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Directional dominance on stature and cognition in diverse human populations

Homozygosity has long been associated with rare, often devastating, Mendelian disorders1 and Darwin was one of the first to recognise that inbreeding reduces evolutionary fitness2. However, the effect of the more distant parental relatedness common in modern human populations is less well understood... Full description

Journal Title: Nature 2015
Main Author: Peter K. Joshi
Other Authors: Tonu Esko , Hannele Mattsson , Niina Eklund , Ilaria Gandin , Teresa Nutile , Anne U. Jackson , Claudia Schurmann , Albert V. Smith , Weihua Zhang , Yukinori Okada , Alena Stančáková , Jessica D. Faul , Wei Zhao , Traci M. Bartz , Maria Pina Concas , Nora Franceschini , Stefan Enroth , Veronique Vitart , Stella Trompet , Xiuqing Guo , Daniel I. Chasman , Jeffrey R. O'Connel , Tanguy Corre , Suraj S. Nongmaithem , Yuning Chen , Massimo Mangino , Daniela Ruggiero , Michela Traglia , Aliki-Eleni Farmaki , Tim Kacprowski , Andrew Bjonnes , Ashley Van Der Spek , Ying Wu , Anil K. Giri , Lisa R. Yanek , Lihua Wang , Edith Hofer , Cornelius A. Rietveld , Olga Mcleod , Marilyn C. Cornelis , Cristian Pattaro , Niek Verweij , Clemens Baumbach , Abdel Abdellaoui , Helen R. Warren , Dragana Vuckovic , Hao Mei , Claude Bouchard , John R. B. Perry , Stefania Cappellani , Saira S. Mirza , Miles C. Benton , Ulrich Broeckel , Sarah E. Medland , Penelope A. Lind , Giovanni Malerba , Alexander Drong , Loic Yengo , Lawrence F. Bielak , Degui Zhi , Peter J. Van Der Most , Daniel Shriner , Reedik Mägi , Gibran Hemani , Tugce Karaderi , Zhaoming Wang , Tian Liu , Ilja Demuth , Jing Hua Zhao , Weihua Meng , Lazaros Lataniotis , Sander W. Van Der Laan , Jonathan P. Bradfield , Andrew R. Wood , Amelie Bonnefond , Tarunveer S. Ahluwalia , Leanne M. Hall , Erika Salvi , Seyhan Yazar , Lisbeth Carstensen , Hugoline G. De Haan , Mark Abney , Uzma Afzal , Matthew A. Allison , Najaf Amin , Folkert W. Asselbergs , Stephan J. L. Bakker , R. Graham Barr , Sebastian E. Baumeister , Daniel J. Benjamin , Sven Bergmann , Eric Boerwinkle , Erwin P. Bottinger , Archie Campbell , Aravinda Chakravarti , Yingleong Chan , Stephen J. Chanock , Constance Chen , Y.-D. Ida Chen , Francis S. Collins , John Connell , Adolfo Correa , L. Adrienne Cupples , George Davey Smith , Gail Davies , Marcus Dörr , Georg Ehret , Stephen B. Ellis , Bjarke Feenstra , Mary F. Feitosa , Ian Ford , Caroline S. Fox , Timothy M. Frayling , Nele Friedrich , Frank Geller , Generation Scotland , Irina Gillham-Nasenya , Omri Gottesman , Misa Graff , Francine Grodstein , Charles Gu , Chris Haley , Christopher J. Hammond , Sarah E. Harris , Tamara B. Harris , Nicholas D. Hastie , Nancy L. Heard-Costa , Kauko Heikkilä , Lynne J. Hocking , Georg Homuth , Jouke-Jan Hottenga , Jinyan Huang , Jennifer E. Huffman , Pirro G. Hysi , M. Arfan Ikram , Erik Ingelsson , Anni Joensuu , Åsa Johansson , Pekka Jousilahti , J. Wouter Jukema , Mika Kähönen , Yoichiro Kamatani , Stavroula Kanoni , Shona M. Kerr , Nazir M. Khan , Philipp Koellinger , Heikki A. Koistinen , Manraj K. Kooner , Michiaki Kubo , Johanna Kuusisto , Jari Lahti , Lenore J. Launer , Rodney A. Lea , Benjamin Lehne , Terho Lehtimäki , David C.M. Liewald , Lars Lind , Marie Loh , Marja-Liisa Lokki , Stephanie J. London , Stephanie J. Loomis , Anu Loukola , Yingchang Lu , Thomas Lumley , Annamari Lundqvist , Satu Männistö , Pedro Marques-Vidal , Corrado Masciullo , Angela Matchan , Rasika A. Mathias , Koichi Matsuda , James B. Meigs , Christa Meisinger , Thomas Meitinger , Cristina Menni , Frank D. Mentch , Evelin Mihailov , Lili Milani , May E. Montasser , Grant W. Montgomery , Alanna Morrison , Richard H. Myers , Rajiv Nadukuru , Pau Navarro , Mari Nelis , Markku S. Nieminen , Ilja M. Nolte , George T. O'Connor , Adesola Ogunniyi , Sandosh Padmanabhan , Walter R. Palmas , James S. Pankow , Inga Patarcic , Francesca Pavani , Patricia A. Peyser , Kirsi Pietilainen , Neil Poulter , Inga Prokopenko , Sarju Ralhan , Paul Redmond , Stephen S. Rich , Harri Rissanen , Antonietta Robino , Lynda M. Rose , Richard Rose , Cinzia Sala , Babatunde Salako , Veikko Salomaa , Antti-Pekka Sarin , Richa Saxena , Helena Schmidt , Laura J. Scott , William R. Scott , Bengt Sennblad , Sudha Seshadri , Peter Sever , Smeeta Shrestha , Blair H. Smith , Jennifer A. Smith , Nicole Soranzo , Nona Sotoodehnia , Lorraine Southam , Alice V. Stanton , Maria G. Stathopoulou , Konstantin Strauch , Rona J. Strawbridge , Matthew J. Suderman , Nikhil Tandon , Sian-Tsun Tang , Kent D. Taylor , Bamidele O. Tayo , Anna Maria Töglhofer , Maciej Tomaszewski , Natalia Tšernikova , Jaakko Tuomilehto , Andre G. Uitterlinden , Dhananjay Vaidya , Astrid Van Hylckama Vlieg , Jessica Van Setten , Tuula Vasankari , Sailaja Vedantam , Efthymia Vlachopoulou , Diego Vozzi , Eero Vuoksimaa , Melanie Waldenberger , Erin B. Ware , William Wentworth-Shields , John B. Whitfield , Sarah Wild , Gonneke Willemsen , Chittaranjan S. Yajnik , Jie Yao , Gianluigi Zaza , Xiaofeng Zhu , Rany M. Salem , Mads Melbye , Hans Bisgaard , Nilesh J. Samani , Daniele Cusi , David A. Mackey , Richard S. Cooper , Philippe Froguel , Gerard Pasterkamp , Struan F.A. Grant , Hakon Hakonarson , Luigi Ferrucci , Robert A. Scott , Andrew D. Morris , Colin N. A. Palmer , George Dedoussis , Panos Deloukas , Lars Bertram , Ulman Lindenberger , Sonja I. Berndt , Cecilia M. Lindgren , Nicholas J. Timpson , Anke Tönjes , Patricia B. Munroe , Thorkild I. A. Sørensen , Charles N. Rotimi , Donna K. Arnett , Albertine J. Oldehinkel , Sharon L. R. Kardia , Beverley Balkau , Giovanni Gambaro , Andrew P. Morris , Johan G. Eriksson , Margie J. Wright , Nicholas G. Martin , Steven C. Hunt , John M. Starr , Ian J. Deary , Lyn R. Griffiths , Henning Tiemeier , Nicola Pirastu , Jaakko Kaprio , Nicholas J. Wareham , Louis Pérusse , James G. Wilson , Giorgia Girotto , Mark J. Caulfield , Olli Raitakari , Dorret I. Boomsma , Christian Gieger , Pim Van Der Harst , Andrew A. Hicks , Peter Kraft , Juha Sinisalo , Paul Knekt , Magnus Johannesson , Patrik K. E. Magnusson , Anders Hamsten , Reinhold Schmidt , Ingrid B. Borecki , Erkki Vartiainen , Diane M. Becker , Dwaipayan Bharadwaj , Karen L. Mohlke , Michael Boehnke , Cornelia M. Van Duijn , Dharambir K. Sanghera , Alexander Teumer , Eleftheria Zeggini , Andres Metspalu , Paolo Gasparini , Sheila Ulivi , Carole Ober , Daniela Toniolo , Igor Rudan , David J. Porteous , Marina Ciullo , Tim D. Spector , Caroline Hayward , Josée Dupuis , Ruth J. F. Loos , Alan F. Wright , Giriraj R. Chandak , Peter Vollenweider , Alan R. Shuldiner , Paul M. Ridker , Jerome I. Rotter , Naveed Sattar , Ulf Gyllensten , Kari E. North , Mario Pirastu , Bruce M. Psaty , David R. Weir , Markku Laakso , Vilmundur Gudnason , Atsushi Takahashi , John C. Chambers , Jaspal S. Kooner , David P. Strachan , Harry Campbell , Joel N. Hirschhorn , Markus Perola , Ozren Polašek , James F. Wilson
Format: Electronic Article Electronic Article
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Subjects:
ID: ISSN: 0028-0836 ; E-ISSN: 1476-4687 ; DOI: 10.1038/nature14618
Link: http://dx.doi.org/10.1038/nature14618
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recordid: nature_a10.1038/nature14618
title: Directional dominance on stature and cognition in diverse human populations
format: Article
creator:
  • Peter K. Joshi
  • Tonu Esko
  • Hannele Mattsson
  • Niina Eklund
  • Ilaria Gandin
  • Teresa Nutile
  • Anne U. Jackson
  • Claudia Schurmann
  • Albert V. Smith
  • Weihua Zhang
  • Yukinori Okada
  • Alena Stančáková
  • Jessica D. Faul
  • Wei Zhao
  • Traci M. Bartz
  • Maria Pina Concas
  • Nora Franceschini
  • Stefan Enroth
  • Veronique Vitart
  • Stella Trompet
  • Xiuqing Guo
  • Daniel I. Chasman
  • Jeffrey R. O'Connel
  • Tanguy Corre
  • Suraj S. Nongmaithem
  • Yuning Chen
  • Massimo Mangino
  • Daniela Ruggiero
  • Michela Traglia
  • Aliki-Eleni Farmaki
  • Tim Kacprowski
  • Andrew Bjonnes
  • Ashley Van Der Spek
  • Ying Wu
  • Anil K. Giri
  • Lisa R. Yanek
  • Lihua Wang
  • Edith Hofer
  • Cornelius A. Rietveld
  • Olga Mcleod
  • Marilyn C. Cornelis
  • Cristian Pattaro
  • Niek Verweij
  • Clemens Baumbach
  • Abdel Abdellaoui
  • Helen R. Warren
  • Dragana Vuckovic
  • Hao Mei
  • Claude Bouchard
  • John R. B. Perry
  • Stefania Cappellani
  • Saira S. Mirza
  • Miles C. Benton
  • Ulrich Broeckel
  • Sarah E. Medland
  • Penelope A. Lind
  • Giovanni Malerba
  • Alexander Drong
  • Loic Yengo
  • Lawrence F. Bielak
  • Degui Zhi
  • Peter J. Van Der Most
  • Daniel Shriner
  • Reedik Mägi
  • Gibran Hemani
  • Tugce Karaderi
  • Zhaoming Wang
  • Tian Liu
  • Ilja Demuth
  • Jing Hua Zhao
  • Weihua Meng
  • Lazaros Lataniotis
  • Sander W. Van Der Laan
  • Jonathan P. Bradfield
  • Andrew R. Wood
  • Amelie Bonnefond
  • Tarunveer S. Ahluwalia
  • Leanne M. Hall
  • Erika Salvi
  • Seyhan Yazar
  • Lisbeth Carstensen
  • Hugoline G. De Haan
  • Mark Abney
  • Uzma Afzal
  • Matthew A. Allison
  • Najaf Amin
  • Folkert W. Asselbergs
  • Stephan J. L. Bakker
  • R. Graham Barr
  • Sebastian E. Baumeister
  • Daniel J. Benjamin
  • Sven Bergmann
  • Eric Boerwinkle
  • Erwin P. Bottinger
  • Archie Campbell
  • Aravinda Chakravarti
  • Yingleong Chan
  • Stephen J. Chanock
  • Constance Chen
  • Y.-D. Ida Chen
  • Francis S. Collins
  • John Connell
  • Adolfo Correa
  • L. Adrienne Cupples
  • George Davey Smith
  • Gail Davies
  • Marcus Dörr
  • Georg Ehret
  • Stephen B. Ellis
  • Bjarke Feenstra
  • Mary F. Feitosa
  • Ian Ford
