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Infant diet and metabolic outcomes in school-age children. The Generation R Study

BACKGROUND: Breastfeeding duration is associated with the risks of cardio- metabolic diseases in adulthood. We examined the associations of infant feeding patterns with metabolic outcomes in children and whether any association was explained by family-based socio-demographic, maternal lifestyle-rela... Full description

Journal Title: European Journal of Clinical Nutrition 2014
Main Author: O Gishti
Other Authors: R Gaillard , B Durmuş , A Hofman , L Duijts , O H Franco , V W V Jaddoe
Format: Electronic Article Electronic Article
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Subjects:
ID: ISSN: 0954-3007 ; E-ISSN: 1476-5640 ; DOI: 10.1038/ejcn.2014.81
Link: http://dx.doi.org/10.1038/ejcn.2014.81
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recordid: nature_a10.1038/ejcn.2014.81
title: Infant diet and metabolic outcomes in school-age children. The Generation R Study
format: Article
creator:
  • O Gishti
  • R Gaillard
  • B Durmuş
  • A Hofman
  • L Duijts
  • O H Franco
  • V W V Jaddoe
subjects:
  • Infant Nutrition – Research
  • Breast Feeding – Health Aspects
ispartof: European Journal of Clinical Nutrition, 2014
description: BACKGROUND: Breastfeeding duration is associated with the risks of cardio- metabolic diseases in adulthood. We examined the associations of infant feeding patterns with metabolic outcomes in children and whether any association was explained by family-based socio-demographic, maternal lifestyle-related or childhood factors. SUBJECTS/METHODS: We performed a population-based prospective cohort study in 3417 children to examine the associations of breastfeeding duration and exclusivity and age at introduction of solid foods with blood levels of lipids, insulin and C-peptide and risk of clustering of cardio-metabolic risk factors at the median age of 6.0 years (90% range 5.7-6.8). RESULTS: We observed that, in the models only adjusted for child's age and sex, ever breastfeeding was not associated with childhood blood levels of lipids but was associated with higher insulin and C- peptide concentrations (P-value < 0.05). Breastfeeding duration and exclusivity were not consistently associated with metabolic outcomes. Early introduction of solid foods was associated with higher levels of total cholesterol (P-value < 0.05) but not with high- density lipoprotein and low-density lipoprotein cholesterol, triglycerides and insulin levels. Shorter breastfeeding duration and exclusive breastfeeding were associated with increased risks of clustering of cardio-metabolic risk factors. After additional adjustment for family, maternal and childhood factors, none of these associations remained significant. CONCLUSIONS: In conclusion, we found no consistent associations of infant feeding patterns with metabolic outcomes at school age, after taking into account family-based socio-demographic, maternal lifestyle-related or childhood factors. Whether infant diet composition influences metabolic outcomes in later life should be further studied. European Journal of Clinical Nutrition (2014) 68, 1008-1015; doi: 10.1038/ejcn.2014.81; published online 30 April 2014
language:
source:
identifier: ISSN: 0954-3007 ; E-ISSN: 1476-5640 ; DOI: 10.1038/ejcn.2014.81
fulltext: fulltext
issn:
  • 0954-3007
  • 09543007
  • 1476-5640
  • 14765640
url: Link


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titleInfant diet and metabolic outcomes in school-age children. The Generation R Study
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descriptionBACKGROUND: Breastfeeding duration is associated with the risks of cardio- metabolic diseases in adulthood. We examined the associations of infant feeding patterns with metabolic outcomes in children and whether any association was explained by family-based socio-demographic, maternal lifestyle-related or childhood factors. SUBJECTS/METHODS: We performed a population-based prospective cohort study in 3417 children to examine the associations of breastfeeding duration and exclusivity and age at introduction of solid foods with blood levels of lipids, insulin and C-peptide and risk of clustering of cardio-metabolic risk factors at the median age of 6.0 years (90% range 5.7-6.8). RESULTS: We observed that, in the models only adjusted for child's age and sex, ever breastfeeding was not associated with childhood blood levels of lipids but was associated with higher insulin and C- peptide concentrations (P-value < 0.05). Breastfeeding duration and exclusivity were not consistently associated with metabolic outcomes. Early introduction of solid foods was associated with higher levels of total cholesterol (P-value < 0.05) but not with high- density lipoprotein and low-density lipoprotein cholesterol, triglycerides and insulin levels. Shorter breastfeeding duration and exclusive breastfeeding were associated with increased risks of clustering of cardio-metabolic risk factors. After additional adjustment for family, maternal and childhood factors, none of these associations remained significant. CONCLUSIONS: In conclusion, we found no consistent associations of infant feeding patterns with metabolic outcomes at school age, after taking into account family-based socio-demographic, maternal lifestyle-related or childhood factors. Whether infant diet composition influences metabolic outcomes in later life should be further studied. European Journal of Clinical Nutrition (2014) 68, 1008-1015; doi: 10.1038/ejcn.2014.81; published online 30 April 2014
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