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Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylati... Full description

Journal Title: Nature communications 23 April 2019, Vol.10(1), pp.1893
Main Author: Küpers, Leanne K
Other Authors: Monnereau, Claire , Sharp, Gemma C , Yousefi, Paul , Salas, Lucas A , Ghantous, Akram , Page, Christian M , Reese, Sarah E , Wilcox, Allen J , Czamara, Darina , Starling, Anne P , Novoloaca, Alexei , Lent, Samantha , Roy, Ritu , Hoyo, Cathrine , Breton, Carrie V , Allard, Catherine , Just, Allan C , Bakulski
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 2041-1723 ; PMID: 31015461 Version:1 ; DOI: 10.1038/s41467-019-09671-3
Link: http://pubmed.gov/31015461
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title: Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
format: Article
creator:
  • Küpers, Leanne K
  • Monnereau, Claire
  • Sharp, Gemma C
  • Yousefi, Paul
  • Salas, Lucas A
  • Ghantous, Akram
  • Page, Christian M
  • Reese, Sarah E
  • Wilcox, Allen J
  • Czamara, Darina
  • Starling, Anne P
  • Novoloaca, Alexei
  • Lent, Samantha
  • Roy, Ritu
  • Hoyo, Cathrine
  • Breton, Carrie V
  • Allard, Catherine
  • Just, Allan C
  • Bakulski
subjects:
  • Epigenesis, Genetic
  • Genome, Human
  • Birth Weight -- Genetics
  • DNA -- Metabolism
ispartof: Nature communications, 23 April 2019, Vol.10(1), pp.1893
description: Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (P 
language: eng
source:
identifier: E-ISSN: 2041-1723 ; PMID: 31015461 Version:1 ; DOI: 10.1038/s41467-019-09671-3
fulltext: fulltext
issn:
  • 20411723
  • 2041-1723
url: Link


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titleMeta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
creatorKüpers, Leanne K ; Monnereau, Claire ; Sharp, Gemma C ; Yousefi, Paul ; Salas, Lucas A ; Ghantous, Akram ; Page, Christian M ; Reese, Sarah E ; Wilcox, Allen J ; Czamara, Darina ; Starling, Anne P ; Novoloaca, Alexei ; Lent, Samantha ; Roy, Ritu ; Hoyo, Cathrine ; Breton, Carrie V ; Allard, Catherine ; Just, Allan C ; Bakulski
ispartofNature communications, 23 April 2019, Vol.10(1), pp.1893
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subjectEpigenesis, Genetic ; Genome, Human ; Birth Weight -- Genetics ; DNA -- Metabolism
descriptionBirthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (P < 1.06 x 10). In additional analyses in 7,278 participants, <1.3% of birthweight-associated differential methylation is also observed in childhood and adolescence, but not adulthood. Birthweight-related CpGs overlap with some Bonferroni-significant CpGs that were previously reported to be related to maternal smoking (55/914, p = 6.12 x 10) and BMI in pregnancy (3/914, p = 1.13x10), but not with those related to folate levels in pregnancy. Whether the associations that we observe are causal or explained by confounding or fetal growth...
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8Wilcox, Allen J
9Czamara, Darina
10Starling, Anne P
11Novoloaca, Alexei
12Lent, Samantha
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14Hoyo, Cathrine
15Breton, Carrie V
16Allard, Catherine
17Just, Allan C
18Bakulski, Kelly M
19Holloway, John W
20Everson, Todd M
21Xu, Cheng-Jian
22Huang, Rae-Chi
23van der Plaat, Diana A
24Wielscher, Matthias
25Merid, Simon Kebede
26Ullemar, Vilhelmina
27Rezwan, Faisal I
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30Langie, Sabine A S
31Richardson, Tom G
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36Zhao, Shanshan
37Zhang, Weiming
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47Hertz-Picciotto, Irva
48Zhang, Hongmei
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50Gehring, Ulrike
51Marsit, Carmen J
52Beilin, Lawrence J
53Vonk, Judith M
54Jarvelin, Marjo-Riitta
55Bergström, Anna
56Örtqvist, Anne K
57Ewart, Susan
58Villa, Pia M
59Moore, Sophie E
60Willemsen, Gonneke
61Standaert, Arnout R L
62Håberg, Siri E
63Sørensen, Thorkild I A
64Taylor, Jack A
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66Yang, Ivana V
67Kechris, Katerina
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96Moisse, Matthieu
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98Melén, Erik
99Prentice, Andrew M
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titleMeta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
descriptionBirthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (P < 1.06 x 10). In additional analyses in 7,278 participants, <1.3% of birthweight-associated differential methylation is also observed in childhood and adolescence, but not adulthood. Birthweight-related CpGs overlap with some Bonferroni-significant CpGs that were previously reported to be related to maternal smoking (55/914, p = 6.12 x 10) and BMI in pregnancy (3/914, p = 1.13x10), but not with those related to folate levels in pregnancy. Whether the associations that we observe are causal or explained by confounding or fetal growth...
