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Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing

Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage and jaundice. In more severe cases, massive pulmonary haemorrhages, including fatal sudden haemoptysis, can occur. Here we report the comp... Full description

Journal Title: Nature 2003, Vol.422(6934), p.888
Main Author: Shuang-Xi Ren
Other Authors: Gang Fu , Xiu-Gao Jiang , Rong Zeng , You-Gang Miao , Hai Xu , Yi-Xuan Zhang , Hui Xiong , Gang Lu , Ling-Feng Lu , Hong-Quan Jiang , Jia Jia , Yue-Feng Tu , Ju-Xing Jiang , Wen-Yi Gu , Yue-Qing Zhang , Zhen Cai , Hai-Hui Sheng , Hai-Feng Yin , Yi Zhang , Gen-Feng Zhu , Ma Wan , Hong-Lei Huang , Zhen Qian , Sheng-Yue Wang , Wei Ma , Zhi-Jian Yao , Yan Shen , Bo-Qin Qiang , Qi-Chang Xia , Xiao-Kui Guo , Antoine Danchin , Isabelle Saint Girons , Ronald L. Somerville , Yu-Mei Wen , Man-Hua Shi , Zhu Chen , Jian-Guo Xu , Guo-Ping Zhao
Format: Electronic Article Electronic Article
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ID: ISSN: 0028-0836 ; E-ISSN: 1476-4687 ; DOI: 10.1038/nature01597
Link: http://dx.doi.org/10.1038/nature01597
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recordid: nature_a10.1038/nature01597
title: Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing
format: Article
creator:
  • Shuang-Xi Ren
  • Gang Fu
  • Xiu-Gao Jiang
  • Rong Zeng
  • You-Gang Miao
  • Hai Xu
  • Yi-Xuan Zhang
  • Hui Xiong
  • Gang Lu
  • Ling-Feng Lu
  • Hong-Quan Jiang
  • Jia Jia
  • Yue-Feng Tu
  • Ju-Xing Jiang
  • Wen-Yi Gu
  • Yue-Qing Zhang
  • Zhen Cai
  • Hai-Hui Sheng
  • Hai-Feng Yin
  • Yi Zhang
  • Gen-Feng Zhu
  • Ma Wan
  • Hong-Lei Huang
  • Zhen Qian
  • Sheng-Yue Wang
  • Wei Ma
  • Zhi-Jian Yao
  • Yan Shen
  • Bo-Qin Qiang
  • Qi-Chang Xia
  • Xiao-Kui Guo
  • Antoine Danchin
  • Isabelle Saint Girons
  • Ronald L. Somerville
  • Yu-Mei Wen
  • Man-Hua Shi
  • Zhu Chen
  • Jian-Guo Xu
  • Guo-Ping Zhao
subjects:
  • Sciences (General)
  • Physics
ispartof: Nature, 2003, Vol.422(6934), p.888
description: Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage and jaundice. In more severe cases, massive pulmonary haemorrhages, including fatal sudden haemoptysis, can occur. Here we report the complete genomic sequence of a representative virulent serovar type strain (Lai) of Leptospira interrogans serogroup Icterohaemorrhagiae consisting of a 4.33-megabase large chromosome and a 359-kilobase small chromosome, with a total of 4,768 predicted genes. In terms of the genetic determinants of physiological characteristics, the facultatively parasitic L. interrogans differs extensively from two other strictly parasitic pathogenic spirochaetes, Treponema pallidum and Borrelia burgdorferi, although similarities exist in the genes that govern their unique morphological features. A comprehensive analysis of the L. interrogans genes for chemotaxis/motility and lipopolysaccharide synthesis provides a basis for in-depth studies of virulence and pathogenesis. The discovery of a series of genes possibly related to adhesion, invasion and the haematological changes that characterize leptospirosis has provided clues about how an environmental organism might evolve into an important human pathogen.
language:
source:
identifier: ISSN: 0028-0836 ; E-ISSN: 1476-4687 ; DOI: 10.1038/nature01597
fulltext: fulltext
issn:
  • 0028-0836
  • 00280836
  • 1476-4687
  • 14764687
url: Link


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titleUnique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing
creatorShuang-Xi Ren ; Gang Fu ; Xiu-Gao Jiang ; Rong Zeng ; You-Gang Miao ; Hai Xu ; Yi-Xuan Zhang ; Hui Xiong ; Gang Lu ; Ling-Feng Lu ; Hong-Quan Jiang ; Jia Jia ; Yue-Feng Tu ; Ju-Xing Jiang ; Wen-Yi Gu ; Yue-Qing Zhang ; Zhen Cai ; Hai-Hui Sheng ; Hai-Feng Yin ; Yi Zhang ; Gen-Feng Zhu ; Ma Wan ; Hong-Lei Huang ; Zhen Qian ; Sheng-Yue Wang ; Wei Ma ; Zhi-Jian Yao ; Yan Shen ; Bo-Qin Qiang ; Qi-Chang Xia ; Xiao-Kui Guo ; Antoine Danchin ; Isabelle Saint Girons ; Ronald L. Somerville ; Yu-Mei Wen ; Man-Hua Shi ; Zhu Chen ; Jian-Guo Xu ; Guo-Ping Zhao
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descriptionLeptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage and jaundice. In more severe cases, massive pulmonary haemorrhages, including fatal sudden haemoptysis, can occur. Here we report the complete genomic sequence of a representative virulent serovar type strain (Lai) of Leptospira interrogans serogroup Icterohaemorrhagiae consisting of a 4.33-megabase large chromosome and a 359-kilobase small chromosome, with a total of 4,768 predicted genes. In terms of the genetic determinants of physiological characteristics, the facultatively parasitic L. interrogans differs extensively from two other strictly parasitic pathogenic spirochaetes, Treponema pallidum and Borrelia burgdorferi, although similarities exist in the genes that govern their unique morphological features. A comprehensive analysis of the L. interrogans genes for chemotaxis/motility and lipopolysaccharide synthesis provides a basis for in-depth studies of virulence and pathogenesis. The discovery of a series of genes possibly related to adhesion, invasion and the haematological changes that characterize leptospirosis has provided clues about how an environmental organism might evolve into an important human pathogen.
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titleUnique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing
authorShuang-Xi Ren ; Gang Fu ; Xiu-Gao Jiang ; Rong Zeng ; You-Gang Miao ; Hai Xu ; Yi-Xuan Zhang ; Hui Xiong ; Gang Lu ; Ling-Feng Lu ; Hong-Quan Jiang ; Jia Jia ; Yue-Feng Tu ; Ju-Xing Jiang ; Wen-Yi Gu ; Yue-Qing Zhang ; Zhen Cai ; Hai-Hui Sheng ; Hai-Feng Yin ; Yi Zhang ; Gen-Feng Zhu ; Ma Wan ; Hong-Lei Huang ; Zhen Qian ; Sheng-Yue Wang ; Wei Ma ; Zhi-Jian Yao ; Yan Shen ; Bo-Qin Qiang ; Qi-Chang Xia ; Xiao-Kui Guo ; Antoine Danchin ; Isabelle Saint Girons ; Ronald L. Somerville ; Yu-Mei Wen ; Man-Hua Shi ; Zhu Chen ; Jian-Guo Xu ; Guo-Ping Zhao
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