  • Caroline S. Fox
  • Timothy M. Frayling
  • Nele Friedrich
  • Frank Geller
  • Generation Scotland
  • Irina Gillham-Nasenya
  • Omri Gottesman
  • Misa Graff
  • Francine Grodstein
  • Charles Gu
  • Chris Haley
  • Christopher J. Hammond
  • Sarah E. Harris
  • Tamara B. Harris
  • Nicholas D. Hastie
  • Nancy L. Heard-Costa
  • Kauko Heikkilä
  • Lynne J. Hocking
  • Georg Homuth
  • Jouke-Jan Hottenga
  • Jinyan Huang
  • Jennifer E. Huffman
  • Pirro G. Hysi
  • M. Arfan Ikram
  • Erik Ingelsson
  • Anni Joensuu
  • Åsa Johansson
  • Pekka Jousilahti
  • J. Wouter Jukema
  • Mika Kähönen
  • Yoichiro Kamatani
  • Stavroula Kanoni
  • Shona M. Kerr
  • Nazir M. Khan
  • Philipp Koellinger
  • Heikki A. Koistinen
  • Manraj K. Kooner
  • Michiaki Kubo
  • Johanna Kuusisto
  • Jari Lahti
  • Lenore J. Launer
  • Rodney A. Lea
  • Benjamin Lehne
  • Terho Lehtimäki
  • David C.M. Liewald
  • Lars Lind
  • Marie Loh
  • Marja-Liisa Lokki
  • Stephanie J. London
  • Stephanie J. Loomis
  • Anu Loukola
  • Yingchang Lu
  • Thomas Lumley
  • Annamari Lundqvist
  • Satu Männistö
  • Pedro Marques-Vidal
  • Corrado Masciullo
  • Angela Matchan
  • Rasika A. Mathias
  • Koichi Matsuda
  • James B. Meigs
  • Christa Meisinger
  • Thomas Meitinger
  • Cristina Menni
  • Frank D. Mentch
  • Evelin Mihailov
  • Lili Milani
  • May E. Montasser
  • Grant W. Montgomery
  • Alanna Morrison
  • Richard H. Myers
  • Rajiv Nadukuru
  • Pau Navarro
  • Mari Nelis
  • Markku S. Nieminen
  • Ilja M. Nolte
  • George T. O'Connor
  • Adesola Ogunniyi
  • Sandosh Padmanabhan
  • Walter R. Palmas
  • James S. Pankow
  • Inga Patarcic
  • Francesca Pavani
  • Patricia A. Peyser
  • Kirsi Pietilainen
  • Neil Poulter
  • Inga Prokopenko
  • Sarju Ralhan
  • Paul Redmond
  • Stephen S. Rich
  • Harri Rissanen
  • Antonietta Robino
  • Lynda M. Rose
  • Richard Rose
  • Cinzia Sala
  • Babatunde Salako
  • Veikko Salomaa
  • Antti-Pekka Sarin
  • Richa Saxena
  • Helena Schmidt
  • Laura J. Scott
  • William R. Scott
  • Bengt Sennblad
  • Sudha Seshadri
  • Peter Sever
  • Smeeta Shrestha
  • Blair H. Smith
  • Jennifer A. Smith
  • Nicole Soranzo
  • Nona Sotoodehnia
  • Lorraine Southam
  • Alice V. Stanton
  • Maria G. Stathopoulou
  • Konstantin Strauch
  • Rona J. Strawbridge
  • Matthew J. Suderman
  • Nikhil Tandon
  • Sian-Tsun Tang
  • Kent D. Taylor
  • Bamidele O. Tayo
  • Anna Maria Töglhofer
  • Maciej Tomaszewski
  • Natalia Tšernikova
  • Jaakko Tuomilehto
  • Andre G. Uitterlinden
  • Dhananjay Vaidya
  • Astrid Van Hylckama Vlieg
  • Jessica Van Setten
  • Tuula Vasankari
  • Sailaja Vedantam
  • Efthymia Vlachopoulou
  • Diego Vozzi
  • Eero Vuoksimaa
  • Melanie Waldenberger
  • Erin B. Ware
  • William Wentworth-Shields
  • John B. Whitfield
  • Sarah Wild
  • Gonneke Willemsen
  • Chittaranjan S. Yajnik
  • Jie Yao
  • Gianluigi Zaza
  • Xiaofeng Zhu
  • Rany M. Salem
  • Mads Melbye
  • Hans Bisgaard
  • Nilesh J. Samani
  • Daniele Cusi
  • David A. Mackey
  • Richard S. Cooper
  • Philippe Froguel
  • Gerard Pasterkamp
  • Struan F.A. Grant
  • Hakon Hakonarson
  • Luigi Ferrucci
  • Robert A. Scott
  • Andrew D. Morris
  • Colin N. A. Palmer
  • George Dedoussis
  • Panos Deloukas
  • Lars Bertram
  • Ulman Lindenberger
  • Sonja I. Berndt
  • Cecilia M. Lindgren
  • Nicholas J. Timpson
  • Anke Tönjes
  • Patricia B. Munroe
  • Thorkild I. A. Sørensen
  • Charles N. Rotimi
  • Donna K. Arnett
  • Albertine J. Oldehinkel
  • Sharon L. R. Kardia
  • Beverley Balkau
  • Giovanni Gambaro
  • Andrew P. Morris
  • Johan G. Eriksson
  • Margie J. Wright
  • Nicholas G. Martin
  • Steven C. Hunt
  • John M. Starr
  • Ian J. Deary
  • Lyn R. Griffiths
  • Henning Tiemeier
  • Nicola Pirastu
  • Jaakko Kaprio
  • Nicholas J. Wareham
  • Louis Pérusse
  • James G. Wilson
  • Giorgia Girotto
  • Mark J. Caulfield
  • Olli Raitakari
  • Dorret I. Boomsma
  • Christian Gieger
  • Pim Van Der Harst
  • Andrew A. Hicks
  • Peter Kraft
  • Juha Sinisalo
  • Paul Knekt
  • Magnus Johannesson
  • Patrik K. E. Magnusson
  • Anders Hamsten
  • Reinhold Schmidt
  • Ingrid B. Borecki
  • Erkki Vartiainen
  • Diane M. Becker
  • Dwaipayan Bharadwaj
  • Karen L. Mohlke
  • Michael Boehnke
  • Cornelia M. Van Duijn
  • Dharambir K. Sanghera
  • Alexander Teumer
  • Eleftheria Zeggini
  • Andres Metspalu
  • Paolo Gasparini
  • Sheila Ulivi
  • Carole Ober
  • Daniela Toniolo
  • Igor Rudan
  • David J. Porteous
  • Marina Ciullo
  • Tim D. Spector
  • Caroline Hayward
  • Josée Dupuis
  • Ruth J. F. Loos
  • Alan F. Wright
  • Giriraj R. Chandak
  • Peter Vollenweider
  • Alan R. Shuldiner
  • Paul M. Ridker
  • Jerome I. Rotter
  • Naveed Sattar
  • Ulf Gyllensten
  • Kari E. North
  • Mario Pirastu
  • Bruce M. Psaty
  • David R. Weir
  • Markku Laakso