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titleMeta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
authorKüpers, Leanne K ; Monnereau, Claire ; Sharp, Gemma C ; Yousefi, Paul ; Salas, Lucas A ; Ghantous, Akram ; Page, Christian M ; Reese, Sarah E ; Wilcox, Allen J ; Czamara, Darina ; Starling, Anne P ; Novoloaca, Alexei ; Lent, Samantha ; Roy, Ritu ; Hoyo, Cathrine ; Breton, Carrie V ; Allard, Catherine ; Just, Allan C ; Bakulski
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0Küpers, Leanne K
1Monnereau, Claire
2Sharp, Gemma C
3Yousefi, Paul
4Salas, Lucas A
5Ghantous, Akram
6Page, Christian M
7Reese, Sarah E
8Wilcox, Allen J
9Czamara, Darina
10Starling, Anne P
11Novoloaca, Alexei
12Lent, Samantha
13Roy, Ritu
14Hoyo, Cathrine
15Breton, Carrie V
16Allard, Catherine
17Just, Allan C
18Bakulski, Kelly M
19Holloway, John W
20Everson, Todd M
21Xu, Cheng-Jian
22Huang, Rae-Chi
23Van Der Plaat, Diana A
24Wielscher, Matthias
25Merid, Simon Kebede
26Ullemar, Vilhelmina
27Rezwan, Faisal I
28Lahti, Jari
29Van Dongen, Jenny
30Langie, Sabine A S
31Richardson, Tom G
32Magnus, Maria C
33Nohr, Ellen A
34Xu, Zongli
35Duijts, Liesbeth
36Zhao, Shanshan
37Zhang, Weiming
38Plusquin, Michelle
39Demeo, Dawn L
40Solomon, Olivia
41Heimovaara, Joosje H
42Jima, Dereje D
43Gao, Lu
44Bustamante, Mariona
45Perron, Patrice
46Wright, Robert O
47Hertz-Picciotto, Irva
48Zhang, Hongmei
49Karagas, Margaret R
50Gehring, Ulrike
51Marsit, Carmen J
52Beilin, Lawrence J
53Vonk, Judith M
54Jarvelin, Marjo-Riitta
55Bergström, Anna
56Örtqvist, Anne K
57Ewart, Susan
58Villa, Pia M
59Moore, Sophie E
60Willemsen, Gonneke
61Standaert, Arnout R L
62Håberg, Siri E
63Sørensen, Thorkild I A
64Taylor, Jack A
65Räikkönen, Katri
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67Kechris, Katerina
68Nawrot, Tim S
69Silver, Matt J
70Gong, Yun Yun
71Richiardi, Lorenzo
72Kogevinas, Manolis
73Litonjua, Augusto A
74Eskenazi, Brenda
75Huen, Karen
76Mbarek, Hamdi
77Maguire, Rachel L
78Dwyer, Terence
79Vrijheid, Martine
80Bouchard, Luigi
81Baccarelli, Andrea A
82Croen, Lisa A
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85De Vries, Maaike
86Sebert, Sylvain
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89Arshad, Syed Hasan
90Hämäläinen, Esa
91Routledge, Michael N
92Boomsma, Dorret I
93Feinberg, Andrew P
94Newschaffer, Craig J
95Govarts, Eva
96Moisse, Matthieu
97Fallin, M Daniele
98Melén, Erik
99Prentice, Andrew M
100...
