schliessen

Filtern

 

Bibliotheken

Effects of methanolic and aqueous extracts of Ipomoea batatas L on mineral contents level (calcium and magnesium) in alloxan-induced diabetic rats

In diabetic patients, electrolyte disorders frequently occur with the characteristic changes in minerals like calcium and magnesium etc. Several medicines are used to manage diabetes mellitus but they exert adverse effects. Plants are a valuable alternative to synthetic medicines because they are ea... Full description

Journal Title: Pakistan journal of pharmaceutical sciences September 2018, Vol.31(5(Supplementary)), pp.2077-2083
Main Author: Tahir, Imtiaz Mahmood
Other Authors: Akhter, Naheed , Parveen, Abida , Mehboob, Huma , Saleem, Sadaf , Munir, Naveed , Shah, Syed Muhammad-Ali , Zaheer, Jawad , Khan, Fahad Said , Sultana, Sabira , Akram, Muhammad
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1011-601X ; PMID: 30393215 Version:1
Link: http://pubmed.gov/30393215
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: medline30393215
title: Effects of methanolic and aqueous extracts of Ipomoea batatas L on mineral contents level (calcium and magnesium) in alloxan-induced diabetic rats
format: Article
creator:
  • Tahir, Imtiaz Mahmood
  • Akhter, Naheed
  • Parveen, Abida
  • Mehboob, Huma
  • Saleem, Sadaf
  • Munir, Naveed
  • Shah, Syed Muhammad-Ali
  • Zaheer, Jawad
  • Khan, Fahad Said
  • Sultana, Sabira
  • Akram, Muhammad
subjects:
  • Ipomoea Batatas
  • Calcium -- Metabolism
  • Diabetes Mellitus, Experimental -- Metabolism
  • Hypoglycemic Agents -- Therapeutic Use
  • Magnesium -- Metabolism
  • Plant Extracts -- Therapeutic Use
ispartof: Pakistan journal of pharmaceutical sciences, September 2018, Vol.31(5(Supplementary)), pp.2077-2083
description: In diabetic patients, electrolyte disorders frequently occur with the characteristic changes in minerals like calcium and magnesium etc. Several medicines are used to manage diabetes mellitus but they exert adverse effects. Plants are a valuable alternative to synthetic medicines because they are easily available, economical and have fewer side effects. Ipomoea batatas L is a well-known antidiabetic plant (sweet potato) but its effects on calcium and magnesium concentration have not studied. The prime focus of this study is to estimate the potential of Ipomoea batatas L peel-off on magnesium and calcium level in Alloxan-induced diabetic rats. Alloxan monohydrate was mixed in 0.9% NaCl solution and administrated [150 mg/kg (S/C)] to male Wistar rats to induce diabetes. After three days blood samples were collected and blood glucose level was recorded. Wistar rats having a blood glucose level of 200 mg/dl and above were selected for the study. Methanol and water extract of Ipomoea batatas L peel-off was given orally with a dose rate of 4g/day. Calcium and magnesium estimation was done using an atomic absorption spectrophotometer. Our results revealed an increase in both the calcium and magnesium level in heart, brain, liver, hind limb, and forelimb after Ipomoea batatas extract treatment. In kidneys decreased calcium level was noted as they excrete calcium. Mineral (Calcium, magnesium) level was increased in all organs except kidney after both extracts treatment. Ipomoea batatas being anti-diabetic in nature also maintain the homeostasis of calcium and magnesium in diabetes. Therefore, we propose the long-term use of such agents might help in the prevention of diabetes-associated complications. However, the validation of these results to human population needs further extensive study.
language: eng
source:
identifier: ISSN: 1011-601X ; PMID: 30393215 Version:1
fulltext: fulltext
issn:
  • 1011601X
  • 1011-601X
url: Link