  • Vilmundur Gudnason
  • Atsushi Takahashi
  • John C. Chambers
  • Jaspal S. Kooner
  • David P. Strachan
  • Harry Campbell
  • Joel N. Hirschhorn
  • Markus Perola
  • Ozren Polašek
  • James F. Wilson
subjects:
  • Science & Technology
  • Multidisciplinary Sciences
  • Science & Technology - Other Topics
  • Biological Evolution
  • Blood Pressure
  • Body Height
  • Cholesterol, LDL
  • Cognition
  • Cohort Studies
  • Educational Status
  • Female
  • Forced Expiratory Volume
  • Genome, Human
  • Homozygote
  • Humans
  • Lung Volume Measurements
  • Male
  • Phenotype
  • Biobank Japan Project
  • Humans
  • Lung Volume Measurements
  • Forced Expiratory Volume
  • Body Height
  • Cohort Studies
  • Cognition
  • Blood Pressure
  • Homozygote
  • Phenotype
  • Genome, Human
  • Educational Status
  • Female
  • Male
  • Cholesterol, LDL
  • Biological Evolution
  • General Science & Technology
  • MD Multidisciplinary
ispartof: Nature, 2015
description: Homozygosity has long been associated with rare, often devastating, Mendelian disorders1 and Darwin was one of the first to recognise that inbreeding reduces evolutionary fitness2. However, the effect of the more distant parental relatedness common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity, ROH), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power3,4. Here we use ROH to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts and find statistically significant associations between summed runs of homozygosity (SROH) and four complex traits: height, forced expiratory lung volume in 1 second (FEV1), general cognitive ability (g) and educational attainment (nominal p
language:
source:
identifier: ISSN: 0028-0836 ; E-ISSN: 1476-4687 ; DOI: 10.1038/nature14618
fulltext: fulltext
issn:
  • 0028-0836
  • 00280836
  • 1476-4687
  • 14764687
url: Link


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titleDirectional dominance on stature and cognition in diverse human populations
creatorPeter K. Joshi ; Tonu Esko ; Hannele Mattsson ; Niina Eklund ; Ilaria Gandin ; Teresa Nutile ; Anne U. Jackson ; Claudia Schurmann ; Albert V. Smith ; Weihua Zhang ; Yukinori Okada ; Alena Stančáková ; Jessica D. Faul ; Wei Zhao ; Traci M. Bartz ; Maria Pina Concas ; Nora Franceschini ; Stefan Enroth ; Veronique Vitart ; Stella Trompet ; Xiuqing Guo ; Daniel I. Chasman ; Jeffrey R. O'Connel ; Tanguy Corre ; Suraj S. Nongmaithem ; Yuning Chen ; Massimo Mangino ; Daniela Ruggiero ; Michela Traglia ; Aliki-Eleni Farmaki ; Tim Kacprowski ; Andrew Bjonnes ; Ashley Van Der Spek ; Ying Wu ; Anil K. Giri ; Lisa R. Yanek ; Lihua Wang ; Edith Hofer ; Cornelius A. Rietveld ; Olga Mcleod ; Marilyn C. Cornelis ; Cristian Pattaro ; Niek Verweij ; Clemens Baumbach ; Abdel Abdellaoui ; Helen R. Warren ; Dragana Vuckovic ; Hao Mei ; Claude Bouchard ; John R. B. Perry ; Stefania Cappellani ; Saira S. Mirza ; Miles C. Benton ; Ulrich Broeckel ; Sarah E. Medland ; Penelope A. Lind ; Giovanni Malerba ; Alexander Drong ; Loic Yengo ; Lawrence F. Bielak ; Degui Zhi ; Peter J. Van Der Most ; Daniel Shriner ; Reedik Mägi ; Gibran Hemani ; Tugce Karaderi ; Zhaoming Wang ; Tian Liu ; Ilja Demuth ; Jing Hua Zhao ; Weihua Meng ; Lazaros Lataniotis ; Sander W. Van Der Laan ; Jonathan P. Bradfield ; Andrew R. Wood ; Amelie Bonnefond ; Tarunveer S. Ahluwalia ; Leanne M. Hall ; Erika Salvi ; Seyhan Yazar ; Lisbeth Carstensen ; Hugoline G. De Haan ; Mark Abney ; Uzma Afzal ; Matthew A. Allison ; Najaf Amin ; Folkert W. Asselbergs ; Stephan J. L. Bakker ; R. Graham Barr ; Sebastian E. Baumeister ; Daniel J. Benjamin ; Sven Bergmann ; Eric Boerwinkle ; Erwin P. Bottinger ; Archie Campbell ; Aravinda Chakravarti ; Yingleong Chan ; Stephen J. Chanock ; Constance Chen ; Y.-D. Ida Chen ; Francis S. Collins ; John Connell ; Adolfo Correa ; L. Adrienne Cupples ; George Davey Smith ; Gail Davies ; Marcus Dörr ; Georg Ehret ; Stephen B. Ellis ; Bjarke Feenstra ; Mary F. Feitosa ; Ian Ford ; Caroline S. Fox ; Timothy M. Frayling ; Nele Friedrich ; Frank Geller ; Generation Scotland ; Irina Gillham-Nasenya ; Omri Gottesman ; Misa Graff ; Francine Grodstein ; Charles Gu ; Chris Haley ; Christopher J. Hammond ; Sarah E. Harris ; Tamara B. Harris ; Nicholas D. Hastie ; Nancy L. Heard-Costa ; Kauko Heikkilä ; Lynne J. Hocking ; Georg Homuth ; Jouke-Jan Hottenga ; Jinyan Huang ; Jennifer E. Huffman ; Pirro G. Hysi ; M. Arfan Ikram ; Erik Ingelsson ; Anni Joensuu ; Åsa Johansson ; Pekka Jousilahti ; J. Wouter Jukema ; Mika Kähönen ; Yoichiro Kamatani ; Stavroula Kanoni ; Shona M. Kerr ; Nazir M. Khan ; Philipp Koellinger ; Heikki A. Koistinen ; Manraj K. Kooner ; Michiaki Kubo ; Johanna Kuusisto ; Jari Lahti ; Lenore J. Launer ; Rodney A. Lea ; Benjamin Lehne ; Terho Lehtimäki ; David C.M. Liewald ; Lars Lind ; Marie Loh ; Marja-Liisa Lokki ; Stephanie J. London ; Stephanie J. Loomis ; Anu Loukola ; Yingchang Lu ; Thomas Lumley ; Annamari Lundqvist ; Satu Männistö ; Pedro Marques-Vidal ; Corrado Masciullo ; Angela Matchan ; Rasika A. Mathias ; Koichi Matsuda ; James B. Meigs ; Christa Meisinger ; Thomas Meitinger ; Cristina Menni ; Frank D. Mentch ; Evelin Mihailov ; Lili Milani ; May E. Montasser ; Grant W. Montgomery ; Alanna Morrison ; Richard H. Myers ; Rajiv Nadukuru ; Pau Navarro ; Mari Nelis ; Markku S. Nieminen ; Ilja M. Nolte ; George T. O'Connor ; Adesola Ogunniyi ; Sandosh Padmanabhan ; Walter R. Palmas ; James S. Pankow ; Inga Patarcic ; Francesca Pavani ; Patricia A. Peyser ; Kirsi Pietilainen ; Neil Poulter ; Inga Prokopenko ; Sarju Ralhan ; Paul Redmond ; Stephen S. Rich ; Harri Rissanen ; Antonietta Robino ; Lynda M. Rose ; Richard Rose ; Cinzia Sala ; Babatunde Salako ; Veikko Salomaa ; Antti-Pekka Sarin ; Richa Saxena ; Helena Schmidt ; Laura J. Scott ; William R. Scott ; Bengt Sennblad ; Sudha Seshadri ; Peter Sever ; Smeeta Shrestha ; Blair H. Smith ; Jennifer A. Smith ; Nicole Soranzo ; Nona Sotoodehnia ; Lorraine Southam ; Alice V. Stanton ; Maria G. Stathopoulou ; Konstantin Strauch ; Rona J. Strawbridge ; Matthew J. Suderman ; Nikhil Tandon ; Sian-Tsun Tang ; Kent D. Taylor ; Bamidele O. Tayo ; Anna Maria Töglhofer ; Maciej Tomaszewski ; Natalia Tšernikova ; Jaakko Tuomilehto ; Andre G. Uitterlinden ; Dhananjay Vaidya ; Astrid Van Hylckama Vlieg ; Jessica Van Setten ; Tuula Vasankari ; Sailaja Vedantam ; Efthymia Vlachopoulou ; Diego Vozzi ; Eero Vuoksimaa ; Melanie Waldenberger ; Erin B. Ware ; William Wentworth-Shields ; John B. Whitfield ; Sarah Wild ; Gonneke Willemsen ; Chittaranjan S. Yajnik ; Jie Yao ; Gianluigi Zaza ; Xiaofeng Zhu ; Rany M. Salem ; Mads Melbye ; Hans Bisgaard ; Nilesh J. Samani ; Daniele Cusi ; David A. Mackey ; Richard S. Cooper ; Philippe Froguel ; Gerard Pasterkamp ; Struan F.A. Grant ; Hakon Hakonarson ; Luigi Ferrucci ; Robert A. Scott ; Andrew D. Morris ; Colin N. A. Palmer ; George Dedoussis ; Panos Deloukas ; Lars Bertram ; Ulman Lindenberger ; Sonja I. Berndt ; Cecilia M. Lindgren ; Nicholas J. Timpson ; Anke Tönjes ; Patricia B. Munroe ; Thorkild I. A. Sørensen ; Charles N. Rotimi ; Donna K. Arnett ; Albertine J. Oldehinkel ; Sharon L. R. Kardia ; Beverley Balkau ; Giovanni Gambaro ; Andrew P. Morris ; Johan G. Eriksson ; Margie J. Wright ; Nicholas G. Martin ; Steven C. Hunt ; John M. Starr ; Ian J. Deary ; Lyn R. Griffiths ; Henning Tiemeier ; Nicola Pirastu ; Jaakko Kaprio ; Nicholas J. Wareham ; Louis Pérusse ; James G. Wilson ; Giorgia Girotto ; Mark J. Caulfield ; Olli Raitakari ; Dorret I. Boomsma ; Christian Gieger ; Pim Van Der Harst ; Andrew A. Hicks ; Peter Kraft ; Juha Sinisalo ; Paul Knekt ; Magnus Johannesson ; Patrik K. E. Magnusson ; Anders Hamsten ; Reinhold Schmidt ; Ingrid B. Borecki ; Erkki Vartiainen ; Diane M. Becker ; Dwaipayan Bharadwaj ; Karen L. Mohlke ; Michael Boehnke ; Cornelia M. Van Duijn ; Dharambir K. Sanghera ; Alexander Teumer ; Eleftheria Zeggini ; Andres Metspalu ; Paolo Gasparini ; Sheila Ulivi ; Carole Ober ; Daniela Toniolo ; Igor Rudan ; David J. Porteous ; Marina Ciullo ; Tim D. Spector ; Caroline Hayward ; Josée Dupuis ; Ruth J. F. Loos ; Alan F. Wright ; Giriraj R. Chandak ; Peter Vollenweider ; Alan R. Shuldiner ; Paul M. Ridker ; Jerome I. Rotter ; Naveed Sattar ; Ulf Gyllensten ; Kari E. North ; Mario Pirastu ; Bruce M. Psaty ; David R. Weir ; Markku Laakso ; Vilmundur Gudnason ; Atsushi Takahashi ; John C. Chambers ; Jaspal S. Kooner ; David P. Strachan ; Harry Campbell ; Joel N. Hirschhorn ; Markus Perola ; Ozren Polašek ; James F. Wilson
ispartofNature, 2015
identifier
source
descriptionHomozygosity has long been associated with rare, often devastating, Mendelian disorders1 and Darwin was one of the first to recognise that inbreeding reduces evolutionary fitness2. However, the effect of the more distant parental relatedness common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity, ROH), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power3,4. Here we use ROH to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts and find statistically significant associations between summed runs of homozygosity (SROH) and four complex traits: height, forced expiratory lung volume in 1 second (FEV1), general cognitive ability (g) and educational attainment (nominal p<1 × 10−300, 2.1 × 10−6, 2.5 × 10−10, 1.8 × 10−10). In each case increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing convincing evidence for the first time that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples5,6, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein (LDL) cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection7, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been.
