schliessen

Filtern

 

Bibliotheken

Seventy-five genetic loci influencing the human red blood cell

Anaemia is a chief determinant of global ill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related... Full description

Journal Title: Nature 2012, Vol.492(7429), p.369
Main Author: Pim Van Der Harst
Other Authors: Weihua Zhang , Irene Mateo Leach , Augusto Rendon , Niek Verweij , Joban Sehmi , Dirk S. Paul , Ulrich Elling , Hooman Allayee , Xinzhong Li , Aparna Radhakrishnan , Sian-Tsung Tan , Katrin Voss , Christian X. Weichenberger , Cornelis A. Albers , Abtehale Al-Hussani , Folkert W. Asselbergs , Marina Ciullo , Fabrice Danjou , Christian Dina , Tõnu Esko , David M. Evans , Lude Franke , Martin Gögele , Jaana Hartiala , Micha Hersch , Hilma Holm , Jouke-Jan Hottenga , Stavroula Kanoni , Marcus E. Kleber , Vasiliki Lagou , Claudia Langenberg , Lorna M. Lopez , Leo-Pekka Lyytikäinen , Olle Melander , Federico Murgia , Ilja M. Nolte , Paul F. O’reilly , Sandosh Padmanabhan , Afshin Parsa , Nicola Pirastu , Eleonora Porcu , Laura Portas , Inga Prokopenko , Janina S. Ried , So-Youn Shin , Clara S. Tang , Alexander Teumer , Michela Traglia , Sheila Ulivi , Harm-Jan Westra , Jian Yang , Jing Hua Zhao , Franco Anni , Abdel Abdellaoui , Antony Attwood , Beverley Balkau , Stefania Bandinelli , François Bastardot , Beben Benyamin , Bernhard O. Boehm , William O. Cookson , Debashish Das , Paul I. W. De Bakker , Rudolf A. De Boer , Eco J. C. De Geus , Marleen H. De Moor , Maria Dimitriou , Francisco S. Domingues , Angela Döring , Gunnar Engström , Gudmundur Ingi Eyjolfsson , Luigi Ferrucci , Krista Fischer , Renzo Galanello , Stephen F. Garner , Bernd Genser , Quince D. Gibson , Giorgia Girotto , Daniel Fannar Gudbjartsson , Sarah E. Harris , Anna-Liisa Hartikainen , Claire E. Hastie , Bo Hedblad , Thomas Illig , Jennifer Jolley , Mika Kähönen , Ido P. Kema , John P. Kemp , Liming Liang , Heather Lloyd-Jones , Ruth J. F. Loos , Stuart Meacham , Sarah E. Medland , Christa Meisinger , Yasin Memari , Evelin Mihailov , Kathy Miller , Miriam F. Moffatt , Matthias Nauck , Maria Novatchkova , Teresa Nutile , Isleifur Olafsson , Pall T. Onundarson , Debora Parracciani , Brenda W. Penninx , Lucia Perseu , Antonio Piga , Giorgio Pistis , Anneli Pouta , Ursula Puc , Olli Raitakari , Susan M. Ring , Antonietta Robino , Daniela Ruggiero , Aimo Ruokonen , Aude Saint-Pierre , Cinzia Sala , Andres Salumets , Jennifer Sambrook , Hein Schepers , Carsten Oliver Schmidt , Herman H. W. Silljé , Rob Sladek , Johannes H. Smit , John M. Starr , Jonathan Stephens , Patrick Sulem , Toshiko Tanaka , Unnur Thorsteinsdottir , Vinicius Tragante , Wiek H. Van Gilst , L. Joost Van Pelt , Dirk J. Van Veldhuisen , Uwe Völker , John B. Whitfield , Gonneke Willemsen , Bernhard R. Winkelmann , Gerald Wirnsberger , Ale Algra , Francesco Cucca , Adamo Pio D’adamo , John Danesh , Ian J. Deary , Anna F. Dominiczak , Paul Elliott , Paolo Fortina , Philippe Froguel , Paolo Gasparini , Andreas Greinacher , Stanley L. Hazen , Marjo-Riitta Jarvelin , Kay Tee Khaw , Terho Lehtimäki , Winfried Maerz , Nicholas G. Martin , Andres Metspalu , Braxton D. Mitchell , Grant W. Montgomery , Carmel Moore , Gerjan Navis , Mario Pirastu , Peter P. Pramstaller , Ramiro Ramirez-Solis , Eric Schadt , James Scott , Alan R. Shuldiner , George Davey Smith , J. Gustav Smith , Harold Snieder , Rossella Sorice , Tim D. Spector , Kari Stefansson , Michael Stumvoll , W. H. Wilson Tang , Daniela Toniolo , Anke Tönjes , Peter M. Visscher , Peter Vollenweider , Nicholas J. Wareham , Bruce H. R. Wolffenbuttel , Dorret I. Boomsma , Jacques S. Beckmann , George V. Dedoussis , Panos Deloukas , Manuel A. Ferreira , Serena Sanna , Manuela Uda , Andrew A. Hicks , Josef Martin Penninger , Christian Gieger , Jaspal S. Kooner , Willem H. Ouwehand , Nicole Soranzo , John C. Chambers
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: ISSN: 0028-0836 ; E-ISSN: 1476-4687 ; DOI: 10.1038/nature11677
Link: http://dx.doi.org/10.1038/nature11677
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: nature_a10.1038/nature11677
title: Seventy-five genetic loci influencing the human red blood cell
format: Article
creator:
  • Pim Van Der Harst
  • Weihua Zhang
  • Irene Mateo Leach
  • Augusto Rendon
  • Niek Verweij
  • Joban Sehmi
  • Dirk S. Paul
  • Ulrich Elling
  • Hooman Allayee
  • Xinzhong Li
  • Aparna Radhakrishnan
  • Sian-Tsung Tan
  • Katrin Voss
  • Christian X. Weichenberger
  • Cornelis A. Albers
  • Abtehale Al-Hussani
  • Folkert W. Asselbergs
  • Marina Ciullo
  • Fabrice Danjou
  • Christian Dina
  • Tõnu Esko
  • David M. Evans
  • Lude Franke
  • Martin Gögele
  • Jaana Hartiala
  • Micha Hersch
  • Hilma Holm
  • Jouke-Jan Hottenga
  • Stavroula Kanoni
  • Marcus E. Kleber
  • Vasiliki Lagou
  • Claudia Langenberg
  • Lorna M. Lopez
  • Leo-Pekka Lyytikäinen
  • Olle Melander
  • Federico Murgia
  • Ilja M. Nolte
  • Paul F. O’reilly
  • Sandosh Padmanabhan
  • Afshin Parsa
  • Nicola Pirastu
  • Eleonora Porcu
  • Laura Portas
  • Inga Prokopenko
  • Janina S. Ried
  • So-Youn Shin
  • Clara S. Tang
  • Alexander Teumer
  • Michela Traglia
  • Sheila Ulivi
  • Harm-Jan Westra
  • Jian Yang
  • Jing Hua Zhao
  • Franco Anni
  • Abdel Abdellaoui
  • Antony Attwood
  • Beverley Balkau
  • Stefania Bandinelli
  • François Bastardot
  • Beben Benyamin
  • Bernhard O. Boehm
  • William O. Cookson
  • Debashish Das
  • Paul I. W. De Bakker
  • Rudolf A. De Boer
  • Eco J. C. De Geus
  • Marleen H. De Moor
  • Maria Dimitriou
  • Francisco S. Domingues
  • Angela Döring
  • Gunnar Engström
  • Gudmundur Ingi Eyjolfsson
  • Luigi Ferrucci
  • Krista Fischer
  • Renzo Galanello
  • Stephen F. Garner
  • Bernd Genser
  • Quince D. Gibson
  • Giorgia Girotto
  • Daniel Fannar Gudbjartsson
  • Sarah E. Harris
  • Anna-Liisa Hartikainen
  • Claire E. Hastie
  • Bo Hedblad
  • Thomas Illig
  • Jennifer Jolley
  • Mika Kähönen
  • Ido P. Kema
  • John P. Kemp
  • Liming Liang
  • Heather Lloyd-Jones
  • Ruth J. F. Loos
  • Stuart Meacham
  • Sarah E. Medland
  • Christa Meisinger
  • Yasin Memari
  • Evelin Mihailov
  • Kathy Miller
  • Miriam F. Moffatt
