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Interleukin-1 beta production in the rabbit brain during endotoxin-induced fever

Interleukin-1 beta (IL-1 beta) production in the brain and the spleen was investigated in rabbits made febrile by intravenous (I.V.) injection of endotoxin, or human recombinant IL-1 beta (hIL-1 beta). The endotoxin used in the present study was the lipopolysaccharide (LPS) of Salmonella typhosa end... Full description

Journal Title: The Journal of physiology 01 April 1994, Vol.476(1), pp.177-86
Main Author: Nakamori, T
Other Authors: Morimoto, A , Yamaguchi, K , Watanabe, T , Murakami, N
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0022-3751 ; PMID: 8046632 Version:1
Link: http://pubmed.gov/8046632
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recordid: medline8046632
title: Interleukin-1 beta production in the rabbit brain during endotoxin-induced fever
format: Article
creator:
  • Nakamori, T
  • Morimoto, A
  • Yamaguchi, K
  • Watanabe, T
  • Murakami, N
subjects:
  • Bacterial Toxins
  • Endotoxins
  • Brain Chemistry -- Drug Effects
  • Fever -- Metabolism
  • Interleukin-1 -- Biosynthesis
  • Salmonella Typhi -- Metabolism
ispartof: The Journal of physiology, 01 April 1994, Vol.476(1), pp.177-86
description: Interleukin-1 beta (IL-1 beta) production in the brain and the spleen was investigated in rabbits made febrile by intravenous (I.V.) injection of endotoxin, or human recombinant IL-1 beta (hIL-1 beta). The endotoxin used in the present study was the lipopolysaccharide (LPS) of Salmonella typhosa endotoxin. Monophasic fever was induced by I.V. injection of a low dose of LPS (0.02 micrograms kg-1) and biphasic fever by I.V. injection of a large dose of LPS (4 micrograms kg-1), a sublethal dose of LPS (40 micrograms kg-1) or hIL-1 beta (2 micrograms kg-1). In situ hybridization and immunohistochemical studies revealed that, although no IL-1 beta production was observed in the brain at 1 and 3 h after injection of a low dose of LPS (0.02 micrograms kg-1) or of hIL-1 beta (2 micrograms kg-1), IL-1 beta production was demonstrated in organum vasculosum laminae terminalis (OVLT) and some cells around the blood vessels in the parenchyma 1 h after 4 micrograms kg-1 LPS. IL-1 beta production was...
language: eng
source:
identifier: ISSN: 0022-3751 ; PMID: 8046632 Version:1
fulltext: fulltext
issn:
  • 00223751
  • 0022-3751
url: Link


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titleInterleukin-1 beta production in the rabbit brain during endotoxin-induced fever
creatorNakamori, T ; Morimoto, A ; Yamaguchi, K ; Watanabe, T ; Murakami, N
ispartofThe Journal of physiology, 01 April 1994, Vol.476(1), pp.177-86
identifierISSN: 0022-3751 ; PMID: 8046632 Version:1
subjectBacterial Toxins ; Endotoxins ; Brain Chemistry -- Drug Effects ; Fever -- Metabolism ; Interleukin-1 -- Biosynthesis ; Salmonella Typhi -- Metabolism
descriptionInterleukin-1 beta (IL-1 beta) production in the brain and the spleen was investigated in rabbits made febrile by intravenous (I.V.) injection of endotoxin, or human recombinant IL-1 beta (hIL-1 beta). The endotoxin used in the present study was the lipopolysaccharide (LPS) of Salmonella typhosa endotoxin. Monophasic fever was induced by I.V. injection of a low dose of LPS (0.02 micrograms kg-1) and biphasic fever by I.V. injection of a large dose of LPS (4 micrograms kg-1), a sublethal dose of LPS (40 micrograms kg-1) or hIL-1 beta (2 micrograms kg-1). In situ hybridization and immunohistochemical studies revealed that, although no IL-1 beta production was observed in the brain at 1 and 3 h after injection of a low dose of LPS (0.02 micrograms kg-1) or of hIL-1 beta (2 micrograms kg-1), IL-1 beta production was demonstrated in organum vasculosum laminae terminalis (OVLT) and some cells around the blood vessels in the parenchyma 1 h after 4 micrograms kg-1 LPS. IL-1 beta production was...
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abstractInterleukin-1 beta (IL-1 beta) production in the brain and the spleen was investigated in rabbits made febrile by intravenous (I.V.) injection of endotoxin, or human recombinant IL-1 beta (hIL-1 beta). The endotoxin used in the present study was the lipopolysaccharide (LPS) of Salmonella typhosa endotoxin. Monophasic fever was induced by I.V. injection of a low dose of LPS (0.02 micrograms kg-1) and biphasic fever by I.V. injection of a large dose of LPS (4 micrograms kg-1), a sublethal dose of LPS (40 micrograms kg-1) or hIL-1 beta (2 micrograms kg-1). In situ hybridization and immunohistochemical studies revealed that, although no IL-1 beta production was observed in the brain at 1 and 3 h after injection of a low dose of LPS (0.02 micrograms kg-1) or of hIL-1 beta (2 micrograms kg-1), IL-1 beta production was demonstrated in organum vasculosum laminae terminalis (OVLT) and some cells around the blood vessels in the parenchyma 1 h after 4 micrograms kg-1 LPS. IL-1 beta production was...
pmid8046632
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