subjectScience & Technology ; Multidisciplinary Sciences ; Science & Technology - Other Topics ; Biological Evolution ; Blood Pressure ; Body Height ; Cholesterol, LDL ; Cognition ; Cohort Studies ; Educational Status ; Female ; Forced Expiratory Volume ; Genome, Human ; Homozygote ; Humans ; Lung Volume Measurements ; Male ; Phenotype ; Biobank Japan Project ; Humans ; Lung Volume Measurements ; Forced Expiratory Volume ; Body Height ; Cohort Studies ; Cognition ; Blood Pressure ; Homozygote ; Phenotype ; Genome, Human ; Educational Status ; Female ; Male ; Cholesterol, LDL ; Biological Evolution ; General Science & Technology ; MD Multidisciplinary;
version3
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://dx.doi.org/10.1038/nature14618$$EView_this_record_in_Nature
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search
creatorcontrib
0Peter K. Joshi
1Tonu Esko
2Hannele Mattsson
3Niina Eklund
4Ilaria Gandin
5Teresa Nutile
6Anne U. Jackson
7Claudia Schurmann
8Albert V. Smith
9Weihua Zhang
10Yukinori Okada
11Alena Stančáková
12Jessica D. Faul
13Wei Zhao
14Traci M. Bartz
15Maria Pina Concas
16Nora Franceschini
17Stefan Enroth
18Veronique Vitart
19Stella Trompet
20Xiuqing Guo
21Daniel I. Chasman
22Jeffrey R. O'Connel
23Tanguy Corre
24Suraj S. Nongmaithem
25Yuning Chen
26Massimo Mangino
27Daniela Ruggiero
28Michela Traglia
29Aliki-Eleni Farmaki
30Tim Kacprowski
31Andrew Bjonnes
32Ashley Van Der Spek
33Ying Wu
34Anil K. Giri
35Lisa R. Yanek
36Lihua Wang
37Edith Hofer
38Cornelius A. Rietveld
39Olga Mcleod
40Marilyn C. Cornelis
41Cristian Pattaro
42Niek Verweij
43Clemens Baumbach
44Abdel Abdellaoui
45Helen R. Warren
46Dragana Vuckovic
47Hao Mei
48Claude Bouchard
49John R. B. Perry
50Stefania Cappellani
51Saira S. Mirza
52Miles C. Benton
53Ulrich Broeckel
54Sarah E. Medland
55Penelope A. Lind
56Giovanni Malerba
57Alexander Drong
58Loic Yengo
59Lawrence F. Bielak
60Degui Zhi
61Peter J. Van Der Most
62Daniel Shriner
63Reedik Mägi
64Gibran Hemani
65Tugce Karaderi
66Zhaoming Wang
67Tian Liu
68Ilja Demuth
69Jing Hua Zhao
70Weihua Meng
71Lazaros Lataniotis
72Sander W. Van Der Laan
73Jonathan P. Bradfield
74Andrew R. Wood
75Amelie Bonnefond
76Tarunveer S. Ahluwalia
77Leanne M. Hall
78Erika Salvi
79Seyhan Yazar
80Lisbeth Carstensen
81Hugoline G. De Haan
82Mark Abney
83Uzma Afzal
84Matthew A. Allison
85Najaf Amin
86Folkert W. Asselbergs
87Stephan J. L. Bakker
88R. Graham Barr
89Sebastian E. Baumeister
90Daniel J. Benjamin
91Sven Bergmann
92Eric Boerwinkle
93Erwin P. Bottinger
94Archie Campbell
95Aravinda Chakravarti
96Yingleong Chan
97Stephen J. Chanock
98Constance Chen
99Y.-D. Ida Chen
100...
titleDirectional dominance on stature and cognition in diverse human populations
general
0Nature Publishing Group
110.1038/nature14618
2nature.com (Nature Publishing Group)
sourceidnature_a
recordidnature_a10.1038/nature14618
issn
00028-0836
100280836
21476-4687
314764687
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titleDirectional dominance on stature and cognition in diverse human populations
authorPeter K. Joshi ; Tonu Esko ; Hannele Mattsson ; Niina Eklund ; Ilaria Gandin ; Teresa Nutile ; Anne U. Jackson ; Claudia Schurmann ; Albert V. Smith ; Weihua Zhang ; Yukinori Okada ; Alena Stančáková ; Jessica D. Faul ; Wei Zhao ; Traci M. Bartz ; Maria Pina Concas ; Nora Franceschini ; Stefan Enroth ; Veronique Vitart ; Stella Trompet ; Xiuqing Guo ; Daniel I. Chasman ; Jeffrey R. O'Connel ; Tanguy Corre ; Suraj S. Nongmaithem ; Yuning Chen ; Massimo Mangino ; Daniela Ruggiero ; Michela Traglia ; Aliki-Eleni Farmaki ; Tim Kacprowski ; Andrew Bjonnes ; Ashley Van Der Spek ; Ying Wu ; Anil K. Giri ; Lisa R. Yanek ; Lihua Wang ; Edith Hofer ; Cornelius A. Rietveld ; Olga Mcleod ; Marilyn C. Cornelis ; Cristian Pattaro ; Niek Verweij ; Clemens Baumbach ; Abdel Abdellaoui ; Helen R. Warren ; Dragana Vuckovic ; Hao Mei ; Claude Bouchard ; John R. B. Perry ; Stefania Cappellani ; Saira S. Mirza ; Miles C. Benton ; Ulrich Broeckel ; Sarah E. Medland ; Penelope A. Lind ; Giovanni Malerba ; Alexander Drong ; Loic Yengo ; Lawrence F. Bielak ; Degui Zhi ; Peter J. Van Der Most ; Daniel Shriner ; Reedik Mägi ; Gibran Hemani ; Tugce Karaderi ; Zhaoming Wang ; Tian Liu ; Ilja Demuth ; Jing Hua Zhao ; Weihua Meng ; Lazaros Lataniotis ; Sander W. Van Der Laan ; Jonathan P. Bradfield ; Andrew R. Wood ; Amelie Bonnefond ; Tarunveer S. Ahluwalia ; Leanne M. Hall ; Erika Salvi ; Seyhan Yazar ; Lisbeth Carstensen ; Hugoline G. De Haan ; Mark Abney ; Uzma Afzal ; Matthew A. Allison ; Najaf Amin ; Folkert W. Asselbergs ; Stephan J. L. Bakker ; R. Graham Barr ; Sebastian E. Baumeister ; Daniel J. Benjamin ; Sven Bergmann ; Eric Boerwinkle ; Erwin P. Bottinger ; Archie Campbell ; Aravinda Chakravarti ; Yingleong Chan ; Stephen J. Chanock ; Constance Chen ; Y.