  • Matthias Nauck
  • Maria Novatchkova
  • Teresa Nutile
  • Isleifur Olafsson
  • Pall T. Onundarson
  • Debora Parracciani
  • Brenda W. Penninx
  • Lucia Perseu
  • Antonio Piga
  • Giorgio Pistis
  • Anneli Pouta
  • Ursula Puc
  • Olli Raitakari
  • Susan M. Ring
  • Antonietta Robino
  • Daniela Ruggiero
  • Aimo Ruokonen
  • Aude Saint-Pierre
  • Cinzia Sala
  • Andres Salumets
  • Jennifer Sambrook
  • Hein Schepers
  • Carsten Oliver Schmidt
  • Herman H. W. Silljé
  • Rob Sladek
  • Johannes H. Smit
  • John M. Starr
  • Jonathan Stephens
  • Patrick Sulem
  • Toshiko Tanaka
  • Unnur Thorsteinsdottir
  • Vinicius Tragante
  • Wiek H. Van Gilst
  • L. Joost Van Pelt
  • Dirk J. Van Veldhuisen
  • Uwe Völker
  • John B. Whitfield
  • Gonneke Willemsen
  • Bernhard R. Winkelmann
  • Gerald Wirnsberger
  • Ale Algra
  • Francesco Cucca
  • Adamo Pio D’adamo
  • John Danesh
  • Ian J. Deary
  • Anna F. Dominiczak
  • Paul Elliott
  • Paolo Fortina
  • Philippe Froguel
  • Paolo Gasparini
  • Andreas Greinacher
  • Stanley L. Hazen
  • Marjo-Riitta Jarvelin
  • Kay Tee Khaw
  • Terho Lehtimäki
  • Winfried Maerz
  • Nicholas G. Martin
  • Andres Metspalu
  • Braxton D. Mitchell
  • Grant W. Montgomery
  • Carmel Moore
  • Gerjan Navis
  • Mario Pirastu
  • Peter P. Pramstaller
  • Ramiro Ramirez-Solis
  • Eric Schadt
  • James Scott
  • Alan R. Shuldiner
  • George Davey Smith
  • J. Gustav Smith
  • Harold Snieder
  • Rossella Sorice
  • Tim D. Spector
  • Kari Stefansson
  • Michael Stumvoll
  • W. H. Wilson Tang
  • Daniela Toniolo
  • Anke Tönjes
  • Peter M. Visscher
  • Peter Vollenweider
  • Nicholas J. Wareham
  • Bruce H. R. Wolffenbuttel
  • Dorret I. Boomsma
  • Jacques S. Beckmann
  • George V. Dedoussis
  • Panos Deloukas
  • Manuel A. Ferreira
  • Serena Sanna
  • Manuela Uda
  • Andrew A. Hicks
  • Josef Martin Penninger
  • Christian Gieger
  • Jaspal S. Kooner
  • Willem H. Ouwehand
  • Nicole Soranzo
  • John C. Chambers
subjects:
  • Red Blood Cells – Research
  • Red Blood Cells – Genetic Aspects
  • Hemoglobins – Research
  • Hemoglobins – Genetic Aspects
  • Phenotypes – Research
  • Gene Expression – Research
ispartof: Nature, 2012, Vol.492(7429), p.369
description: Anaemia is a chief determinant of global ill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. Here we identify 75 independent genetic loci associated with one or more red blood cell phenotypes at P < [10.sup.-8], which together explain 4-9% of the phenotypic variance per trait. Using expression quantitative trait loci and bioinformatic strategies, we identify 121 candidate genes enriched in functions relevant to red blood cell biology. The candidate genes are expressed preferentially in red blood cell precursors, and 43 have haematopoietic phenotypes in Mus musculus or Drosophila melanogaster. Through open-chromatin and coding-variant analyses we identify potential causal genetic variants at 41 loci. Our findings provide extensive new insights into genetic mechanisms and biological pathways controlling red blood cell formation and function.
