schliessen

Filtern

 

Bibliotheken

Distinct roles for ceramide and glucosylceramide at different stages of neuronal growth

Sphingolipids (SLs) are important structural and regulatory components of neuronal plasma membranes. Previous studies using fumonisin B1, an inhibitor of the synthesis of ceramide, the precursor of all SLs, demonstrated that ceramide synthesis is required to sustain axonal growth in hippocampal neur... Full description

Journal Title: The Journal of neuroscience : the official journal of the Society for Neuroscience 01 May 1997, Vol.17(9), pp.2929-38
Main Author: Schwarz, A
Other Authors: Futerman, A H
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0270-6474 ; PMID: 9096129 Version:1
Link: http://pubmed.gov/9096129
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: medline9096129
title: Distinct roles for ceramide and glucosylceramide at different stages of neuronal growth
format: Article
creator:
  • Schwarz, A
  • Futerman, A H
subjects:
  • Cell Differentiation -- Drug Effects
  • Cell Division -- Drug Effects
  • Ceramides -- Pharmacology
  • Glucosylceramides -- Pharmacology
  • Neurons -- Drug Effects
ispartof: The Journal of neuroscience : the official journal of the Society for Neuroscience, 01 May 1997, Vol.17(9), pp.2929-38
description: Sphingolipids (SLs) are important structural and regulatory components of neuronal plasma membranes. Previous studies using fumonisin B1, an inhibitor of the synthesis of ceramide, the precursor of all SLs, demonstrated that ceramide synthesis is required to sustain axonal growth in hippocampal neurons (; ) and dendritic growth in cerebellar Purkinje cells (). We now show that ceramide plays distinct roles at different stages of neuronal development. (1) During axon growth, ceramide must be metabolized to glucosylceramide (GlcCer) to sustain growth. Thus, whereas D-erythro-ceramide, which is metabolized to GlcCer, is able to antagonize the disruptive effects of fumonisin B1 on axon growth, L-threo-ceramide, which is not metabolized to GlcCer, is ineffective. (2) The formation of minor processes from lamellipodia can be stimulated by incubation with short-acyl chain analogs of ceramide that are active in ceramide-mediated signaling pathways, or by generation of endogenous ceramide by incubation...
language: eng
source:
identifier: ISSN: 0270-6474 ; PMID: 9096129 Version:1
fulltext: fulltext
issn:
  • 02706474
  • 0270-6474
url: Link