-D. Ida Chen ; Francis S. Collins ; John Connell ; Adolfo Correa ; L. Adrienne Cupples ; George Davey Smith ; Gail Davies ; Marcus Dörr ; Georg Ehret ; Stephen B. Ellis ; Bjarke Feenstra ; Mary F. Feitosa ; Ian Ford ; Caroline S. Fox ; Timothy M. Frayling ; Nele Friedrich ; Frank Geller ; Generation Scotland ; Irina Gillham-Nasenya ; Omri Gottesman ; Misa Graff ; Francine Grodstein ; Charles Gu ; Chris Haley ; Christopher J. Hammond ; Sarah E. Harris ; Tamara B. Harris ; Nicholas D. Hastie ; Nancy L. Heard-Costa ; Kauko Heikkilä ; Lynne J. Hocking ; Georg Homuth ; Jouke-Jan Hottenga ; Jinyan Huang ; Jennifer E. Huffman ; Pirro G. Hysi ; M. Arfan Ikram ; Erik Ingelsson ; Anni Joensuu ; Åsa Johansson ; Pekka Jousilahti ; J. Wouter Jukema ; Mika Kähönen ; Yoichiro Kamatani ; Stavroula Kanoni ; Shona M. Kerr ; Nazir M. Khan ; Philipp Koellinger ; Heikki A. Koistinen ; Manraj K. Kooner ; Michiaki Kubo ; Johanna Kuusisto ; Jari Lahti ; Lenore J. Launer ; Rodney A. Lea ; Benjamin Lehne ; Terho Lehtimäki ; David C.M. Liewald ; Lars Lind ; Marie Loh ; Marja-Liisa Lokki ; Stephanie J. London ; Stephanie J. Loomis ; Anu Loukola ; Yingchang Lu ; Thomas Lumley ; Annamari Lundqvist ; Satu Männistö ; Pedro Marques-Vidal ; Corrado Masciullo ; Angela Matchan ; Rasika A. Mathias ; Koichi Matsuda ; James B. Meigs ; Christa Meisinger ; Thomas Meitinger ; Cristina Menni ; Frank D. Mentch ; Evelin Mihailov ; Lili Milani ; May E. Montasser ; Grant W. Montgomery ; Alanna Morrison ; Richard H. Myers ; Rajiv Nadukuru ; Pau Navarro ; Mari Nelis ; Markku S. Nieminen ; Ilja M. Nolte ; George T. O'Connor ; Adesola Ogunniyi ; Sandosh Padmanabhan ; Walter R. Palmas ; James S. Pankow ; Inga Patarcic ; Francesca Pavani ; Patricia A. Peyser ; Kirsi Pietilainen ; Neil Poulter ; Inga Prokopenko ; Sarju Ralhan ; Paul Redmond ; Stephen S. Rich ; Harri Rissanen ; Antonietta Robino ; Lynda M. Rose ; Richard Rose ; Cinzia Sala ; Babatunde Salako ; Veikko Salomaa ; Antti-Pekka Sarin ; Richa Saxena ; Helena Schmidt ; Laura J. Scott ; William R. Scott ; Bengt Sennblad ; Sudha Seshadri ; Peter Sever ; Smeeta Shrestha ; Blair H. Smith ; Jennifer A. Smith ; Nicole Soranzo ; Nona Sotoodehnia ; Lorraine Southam ; Alice V. Stanton ; Maria G. Stathopoulou ; Konstantin Strauch ; Rona J. Strawbridge ; Matthew J. Suderman ; Nikhil Tandon ; Sian-Tsun Tang ; Kent D. Taylor ; Bamidele O. Tayo ; Anna Maria Töglhofer ; Maciej Tomaszewski ; Natalia Tšernikova ; Jaakko Tuomilehto ; Andre G. Uitterlinden ; Dhananjay Vaidya ; Astrid Van Hylckama Vlieg ; Jessica Van Setten ; Tuula Vasankari ; Sailaja Vedantam ; Efthymia Vlachopoulou ; Diego Vozzi ; Eero Vuoksimaa ; Melanie Waldenberger ; Erin B. Ware ; William Wentworth-Shields ; John B. Whitfield ; Sarah Wild ; Gonneke Willemsen ; Chittaranjan S. Yajnik ; Jie Yao ; Gianluigi Zaza ; Xiaofeng Zhu ; Rany M. Salem ; Mads Melbye ; Hans Bisgaard ; Nilesh J. Samani ; Daniele Cusi ; David A. Mackey ; Richard S. Cooper ; Philippe Froguel ; Gerard Pasterkamp ; Struan F.A. Grant ; Hakon Hakonarson ; Luigi Ferrucci ; Robert A. Scott ; Andrew D. Morris ; Colin N. A. Palmer ; George Dedoussis ; Panos Deloukas ; Lars Bertram ; Ulman Lindenberger ; Sonja I. Berndt ; Cecilia M. Lindgren ; Nicholas J. Timpson ; Anke Tönjes ; Patricia B. Munroe ; Thorkild I. A. Sørensen ; Charles N. Rotimi ; Donna K. Arnett ; Albertine J. Oldehinkel ; Sharon L. R. Kardia ; Beverley Balkau ; Giovanni Gambaro ; Andrew P. Morris ; Johan G. Eriksson ; Margie J. Wright ; Nicholas G. Martin ; Steven C. Hunt ; John M. Starr ; Ian J. Deary ; Lyn R. Griffiths ; Henning Tiemeier ; Nicola Pirastu ; Jaakko Kaprio ; Nicholas J. Wareham ; Louis Pérusse ; James G. Wilson ; Giorgia Girotto ; Mark J. Caulfield ; Olli Raitakari ; Dorret I. Boomsma ; Christian Gieger ; Pim Van Der Harst ; Andrew A. Hicks ; Peter Kraft ; Juha Sinisalo ; Paul Knekt ; Magnus Johannesson ; Patrik K. E. Magnusson ; Anders Hamsten ; Reinhold Schmidt ; Ingrid B. Borecki ; Erkki Vartiainen ; Diane M. Becker ; Dwaipayan Bharadwaj ; Karen L. Mohlke ; Michael Boehnke ; Cornelia M. Van Duijn ; Dharambir K. Sanghera ; Alexander Teumer ; Eleftheria Zeggini ; Andres Metspalu ; Paolo Gasparini ; Sheila Ulivi ; Carole Ober ; Daniela Toniolo ; Igor Rudan ; David J. Porteous ; Marina Ciullo ; Tim D. Spector ; Caroline Hayward ; Josée Dupuis ; Ruth J. F. Loos ; Alan F. Wright ; Giriraj R. Chandak ; Peter Vollenweider ; Alan R. Shuldiner ; Paul M. Ridker ; Jerome I. Rotter ; Naveed Sattar ; Ulf Gyllensten ; Kari E. North ; Mario Pirastu ; Bruce M. Psaty ; David R. Weir ; Markku Laakso ; Vilmundur Gudnason ; Atsushi Takahashi ; John C. Chambers ; Jaspal S. Kooner ; David P. Strachan ; Harry Campbell ; Joel N. Hirschhorn ; Markus Perola ; Ozren Polašek ; James F. Wilson
