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Differential spatiotemporal expression of K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro

Hippocampal neurons are highly plastic in their excitable properties, both during development and in the adult brain. As voltage-sensitive K+ channels are major determinants of membrane excitability, one mechanism for generating plasticity is through regulation of K+ channel activity. To gain insigh... Full description

Journal Title: The Journal of neuroscience : the official journal of the Society for Neuroscience May 1995, Vol.15(5 Pt 2), pp.3840-51
Main Author: Maletic-Savatic, M
Other Authors: Lenn, N J , Trimmer, J S
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0270-6474 ; PMID: 7751950 Version:1
Link: http://pubmed.gov/7751950
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recordid: medline7751950
title: Differential spatiotemporal expression of K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro
format: Article
creator:
  • Maletic-Savatic, M
  • Lenn, N J
  • Trimmer, J S
subjects:
  • Aging -- Metabolism
  • Hippocampus -- Metabolism
  • Neurons -- Metabolism
  • Potassium Channels -- Biosynthesis
ispartof: The Journal of neuroscience : the official journal of the Society for Neuroscience, May 1995, Vol.15(5 Pt 2), pp.3840-51
description: Hippocampal neurons are highly plastic in their excitable properties, both during development and in the adult brain. As voltage-sensitive K+ channels are major determinants of membrane excitability, one mechanism for generating plasticity is through regulation of K+ channel activity. To gain insights into the regulation of K+ channels in the hippocampus, we have analyzed the spatiotemporal expression patterns of five K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro. Delayed rectifier-type channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites, while A-type channels (Kv1.4 and Kv4.2) are present distally on distinct subpopulations of neurons. The development of these patterns in situ is monotonic; that is, while the time and spatial development varies among the channels, each K+ channel subtype initially appears in its adult pattern, suggesting that the mechanisms underlying spatial patterning operate through development....
language: eng
source:
identifier: ISSN: 0270-6474 ; PMID: 7751950 Version:1
fulltext: fulltext
issn:
  • 02706474
  • 0270-6474
url: Link


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titleDifferential spatiotemporal expression of K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro
creatorMaletic-Savatic, M ; Lenn, N J ; Trimmer, J S
ispartofThe Journal of neuroscience : the official journal of the Society for Neuroscience, May 1995, Vol.15(5 Pt 2), pp.3840-51
identifierISSN: 0270-6474 ; PMID: 7751950 Version:1
subjectAging -- Metabolism ; Hippocampus -- Metabolism ; Neurons -- Metabolism ; Potassium Channels -- Biosynthesis
descriptionHippocampal neurons are highly plastic in their excitable properties, both during development and in the adult brain. As voltage-sensitive K+ channels are major determinants of membrane excitability, one mechanism for generating plasticity is through regulation of K+ channel activity. To gain insights into the regulation of K+ channels in the hippocampus, we have analyzed the spatiotemporal expression patterns of five K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro. Delayed rectifier-type channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites, while A-type channels (Kv1.4 and Kv4.2) are present distally on distinct subpopulations of neurons. The development of these patterns in situ is monotonic; that is, while the time and spatial development varies among the channels, each K+ channel subtype initially appears in its adult pattern, suggesting that the mechanisms underlying spatial patterning operate through development....
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descriptionHippocampal neurons are highly plastic in their excitable properties, both during development and in the adult brain. As voltage-sensitive K+ channels are major determinants of membrane excitability, one mechanism for generating plasticity is through regulation of K+ channel activity. To gain insights into the regulation of K+ channels in the hippocampus, we have analyzed the spatiotemporal expression patterns of five K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro. Delayed rectifier-type channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites, while A-type channels (Kv1.4 and Kv4.2) are present distally on distinct subpopulations of neurons. The development of these patterns in situ is monotonic; that is, while the time and spatial development varies among the channels, each K+ channel subtype initially appears in its adult pattern, suggesting that the mechanisms underlying spatial patterning operate through development....
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abstractHippocampal neurons are highly plastic in their excitable properties, both during development and in the adult brain. As voltage-sensitive K+ channels are major determinants of membrane excitability, one mechanism for generating plasticity is through regulation of K+ channel activity. To gain insights into the regulation of K+ channels in the hippocampus, we have analyzed the spatiotemporal expression patterns of five K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro. Delayed rectifier-type channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites, while A-type channels (Kv1.4 and Kv4.2) are present distally on distinct subpopulations of neurons. The development of these patterns in situ is monotonic; that is, while the time and spatial development varies among the channels, each K+ channel subtype initially appears in its adult pattern, suggesting that the mechanisms underlying spatial patterning operate through development....
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