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Characterization of Mauritian Cynomolgus Macaque FcγR Alleles Using Long-Read Sequencing

The FcγRs are immune cell surface proteins that bind IgG and facilitate cytokine production, phagocytosis, and Ab-dependent, cell-mediated cytotoxicity. FcγRs play a critical role in immunity; variation in these genes is implicated in autoimmunity and other diseases. Cynomolgus macaques are an excel... Full description

Journal Title: Journal of immunology (Baltimore Md. : 1950), 01 January 2019, Vol.202(1), pp.151-159
Main Author: Haj, Amelia K
Other Authors: Arbanas, Jaren M , Yamniuk, Aaron P , Karl, Julie A , Bussan, Hailey E , Drinkwater, Kenneth Y , Graham, Michael E , Ericsen, Adam J , Prall, Trent M , Moore, Kristina , Cheng, Lin , Gao, Mian , Graziano, Robert F , Loffredo, John T , Wiseman, Roger W , O'Connor, David H
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1550-6606 ; PMID: 30530595 Version:1 ; DOI: 10.4049/jimmunol.1800843
Link: http://pubmed.gov/30530595
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recordid: medline30530595
title: Characterization of Mauritian Cynomolgus Macaque FcγR Alleles Using Long-Read Sequencing
format: Article
creator:
  • Haj, Amelia K
  • Arbanas, Jaren M
  • Yamniuk, Aaron P
  • Karl, Julie A
  • Bussan, Hailey E
  • Drinkwater, Kenneth Y
  • Graham, Michael E
  • Ericsen, Adam J
  • Prall, Trent M
  • Moore, Kristina
  • Cheng, Lin
  • Gao, Mian
  • Graziano, Robert F
  • Loffredo, John T
  • Wiseman, Roger W
  • O'Connor, David H
subjects:
  • Genotype
  • Macaca Fascicularis
  • Receptors, Igg -- Genetics
ispartof: Journal of immunology (Baltimore, Md. : 1950), 01 January 2019, Vol.202(1), pp.151-159
description: The FcγRs are immune cell surface proteins that bind IgG and facilitate cytokine production, phagocytosis, and Ab-dependent, cell-mediated cytotoxicity. FcγRs play a critical role in immunity; variation in these genes is implicated in autoimmunity and other diseases. Cynomolgus macaques are an excellent animal model for many human diseases, and Mauritian cynomolgus macaques (MCMs) are particularly useful because of their restricted genetic diversity. Previous studies of MCM immune gene diversity have focused on the MHC and killer cell Ig-like receptor. In this study, we characterize FcγR diversity in 48 MCMs using PacBio long-read sequencing to identify novel alleles of each of the four expressed MCM genes. We also developed a high-throughput genotyping assay, which we used to determine allele frequencies and identify haplotypes in more than 500 additional MCMs. We found three alleles for , seven each for and , and four for ; these segregate into eight haplotypes. We also assessed whether...
language: eng
source:
identifier: E-ISSN: 1550-6606 ; PMID: 30530595 Version:1 ; DOI: 10.4049/jimmunol.1800843
fulltext: fulltext
issn:
  • 15506606
  • 1550-6606
url: Link


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titleCharacterization of Mauritian Cynomolgus Macaque FcγR Alleles Using Long-Read Sequencing
creatorHaj, Amelia K ; Arbanas, Jaren M ; Yamniuk, Aaron P ; Karl, Julie A ; Bussan, Hailey E ; Drinkwater, Kenneth Y ; Graham, Michael E ; Ericsen, Adam J ; Prall, Trent M ; Moore, Kristina ; Cheng, Lin ; Gao, Mian ; Graziano, Robert F ; Loffredo, John T ; Wiseman, Roger W ; O'Connor, David H
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subjectGenotype ; Macaca Fascicularis ; Receptors, Igg -- Genetics
descriptionThe FcγRs are immune cell surface proteins that bind IgG and facilitate cytokine production, phagocytosis, and Ab-dependent, cell-mediated cytotoxicity. FcγRs play a critical role in immunity; variation in these genes is implicated in autoimmunity and other diseases. Cynomolgus macaques are an excellent animal model for many human diseases, and Mauritian cynomolgus macaques (MCMs) are particularly useful because of their restricted genetic diversity. Previous studies of MCM immune gene diversity have focused on the MHC and killer cell Ig-like receptor. In this study, we characterize FcγR diversity in 48 MCMs using PacBio long-read sequencing to identify novel alleles of each of the four expressed MCM genes. We also developed a high-throughput genotyping assay, which we used to determine allele frequencies and identify haplotypes in more than 500 additional MCMs. We found three alleles for , seven each for and , and four for ; these segregate into eight haplotypes. We also assessed whether...
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titleCharacterization of Mauritian Cynomolgus Macaque FcγR Alleles Using Long-Read Sequencing
descriptionThe FcγRs are immune cell surface proteins that bind IgG and facilitate cytokine production, phagocytosis, and Ab-dependent, cell-mediated cytotoxicity. FcγRs play a critical role in immunity; variation in these genes is implicated in autoimmunity and other diseases. Cynomolgus macaques are an excellent animal model for many human diseases, and Mauritian cynomolgus macaques (MCMs) are particularly useful because of their restricted genetic diversity. Previous studies of MCM immune gene diversity have focused on the MHC and killer cell Ig-like receptor. In this study, we characterize FcγR diversity in 48 MCMs using PacBio long-read sequencing to identify novel alleles of each of the four expressed MCM genes. We also developed a high-throughput genotyping assay, which we used to determine allele frequencies and identify haplotypes in more than 500 additional MCMs. We found three alleles for , seven each for and , and four for ; these segregate into eight haplotypes. We also assessed whether...
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atitleCharacterization of Mauritian Cynomolgus Macaque FcγR Alleles Using Long-Read Sequencing
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abstractThe FcγRs are immune cell surface proteins that bind IgG and facilitate cytokine production, phagocytosis, and Ab-dependent, cell-mediated cytotoxicity. FcγRs play a critical role in immunity; variation in these genes is implicated in autoimmunity and other diseases. Cynomolgus macaques are an excellent animal model for many human diseases, and Mauritian cynomolgus macaques (MCMs) are particularly useful because of their restricted genetic diversity. Previous studies of MCM immune gene diversity have focused on the MHC and killer cell Ig-like receptor. In this study, we characterize FcγR diversity in 48 MCMs using PacBio long-read sequencing to identify novel alleles of each of the four expressed MCM genes. We also developed a high-throughput genotyping assay, which we used to determine allele frequencies and identify haplotypes in more than 500 additional MCMs. We found three alleles for , seven each for and , and four for ; these segregate into eight haplotypes. We also assessed whether...
doi10.4049/jimmunol.1800843
pmid30530595
date2019-01-01