schliessen

Filtern

 

Bibliotheken

The opium poppy genome and morphinan production

Morphinan-based painkillers are derived from opium poppy ( L.). We report a draft of the opium poppy genome, with 2.72 gigabases assembled into 11 chromosomes with contig N50 and scaffold N50 of 1.77 and 204 megabases, respectively. Synteny analysis suggests a whole-genome duplication at ~7.8 millio... Full description

Journal Title: Science (New York N.Y.), 19 October 2018, Vol.362(6412), pp.343-347
Main Author: Guo, Li
Other Authors: Winzer, Thilo , Yang, Xiaofei , Li, Yi , Ning, Zemin , He, Zhesi , Teodor, Roxana , Lu, Ying , Bowser, Tim A , Graham, Ian A , Ye, Kai
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1095-9203 ; PMID: 30166436 Version:1 ; DOI: 10.1126/science.aat4096
Link: http://pubmed.gov/30166436
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: medline30166436
title: The opium poppy genome and morphinan production
format: Article
creator:
  • Guo, Li
  • Winzer, Thilo
  • Yang, Xiaofei
  • Li, Yi
  • Ning, Zemin
  • He, Zhesi
  • Teodor, Roxana
  • Lu, Ying
  • Bowser, Tim A
  • Graham, Ian A
  • Ye, Kai
subjects:
  • Evolution, Molecular
  • Gene Duplication
  • Genome, Plant
  • Benzylisoquinolines -- Metabolism
  • Morphinans -- Metabolism
  • Papaver -- Genetics
ispartof: Science (New York, N.Y.), 19 October 2018, Vol.362(6412), pp.343-347
description: Morphinan-based painkillers are derived from opium poppy ( L.). We report a draft of the opium poppy genome, with 2.72 gigabases assembled into 11 chromosomes with contig N50 and scaffold N50 of 1.77 and 204 megabases, respectively. Synteny analysis suggests a whole-genome duplication at ~7.8 million years ago and ancient segmental or whole-genome duplication(s) that occurred before the Papaveraceae-Ranunculaceae divergence 110 million years ago. Syntenic blocks representative of phthalideisoquinoline and morphinan components of a benzylisoquinoline alkaloid cluster of 15 genes provide insight into how this cluster evolved. Paralog analysis identified P450 and oxidoreductase genes that combined to form the gene fusion essential for morphinan biosynthesis in opium poppy. Thus, gene duplication, rearrangement, and fusion events have led to evolution of specialized metabolic products in opium poppy.
language: eng
source:
identifier: E-ISSN: 1095-9203 ; PMID: 30166436 Version:1 ; DOI: 10.1126/science.aat4096
fulltext: no_fulltext
issn:
  • 10959203
  • 1095-9203
url: Link


