the quadratic model in the medium having moisture content 70% and pH 4.5 at 35°C which was verified experimentally to be 2140±93.25µg/g DW of FM (microgram/gram dry weight of fermentation medium), significantly (P0.05) measured by spectrophotometer at 245 nm against standard. It was determined that optimized conditions for the hyper-production of lovastatin from fungal sources have a significant effect.
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abstractLovastatin is a natural competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme-A (HMG-CoA) reductase and inhibits specifically rate limiting step in cholesterol biosynthesis. Further, lovastatin in comparison with synthetic drugs has no well-reported side effects. Four pure isolated filamentous fungal strains including Aspergillus niger IBL, Aspergillus terreus FFCBP-1053, Aspergillus flavus PML and Aspergillus nidulans FFCBP-014 have been cultured by solid state fermentation (SSF) using rice straw as substrate for the synthesis of lovastatin. After selecting Aspergillus terreus FFCBP-1053 as the best producer of lovastatin, various selected physical parameters including pH, temperature, inoculums size and moisture content were optimized through response surface methodology (RSM) under center composite design (CCD) for lovastatin hyper production. Maximum lovastatin production of 2070±91.5 was predicted by the quadratic model in the medium having moisture content 70% and pH 4.5 at 35°C which was verified experimentally to be 2140±93.25µg/g DW of FM (microgram/gram dry weight of fermentation medium), significantly (P0.05) measured by spectrophotometer at 245 nm against standard. It was determined that optimized conditions for the hyper-production of lovastatin from fungal sources have a significant effect.
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