language:
source:
identifier: ISSN: 0028-0836 ; E-ISSN: 1476-4687 ; DOI: 10.1038/nature11677
fulltext: fulltext
issn:
  • 0028-0836
  • 00280836
  • 1476-4687
  • 14764687
url: Link


@attributes
ID1782181742
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1038/nature11677
sourceidnature_a
recordidTN_nature_a10.1038/nature11677
sourcesystemPC
pqid1271872302
galeid359733140
display
typearticle
titleSeventy-five genetic loci influencing the human red blood cell
creatorPim Van Der Harst ; Weihua Zhang ; Irene Mateo Leach ; Augusto Rendon ; Niek Verweij ; Joban Sehmi ; Dirk S. Paul ; Ulrich Elling ; Hooman Allayee ; Xinzhong Li ; Aparna Radhakrishnan ; Sian-Tsung Tan ; Katrin Voss ; Christian X. Weichenberger ; Cornelis A. Albers ; Abtehale Al-Hussani ; Folkert W. Asselbergs ; Marina Ciullo ; Fabrice Danjou ; Christian Dina ; Tõnu Esko ; David M. Evans ; Lude Franke ; Martin Gögele ; Jaana Hartiala ; Micha Hersch ; Hilma Holm ; Jouke-Jan Hottenga ; Stavroula Kanoni ; Marcus E. Kleber ; Vasiliki Lagou ; Claudia Langenberg ; Lorna M. Lopez ; Leo-Pekka Lyytikäinen ; Olle Melander ; Federico Murgia ; Ilja M. Nolte ; Paul F. O’reilly ; Sandosh Padmanabhan ; Afshin Parsa ; Nicola Pirastu ; Eleonora Porcu ; Laura Portas ; Inga Prokopenko ; Janina S. Ried ; So-Youn Shin ; Clara S. Tang ; Alexander Teumer ; Michela Traglia ; Sheila Ulivi ; Harm-Jan Westra ; Jian Yang ; Jing Hua Zhao ; Franco Anni ; Abdel Abdellaoui ; Antony Attwood ; Beverley Balkau ; Stefania Bandinelli ; François Bastardot ; Beben Benyamin ; Bernhard O. Boehm ; William O. Cookson ; Debashish Das ; Paul I. W. De Bakker ; Rudolf A. De Boer ; Eco J. C. De Geus ; Marleen H. De Moor ; Maria Dimitriou ; Francisco S. Domingues ; Angela Döring ; Gunnar Engström ; Gudmundur Ingi Eyjolfsson ; Luigi Ferrucci ; Krista Fischer ; Renzo Galanello ; Stephen F. Garner ; Bernd Genser ; Quince D. Gibson ; Giorgia Girotto ; Daniel Fannar Gudbjartsson ; Sarah E. Harris ; Anna-Liisa Hartikainen ; Claire E. Hastie ; Bo Hedblad ; Thomas Illig ; Jennifer Jolley ; Mika Kähönen ; Ido P. Kema ; John P. Kemp ; Liming Liang ; Heather Lloyd-Jones ; Ruth J. F. Loos ; Stuart Meacham ; Sarah E. Medland ; Christa Meisinger ; Yasin Memari ; Evelin Mihailov ; Kathy Miller ; Miriam F. Moffatt ; Matthias Nauck ; Maria Novatchkova ; Teresa Nutile ; Isleifur Olafsson ; Pall T. Onundarson ; Debora Parracciani ; Brenda W. Penninx ; Lucia Perseu ; Antonio Piga ; Giorgio Pistis ; Anneli Pouta ; Ursula Puc ; Olli Raitakari ; Susan M. Ring ; Antonietta Robino ; Daniela Ruggiero ; Aimo Ruokonen ; Aude Saint-Pierre ; Cinzia Sala ; Andres Salumets ; Jennifer Sambrook ; Hein Schepers ; Carsten Oliver Schmidt ; Herman H. W. Silljé ; Rob Sladek ; Johannes H. Smit ; John M. Starr ; Jonathan Stephens ; Patrick Sulem ; Toshiko Tanaka ; Unnur Thorsteinsdottir ; Vinicius Tragante ; Wiek H. Van Gilst ; L. Joost Van Pelt ; Dirk J. Van Veldhuisen ; Uwe Völker ; John B. Whitfield ; Gonneke Willemsen ; Bernhard R. Winkelmann ; Gerald Wirnsberger ; Ale Algra ; Francesco Cucca ; Adamo Pio D’adamo ; John Danesh ; Ian J. Deary ; Anna F. Dominiczak ; Paul Elliott ; Paolo Fortina ; Philippe Froguel ; Paolo Gasparini ; Andreas Greinacher ; Stanley L. Hazen ; Marjo-Riitta Jarvelin ; Kay Tee Khaw ; Terho Lehtimäki ; Winfried Maerz ; Nicholas G. Martin ; Andres Metspalu ; Braxton D. Mitchell ; Grant W. Montgomery ; Carmel Moore ; Gerjan Navis ; Mario Pirastu ; Peter P. Pramstaller ; Ramiro Ramirez-Solis ; Eric Schadt ; James Scott ; Alan R. Shuldiner ; George Davey Smith ; J. Gustav Smith ; Harold Snieder ; Rossella Sorice ; Tim D. Spector ; Kari Stefansson ; Michael Stumvoll ; W. H. Wilson Tang ; Daniela Toniolo ; Anke Tönjes ; Peter M. Visscher ; Peter Vollenweider ; Nicholas J. Wareham ; Bruce H. R. Wolffenbuttel ; Dorret I. Boomsma ; Jacques S. Beckmann ; George V. Dedoussis ; Panos Deloukas ; Manuel A. Ferreira ; Serena Sanna ; Manuela Uda ; Andrew A. Hicks ; Josef Martin Penninger ; Christian Gieger ; Jaspal S. Kooner ; Willem H. Ouwehand ; Nicole Soranzo ; John C. Chambers