@attributes
ID1296631596
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid30166436
sourceidmedline
recordidTN_medline30166436
sourceformatXML
sourcesystemPC
pqid2098770216
galeid562237830
display
typearticle
titleThe opium poppy genome and morphinan production
creatorGuo, Li ; Winzer, Thilo ; Yang, Xiaofei ; Li, Yi ; Ning, Zemin ; He, Zhesi ; Teodor, Roxana ; Lu, Ying ; Bowser, Tim A ; Graham, Ian A ; Ye, Kai
ispartofScience (New York, N.Y.), 19 October 2018, Vol.362(6412), pp.343-347
identifier
subjectEvolution, Molecular ; Gene Duplication ; Genome, Plant ; Benzylisoquinolines -- Metabolism ; Morphinans -- Metabolism ; Papaver -- Genetics
descriptionMorphinan-based painkillers are derived from opium poppy ( L.). We report a draft of the opium poppy genome, with 2.72 gigabases assembled into 11 chromosomes with contig N50 and scaffold N50 of 1.77 and 204 megabases, respectively. Synteny analysis suggests a whole-genome duplication at ~7.8 million years ago and ancient segmental or whole-genome duplication(s) that occurred before the Papaveraceae-Ranunculaceae divergence 110 million years ago. Syntenic blocks representative of phthalideisoquinoline and morphinan components of a benzylisoquinoline alkaloid cluster of 15 genes provide insight into how this cluster evolved. Paralog analysis identified P450 and oxidoreductase genes that combined to form the gene fusion essential for morphinan biosynthesis in opium poppy. Thus, gene duplication, rearrangement, and fusion events have led to evolution of specialized metabolic products in opium poppy.
languageeng
source
version6
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://pubmed.gov/30166436$$EView_this_record_in_MEDLINE/PubMed
openurlfulltext$$Topenurlfull_article
addlink$$Uhttp://exlibris-pub.s3.amazonaws.com/aboutMedline.html$$EView_the_MEDLINE/PubMed_Copyright_Statement
search
creatorcontrib
0Guo, Li
1Winzer, Thilo
2Yang, Xiaofei
3Li, Yi
4Ning, Zemin
5He, Zhesi
6Teodor, Roxana
7Lu, Ying
8Bowser, Tim A
9Graham, Ian A
10Ye, Kai
titleThe opium poppy genome and morphinan production
descriptionMorphinan-based painkillers are derived from opium poppy ( L.). We report a draft of the opium poppy genome, with 2.72 gigabases assembled into 11 chromosomes with contig N50 and scaffold N50 of 1.77 and 204 megabases, respectively. Synteny analysis suggests a whole-genome duplication at ~7.8 million years ago and ancient segmental or whole-genome duplication(s) that occurred before the Papaveraceae-Ranunculaceae divergence 110 million years ago. Syntenic blocks representative of phthalideisoquinoline and morphinan components of a benzylisoquinoline alkaloid cluster of 15 genes provide insight into how this cluster evolved. Paralog analysis identified P450 and oxidoreductase genes that combined to form the gene fusion essential for morphinan biosynthesis in opium poppy. Thus, gene duplication, rearrangement, and fusion events have led to evolution of specialized metabolic products in opium poppy.
subject
0Evolution, Molecular
1Gene Duplication
2Genome, Plant
3Benzylisoquinolines -- Metabolism
4Morphinans -- Metabolism
5Papaver -- Genetics
general
030166436
1English
2MEDLINE/PubMed (U.S. National Library of Medicine)
310.1126/science.aat4096
4MEDLINE/PubMed (NLM)
sourceidmedline
recordidmedline30166436
issn
010959203
11095-9203
rsrctypearticle
creationdate2018
addtitleScience (New York, N.Y.)
searchscope
0medline
1nlm_medline
2MEDLINE
scope
0medline
1nlm_medline
2MEDLINE
lsr41201819
citationpf 343 vol 362 issue 6412
startdate20181019
enddate20181019
lsr30VSR-Enriched:[galeid, pqid]
sort
titleThe opium poppy genome and morphinan production
authorGuo, Li ; Winzer, Thilo ; Yang, Xiaofei ; Li, Yi ; Ning, Zemin ; He, Zhesi ; Teodor, Roxana ; Lu, Ying ; Bowser, Tim A ; Graham, Ian A ; Ye, Kai
creationdate20181019
lso0120181019
facets
frbrgroupid8496191342773951777
frbrtype5
newrecords20190701
languageeng
creationdate2018
topic
0Evolution, Molecular
1Gene Duplication
2Genome, Plant
3Benzylisoquinolines–Metabolism
4Morphinans–Metabolism
5Papaver–Genetics
collectionMEDLINE/PubMed (NLM)
prefilterarticles
rsrctypearticles
creatorcontrib
0Guo, Li
1Winzer, Thilo
2Yang, Xiaofei
3Li, Yi
4Ning, Zemin
5He, Zhesi
6Teodor, Roxana
7Lu, Ying
8Bowser, Tim A
9Graham, Ian A
10Ye, Kai
jtitleScience (New York, N.Y.)
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
aulast
0Guo
1Winzer
2Yang
3Li
4Ning
5He
6Teodor
7Lu
8Bowser
9Graham
10Ye
aufirst
0Li
1Thilo
2Xiaofei
3Yi
4Zemin
5Zhesi
6Roxana
7Ying
8Tim A
9Ian A
10Kai
au
0Guo, Li
1Winzer, Thilo
2Yang, Xiaofei
3Li, Yi
4Ning, Zemin
5He, Zhesi
6Teodor, Roxana
7Lu, Ying
8Bowser, Tim A
9Graham, Ian A
10Ye, Kai
atitleThe opium poppy genome and morphinan production
jtitleScience (New York, N.Y.)
risdate20181019
volume362
issue6412
spage343
pages343-347
issn0036-8075
eissn1095-9203
formatjournal
genrearticle
ristypeJOUR
abstractMorphinan-based painkillers are derived from opium poppy ( L.). We report a draft of the opium poppy genome, with 2.72 gigabases assembled into 11 chromosomes with contig N50 and scaffold N50 of 1.77 and 204 megabases, respectively. Synteny analysis suggests a whole-genome duplication at ~7.8 million years ago and ancient segmental or whole-genome duplication(s) that occurred before the Papaveraceae-Ranunculaceae divergence 110 million years ago. Syntenic blocks representative of phthalideisoquinoline and morphinan components of a benzylisoquinoline alkaloid cluster of 15 genes provide insight into how this cluster evolved. Paralog analysis identified P450 and oxidoreductase genes that combined to form the gene fusion essential for morphinan biosynthesis in opium poppy. Thus, gene duplication, rearrangement, and fusion events have led to evolution of specialized metabolic products in opium poppy.
doi10.1126/science.aat4096
pmid30166436
date2018-10-19