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Recovery of learning and memory is associated with chromatin remodelling

Neurodegenerative diseases of the central nervous system are often associated with impaired learning and memory, eventually leading to dementia. An important aspect in pre-clinical research is the exploration of strategies to re-establish learning ability and access to long-term memories. By using a... Full description

Journal Title: Nature 2007, Vol.447(7141), p.178
Main Author: Andre Fischer
Other Authors: Farahnaz Sananbenesi , Xinyu Wang , Matthew Dobbin , Li-Huei Tsai
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: ISSN: 0028-0836 ; E-ISSN: 1476-4687 ; DOI: 10.1038/nature05772
Link: http://dx.doi.org/10.1038/nature05772
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recordid: nature_a10.1038/nature05772
title: Recovery of learning and memory is associated with chromatin remodelling
format: Article
creator:
  • Andre Fischer
  • Farahnaz Sananbenesi
  • Xinyu Wang
  • Matthew Dobbin
  • Li-Huei Tsai
subjects:
  • Histones
  • Learning
  • Inhibitors
  • Diseases
  • Enrichment
  • Recovery
  • Acetylation
  • Central Nervous System
  • General and Nonclassified (MD)
  • General and Nonclassified (EC)
  • General and Nonclassified (Ed)
  • General and Nonclassified (Ep)
  • Surveying, Theory, and Analysis (CE)
  • Design Principles, Theory, and Analysis (Mt)
  • Computing Milieux (General) (Ci)
  • Electronics and Communications Milieux (General) (Ea)
  • Solid State Milieux (General) (So)
  • Article
ispartof: Nature, 2007, Vol.447(7141), p.178
description: Neurodegenerative diseases of the central nervous system are often associated with impaired learning and memory, eventually leading to dementia. An important aspect in pre-clinical research is the exploration of strategies to re-establish learning ability and access to long-term memories. By using a mouse model that allows temporally and spatially restricted induction of neuronal loss, we show here that environmental enrichment reinstated learning behaviour and re-established access to long-term memories after significant brain atrophy and neuronal loss had already occurred. Environmental enrichment correlated with chromatin modifications (increased histone-tail acetylation). Moreover, increased histone acetylation by inhibitors of histone deacetylases induced sprouting of dendrites, an increased number of synapses, and reinstated learning behaviour and access to long-term memories. These data suggest that inhibition of histone deacetylases might be a suitable therapeutic avenue for neurodegenerative diseases associated with learning and memory impairment, and raises the possibility of recovery of long-term memories in patients with dementia. [PUBLICATION ]
language:
source:
identifier: ISSN: 0028-0836 ; E-ISSN: 1476-4687 ; DOI: 10.1038/nature05772
fulltext: fulltext
issn:
  • 0028-0836
  • 00280836
  • 1476-4687
  • 14764687
url: Link


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titleRecovery of learning and memory is associated with chromatin remodelling
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subjectHistones ; Learning ; Inhibitors ; Diseases ; Enrichment ; Recovery ; Acetylation ; Central Nervous System ; General and Nonclassified (MD) ; General and Nonclassified (EC) ; General and Nonclassified (Ed) ; General and Nonclassified (Ep) ; Surveying, Theory, and Analysis (CE) ; Design Principles, Theory, and Analysis (Mt) ; Computing Milieux (General) (Ci) ; Electronics and Communications Milieux (General) (Ea) ; Solid State Milieux (General) (So) ; Article;
descriptionNeurodegenerative diseases of the central nervous system are often associated with impaired learning and memory, eventually leading to dementia. An important aspect in pre-clinical research is the exploration of strategies to re-establish learning ability and access to long-term memories. By using a mouse model that allows temporally and spatially restricted induction of neuronal loss, we show here that environmental enrichment reinstated learning behaviour and re-established access to long-term memories after significant brain atrophy and neuronal loss had already occurred. Environmental enrichment correlated with chromatin modifications (increased histone-tail acetylation). Moreover, increased histone acetylation by inhibitors of histone deacetylases induced sprouting of dendrites, an increased number of synapses, and reinstated learning behaviour and access to long-term memories. These data suggest that inhibition of histone deacetylases might be a suitable therapeutic avenue for neurodegenerative diseases associated with learning and memory impairment, and raises the possibility of recovery of long-term memories in patients with dementia. [PUBLICATION ]
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