schliessen

Filtern

 

Bibliotheken

The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans

At synaptic junctions, specialized subcellular structures occur in both pre- and postsynaptic cells. Most presynaptic termini contain electron-dense membrane structures, often referred to as active zones, which function in vesicle docking and release. The components of those active zones and how the... Full description

Journal Title: Nature 1999, Vol.401(6751), p.371
Main Author: Mei Zhen
Other Authors: Yishi Jin
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: ISSN: 0028-0836 ; E-ISSN: 1476-4687 ; DOI: 10.1038/43886
Link: http://dx.doi.org/10.1038/43886
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: nature_a10.1038/43886
title: The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans
format: Article
creator:
  • Mei Zhen
  • Yishi Jin
subjects:
  • Sciences (General)
  • Physics
ispartof: Nature, 1999, Vol.401(6751), p.371
description: At synaptic junctions, specialized subcellular structures occur in both pre- and postsynaptic cells. Most presynaptic termini contain electron-dense membrane structures, often referred to as active zones, which function in vesicle docking and release. The components of those active zones and how they are formed are largely unknown. We report here that a mutation in the Caenorhabditis elegans syd-2 (for synapse-defective) gene causes a diffused localization of several presynaptic proteins and of a synaptic-vesicle membrane associated green fluorescent protein (GFP) marker. Ultrastructural analysis revealed that the active zones of syd-2 mutants were significantly lengthened, whereas the total number of vesicles per synapse and the number of vesicles at the prominent active zones were comparable to those in wild-type animals. Synaptic transmission is partially impaired in syd-2 mutants. syd-2 encodes a member of the liprin (for LAR-interacting protein) family of proteins which interact with LAR-type (for leukocyte common antigen related) receptor proteins with tyrosine phosphatase activity (RPTPs). SYD-2 protein is localized at presynaptic termini independently of the presence of vesicles, and functions cell autonomously. We propose that SYD-2 regulates the differentiation of presynaptic termini in particular the formation of the active zone, by acting as an intracellular anchor for RPTP signalling at synaptic junctions.
language:
source:
identifier: ISSN: 0028-0836 ; E-ISSN: 1476-4687 ; DOI: 10.1038/43886
fulltext: fulltext
issn:
  • 0028-0836
  • 00280836
  • 1476-4687
  • 14764687
url: Link


@attributes
ID1646116170
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1038/43886
sourceidnature_a
recordidTN_nature_a10.1038/43886
sourcesystemPC
pqid743762545
galeid56698488
display
typearticle
titleThe liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans
creatorMei Zhen ; Yishi Jin
ispartofNature, 1999, Vol.401(6751), p.371
identifier
source
descriptionAt synaptic junctions, specialized subcellular structures occur in both pre- and postsynaptic cells. Most presynaptic termini contain electron-dense membrane structures, often referred to as active zones, which function in vesicle docking and release. The components of those active zones and how they are formed are largely unknown. We report here that a mutation in the Caenorhabditis elegans syd-2 (for synapse-defective) gene causes a diffused localization of several presynaptic proteins and of a synaptic-vesicle membrane associated green fluorescent protein (GFP) marker. Ultrastructural analysis revealed that the active zones of syd-2 mutants were significantly lengthened, whereas the total number of vesicles per synapse and the number of vesicles at the prominent active zones were comparable to those in wild-type animals. Synaptic transmission is partially impaired in syd-2 mutants. syd-2 encodes a member of the liprin (for LAR-interacting protein) family of proteins which interact with LAR-type (for leukocyte common antigen related) receptor proteins with tyrosine phosphatase activity (RPTPs). SYD-2 protein is localized at presynaptic termini independently of the presence of vesicles, and functions cell autonomously. We propose that SYD-2 regulates the differentiation of presynaptic termini in particular the formation of the active zone, by acting as an intracellular anchor for RPTP signalling at synaptic junctions.
subjectSciences (General) ; Physics;
version10
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://dx.doi.org/10.1038/43886$$EView_this_record_in_Nature
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Mei Zhen
1Yishi Jin
titleThe liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans
general
0Nature Publishing Group
110.1038/43886
2nature.com (Nature Publishing Group)
sourceidnature_a
recordidnature_a10.1038/43886
issn
00028-0836
100280836
21476-4687
314764687
rsrctypearticle
creationdate1999
searchscopenature_a
scopenature_a
lsr30VSR-Enriched:[description, pages, pqid, galeid, subject]
sort
titleThe liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans
authorMei Zhen ; Yishi Jin
creationdate19990923
facets
frbrgroupid8074120754555340119
frbrtype5
creationdate1999
collectionnature.com (Nature Publishing Group)
prefilterarticles
rsrctypearticles
creatorcontrib
0Mei Zhen
1Yishi Jin
jtitleNature
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Mei Zhen
1Yishi Jin
atitleThe liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans
jtitleNature
risdate19990923
volume401
issue6751
spage371
issn0028-0836
eissn1476-4687
genrearticle
ristypeJOUR
pubNature Publishing Group
doi10.1038/43886
pages371-375
date1999-09-23