ispartofNature, 2012, Vol.492(7429), p.369
identifier
source
subjectRed Blood Cells – Research ; Red Blood Cells – Genetic Aspects ; Hemoglobins – Research ; Hemoglobins – Genetic Aspects ; Phenotypes – Research ; Gene Expression – Research;
descriptionAnaemia is a chief determinant of global ill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. Here we identify 75 independent genetic loci associated with one or more red blood cell phenotypes at P < [10.sup.-8], which together explain 4-9% of the phenotypic variance per trait. Using expression quantitative trait loci and bioinformatic strategies, we identify 121 candidate genes enriched in functions relevant to red blood cell biology. The candidate genes are expressed preferentially in red blood cell precursors, and 43 have haematopoietic phenotypes in Mus musculus or Drosophila melanogaster. Through open-chromatin and coding-variant analyses we identify potential causal genetic variants at 41 loci. Our findings provide extensive new insights into genetic mechanisms and biological pathways controlling red blood cell formation and function.
version11
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://dx.doi.org/10.1038/nature11677$$EView_this_record_in_Nature
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Pim Van Der Harst
1Weihua Zhang
2Irene Mateo Leach
3Augusto Rendon
4Niek Verweij
5Joban Sehmi
6Dirk S. Paul
7Ulrich Elling
8Hooman Allayee
9Xinzhong Li
10Aparna Radhakrishnan
11Sian-Tsung Tan
12Katrin Voss
13Christian X. Weichenberger
14Cornelis A. Albers
15Abtehale Al-Hussani
16Folkert W. Asselbergs
17Marina Ciullo
18Fabrice Danjou
19Christian Dina
20Tõnu Esko
21David M. Evans
22Lude Franke
23Martin Gögele
24Jaana Hartiala
25Micha Hersch
26Hilma Holm
27Jouke-Jan Hottenga
28Stavroula Kanoni
29Marcus E. Kleber
30Vasiliki Lagou
31Claudia Langenberg
32Lorna M. Lopez
33Leo-Pekka Lyytikäinen
34Olle Melander
35Federico Murgia
36Ilja M. Nolte
37Paul F. O’reilly
38Sandosh Padmanabhan
39Afshin Parsa
40Nicola Pirastu
41Eleonora Porcu
42Laura Portas
43Inga Prokopenko
44Janina S. Ried
45So-Youn Shin
46Clara S. Tang
47Alexander Teumer
48Michela Traglia
49Sheila Ulivi
50Harm-Jan Westra
51Jian Yang
52Jing Hua Zhao
53Franco Anni
54Abdel Abdellaoui
55Antony Attwood
56Beverley Balkau
57Stefania Bandinelli
58François Bastardot
59Beben Benyamin
60Bernhard O. Boehm
61William O. Cookson
62Debashish Das
63Paul I. W. De Bakker
64Rudolf A. De Boer
65Eco J. C. De Geus
66Marleen H. De Moor
67Maria Dimitriou
68Francisco S. Domingues
69Angela Döring
70Gunnar Engström
71Gudmundur Ingi Eyjolfsson
72Luigi Ferrucci
73Krista Fischer
74Renzo Galanello
75Stephen F. Garner
76Bernd Genser
77Quince D. Gibson
78Giorgia Girotto
79Daniel Fannar Gudbjartsson
80Sarah E. Harris
81Anna-Liisa Hartikainen
82Claire E. Hastie
83Bo Hedblad
84Thomas Illig
85Jennifer Jolley
86Mika Kähönen
87Ido P. Kema
88John P. Kemp
89Liming Liang
90Heather Lloyd-Jones
91Ruth J. F. Loos
92Stuart Meacham
93Sarah E. Medland
94Christa Meisinger
95Yasin Memari
96Evelin Mihailov
97Kathy Miller
98Miriam F. Moffatt
99Matthias Nauck
100...
