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Nucleation of microtubule assembly by a γ-tubulin-containing ring complex

A study of the microtubule cytoskeleton in eukaryotes using unfertilized Xenopus eggs show that the highly conserved protein, gamma-tubulin, plays an important role in microtubule nucleation. Analysis of the protein using electron microscopy revealed at least seven proteins, with each protein having... Full description

Journal Title: Nature 1995, Vol.378(6557), p.578
Main Author: Yixian Zheng
Other Authors: Mei Lie Wong , Bruce Alberts , Tim Mitchison
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: ISSN: 0028-0836 ; E-ISSN: 1476-4687 ; DOI: 10.1038/378578a0
Link: http://dx.doi.org/10.1038/378578a0
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recordid: nature_a10.1038/378578a0
title: Nucleation of microtubule assembly by a γ-tubulin-containing ring complex
format: Article
creator:
  • Yixian Zheng
  • Mei Lie Wong
  • Bruce Alberts
  • Tim Mitchison
subjects:
  • Xenopus -- Research
  • Microtubules -- Research
  • Tubulin -- Research
  • Cytoskeleton -- Research
ispartof: Nature, 1995, Vol.378(6557), p.578
description: A study of the microtubule cytoskeleton in eukaryotes using unfertilized Xenopus eggs show that the highly conserved protein, gamma-tubulin, plays an important role in microtubule nucleation. Analysis of the protein using electron microscopy revealed at least seven proteins, with each protein having an open ring structure. Further analysis of the proteins showed that the ring structure contains a microtubule-nucleating unit that produces a new minus end of a microtubule.
language:
source:
identifier: ISSN: 0028-0836 ; E-ISSN: 1476-4687 ; DOI: 10.1038/378578a0
fulltext: fulltext
issn:
  • 0028-0836
  • 00280836
  • 1476-4687
  • 14764687
url: Link


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descriptionA study of the microtubule cytoskeleton in eukaryotes using unfertilized Xenopus eggs show that the highly conserved protein, gamma-tubulin, plays an important role in microtubule nucleation. Analysis of the protein using electron microscopy revealed at least seven proteins, with each protein having an open ring structure. Further analysis of the proteins showed that the ring structure contains a microtubule-nucleating unit that produces a new minus end of a microtubule.
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