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27Faisal I
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29Jenny
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57Susan
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63Thorkild I A
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69Matt J
70Yun Yun
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72Manolis
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75Karen
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77Rachel L
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79Martine
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82Lisa A
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84Denise
85Maaike
86Sylvain
87Juha
88Robert
89Syed Hasan
90Esa
91Michael N
92Dorret I
93Andrew P
94Craig J
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97M Daniele
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99Andrew M
100...
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0Küpers, Leanne K
1Monnereau, Claire
2Sharp, Gemma C
3Yousefi, Paul
4Salas, Lucas A
5Ghantous, Akram
6Page, Christian M
7Reese, Sarah E
8Wilcox, Allen J
9Czamara, Darina
10Starling, Anne P
11Novoloaca, Alexei
12Lent, Samantha
13Roy, Ritu
14Hoyo, Cathrine
15Breton, Carrie V
16Allard, Catherine
17Just, Allan C
18Bakulski, Kelly M
19Holloway, John W
20Everson, Todd M
21Xu, Cheng-Jian
22Huang, Rae-Chi
23van Der Plaat, Diana A
24Wielscher, Matthias
25Merid, Simon Kebede
26Ullemar, Vilhelmina
27Rezwan, Faisal I
28Lahti, Jari
29van Dongen, Jenny
30Langie, Sabine A S
31Richardson, Tom G
32Magnus, Maria C
33Nohr, Ellen A
34Xu, Zongli
35Duijts, Liesbeth
36Zhao, Shanshan
37Zhang, Weiming
38Plusquin, Michelle
39Demeo, Dawn L
40Solomon, Olivia
41Heimovaara, Joosje H
42Jima, Dereje D
43Gao, Lu
44Bustamante, Mariona
45Perron, Patrice
46Wright, Robert O
47Hertz-Picciotto, Irva
48Zhang, Hongmei
49Karagas, Margaret R
50Gehring, Ulrike
51Marsit, Carmen J
52Beilin, Lawrence J
53Vonk, Judith M
54Jarvelin, Marjo-Riitta
55Bergström, Anna
56Örtqvist, Anne K
57Ewart, Susan
58Villa, Pia M
59Moore, Sophie E
60Willemsen, Gonneke
61Standaert, Arnout R L
62Håberg, Siri E
63Sørensen, Thorkild I A
64Taylor, Jack A
65Räikkönen, Katri
66Yang, Ivana V
67Kechris, Katerina
68Nawrot, Tim S
69Silver, Matt J
70Gong, Yun Yun
71Richiardi, Lorenzo
72Kogevinas, Manolis
73Litonjua, Augusto A
74Eskenazi, Brenda
75Huen, Karen
76Mbarek, Hamdi
77Maguire, Rachel L
78Dwyer, Terence
79Vrijheid, Martine
80Bouchard, Luigi
81Baccarelli, Andrea A
82Croen, Lisa A
83Karmaus, Wilfried
84Anderson, Denise
85de Vries, Maaike
86Sebert, Sylvain
87Kere, Juha
88Karlsson, Robert
89Arshad, Syed Hasan
90Hämäläinen, Esa
91Routledge, Michael N
92Boomsma, Dorret I
93Feinberg, Andrew P
94Newschaffer, Craig J
95Govarts, Eva
96Moisse, Matthieu
97Fallin, M Daniele
98Melén, Erik
99Prentice, Andrew M
100...
atitleMeta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
jtitleNature communications
risdate20190423
volume10
issue1
spage1893
pages1893
issn2041-1723
eissn2041-1723
formatjournal
genrearticle
ristypeJOUR
abstractBirthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (P < 1.06 x 10). In additional analyses in 7,278 participants, <1.3% of birthweight-associated differential methylation is also observed in childhood and adolescence, but not adulthood. Birthweight-related CpGs overlap with some Bonferroni-significant CpGs that were previously reported to be related to maternal smoking (55/914, p = 6.12 x 10) and BMI in pregnancy (3/914, p = 1.13x10), but not with those related to folate levels in pregnancy. Whether the associations that we observe are causal or explained by confounding or fetal growth...
doi10.1038/s41467-019-09671-3
pmid31015461
orcidid0000-0003-2906-4035
isbn4146701909671
date2019-04-23