@attributes
ID781601866
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid9096129
sourceidmedline
recordidTN_medline9096129
sourceformatXML
sourcesystemPC
pqid78947440
display
typearticle
titleDistinct roles for ceramide and glucosylceramide at different stages of neuronal growth
creatorSchwarz, A ; Futerman, A H
ispartofThe Journal of neuroscience : the official journal of the Society for Neuroscience, 01 May 1997, Vol.17(9), pp.2929-38
identifierISSN: 0270-6474 ; PMID: 9096129 Version:1
subjectCell Differentiation -- Drug Effects ; Cell Division -- Drug Effects ; Ceramides -- Pharmacology ; Glucosylceramides -- Pharmacology ; Neurons -- Drug Effects
descriptionSphingolipids (SLs) are important structural and regulatory components of neuronal plasma membranes. Previous studies using fumonisin B1, an inhibitor of the synthesis of ceramide, the precursor of all SLs, demonstrated that ceramide synthesis is required to sustain axonal growth in hippocampal neurons (; ) and dendritic growth in cerebellar Purkinje cells (). We now show that ceramide plays distinct roles at different stages of neuronal development. (1) During axon growth, ceramide must be metabolized to glucosylceramide (GlcCer) to sustain growth. Thus, whereas D-erythro-ceramide, which is metabolized to GlcCer, is able to antagonize the disruptive effects of fumonisin B1 on axon growth, L-threo-ceramide, which is not metabolized to GlcCer, is ineffective. (2) The formation of minor processes from lamellipodia can be stimulated by incubation with short-acyl chain analogs of ceramide that are active in ceramide-mediated signaling pathways, or by generation of endogenous ceramide by incubation...
languageeng
source
version4
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://pubmed.gov/9096129$$EView_this_record_in_MEDLINE/PubMed
openurlfulltext$$Topenurlfull_article
addlink$$Uhttp://exlibris-pub.s3.amazonaws.com/aboutMedline.html$$EView_the_MEDLINE/PubMed_Copyright_Statement
search
creatorcontrib
0Schwarz, A
1Futerman, A H
titleDistinct roles for ceramide and glucosylceramide at different stages of neuronal growth
descriptionSphingolipids (SLs) are important structural and regulatory components of neuronal plasma membranes. Previous studies using fumonisin B1, an inhibitor of the synthesis of ceramide, the precursor of all SLs, demonstrated that ceramide synthesis is required to sustain axonal growth in hippocampal neurons (; ) and dendritic growth in cerebellar Purkinje cells (). We now show that ceramide plays distinct roles at different stages of neuronal development. (1) During axon growth, ceramide must be metabolized to glucosylceramide (GlcCer) to sustain growth. Thus, whereas D-erythro-ceramide, which is metabolized to GlcCer, is able to antagonize the disruptive effects of fumonisin B1 on axon growth, L-threo-ceramide, which is not metabolized to GlcCer, is ineffective. (2) The formation of minor processes from lamellipodia can be stimulated by incubation with short-acyl chain analogs of ceramide that are active in ceramide-mediated signaling pathways, or by generation of endogenous ceramide by incubation...
subject
0Cell Differentiation -- Drug Effects
1Cell Division -- Drug Effects
2Ceramides -- Pharmacology
3Glucosylceramides -- Pharmacology
4Neurons -- Drug Effects
general
09096129
1English
2MEDLINE/PubMed (U.S. National Library of Medicine)
3MEDLINE/PubMed (NLM)
sourceidmedline
recordidmedline9096129
issn
002706474
10270-6474
rsrctypearticle
creationdate1997
addtitleThe Journal of neuroscience : the official journal of the Society for Neuroscience
searchscope
0medline
1nlm_medline
2MEDLINE
scope
0medline
1nlm_medline
2MEDLINE
lsr4119970501
citationpf 2929 vol 17 issue 9
startdate19970501
enddate19970501
lsr30VSR-Enriched:[doi, pqid, pages, eissn]
sort
titleDistinct roles for ceramide and glucosylceramide at different stages of neuronal growth
authorSchwarz, A ; Futerman, A H
creationdate19970501
lso0119970501
facets
frbrgroupid6725635283883884242
frbrtype5
newrecords20190702
languageeng
creationdate1997
topic
0Cell Differentiation–Drug Effects
1Cell Division–Drug Effects
2Ceramides–Pharmacology
3Glucosylceramides–Pharmacology
4Neurons–Drug Effects
collectionMEDLINE/PubMed (NLM)
prefilterarticles
rsrctypearticles
creatorcontrib
0Schwarz, A
1Futerman, A H
jtitleJournal Of Neuroscience : The Official Journal Of The Society For Neuroscience
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Schwarz
1Futerman
aufirst
0A
1A H
au
0Schwarz, A
1Futerman, A H
atitleDistinct roles for ceramide and glucosylceramide at different stages of neuronal growth
jtitleThe Journal of neuroscience : the official journal of the Society for Neuroscience
risdate19970501
volume17
issue9
spage2929
pages2929-2938
issn0270-6474
formatjournal
genrearticle
ristypeJOUR
abstractSphingolipids (SLs) are important structural and regulatory components of neuronal plasma membranes. Previous studies using fumonisin B1, an inhibitor of the synthesis of ceramide, the precursor of all SLs, demonstrated that ceramide synthesis is required to sustain axonal growth in hippocampal neurons (; ) and dendritic growth in cerebellar Purkinje cells (). We now show that ceramide plays distinct roles at different stages of neuronal development. (1) During axon growth, ceramide must be metabolized to glucosylceramide (GlcCer) to sustain growth. Thus, whereas D-erythro-ceramide, which is metabolized to GlcCer, is able to antagonize the disruptive effects of fumonisin B1 on axon growth, L-threo-ceramide, which is not metabolized to GlcCer, is ineffective. (2) The formation of minor processes from lamellipodia can be stimulated by incubation with short-acyl chain analogs of ceramide that are active in ceramide-mediated signaling pathways, or by generation of endogenous ceramide by incubation...
pmid9096129
doi10.1523/JNEUROSCI.17-09-02929.1997
eissn15292401
date1997-05-01