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Zinc finger protein 32 promotes breast cancer stem cell-like properties through directly promoting GPER transcription

Breast cancer is one of the leading causes of death in women. Due to the existence of a small fraction of stem cell-like subpopulations, some breast cancer subtypes exhibit very high malignancy and resistance to multiple therapies. The underlying mechanisms of how these subtypes acquire stem cell-li... Full description

Journal Title: Cell death & disease 2018, Vol.9(12), pp.urn:issn:2041-4889
Main Author: Li, Yanyan
Other Authors: Gong, Di , Zhang, Le , Li, Hongjiang , Zhang, Shu , Zhang, Jie , Li, Kai , Zheng, Qian Wen , Zhao, Gang , Zhang, Yue , Chen, Yue , Guo, Yafei , Xiang, Rong , Lin, Ping , Wei, Yuquan
Format: Electronic Article Electronic Article
Language: English
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ID: ISSN: ; ISSN: 2041-4889
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title: Zinc finger protein 32 promotes breast cancer stem cell-like properties through directly promoting GPER transcription
format: Article
creator:
  • Li, Yanyan
  • Gong, Di
  • Zhang, Le
  • Li, Hongjiang
  • Zhang, Shu
  • Zhang, Jie
  • Li, Kai
  • Zheng, Qian Wen
  • Zhao, Gang
  • Zhang, Yue
  • Chen, Yue
  • Guo, Yafei
  • Xiang, Rong
  • Lin, Ping
  • Wei, Yuquan
subjects:
  • Article
ispartof: Cell death & disease, 2018, Vol.9(12), pp.urn:issn:2041-4889
description: Breast cancer is one of the leading causes of death in women. Due to the existence of a small fraction of stem cell-like subpopulations, some breast cancer subtypes exhibit very high malignancy and resistance to multiple therapies. The underlying mechanisms of how these subtypes acquire stem cell-like properties and progress more aggressively remain largely unknown. Zinc finger protein 32 (ZNF32), a newly discovered transcription factor, has been reported to be associated with breast cancer progression. However, many questions remain about its target genes and its exact mechanisms in regulating stem cell-like properties and drug resistance. In the present study, we examined the relationship between ZNF32 and GPER, a membrane-associated estrogen receptor, and we addressed their roles in stemness regulation in human breast cancer cell lines. Our results showed that ZNF32 could induce expansion of stem cell-like subpopulations and increase drug resistance by upregulating GPER expression, in...
language: eng
source:
identifier: ISSN: ; ISSN: 2041-4889
fulltext: fulltext_linktorsrc
issn:
  • 2041-4889
url: Link


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titleZinc finger protein 32 promotes breast cancer stem cell-like properties through directly promoting GPER transcription
creatorLi, Yanyan ; Gong, Di ; Zhang, Le ; Li, Hongjiang ; Zhang, Shu ; Zhang, Jie ; Li, Kai ; Zheng, Qian Wen ; Zhao, Gang ; Zhang, Yue ; Chen, Yue ; Guo, Yafei ; Xiang, Rong ; Lin, Ping ; Wei, Yuquan
contributorGraduate School ; CCA - Cancer biology and immunology ; CCA - Imaging and biomarkers ; AG&M - Re-generation and cancer of the digestive system
ispartofCell death & disease, 2018, Vol.9(12), pp.urn:issn:2041-4889
identifierISSN: ; ISSN: 2041-4889
descriptionBreast cancer is one of the leading causes of death in women. Due to the existence of a small fraction of stem cell-like subpopulations, some breast cancer subtypes exhibit very high malignancy and resistance to multiple therapies. The underlying mechanisms of how these subtypes acquire stem cell-like properties and progress more aggressively remain largely unknown. Zinc finger protein 32 (ZNF32), a newly discovered transcription factor, has been reported to be associated with breast cancer progression. However, many questions remain about its target genes and its exact mechanisms in regulating stem cell-like properties and drug resistance. In the present study, we examined the relationship between ZNF32 and GPER, a membrane-associated estrogen receptor, and we addressed their roles in stemness regulation in human breast cancer cell lines. Our results showed that ZNF32 could induce expansion of stem cell-like subpopulations and increase drug resistance by upregulating GPER expression, in...
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titleZinc finger protein 32 promotes breast cancer stem cell-like properties through directly promoting GPER transcription
descriptionBreast cancer is one of the leading causes of death in women. Due to the existence of a small fraction of stem cell-like subpopulations, some breast cancer subtypes exhibit very high malignancy and resistance to multiple therapies. The underlying mechanisms of how these subtypes acquire stem cell-like properties and progress more aggressively remain largely unknown. Zinc finger protein 32 (ZNF32), a newly discovered transcription factor, has been reported to be associated with breast cancer progression. However, many questions remain about its target genes and its exact mechanisms in regulating stem cell-like properties and drug resistance. In the present study, we examined the relationship between ZNF32 and GPER, a membrane-associated estrogen receptor, and we addressed their roles in stemness regulation in human breast cancer cell lines. Our results showed that ZNF32 could induce expansion of stem cell-like subpopulations and increase drug resistance by upregulating GPER expression, in...
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authorLi, Yanyan ; Gong, Di ; Zhang, Le ; Li, Hongjiang ; Zhang, Shu ; Zhang, Jie ; Li, Kai ; Zheng, Qian Wen ; Zhao, Gang ; Zhang, Yue ; Chen, Yue ; Guo, Yafei ; Xiang, Rong ; Lin, Ping ; Wei, Yuquan
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