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Towards a transgenic model of Huntington’s disease in a non-human primate

Non-human primates are valuable for modelling human disorders and for developing therapeutic strategies; however, little work has been reported in establishing transgenic non-human primate models of human diseases. Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder charact... Full description

Journal Title: Nature 2008, Vol.453(7197), p.921
Main Author: Shang-Hsun Yang
Other Authors: Pei-Hsun Cheng , Heather Banta , Karolina Piotrowska-Nitsche , Jin-Jing Yang , Eric C. H. Cheng , Brooke Snyder , Katherine Larkin , Jun Liu , Jack Orkin , Zhi-Hui Fang , Yoland Smith , Jocelyne Bachevalier , Stuart M. Zola , Shi-Hua Li , Xiao-Jiang Li , Anthony W. S. Chan
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ID: ISSN: 0028-0836 ; E-ISSN: 1476-4687 ; DOI: 10.1038/nature06975
Link: http://dx.doi.org/10.1038/nature06975
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recordid: nature_a10.1038/nature06975
title: Towards a transgenic model of Huntington’s disease in a non-human primate
format: Article
creator:
  • Shang-Hsun Yang
  • Pei-Hsun Cheng
  • Heather Banta
  • Karolina Piotrowska-Nitsche
  • Jin-Jing Yang
  • Eric C. H. Cheng
  • Brooke Snyder
  • Katherine Larkin
  • Jun Liu
  • Jack Orkin
  • Zhi-Hui Fang
  • Yoland Smith
  • Jocelyne Bachevalier
  • Stuart M. Zola
  • Shi-Hua Li
  • Xiao-Jiang Li
  • Anthony W. S. Chan
subjects:
  • Sciences (General)
  • Physics
ispartof: Nature, 2008, Vol.453(7197), p.921
description: Non-human primates are valuable for modelling human disorders and for developing therapeutic strategies; however, little work has been reported in establishing transgenic non-human primate models of human diseases. Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor impairment, cognitive deterioration and psychiatric disturbances followed by death within 10-15 years of the onset of the symptoms. HD is caused by the expansion of cytosine-adenine-guanine (CAG, translated into glutamine) trinucleotide repeats in the first exon of the human huntingtin (HTT) gene. Mutant HTT with expanded polyglutamine (polyQ) is widely expressed in the brain and peripheral tissues, but causes selective neurodegeneration that is most prominent in the striatum and cortex of the brain. Although rodent models of HD have been developed, these models do not satisfactorily parallel the brain changes and behavioural features observed in HD patients. Because of the close physiological, neurological and genetic similarities between humans and higher primates, monkeys can serve as very useful models for understanding human physiology and diseases. Here we report our progress in developing a transgenic model of HD in a rhesus macaque that expresses polyglutamine-expanded HTT. Hallmark features of HD, including nuclear inclusions and neuropil aggregates, were observed in the brains of the HD transgenic monkeys. Additionally, the transgenic monkeys showed important clinical features of HD, including dystonia and chorea. A transgenic HD monkey model may open the way to understanding the underlying biology of HD better, and to the development of potential therapies. Moreover, our data suggest that it will be feasible to generate valuable non-human primate models of HD and possibly other human genetic diseases.
language:
source:
identifier: ISSN: 0028-0836 ; E-ISSN: 1476-4687 ; DOI: 10.1038/nature06975
fulltext: fulltext
issn:
  • 0028-0836
  • 00280836
  • 1476-4687
  • 14764687
url: Link


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titleTowards a transgenic model of Huntington’s disease in a non-human primate
creatorShang-Hsun Yang ; Pei-Hsun Cheng ; Heather Banta ; Karolina Piotrowska-Nitsche ; Jin-Jing Yang ; Eric C. H. Cheng ; Brooke Snyder ; Katherine Larkin ; Jun Liu ; Jack Orkin ; Zhi-Hui Fang ; Yoland Smith ; Jocelyne Bachevalier ; Stuart M. Zola ; Shi-Hua Li ; Xiao-Jiang Li ; Anthony W. S. Chan
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descriptionNon-human primates are valuable for modelling human disorders and for developing therapeutic strategies; however, little work has been reported in establishing transgenic non-human primate models of human diseases. Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor impairment, cognitive deterioration and psychiatric disturbances followed by death within 10-15 years of the onset of the symptoms. HD is caused by the expansion of cytosine-adenine-guanine (CAG, translated into glutamine) trinucleotide repeats in the first exon of the human huntingtin (HTT) gene. Mutant HTT with expanded polyglutamine (polyQ) is widely expressed in the brain and peripheral tissues, but causes selective neurodegeneration that is most prominent in the striatum and cortex of the brain. Although rodent models of HD have been developed, these models do not satisfactorily parallel the brain changes and behavioural features observed in HD patients. Because of the close physiological, neurological and genetic similarities between humans and higher primates, monkeys can serve as very useful models for understanding human physiology and diseases. Here we report our progress in developing a transgenic model of HD in a rhesus macaque that expresses polyglutamine-expanded HTT. Hallmark features of HD, including nuclear inclusions and neuropil aggregates, were observed in the brains of the HD transgenic monkeys. Additionally, the transgenic monkeys showed important clinical features of HD, including dystonia and chorea. A transgenic HD monkey model may open the way to understanding the underlying biology of HD better, and to the development of potential therapies. Moreover, our data suggest that it will be feasible to generate valuable non-human primate models of HD and possibly other human genetic diseases.
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