schliessen

Filtern

 

Bibliotheken

Effect of carvacrol on IL-6/STAT3 pathway after partial hepatectomy in rat liver

Carvacrol is a component in the essential oil of Lamiaceae family. Beside its antihepatotoxic and hepatoprotective properties it is known to be a contribution to liver regeneration. This study aimed to investigate the effects of carvacrol in rat liver regeneration after 70 % partial hepatectomy (PHx... Full description

Journal Title: Bratislavske lekarske listy 2018, Vol.119(9), pp.593-601
Main Author: Ozen, B Durmus
Other Authors: Uyanoglu, M
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0006-9248 ; PMID: 30226072 Version:1 ; DOI: 10.4149/BLL_2018_107
Link: http://pubmed.gov/30226072
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: medline30226072
title: Effect of carvacrol on IL-6/STAT3 pathway after partial hepatectomy in rat liver
format: Article
creator:
  • Ozen, B Durmus
  • Uyanoglu, M
subjects:
  • Il-6/Stat3 Pathway
  • Mapk Pathway Pcna Index.
  • Socs3
  • Liver Regeneration
ispartof: Bratislavske lekarske listy, 2018, Vol.119(9), pp.593-601
description: Carvacrol is a component in the essential oil of Lamiaceae family. Beside its antihepatotoxic and hepatoprotective properties it is known to be a contribution to liver regeneration. This study aimed to investigate the effects of carvacrol in rat liver regeneration after 70 % partial hepatectomy (PHx) through interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) and mitogen-activated protein kinases (MAPK) pathways. In our study six groups were formed from 3-month old Wistar albino male rats. Group I and II were Sham operated; Group III and IV received 1 mL 0.9 % NaCl; and Group V and VI were the groups that were treated with 73 mg/kg carvacrol. Group III, IV, V, and VI animals underwent 68-70 % PHx. Dissection was performed 24 and 48 after surgical procedure. Serum Alanine transaminase (ALT) levels were determined. The liver regeneration rate (RR) was calculated. Histopathological analysis was performed by Hematoxylin(et)Eosin staining and the proliferation by proliferating cell nuclear antigen (PCNA) immunohistochemical staining in liver samples. In the liver, certain genes expressions in IL-6/STAT3 and MAPK pathways with RT-PCR analysis and protein expression with Western blot analysis were measured. Carvacrol showed a positive effect on hepatocyte proliferation and liver regeneration 24 and 48 hours after PHx (Tab. 1, Fig. 7, Ref. 39).
language: eng
source:
identifier: ISSN: 0006-9248 ; PMID: 30226072 Version:1 ; DOI: 10.4149/BLL_2018_107
fulltext: no_fulltext
issn:
  • 00069248
  • 0006-9248
url: Link