@attributes
ID1194857087
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid30393215
sourceidmedline
recordidTN_medline30393215
sourceformatXML
sourcesystemOther
pqid2130056265
display
typearticle
titleEffects of methanolic and aqueous extracts of Ipomoea batatas L on mineral contents level (calcium and magnesium) in alloxan-induced diabetic rats
creatorTahir, Imtiaz Mahmood ; Akhter, Naheed ; Parveen, Abida ; Mehboob, Huma ; Saleem, Sadaf ; Munir, Naveed ; Shah, Syed Muhammad-Ali ; Zaheer, Jawad ; Khan, Fahad Said ; Sultana, Sabira ; Akram, Muhammad
ispartofPakistan journal of pharmaceutical sciences, September 2018, Vol.31(5(Supplementary)), pp.2077-2083
identifierISSN: 1011-601X ; PMID: 30393215 Version:1
subjectIpomoea Batatas ; Calcium -- Metabolism ; Diabetes Mellitus, Experimental -- Metabolism ; Hypoglycemic Agents -- Therapeutic Use ; Magnesium -- Metabolism ; Plant Extracts -- Therapeutic Use
descriptionIn diabetic patients, electrolyte disorders frequently occur with the characteristic changes in minerals like calcium and magnesium etc. Several medicines are used to manage diabetes mellitus but they exert adverse effects. Plants are a valuable alternative to synthetic medicines because they are easily available, economical and have fewer side effects. Ipomoea batatas L is a well-known antidiabetic plant (sweet potato) but its effects on calcium and magnesium concentration have not studied. The prime focus of this study is to estimate the potential of Ipomoea batatas L peel-off on magnesium and calcium level in Alloxan-induced diabetic rats. Alloxan monohydrate was mixed in 0.9% NaCl solution and administrated [150 mg/kg (S/C)] to male Wistar rats to induce diabetes. After three days blood samples were collected and blood glucose level was recorded. Wistar rats having a blood glucose level of 200 mg/dl and above were selected for the study. Methanol and water extract of Ipomoea batatas L peel-off was given orally with a dose rate of 4g/day. Calcium and magnesium estimation was done using an atomic absorption spectrophotometer. Our results revealed an increase in both the calcium and magnesium level in heart, brain, liver, hind limb, and forelimb after Ipomoea batatas extract treatment. In kidneys decreased calcium level was noted as they excrete calcium. Mineral (Calcium, magnesium) level was increased in all organs except kidney after both extracts treatment. Ipomoea batatas being anti-diabetic in nature also maintain the homeostasis of calcium and magnesium in diabetes. Therefore, we propose the long-term use of such agents might help in the prevention of diabetes-associated complications. However, the validation of these results to human population needs further extensive study.
languageeng
source
version2
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://pubmed.gov/30393215$$EView_this_record_in_MEDLINE/PubMed
openurlfulltext$$Topenurlfull_article
addlink$$Uhttp://exlibris-pub.s3.amazonaws.com/aboutMedline.html$$EView_the_MEDLINE/PubMed_Copyright_Statement
search
creatorcontrib
0Tahir, Imtiaz Mahmood
1Akhter, Naheed
2Parveen, Abida
3Mehboob, Huma
4Saleem, Sadaf
5Munir, Naveed
6Shah, Syed Muhammad-Ali
7Zaheer, Jawad
8Khan, Fahad Said
9Sultana, Sabira
10Akram, Muhammad
titleEffects of methanolic and aqueous extracts of Ipomoea batatas L on mineral contents level (calcium and magnesium) in alloxan-induced diabetic rats
descriptionIn diabetic patients, electrolyte disorders frequently occur with the characteristic changes in minerals like calcium and magnesium etc. Several medicines are used to manage diabetes mellitus but they exert adverse effects. Plants are a valuable alternative to synthetic medicines because they are easily available, economical and have fewer side effects. Ipomoea batatas L is a well-known antidiabetic plant (sweet potato) but its effects on calcium and magnesium concentration have not studied. The prime focus of this study is to estimate the potential of Ipomoea batatas L peel-off on magnesium and calcium level in Alloxan-induced diabetic rats. Alloxan monohydrate was mixed in 0.9% NaCl solution and administrated [150 mg/kg (S/C)] to male Wistar rats to induce diabetes. After three days blood samples were collected and blood glucose level was recorded. Wistar rats having a blood glucose level of 200 mg/dl and above were selected for the study. Methanol and water extract of Ipomoea batatas L peel-off was given orally with a dose rate of 4g/day. Calcium and magnesium estimation was done using an atomic absorption spectrophotometer. Our results revealed an increase in both the calcium and magnesium level in heart, brain, liver, hind limb, and forelimb after Ipomoea batatas extract treatment. In kidneys decreased calcium level was noted as they excrete calcium. Mineral (Calcium, magnesium) level was increased in all organs except kidney after both extracts treatment. Ipomoea batatas being anti-diabetic in nature also maintain the homeostasis of calcium and magnesium in diabetes. Therefore, we propose the long-term use of such agents might help in the prevention of diabetes-associated complications. However, the validation of these results to human population needs further extensive study.
