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Low-Density Lipoprotein Cholesterol and Risk of Hemorrhagic Stroke: a Systematic Review and Dose-Response Meta-analysis of Prospective Studies

To systematically examine the association between low-density lipoprotein cholesterol (LDL-C) and risk of hemorrhagic stroke. A previous meta-analysis of prospective studies published in 2013 showed that higher concentrations of LDL-C were associated with lower risk of hemorrhagic stroke. Recently,... Full description

Journal Title: Current atherosclerosis reports 20 November 2019, Vol.21(12), pp.52
Main Author: Ma, Chaoran
Other Authors: Na, Muzi , Neumann, Samantha , Gao, Xiang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1534-6242 ; PMID: 31748963 Version:1 ; DOI: 10.1007/s11883-019-0815-5
Link: http://pubmed.gov/31748963
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recordid: medline31748963
title: Low-Density Lipoprotein Cholesterol and Risk of Hemorrhagic Stroke: a Systematic Review and Dose-Response Meta-analysis of Prospective Studies
format: Article
creator:
  • Ma, Chaoran
  • Na, Muzi
  • Neumann, Samantha
  • Gao, Xiang
subjects:
  • Dose-Response
  • Hemorrhagic Stroke
  • LDL-C
  • Meta-Analysis
  • Prospective Studies
ispartof: Current atherosclerosis reports, 20 November 2019, Vol.21(12), pp.52
description: To systematically examine the association between low-density lipoprotein cholesterol (LDL-C) and risk of hemorrhagic stroke. A previous meta-analysis of prospective studies published in 2013 showed that higher concentrations of LDL-C were associated with lower risk of hemorrhagic stroke. Recently, seven large cohort studies were published examining LDL-C and risk of hemorrhagic stroke in different populations. Twelve prospective studies with 476,173 participants and 7587 hemorrhagic stroke cases were included in the current meta-analysis. The results showed that a 10 mg/dL increase in LDL-C was associated with 3% lower risk of hemorrhagic stroke (pooled relative risk [RR] 0.97, 95% confidence interval [CI] 0.95-0.98). The association appeared to be more pronounced in Asians (pooled RR 0.95, 95% CI 0.92-0.98), relative to Caucasians (pooled RR 0.98, 95% CI 0.97-1.00), with a p heterogeneity of 0.05 between two ethnic groups. Further genetic studies and clinical trials with a stricter safety monitoring strategy are warranted to understand the underlying pathogenesis and determine the treatment target of LDL-C range...
language: eng
source:
identifier: E-ISSN: 1534-6242 ; PMID: 31748963 Version:1 ; DOI: 10.1007/s11883-019-0815-5
fulltext: fulltext
issn:
  • 15346242
  • 1534-6242
url: Link


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titleLow-Density Lipoprotein Cholesterol and Risk of Hemorrhagic Stroke: a Systematic Review and Dose-Response Meta-analysis of Prospective Studies
creatorMa, Chaoran ; Na, Muzi ; Neumann, Samantha ; Gao, Xiang
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subjectDose-Response ; Hemorrhagic Stroke ; LDL-C ; Meta-Analysis ; Prospective Studies
descriptionTo systematically examine the association between low-density lipoprotein cholesterol (LDL-C) and risk of hemorrhagic stroke. A previous meta-analysis of prospective studies published in 2013 showed that higher concentrations of LDL-C were associated with lower risk of hemorrhagic stroke. Recently, seven large cohort studies were published examining LDL-C and risk of hemorrhagic stroke in different populations. Twelve prospective studies with 476,173 participants and 7587 hemorrhagic stroke cases were included in the current meta-analysis. The results showed that a 10 mg/dL increase in LDL-C was associated with 3% lower risk of hemorrhagic stroke (pooled relative risk [RR] 0.97, 95% confidence interval [CI] 0.95-0.98). The association appeared to be more pronounced in Asians (pooled RR 0.95, 95% CI 0.92-0.98), relative to Caucasians (pooled RR 0.98, 95% CI 0.97-1.00), with a p heterogeneity of 0.05 between two ethnic groups. Further genetic studies and clinical trials with a stricter safety monitoring strategy are warranted to understand the underlying pathogenesis and determine the treatment target of LDL-C range...
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abstractTo systematically examine the association between low-density lipoprotein cholesterol (LDL-C) and risk of hemorrhagic stroke.
doi10.1007/s11883-019-0815-5
pmid31748963
date2019-11-20