@attributes
ID705003219
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid30226072
sourceidmedline
recordidTN_medline30226072
sourceformatXML
sourcesystemOther
pqid2109329812
display
typearticle
titleEffect of carvacrol on IL-6/STAT3 pathway after partial hepatectomy in rat liver
creatorOzen, B Durmus ; Uyanoglu, M
ispartofBratislavske lekarske listy, 2018, Vol.119(9), pp.593-601
identifier
subjectIl-6/Stat3 Pathway ; Mapk Pathway Pcna Index. ; Socs3 ; Liver Regeneration
descriptionCarvacrol is a component in the essential oil of Lamiaceae family. Beside its antihepatotoxic and hepatoprotective properties it is known to be a contribution to liver regeneration. This study aimed to investigate the effects of carvacrol in rat liver regeneration after 70 % partial hepatectomy (PHx) through interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) and mitogen-activated protein kinases (MAPK) pathways. In our study six groups were formed from 3-month old Wistar albino male rats. Group I and II were Sham operated; Group III and IV received 1 mL 0.9 % NaCl; and Group V and VI were the groups that were treated with 73 mg/kg carvacrol. Group III, IV, V, and VI animals underwent 68-70 % PHx. Dissection was performed 24 and 48 after surgical procedure. Serum Alanine transaminase (ALT) levels were determined. The liver regeneration rate (RR) was calculated. Histopathological analysis was performed by Hematoxylin(et)Eosin staining and the proliferation by proliferating cell nuclear antigen (PCNA) immunohistochemical staining in liver samples. In the liver, certain genes expressions in IL-6/STAT3 and MAPK pathways with RT-PCR analysis and protein expression with Western blot analysis were measured. Carvacrol showed a positive effect on hepatocyte proliferation and liver regeneration 24 and 48 hours after PHx (Tab. 1, Fig. 7, Ref. 39).
languageeng
source
version3
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://pubmed.gov/30226072$$EView_this_record_in_MEDLINE/PubMed
openurlfulltext$$Topenurlfull_article
addlink$$Uhttp://exlibris-pub.s3.amazonaws.com/aboutMedline.html$$EView_the_MEDLINE/PubMed_Copyright_Statement
search
creatorcontrib
0Ozen, B Durmus
1Uyanoglu, M
titleEffect of carvacrol on IL-6/STAT3 pathway after partial hepatectomy in rat liver
description
0Carvacrol is a component in the essential oil of Lamiaceae family. Beside its antihepatotoxic and hepatoprotective properties it is known to be a contribution to liver regeneration.
1This study aimed to investigate the effects of carvacrol in rat liver regeneration after 70 % partial hepatectomy (PHx) through interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) and mitogen-activated protein kinases (MAPK) pathways.
2In our study six groups were formed from 3-month old Wistar albino male rats. Group I and II were Sham operated; Group III and IV received 1 mL 0.9 % NaCl; and Group V and VI were the groups that were treated with 73 mg/kg carvacrol. Group III, IV, V, and VI animals underwent 68-70 % PHx. Dissection was performed 24 and 48 after surgical procedure. Serum Alanine transaminase (ALT) levels were determined. The liver regeneration rate (RR) was calculated. Histopathological analysis was performed by Hematoxylin(et)Eosin staining and the proliferation by proliferating cell nuclear antigen (PCNA) immunohistochemical staining in liver samples. In the liver, certain genes expressions in IL-6/STAT3 and MAPK pathways with RT-PCR analysis and protein expression with Western blot analysis were measured.
3Carvacrol showed a positive effect on hepatocyte proliferation and liver regeneration 24 and 48 hours after PHx (Tab. 1, Fig. 7, Ref. 39).
subject
0Il-6/Stat3 Pathway
1Mapk Pathway Pcna Index.
2Socs3
3Liver Regeneration
general
030226072
1English
2MEDLINE/PubMed (U.S. National Library of Medicine)
310.4149/BLL_2018_107
4MEDLINE/PubMed (NLM)
sourceidmedline
recordidmedline30226072
issn
000069248
10006-9248
rsrctypearticle
creationdate2018
addtitleBratislavske lekarske listy
searchscope
0medline
1nlm_medline
2MEDLINE
scope
0medline
1nlm_medline
2MEDLINE
citationpf 593 vol 119 issue 9
startdate20180101
enddate20181231
lsr30VSR-Enriched:[eissn, pqid]
sort
titleEffect of carvacrol on IL-6/STAT3 pathway after partial hepatectomy in rat liver
authorOzen, B Durmus ; Uyanoglu, M
creationdate20180000
lso0120180000
facets
frbrgroupid4494819292820197635
frbrtype5
newrecords20190701
languageeng
creationdate2018
topic
0Il-6/Stat3 Pathway
1Mapk Pathway Pcna Index.
2Socs3
3Liver Regeneration
collectionMEDLINE/PubMed (NLM)
prefilterarticles
rsrctypearticles
creatorcontrib
0Ozen, B Durmus
1Uyanoglu, M
jtitleBratislavske Lekarske Listy
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
aulast
0Ozen
1Uyanoglu
aufirst
0B Durmus
1M
au
0Ozen, B Durmus
1Uyanoglu, M
atitleEffect of carvacrol on IL-6/STAT3 pathway after partial hepatectomy in rat liver
jtitleBratislavske lekarske listy
date2018
risdate2018
volume119
issue9
spage593
pages593-601
issn0006-9248
formatjournal
genrearticle
ristypeJOUR
abstractCarvacrol is a component in the essential oil of Lamiaceae family. Beside its antihepatotoxic and hepatoprotective properties it is known to be a contribution to liver regeneration.
doi10.4149/BLL_2018_107
pmid30226072
eissn13360345
oafree_for_read