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Phenolic compounds of Triplaris gardneriana can protect cells against oxidative stress and restore oxidative balance

This work aimed to add value to an underexploited plant species from Brazil, Triplaris gardneriana. To that, the phenolic compounds profile of its seed ethanolic extract and fractions was examined by HPLC and the antioxidant capacity assessed using chemical assays as well as in vitro cell imaging. T... Full description

Journal Title: Biomedicine and Pharmacotherapy 2017, Vol.93, pp.1261-1268
Main Author: Almeida, de, Thiago Silva
Other Authors: Neto, José Joaquim Lopes , Sousa, de, Nathanna Mateus , Pessoa, Igor Parra , Vieira, Leonardo Rogério , Medeiros, De, Jackeline Lima , Boligon, Aline Augusti , Hamers, Astrid R.M. , Farias, Davi Felipe , Peijnenburg, Ad , Carvalho, Ana Fontenele Urano
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: NARCIS (National Academic Research and Collaborations Information System)
ID: ISSN: ; ISSN: 0753-3322
Link: http://library.wur.nl/WebQuery/wurpubs/524462
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recordid: narciswur:oai:library.wur.nl:wurpubs/524462
title: Phenolic compounds of Triplaris gardneriana can protect cells against oxidative stress and restore oxidative balance
format: Article
creator:
  • Almeida, de, Thiago Silva
  • Neto, José Joaquim Lopes
  • Sousa, de, Nathanna Mateus
  • Pessoa, Igor Parra
  • Vieira, Leonardo Rogério
  • Medeiros, De, Jackeline Lima
  • Boligon, Aline Augusti
  • Hamers, Astrid R.M.
  • Farias, Davi Felipe
  • Peijnenburg, Ad
  • Carvalho, Ana Fontenele Urano
subjects:
  • Cell Imaging
  • Dpph
  • Mcf-7 Cells
  • Medicinal Plant
  • Tbars
ispartof: Biomedicine and Pharmacotherapy, 2017, Vol.93, pp.1261-1268
description: This work aimed to add value to an underexploited plant species from Brazil, Triplaris gardneriana. To that, the phenolic compounds profile of its seed ethanolic extract and fractions was examined by HPLC and the antioxidant capacity assessed using chemical assays as well as in vitro cell imaging. Twelve compounds were quantified and classified as either phenolic acids or flavonoids. The fractionation process did not generate fractions with different compositions except for chloroformic fraction, which showed only 6 out of 12 standard compounds used. DPPH assay revealed samples with a concentration-dependent radical scavenging activity, being methanolic fraction the one with the largest activity (SC50 11.45 ± 0.02 μg/mL). Lipid peroxidation assessment, in the presence and absence of stress inducer, showed that particularly the ethanol extract (IC50 26.75 ± 0.08 μg/mL) and the ethyl acetate fraction (IC50 6.14 ± 0.03 μg/mL) could inhibit lipid peroxidation. The ethyl acetate fraction performed...
language: eng
source: NARCIS (National Academic Research and Collaborations Information System)
identifier: ISSN: ; ISSN: 0753-3322
fulltext: fulltext
issn:
  • 0753-3322
url: Link


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titlePhenolic compounds of Triplaris gardneriana can protect cells against oxidative stress and restore oxidative balance
creatorAlmeida, de, Thiago Silva ; Neto, José Joaquim Lopes ; Sousa, de, Nathanna Mateus ; Pessoa, Igor Parra ; Vieira, Leonardo Rogério ; Medeiros, De, Jackeline Lima ; Boligon, Aline Augusti ; Hamers, Astrid R.M. ; Farias, Davi Felipe ; Peijnenburg, Ad ; Carvalho, Ana Fontenele Urano
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identifierISSN: ; ISSN: 0753-3322
subjectCell Imaging ; Dpph ; Mcf-7 Cells ; Medicinal Plant ; Tbars
descriptionThis work aimed to add value to an underexploited plant species from Brazil, Triplaris gardneriana. To that, the phenolic compounds profile of its seed ethanolic extract and fractions was examined by HPLC and the antioxidant capacity assessed using chemical assays as well as in vitro cell imaging. Twelve compounds were quantified and classified as either phenolic acids or flavonoids. The fractionation process did not generate fractions with different compositions except for chloroformic fraction, which showed only 6 out of 12 standard compounds used. DPPH assay revealed samples with a concentration-dependent radical scavenging activity, being methanolic fraction the one with the largest activity (SC50 11.45 ± 0.02 μg/mL). Lipid peroxidation assessment, in the presence and absence of stress inducer, showed that particularly the ethanol extract (IC50 26.75 ± 0.08 μg/mL) and the ethyl acetate fraction (IC50 6.14 ± 0.03 μg/mL) could inhibit lipid peroxidation. The ethyl acetate fraction performed...
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titlePhenolic compounds of Triplaris gardneriana can protect cells against oxidative stress and restore oxidative balance
descriptionThis work aimed to add value to an underexploited plant species from Brazil, Triplaris gardneriana. To that, the phenolic compounds profile of its seed ethanolic extract and fractions was examined by HPLC and the antioxidant capacity assessed using chemical assays as well as in vitro cell imaging. Twelve compounds were quantified and classified as either phenolic acids or flavonoids. The fractionation process did not generate fractions with different compositions except for chloroformic fraction, which showed only 6 out of 12 standard compounds used. DPPH assay revealed samples with a concentration-dependent radical scavenging activity, being methanolic fraction the one with the largest activity (SC50 11.45 ± 0.02 μg/mL). Lipid peroxidation assessment, in the presence and absence of stress inducer, showed that particularly the ethanol extract (IC50 26.75 ± 0.08 μg/mL) and the ethyl acetate fraction (IC50 6.14 ± 0.03 μg/mL) could inhibit lipid peroxidation. The ethyl acetate fraction performed...
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