titleSeventy-five genetic loci influencing the human red blood cell
general
0Nature Publishing Group
110.1038/nature11677
2nature.com (Nature Publishing Group)
sourceidnature_a
recordidnature_a10.1038/nature11677
issn
00028-0836
100280836
21476-4687
314764687
rsrctypearticle
creationdate2012
searchscopenature_a
scopenature_a
lsr30VSR-Enriched:[pages, pqid, galeid, subject, description, eissn]
sort
titleSeventy-five genetic loci influencing the human red blood cell
authorPim Van Der Harst ; Weihua Zhang ; Irene Mateo Leach ; Augusto Rendon ; Niek Verweij ; Joban Sehmi ; Dirk S. Paul ; Ulrich Elling ; Hooman Allayee ; Xinzhong Li ; Aparna Radhakrishnan ; Sian-Tsung Tan ; Katrin Voss ; Christian X. Weichenberger ; Cornelis A. Albers ; Abtehale Al-Hussani ; Folkert W. Asselbergs ; Marina Ciullo ; Fabrice Danjou ; Christian Dina ; Tõnu Esko ; David M. Evans ; Lude Franke ; Martin Gögele ; Jaana Hartiala ; Micha Hersch ; Hilma Holm ; Jouke-Jan Hottenga ; Stavroula Kanoni ; Marcus E. Kleber ; Vasiliki Lagou ; Claudia Langenberg ; Lorna M. Lopez ; Leo-Pekka Lyytikäinen ; Olle Melander ; Federico Murgia ; Ilja M. Nolte ; Paul F. O’reilly ; Sandosh Padmanabhan ; Afshin Parsa ; Nicola Pirastu ; Eleonora Porcu ; Laura Portas ; Inga Prokopenko ; Janina S. Ried ; So-Youn Shin ; Clara S. Tang ; Alexander Teumer ; Michela Traglia ; Sheila Ulivi ; Harm-Jan Westra ; Jian Yang ; Jing Hua Zhao ; Franco Anni ; Abdel Abdellaoui ; Antony Attwood ; Beverley Balkau ; Stefania Bandinelli ; François Bastardot ; Beben Benyamin ; Bernhard O. Boehm ; William O. Cookson ; Debashish Das ; Paul I. W. De Bakker ; Rudolf A. De Boer ; Eco J. C. De Geus ; Marleen H. De Moor ; Maria Dimitriou ; Francisco S. Domingues ; Angela Döring ; Gunnar Engström ; Gudmundur Ingi Eyjolfsson ; Luigi Ferrucci ; Krista Fischer ; Renzo Galanello ; Stephen F. Garner ; Bernd Genser ; Quince D. Gibson ; Giorgia Girotto ; Daniel Fannar Gudbjartsson ; Sarah E. Harris ; Anna-Liisa Hartikainen ; Claire E. Hastie ; Bo Hedblad ; Thomas Illig ; Jennifer Jolley ; Mika Kähönen ; Ido P. Kema ; John P. Kemp ; Liming Liang ; Heather Lloyd-Jones ; Ruth J. F. Loos ; Stuart Meacham ; Sarah E. Medland ; Christa Meisinger ; Yasin Memari ; Evelin Mihailov ; Kathy Miller ; Miriam F. Moffatt ; Matthias Nauck ; Maria Novatchkova ; Teresa Nutile ; Isleifur Olafsson ; Pall T. Onundarson ; Debora Parracciani ; Brenda W. Penninx ; Lucia Perseu ; Antonio Piga ; Giorgio Pistis ; Anneli Pouta ; Ursula Puc ; Olli Raitakari ; Susan M. Ring ; Antonietta Robino ; Daniela Ruggiero ; Aimo Ruokonen ; Aude Saint-Pierre ; Cinzia Sala ; Andres Salumets ; Jennifer Sambrook ; Hein Schepers ; Carsten Oliver Schmidt ; Herman H. W. Silljé ; Rob Sladek ; Johannes H. Smit ; John M. Starr ; Jonathan Stephens ; Patrick Sulem ; Toshiko Tanaka ; Unnur Thorsteinsdottir ; Vinicius Tragante ; Wiek H. Van Gilst ; L. Joost Van Pelt ; Dirk J. Van Veldhuisen ; Uwe Völker ; John B. Whitfield ; Gonneke Willemsen ; Bernhard R. Winkelmann ; Gerald Wirnsberger ; Ale Algra ; Francesco Cucca ; Adamo Pio D’adamo ; John Danesh ; Ian J. Deary ; Anna F. Dominiczak ; Paul Elliott ; Paolo Fortina ; Philippe Froguel ; Paolo Gasparini ; Andreas Greinacher ; Stanley L. Hazen ; Marjo-Riitta Jarvelin ; Kay Tee Khaw ; Terho Lehtimäki ; Winfried Maerz ; Nicholas G. Martin ; Andres Metspalu ; Braxton D. Mitchell ; Grant W. Montgomery ; Carmel Moore ; Gerjan Navis ; Mario Pirastu ; Peter P. Pramstaller ; Ramiro Ramirez-Solis ; Eric Schadt ; James Scott ; Alan R. Shuldiner ; George Davey Smith ; J. Gustav Smith ; Harold Snieder ; Rossella Sorice ; Tim D. Spector ; Kari Stefansson ; Michael Stumvoll ; W. H. Wilson Tang ; Daniela Toniolo ; Anke Tönjes ; Peter M. Visscher ; Peter Vollenweider ; Nicholas J. Wareham ; Bruce H. R. Wolffenbuttel ; Dorret I. Boomsma ; Jacques S. Beckmann ; George V. Dedoussis ; Panos Deloukas ; Manuel A. Ferreira ; Serena Sanna ; Manuela Uda ; Andrew A. Hicks ; Josef Martin Penninger ; Christian Gieger ; Jaspal S. Kooner ; Willem H. Ouwehand ; Nicole Soranzo ; John C. Chambers
creationdate20121205
facets
frbrgroupid2520536515785242236
frbrtype5
creationdate2012
collectionnature.com (Nature Publishing Group)
prefilterarticles
rsrctypearticles
creatorcontrib
0Pim Van Der Harst
1Weihua Zhang
2Irene Mateo Leach
3Augusto Rendon
4Niek Verweij
5Joban Sehmi
6Dirk S. Paul
7Ulrich Elling
8Hooman Allayee
9Xinzhong Li
10Aparna Radhakrishnan
11Sian-Tsung Tan
12Katrin Voss
13Christian X. Weichenberger
14Cornelis A. Albers
15Abtehale Al-Hussani
16Folkert W. Asselbergs
17Marina Ciullo
18Fabrice Danjou
19Christian Dina
20Tõnu Esko
21David M. Evans
22Lude Franke
23Martin Gögele
24Jaana Hartiala
25Micha Hersch
26Hilma Holm
27Jouke-Jan Hottenga
28Stavroula Kanoni
29Marcus E. Kleber
30Vasiliki Lagou
31Claudia Langenberg
32Lorna M. Lopez
33Leo-Pekka Lyytikäinen
34Olle Melander
35Federico Murgia
36Ilja M. Nolte
37Paul F. O’reilly
38Sandosh Padmanabhan
39Afshin Parsa
40Nicola Pirastu
41Eleonora Porcu
42Laura Portas
43Inga Prokopenko
44Janina S. Ried
45So-Youn Shin
46Clara S. Tang
47Alexander Teumer
48Michela Traglia
49Sheila Ulivi
50Harm-Jan Westra
51Jian Yang
52Jing Hua Zhao
53Franco Anni
54Abdel Abdellaoui
55Antony Attwood
56Beverley Balkau
57Stefania Bandinelli
58François Bastardot
59Beben Benyamin
60Bernhard O. Boehm
61William O. Cookson
62Debashish Das
63Paul I. W. De Bakker
64Rudolf A. De Boer
65Eco J. C. De Geus
66Marleen H. De Moor
67Maria Dimitriou
68Francisco S. Domingues
69Angela Döring
70Gunnar Engström
71Gudmundur Ingi Eyjolfsson
72Luigi Ferrucci
73Krista Fischer
74Renzo Galanello
75Stephen F. Garner
76Bernd Genser
77Quince D. Gibson
78Giorgia Girotto
79Daniel Fannar Gudbjartsson
80Sarah E. Harris
81Anna-Liisa Hartikainen
82Claire E. Hastie
83Bo Hedblad
84Thomas Illig
85Jennifer Jolley
86Mika Kähönen
87Ido P. Kema
88John P. Kemp
89Liming Liang
90Heather Lloyd-Jones
91Ruth J. F. Loos
92Stuart Meacham
93Sarah E. Medland
94Christa Meisinger
95Yasin Memari
96Evelin Mihailov
97Kathy Miller
98Miriam F. Moffatt
99Matthias Nauck
100...
