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Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and trigl... Full description

Journal Title: Nature communications 12 November 2019, Vol.10(1), pp.5121
Main Author: Noordam, Raymond
Other Authors: Bos, Maxime M , Wang, Heming , Winkler, Thomas W , Bentley, Amy R , Kilpeläinen, Tuomas O , De Vries, Paul S , Sung, Yun Ju , Schwander, Karen , Cade, Brian E , Manning, Alisa , Aschard, Hugues , Brown, Michael R , Chen, Han , Franceschini, Nora , Musani, Solomon K , Richard, Melissa , Vojinovic, Dina , Aslibekyan
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 2041-1723 ; PMID: 31719535 Version:1 ; DOI: 10.1038/s41467-019-12958-0
Link: http://pubmed.gov/31719535
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title: Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration
format: Article
creator:
  • Noordam, Raymond
  • Bos, Maxime M
  • Wang, Heming
  • Winkler, Thomas W
  • Bentley, Amy R
  • Kilpeläinen, Tuomas O
  • De Vries, Paul S
  • Sung, Yun Ju
  • Schwander, Karen
  • Cade, Brian E
  • Manning, Alisa
  • Aschard, Hugues
  • Brown, Michael R
  • Chen, Han
  • Franceschini, Nora
  • Musani, Solomon K
  • Richard, Melissa
  • Vojinovic, Dina
  • Aslibekyan
subjects:
  • Article
  • Genome-Wide Association Studies
  • Sleep
  • Dyslipidaemias
  • Epidemiology
ispartof: Nature communications, 12 November 2019, Vol.10(1), pp.5121
description: Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding...
language: eng
source:
identifier: E-ISSN: 2041-1723 ; PMID: 31719535 Version:1 ; DOI: 10.1038/s41467-019-12958-0
fulltext: fulltext
issn:
  • 20411723
  • 2041-1723
url: Link


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titleMulti-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration
creatorNoordam, Raymond ; Bos, Maxime M ; Wang, Heming ; Winkler, Thomas W ; Bentley, Amy R ; Kilpeläinen, Tuomas O ; De Vries, Paul S ; Sung, Yun Ju ; Schwander, Karen ; Cade, Brian E ; Manning, Alisa ; Aschard, Hugues ; Brown, Michael R ; Chen, Han ; Franceschini, Nora ; Musani, Solomon K ; Richard, Melissa ; Vojinovic, Dina ; Aslibekyan
ispartofNature communications, 12 November 2019, Vol.10(1), pp.5121
identifier
descriptionBoth short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding...
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99Uitterlinden, André G
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titleMulti-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration
descriptionBoth short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding...
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titleMulti-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration
authorNoordam, Raymond ; Bos, Maxime M ; Wang, Heming ; Winkler, Thomas W ; Bentley, Amy R ; Kilpeläinen, Tuomas O ; De Vries, Paul S ; Sung, Yun Ju ; Schwander, Karen ; Cade, Brian E ; Manning, Alisa ; Aschard, Hugues ; Brown, Michael R ; Chen, Han ; Franceschini, Nora ; Musani, Solomon K ; Richard, Melissa ; Vojinovic, Dina ; Aslibekyan
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7Sung, Yun Ju
8Schwander, Karen
9Cade, Brian E
10Manning, Alisa
11Aschard, Hugues
12Brown, Michael R
13Chen, Han
14Franceschini, Nora
15Musani, Solomon K
16Richard, Melissa
17Vojinovic, Dina
18Aslibekyan, Stella
19Bartz, Traci M
20De Las Fuentes, Lisa
21Feitosa, Mary
22Horimoto, Andrea R
23Ilkov, Marjan
24Kho, Minjung
25Kraja, Aldi
26Li, Changwei
27Lim, Elise
28Liu, Yongmei
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49Wen, Wanqing
50Yanek, Lisa R
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56Dimou, Niki
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60Gottlieb, Daniel J
61Haba-Rubio, José
62Harris, Tamara B
63Heikkinen, Sami
64Heinzer, Raphaël
65Hixson, James E
66Homuth, Georg
67Ikram, M Arfan
68Komulainen, Pirjo
69Krieger, Jose E
70Lee, Jiwon
71Liu, Jingmin
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73Luik, Annemarie I
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2Wang, Heming
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8Schwander, Karen
9Cade, Brian E
10Manning, Alisa
11Aschard, Hugues
12Brown, Michael R
13Chen, Han
14Franceschini, Nora
15Musani, Solomon K
16Richard, Melissa
17Vojinovic, Dina
18Aslibekyan, Stella
19Bartz, Traci M
20de Las Fuentes, Lisa
21Feitosa, Mary
22Horimoto, Andrea R
23Ilkov, Marjan
24Kho, Minjung
25Kraja, Aldi
26Li, Changwei
27Lim, Elise
28Liu, Yongmei
29Mook-Kanamori, Dennis O
30Rankinen, Tuomo
31Tajuddin, Salman M
32van Der Spek, Ashley
33Wang, Zhe
34Marten, Jonathan
35Laville, Vincent
36Alver, Maris
37Evangelou, Evangelos
38Graff, Maria E
39He, Meian
40Kühnel, Brigitte
41Lyytikäinen, Leo-Pekka
42Marques-Vidal, Pedro
43Nolte, Ilja M
44Palmer, Nicholette D
45Rauramaa, Rainer
46Shu, Xiao-Ou
47Snieder, Harold
48Weiss, Stefan
49Wen, Wanqing
50Yanek, Lisa R
51Adolfo, Correa
52Ballantyne, Christie
53Bielak, Larry
54Biermasz, Nienke R
55Boerwinkle, Eric
56Dimou, Niki
57Eiriksdottir, Gudny
58Gao, Chuan
59Gharib, Sina A
60Gottlieb, Daniel J
61Haba-Rubio, José
62Harris, Tamara B
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65Hixson, James E
66Homuth, Georg
67Ikram, M Arfan
68Komulainen, Pirjo
69Krieger, Jose E
70Lee, Jiwon
71Liu, Jingmin
72Lohman, Kurt K
73Luik, Annemarie I
74Mägi, Reedik
75Martin, Lisa W
76Meitinger, Thomas
77Metspalu, Andres
78Milaneschi, Yuri
79Nalls, Mike A
80O'Connell, Jeff
81Peters, Annette
82Peyser, Patricia
83Raitakari, Olli T
84Reiner, Alex P
85Rensen, Patrick C N
86Rice, Treva K
87Rich, Stephen S
88Roenneberg, Till
89Rotter, Jerome I
90Schreiner, Pamela J
91Shikany, James
92Sidney, Stephen S
93Sims, Mario
94Sitlani, Colleen M
95Sofer, Tamar
96Strauch, Konstantin
97Swertz, Morris A
98Taylor, Kent D
99Uitterlinden, André G
100...
atitleMulti-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration
jtitleNature communications
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abstractBoth short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding...
doi10.1038/s41467-019-12958-0
pmid31719535
orcidid0000-0002-1486-7495
isbn4146701912958
date2019-11-12