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Defective T-cell response in beige mutant mice

Reports of a selective NK deficiency and normal T-cell function in C57BL/6 mice carrying the beige mutation (bg/bg) suggested that these mice might be useful for assessing the relative importance of T-cell and NK-cell systems in immune surveillance. However the deficiency of beige mice is not restri... Full description

Journal Title: Nature 21 January 1982, Vol.295(5846), pp.240-1
Main Author: Saxena, R K
Other Authors: Saxena, Q B , Adler, W H
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0028-0836 ; PMID: 6977094 Version:1
Link: http://pubmed.gov/6977094
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recordid: medline6977094
title: Defective T-cell response in beige mutant mice
format: Article
creator:
  • Saxena, R K
  • Saxena, Q B
  • Adler, W H
subjects:
  • Cytotoxicity, Immunologic
  • Immunity, Cellular
  • T-Lymphocytes -- Immunology
ispartof: Nature, 21 January 1982, Vol.295(5846), pp.240-1
description: Reports of a selective NK deficiency and normal T-cell function in C57BL/6 mice carrying the beige mutation (bg/bg) suggested that these mice might be useful for assessing the relative importance of T-cell and NK-cell systems in immune surveillance. However the deficiency of beige mice is not restricted to NK cells. The generation of cytotoxic T lymphocytes (CLTs) in response to alloimmune challenge in vivo or in vitro was markedly impaired in beige mutants. The results do not support the suggestion that beige mice might be useful as a model of a selective NK deficiency.
language: eng
source:
identifier: ISSN: 0028-0836 ; PMID: 6977094 Version:1
fulltext: fulltext
issn:
  • 00280836
  • 0028-0836
url: Link


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titleDefective T-cell response in beige mutant mice
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descriptionReports of a selective NK deficiency and normal T-cell function in C57BL/6 mice carrying the beige mutation (bg/bg) suggested that these mice might be useful for assessing the relative importance of T-cell and NK-cell systems in immune surveillance. However the deficiency of beige mice is not restricted to NK cells. The generation of cytotoxic T lymphocytes (CLTs) in response to alloimmune challenge in vivo or in vitro was markedly impaired in beige mutants. The results do not support the suggestion that beige mice might be useful as a model of a selective NK deficiency.
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