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Affective symptoms as predictors of Alzheimer's disease in subjects with mild cognitive impairment: a 10-year follow-up study

Background Affective symptoms are common in subjects with mild cognitive impairment (MCI), but there is disagreement whether these symptoms are predictive for Alzheimer's disease (AD). We investigated the predictive accuracy of affective symptoms for AD during a follow-up study in subjects with MCI,... Full description

Journal Title: Psychological Medicine 2010, Vol.40(7), pp.1193-1201
Main Author: Ramakers, I.H.G.B.
Other Authors: Visser, P.J. , Aalten, P. , Kester, A. , Jolles, J. , Verhey, F.R.J.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: ; ISSN: 0033-2917
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recordid: narcisvu:oai:research.vu.nl:publications/cb59eeb9-c739-477f-b1c4-ecc1ebc8d9a3
title: Affective symptoms as predictors of Alzheimer's disease in subjects with mild cognitive impairment: a 10-year follow-up study
format: Article
creator:
  • Ramakers, I.H.G.B.
  • Visser, P.J.
  • Aalten, P.
  • Kester, A.
  • Jolles, J.
  • Verhey, F.R.J.
subjects:
  • Affective Symptoms
  • Alzheimer's Disease
  • Mild Cognitive Impairment
  • Predictor
ispartof: Psychological Medicine, 2010, Vol.40(7), pp.1193-1201
description: Background Affective symptoms are common in subjects with mild cognitive impairment (MCI), but there is disagreement whether these symptoms are predictive for Alzheimer's disease (AD). We investigated the predictive accuracy of affective symptoms for AD during a follow-up study in subjects with MCI, and whether the predictive accuracy was modified by age, the presence of amnestic MCI or the length of follow-up.Method Newly referred subjects (n=263) with MCI older than 55 years were selected from a memory clinic and followed up after 2, 5 and 10 years. Predictors investigated were: symptoms of depression, anxiety, apathy and sleeping problems.Results Affective symptoms were present in 50-70% of the subjects. The average follow-up period was 5.4 years and 79 subjects (29%) developed AD. Sleeping problems were associated with a decreased risk for AD [odds ratio (OR) 0.35, p
language: eng
source:
identifier: ISSN: ; ISSN: 0033-2917
fulltext: fulltext_linktorsrc
issn:
  • 0033-2917
url: Link


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titleAffective symptoms as predictors of Alzheimer's disease in subjects with mild cognitive impairment: a 10-year follow-up study
creatorRamakers, I.H.G.B. ; Visser, P.J. ; Aalten, P. ; Kester, A. ; Jolles, J. ; Verhey, F.R.J.
contributorClinical Child and Family Studies ; Neuroscience Campus Amsterdam - Neurodegeneration ; LEARN! - Brain, learning and development
ispartofPsychological Medicine, 2010, Vol.40(7), pp.1193-1201
identifierISSN: ; ISSN: 0033-2917
descriptionBackground Affective symptoms are common in subjects with mild cognitive impairment (MCI), but there is disagreement whether these symptoms are predictive for Alzheimer's disease (AD). We investigated the predictive accuracy of affective symptoms for AD during a follow-up study in subjects with MCI, and whether the predictive accuracy was modified by age, the presence of amnestic MCI or the length of follow-up.Method Newly referred subjects (n=263) with MCI older than 55 years were selected from a memory clinic and followed up after 2, 5 and 10 years. Predictors investigated were: symptoms of depression, anxiety, apathy and sleeping problems.Results Affective symptoms were present in 50-70% of the subjects. The average follow-up period was 5.4 years and 79 subjects (29%) developed AD. Sleeping problems were associated with a decreased risk for AD [odds ratio (OR) 0.35, p<0.001]. Symptoms of depression (OR 0.61, p=0.059) and anxiety (OR 0.58, p=0.051) showed a trend in the same direction....
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titleAffective symptoms as predictors of Alzheimer's disease in subjects with mild cognitive impairment: a 10-year follow-up study
descriptionBackground Affective symptoms are common in subjects with mild cognitive impairment (MCI), but there is disagreement whether these symptoms are predictive for Alzheimer's disease (AD). We investigated the predictive accuracy of affective symptoms for AD during a follow-up study in subjects with MCI, and whether the predictive accuracy was modified by age, the presence of amnestic MCI or the length of follow-up.Method Newly referred subjects (n=263) with MCI older than 55 years were selected from a memory clinic and followed up after 2, 5 and 10 years. Predictors investigated were: symptoms of depression, anxiety, apathy and sleeping problems.Results Affective symptoms were present in 50-70% of the subjects. The average follow-up period was 5.4 years and 79 subjects (29%) developed AD. Sleeping problems were associated with a decreased risk for AD [odds ratio (OR) 0.35, p<0.001]. Symptoms of depression (OR 0.61, p=0.059) and anxiety (OR 0.58, p=0.051) showed a trend in the same direction....
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