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Influence of Crohn's disease related polymorphisms in innate immune function on ileal microbiome

We have previously identified NOD2 genotype and inflammatory bowel diseases (IBD) phenotype, as associated with shifts in the ileal microbiome ("dysbiosis") in a patient cohort. Here we report an integrative analysis of an expanded number of Crohn's disease (CD) related genetic defects in innate imm... Full description

Journal Title: PloS one 2019, Vol.14(2), pp.e0213108
Main Author: Li, Ellen
Other Authors: Zhang, Yuanhao , Tian, Xinyu , Wang, Xuefeng , Gathungu, Grace , Wolber, Ashley , Shiekh, Shehzad S , Sartor, R Balfour , Davidson, Nicholas O , Ciorba, Matthew A , Zhu, Wei , Nelson, Leah M , Robertson, Charles E , Frank, Daniel N
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; PMID: 30818349 Version:1 ; DOI: 10.1371/journal.pone.0213108
Link: http://pubmed.gov/30818349
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recordid: medline30818349
title: Influence of Crohn's disease related polymorphisms in innate immune function on ileal microbiome
format: Article
creator:
  • Li, Ellen
  • Zhang, Yuanhao
  • Tian, Xinyu
  • Wang, Xuefeng
  • Gathungu, Grace
  • Wolber, Ashley
  • Shiekh, Shehzad S
  • Sartor, R Balfour
  • Davidson, Nicholas O
  • Ciorba, Matthew A
  • Zhu, Wei
  • Nelson, Leah M
  • Robertson, Charles E
  • Frank, Daniel N
subjects:
  • Crohn Disease -- Genetics
  • Gastrointestinal Microbiome -- Immunology
  • Ileum -- Microbiology
  • Immunity, Innate -- Genetics
ispartof: PloS one, 2019, Vol.14(2), pp.e0213108
description: We have previously identified NOD2 genotype and inflammatory bowel diseases (IBD) phenotype, as associated with shifts in the ileal microbiome ("dysbiosis") in a patient cohort. Here we report an integrative analysis of an expanded number of Crohn's disease (CD) related genetic defects in innate immune function (NOD2, ATG16L1, IRGM, CARD9, XBP1, ORMDL3) and composition of the ileal microbiome by combining the initial patient cohort (Batch 1, 2005-2010, n = 165) with a second consecutive patient cohort (Batch 2, 2010-2012, n = 118). These combined patient cohorts were composed of three non-overlapping phenotypes: 1.) 106 ileal CD subjects undergoing initial ileocolic resection for diseased ileum, 2.) 88 IBD colitis subjects without ileal disease (predominantly ulcerative colitis but also Crohn's colitis and indeterminate colitis, and 3.) 89 non-IBD subjects. Significant differences (FDR < 0.05) in microbiota were observed between macroscopically disease unaffected and affected regions of...
language: eng
source:
identifier: E-ISSN: 1932-6203 ; PMID: 30818349 Version:1 ; DOI: 10.1371/journal.pone.0213108
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleInfluence of Crohn's disease related polymorphisms in innate immune function on ileal microbiome
creatorLi, Ellen ; Zhang, Yuanhao ; Tian, Xinyu ; Wang, Xuefeng ; Gathungu, Grace ; Wolber, Ashley ; Shiekh, Shehzad S ; Sartor, R Balfour ; Davidson, Nicholas O ; Ciorba, Matthew A ; Zhu, Wei ; Nelson, Leah M ; Robertson, Charles E ; Frank, Daniel N
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subjectCrohn Disease -- Genetics ; Gastrointestinal Microbiome -- Immunology ; Ileum -- Microbiology ; Immunity, Innate -- Genetics
descriptionWe have previously identified NOD2 genotype and inflammatory bowel diseases (IBD) phenotype, as associated with shifts in the ileal microbiome ("dysbiosis") in a patient cohort. Here we report an integrative analysis of an expanded number of Crohn's disease (CD) related genetic defects in innate immune function (NOD2, ATG16L1, IRGM, CARD9, XBP1, ORMDL3) and composition of the ileal microbiome by combining the initial patient cohort (Batch 1, 2005-2010, n = 165) with a second consecutive patient cohort (Batch 2, 2010-2012, n = 118). These combined patient cohorts were composed of three non-overlapping phenotypes: 1.) 106 ileal CD subjects undergoing initial ileocolic resection for diseased ileum, 2.) 88 IBD colitis subjects without ileal disease (predominantly ulcerative colitis but also Crohn's colitis and indeterminate colitis, and 3.) 89 non-IBD subjects. Significant differences (FDR < 0.05) in microbiota were observed between macroscopically disease unaffected and affected regions of...
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titleInfluence of Crohn's disease related polymorphisms in innate immune function on ileal microbiome
descriptionWe have previously identified NOD2 genotype and inflammatory bowel diseases (IBD) phenotype, as associated with shifts in the ileal microbiome ("dysbiosis") in a patient cohort. Here we report an integrative analysis of an expanded number of Crohn's disease (CD) related genetic defects in innate immune function (NOD2, ATG16L1, IRGM, CARD9, XBP1, ORMDL3) and composition of the ileal microbiome by combining the initial patient cohort (Batch 1, 2005-2010, n = 165) with a second consecutive patient cohort (Batch 2, 2010-2012, n = 118). These combined patient cohorts were composed of three non-overlapping phenotypes: 1.) 106 ileal CD subjects undergoing initial ileocolic resection for diseased ileum, 2.) 88 IBD colitis subjects without ileal disease (predominantly ulcerative colitis but also Crohn's colitis and indeterminate colitis, and 3.) 89 non-IBD subjects. Significant differences (FDR < 0.05) in microbiota were observed between macroscopically disease unaffected and affected regions of...
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abstractWe have previously identified NOD2 genotype and inflammatory bowel diseases (IBD) phenotype, as associated with shifts in the ileal microbiome ("dysbiosis") in a patient cohort. Here we report an integrative analysis of an expanded number of Crohn's disease (CD) related genetic defects in innate immune function (NOD2, ATG16L1, IRGM, CARD9, XBP1, ORMDL3) and composition of the ileal microbiome by combining the initial patient cohort (Batch 1, 2005-2010, n = 165) with a second consecutive patient cohort (Batch 2, 2010-2012, n = 118). These combined patient cohorts were composed of three non-overlapping phenotypes: 1.) 106 ileal CD subjects undergoing initial ileocolic resection for diseased ileum, 2.) 88 IBD colitis subjects without ileal disease (predominantly ulcerative colitis but also Crohn's colitis and indeterminate colitis, and 3.) 89 non-IBD subjects. Significant differences (FDR < 0.05) in microbiota were observed between macroscopically disease unaffected and affected regions of...
doi10.1371/journal.pone.0213108
pmid30818349