subject
0Ipomoea Batatas
1Calcium -- Metabolism
2Diabetes Mellitus, Experimental -- Metabolism
3Hypoglycemic Agents -- Therapeutic Use
4Magnesium -- Metabolism
5Plant Extracts -- Therapeutic Use
general
030393215
1English
2MEDLINE/PubMed (U.S. National Library of Medicine)
3MEDLINE/PubMed (NLM)
sourceidmedline
recordidmedline30393215
issn
01011601X
11011-601X
rsrctypearticle
creationdate2018
addtitlePakistan journal of pharmaceutical sciences
searchscope
0medline
1nlm_medline
2MEDLINE
scope
0medline
1nlm_medline
2MEDLINE
lsr41201809
citationpf 2077 vol 31 issue 5(Supplementary)
startdate20180901
enddate20180931
lsr30VSR-Enriched:[pqid]
sort
titleEffects of methanolic and aqueous extracts of Ipomoea batatas L on mineral contents level (calcium and magnesium) in alloxan-induced diabetic rats
authorTahir, Imtiaz Mahmood ; Akhter, Naheed ; Parveen, Abida ; Mehboob, Huma ; Saleem, Sadaf ; Munir, Naveed ; Shah, Syed Muhammad-Ali ; Zaheer, Jawad ; Khan, Fahad Said ; Sultana, Sabira ; Akram, Muhammad
creationdate20180900
lso0120180900
facets
frbrgroupid6208969194003599554
frbrtype5
newrecords20190701
languageeng
creationdate2018
topic
0Ipomoea Batatas
1Calcium–Metabolism
2Diabetes Mellitus, Experimental–Metabolism
3Hypoglycemic Agents–Therapeutic Use
4Magnesium–Metabolism
5Plant Extracts–Therapeutic Use
collectionMEDLINE/PubMed (NLM)
prefilterarticles
rsrctypearticles
creatorcontrib
0Tahir, Imtiaz Mahmood
1Akhter, Naheed
2Parveen, Abida
3Mehboob, Huma
4Saleem, Sadaf
5Munir, Naveed
6Shah, Syed Muhammad-Ali
7Zaheer, Jawad
8Khan, Fahad Said
9Sultana, Sabira
10Akram, Muhammad
jtitlePakistan Journal Of Pharmaceutical Sciences
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Tahir
1Akhter
2Parveen
3Mehboob
4Saleem
5Munir
6Shah
7Zaheer
8Khan
9Sultana
10Akram
aufirst
0Imtiaz Mahmood
1Naheed
2Abida
3Huma
4Sadaf
5Naveed
6Syed Muhammad-Ali
7Jawad
8Fahad Said
9Sabira
10Muhammad
au
0Tahir, Imtiaz Mahmood
1Akhter, Naheed
2Parveen, Abida
3Mehboob, Huma
4Saleem, Sadaf
5Munir, Naveed
6Shah, Syed Muhammad-Ali
7Zaheer, Jawad
8Khan, Fahad Said
9Sultana, Sabira
10Akram, Muhammad
atitleEffects of methanolic and aqueous extracts of Ipomoea batatas L on mineral contents level (calcium and magnesium) in alloxan-induced diabetic rats
jtitlePakistan journal of pharmaceutical sciences
risdate201809
volume31
issue5(Supplementary)
spage2077
pages2077-2083
issn1011-601X
formatjournal
genrearticle
ristypeJOUR
abstractIn diabetic patients, electrolyte disorders frequently occur with the characteristic changes in minerals like calcium and magnesium etc. Several medicines are used to manage diabetes mellitus but they exert adverse effects. Plants are a valuable alternative to synthetic medicines because they are easily available, economical and have fewer side effects. Ipomoea batatas L is a well-known antidiabetic plant (sweet potato) but its effects on calcium and magnesium concentration have not studied. The prime focus of this study is to estimate the potential of Ipomoea batatas L peel-off on magnesium and calcium level in Alloxan-induced diabetic rats. Alloxan monohydrate was mixed in 0.9% NaCl solution and administrated [150 mg/kg (S/C)] to male Wistar rats to induce diabetes. After three days blood samples were collected and blood glucose level was recorded. Wistar rats having a blood glucose level of 200 mg/dl and above were selected for the study. Methanol and water extract of Ipomoea batatas L peel-off was given orally with a dose rate of 4g/day. Calcium and magnesium estimation was done using an atomic absorption spectrophotometer. Our results revealed an increase in both the calcium and magnesium level in heart, brain, liver, hind limb, and forelimb after Ipomoea batatas extract treatment. In kidneys decreased calcium level was noted as they excrete calcium. Mineral (Calcium, magnesium) level was increased in all organs except kidney after both extracts treatment. Ipomoea batatas being anti-diabetic in nature also maintain the homeostasis of calcium and magnesium in diabetes. Therefore, we propose the long-term use of such agents might help in the prevention of diabetes-associated complications. However, the validation of these results to human population needs further extensive study.
pmid30393215
oafree_for_read
date2018-09