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Cholinergic-dependent plateau potential in hippocampal CA1 pyramidal neurons

Cholinergic stimulation of the hippocampal formation results in excitation and/or seizure. We report here, using whole-cell patch-clamp techniques in the hippocampal slice (34-35 degrees C), a cholinergic-dependent slow afterdepolarization (sADP) and long-lasting plateau potential (PP). In the prese... Full description

Journal Title: The Journal of neuroscience : the official journal of the Society for Neuroscience 01 July 1996, Vol.16(13), pp.4113-28
Main Author: Fraser, D D
Other Authors: Macvicar, B A
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0270-6474 ; PMID: 8753873 Version:1
Link: http://pubmed.gov/8753873
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title: Cholinergic-dependent plateau potential in hippocampal CA1 pyramidal neurons
format: Article
creator:
  • Fraser, D D
  • Macvicar, B A
subjects:
  • Cholinergic Agents -- Pharmacology
  • Hippocampus -- Drug Effects
  • Neurons -- Drug Effects
ispartof: The Journal of neuroscience : the official journal of the Society for Neuroscience, 01 July 1996, Vol.16(13), pp.4113-28
description: Cholinergic stimulation of the hippocampal formation results in excitation and/or seizure. We report here, using whole-cell patch-clamp techniques in the hippocampal slice (34-35 degrees C), a cholinergic-dependent slow afterdepolarization (sADP) and long-lasting plateau potential (PP). In the presence of 20 microM carbachol, action potential firing evoked by weak intracellular current injection elicited an sADP that lasted several seconds. Increased spike firing evoked by stronger depolarizing stimuli resulted in long-duration PPs maintained close to -20 mV. Removal of either Na+ or Ca2+ from the external media, intracellular Ca2+ ([Ca2+]i) chelation with 10 mM bis(2-aminophenoxy)ethane-N,N,N',N'-tetra-acetic acid, or the addition of 100 microM Cd2+ to the perfusate abolished both the sADP and PP. The sADP was depressed and the PP was abolished by either 10 microM nimodipine or 1 microM omega-conotoxin, whereas 1.2 microM tetrodotoxin was ineffective. The involvement of a Na+/Ca2+ exchanger...
language: eng
source:
identifier: ISSN: 0270-6474 ; PMID: 8753873 Version:1
fulltext: fulltext
issn:
  • 02706474
  • 0270-6474
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titleCholinergic-dependent plateau potential in hippocampal CA1 pyramidal neurons
creatorFraser, D D ; Macvicar, B A
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identifierISSN: 0270-6474 ; PMID: 8753873 Version:1
subjectCholinergic Agents -- Pharmacology ; Hippocampus -- Drug Effects ; Neurons -- Drug Effects
descriptionCholinergic stimulation of the hippocampal formation results in excitation and/or seizure. We report here, using whole-cell patch-clamp techniques in the hippocampal slice (34-35 degrees C), a cholinergic-dependent slow afterdepolarization (sADP) and long-lasting plateau potential (PP). In the presence of 20 microM carbachol, action potential firing evoked by weak intracellular current injection elicited an sADP that lasted several seconds. Increased spike firing evoked by stronger depolarizing stimuli resulted in long-duration PPs maintained close to -20 mV. Removal of either Na+ or Ca2+ from the external media, intracellular Ca2+ ([Ca2+]i) chelation with 10 mM bis(2-aminophenoxy)ethane-N,N,N',N'-tetra-acetic acid, or the addition of 100 microM Cd2+ to the perfusate abolished both the sADP and PP. The sADP was depressed and the PP was abolished by either 10 microM nimodipine or 1 microM omega-conotoxin, whereas 1.2 microM tetrodotoxin was ineffective. The involvement of a Na+/Ca2+ exchanger...
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abstractCholinergic stimulation of the hippocampal formation results in excitation and/or seizure. We report here, using whole-cell patch-clamp techniques in the hippocampal slice (34-35 degrees C), a cholinergic-dependent slow afterdepolarization (sADP) and long-lasting plateau potential (PP). In the presence of 20 microM carbachol, action potential firing evoked by weak intracellular current injection elicited an sADP that lasted several seconds. Increased spike firing evoked by stronger depolarizing stimuli resulted in long-duration PPs maintained close to -20 mV. Removal of either Na+ or Ca2+ from the external media, intracellular Ca2+ ([Ca2+]i) chelation with 10 mM bis(2-aminophenoxy)ethane-N,N,N',N'-tetra-acetic acid, or the addition of 100 microM Cd2+ to the perfusate abolished both the sADP and PP. The sADP was depressed and the PP was abolished by either 10 microM nimodipine or 1 microM omega-conotoxin, whereas 1.2 microM tetrodotoxin was ineffective. The involvement of a Na+/Ca2+ exchanger...
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date1996-07-01