jtitleNature
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Pim Van Der Harst
1Weihua Zhang
2Irene Mateo Leach
3Augusto Rendon
4Niek Verweij
5Joban Sehmi
6Dirk S. Paul
7Ulrich Elling
8Hooman Allayee
9Xinzhong Li
10Aparna Radhakrishnan
11Sian-Tsung Tan
12Katrin Voss
13Christian X. Weichenberger
14Cornelis A. Albers
15Abtehale Al-Hussani
16Folkert W. Asselbergs
17Marina Ciullo
18Fabrice Danjou
19Christian Dina
20Tõnu Esko
21David M. Evans
22Lude Franke
23Martin Gögele
24Jaana Hartiala
25Micha Hersch
26Hilma Holm
27Jouke-Jan Hottenga
28Stavroula Kanoni
29Marcus E. Kleber
30Vasiliki Lagou
31Claudia Langenberg
32Lorna M. Lopez
33Leo-Pekka Lyytikäinen
34Olle Melander
35Federico Murgia
36Ilja M. Nolte
37Paul F. O’reilly
38Sandosh Padmanabhan
39Afshin Parsa
40Nicola Pirastu
41Eleonora Porcu
42Laura Portas
43Inga Prokopenko
44Janina S. Ried
45So-Youn Shin
46Clara S. Tang
47Alexander Teumer
48Michela Traglia
49Sheila Ulivi
50Harm-Jan Westra
51Jian Yang
52Jing Hua Zhao
53Franco Anni
54Abdel Abdellaoui
55Antony Attwood
56Beverley Balkau
57Stefania Bandinelli
58François Bastardot
59Beben Benyamin
60Bernhard O. Boehm
61William O. Cookson
62Debashish Das
63Paul I. W. De Bakker
64Rudolf A. De Boer
65Eco J. C. De Geus
66Marleen H. De Moor
67Maria Dimitriou
68Francisco S. Domingues
69Angela Döring
70Gunnar Engström
71Gudmundur Ingi Eyjolfsson
72Luigi Ferrucci
73Krista Fischer
74Renzo Galanello
75Stephen F. Garner
76Bernd Genser
77Quince D. Gibson
78Giorgia Girotto
79Daniel Fannar Gudbjartsson
80Sarah E. Harris
81Anna-Liisa Hartikainen
82Claire E. Hastie
83Bo Hedblad
84Thomas Illig
85Jennifer Jolley
86Mika Kähönen
87Ido P. Kema
88John P. Kemp
89Liming Liang
90Heather Lloyd-Jones
91Ruth J. F. Loos
92Stuart Meacham
93Sarah E. Medland
94Christa Meisinger
95Yasin Memari
96Evelin Mihailov
97Kathy Miller
98Miriam F. Moffatt
99Matthias Nauck
100...
atitleSeventy-five genetic loci influencing the human red blood cell
jtitleNature
risdate20121205
volume492
issue7429
spage369
issn0028-0836
genrearticle
ristypeJOUR
pubNature Publishing Group
doi10.1038/nature11677
pages369-36975
eissn14764687
date2012-12-05