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Hyperthermia-Induced Drug Delivery from Thermosensitive Liposomes Encapsulated in an Injectable Hydrogel for Local Chemotherapy

A novel drug delivery system, enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin-loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivi... Full description

Journal Title: Advanced healthcare materials 2014, Vol.3(6), pp.854-859
Main Author: López-Noriega, Adolfo
Other Authors: Hastings, Conn L. , Ozbakir, Burcin , O'Donnell, Kathleen E. , O'Brien, Fergal J. , Storm, Gerrit , Hennink, Wim E. , Duffy, Garry P. , Ruiz-Hernåndez, Eduardo
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ID: ISSN: ; ISSN: 2192-2640
Link: https://research.utwente.nl/en/publications/hyperthermiainduced-drug-delivery-from-thermosensitive-liposomes-encapsulated-in-an-injectable-hydrogel-for-local-chemotherapy(bd72065e-e937-4ca5-9368-4629c02b7bd6).html
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recordid: narcisut:oai:ris.utwente.nl:publications/bd72065e-e937-4ca5-9368-4629c02b7bd6
title: Hyperthermia-Induced Drug Delivery from Thermosensitive Liposomes Encapsulated in an Injectable Hydrogel for Local Chemotherapy
format: Article
creator:
  • López-Noriega, Adolfo
  • Hastings, Conn L.
  • Ozbakir, Burcin
  • O'Donnell, Kathleen E.
  • O'Brien, Fergal J.
  • Storm, Gerrit
  • Hennink, Wim E.
  • Duffy, Garry P.
  • Ruiz-Hernåndez, Eduardo
subjects:
  • Metis-309473
  • Ir-95144
ispartof: Advanced healthcare materials, 2014, Vol.3(6), pp.854-859
description: A novel drug delivery system, enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin-loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivity of this formulation is detailed. Combining on-demand drug delivery with in situ gelation results in a promising candidate for local chemotherapy
language:
source:
identifier: ISSN: ; ISSN: 2192-2640
fulltext: fulltext
issn:
  • 2192-2640
  • 2192-2659
url: Link


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creatorLópez-Noriega, Adolfo ; Hastings, Conn L. ; Ozbakir, Burcin ; O'Donnell, Kathleen E. ; O'Brien, Fergal J. ; Storm, Gerrit ; Hennink, Wim E. ; Duffy, Garry P. ; Ruiz-Hernåndez, Eduardo
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descriptionA novel drug delivery system, enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin-loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivity of this formulation is detailed. Combining on-demand drug delivery with in situ gelation results in a promising candidate for local chemotherapy
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