creationdate20150701
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creationdate2015
collectionnature.com (Nature Publishing Group)
prefilterarticles
rsrctypearticles
creatorcontrib
0Peter K. Joshi
1Tonu Esko
2Hannele Mattsson
3Niina Eklund
4Ilaria Gandin
5Teresa Nutile
6Anne U. Jackson
7Claudia Schurmann
8Albert V. Smith
9Weihua Zhang
10Yukinori Okada
11Alena Stančáková
12Jessica D. Faul
13Wei Zhao
14Traci M. Bartz
15Maria Pina Concas
16Nora Franceschini
17Stefan Enroth
18Veronique Vitart
19Stella Trompet
20Xiuqing Guo
21Daniel I. Chasman
22Jeffrey R. O'Connel
23Tanguy Corre
24Suraj S. Nongmaithem
25Yuning Chen
26Massimo Mangino
27Daniela Ruggiero
28Michela Traglia
29Aliki-Eleni Farmaki
30Tim Kacprowski
31Andrew Bjonnes
32Ashley Van Der Spek
33Ying Wu
34Anil K. Giri
35Lisa R. Yanek
36Lihua Wang
37Edith Hofer
38Cornelius A. Rietveld
39Olga Mcleod
40Marilyn C. Cornelis
41Cristian Pattaro
42Niek Verweij
43Clemens Baumbach
44Abdel Abdellaoui
45Helen R. Warren
46Dragana Vuckovic
47Hao Mei
48Claude Bouchard
49John R. B. Perry
50Stefania Cappellani
51Saira S. Mirza
52Miles C. Benton
53Ulrich Broeckel
54Sarah E. Medland
55Penelope A. Lind
56Giovanni Malerba
57Alexander Drong
58Loic Yengo
59Lawrence F. Bielak
60Degui Zhi
61Peter J. Van Der Most
62Daniel Shriner
63Reedik Mägi
64Gibran Hemani
65Tugce Karaderi
66Zhaoming Wang
67Tian Liu
68Ilja Demuth
69Jing Hua Zhao
70Weihua Meng
71Lazaros Lataniotis
72Sander W. Van Der Laan
73Jonathan P. Bradfield
74Andrew R. Wood
75Amelie Bonnefond
76Tarunveer S. Ahluwalia
77Leanne M. Hall
78Erika Salvi
79Seyhan Yazar
80Lisbeth Carstensen
81Hugoline G. De Haan
82Mark Abney
83Uzma Afzal
84Matthew A. Allison
85Najaf Amin
86Folkert W. Asselbergs
87Stephan J. L. Bakker
88R. Graham Barr
89Sebastian E. Baumeister
90Daniel J. Benjamin
91Sven Bergmann
92Eric Boerwinkle
93Erwin P. Bottinger
94Archie Campbell
95Aravinda Chakravarti
96Yingleong Chan
97Stephen J. Chanock
98Constance Chen
99Y.-D. Ida Chen
100...
jtitleNature
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au
0Peter K. Joshi
1Tonu Esko
2Hannele Mattsson
3Niina Eklund
4Ilaria Gandin
5Teresa Nutile
6Anne U. Jackson
7Claudia Schurmann
8Albert V. Smith
9Weihua Zhang
10Yukinori Okada
11Alena Stančáková
12Jessica D. Faul
13Wei Zhao
14Traci M. Bartz
15Maria Pina Concas
16Nora Franceschini
17Stefan Enroth
18Veronique Vitart
19Stella Trompet
20Xiuqing Guo
21Daniel I. Chasman
22Jeffrey R. O'Connel
23Tanguy Corre
24Suraj S. Nongmaithem
25Yuning Chen
26Massimo Mangino
27Daniela Ruggiero
28Michela Traglia
29Aliki-Eleni Farmaki
30Tim Kacprowski
31Andrew Bjonnes
32Ashley Van Der Spek
33Ying Wu
34Anil K. Giri
35Lisa R. Yanek
36Lihua Wang
37Edith Hofer
38Cornelius A. Rietveld
39Olga Mcleod
40Marilyn C. Cornelis
41Cristian Pattaro
42Niek Verweij
43Clemens Baumbach
44Abdel Abdellaoui
45Helen R. Warren
46Dragana Vuckovic
47Hao Mei
48Claude Bouchard
49John R. B. Perry
50Stefania Cappellani
51Saira S. Mirza
52Miles C. Benton
53Ulrich Broeckel
54Sarah E. Medland
55Penelope A. Lind
56Giovanni Malerba
57Alexander Drong
58Loic Yengo
59Lawrence F. Bielak
60Degui Zhi
61Peter J. Van Der Most
62Daniel Shriner
63Reedik Mägi
64Gibran Hemani
65Tugce Karaderi
66Zhaoming Wang
67Tian Liu
68Ilja Demuth
69Jing Hua Zhao
70Weihua Meng
71Lazaros Lataniotis
72Sander W. Van Der Laan
73Jonathan P. Bradfield
74Andrew R. Wood
75Amelie Bonnefond
76Tarunveer S. Ahluwalia
77Leanne M. Hall
78Erika Salvi
79Seyhan Yazar
80Lisbeth Carstensen
81Hugoline G. De Haan
82Mark Abney
83Uzma Afzal
84Matthew A. Allison
85Najaf Amin
86Folkert W. Asselbergs
87Stephan J. L. Bakker
88R. Graham Barr
89Sebastian E. Baumeister
90Daniel J. Benjamin
91Sven Bergmann
92Eric Boerwinkle
93Erwin P. Bottinger
94Archie Campbell
95Aravinda Chakravarti
96Yingleong Chan
97Stephen J. Chanock
98Constance Chen
99Y.-D. Ida Chen
100...
atitleDirectional dominance on stature and cognition in diverse human populations
jtitleNature
risdate20150701
issn0028-0836
genrearticle
ristypeJOUR
pubNature Publishing Group
doi10.1038/nature14618
isbn0003583789000
date2015-07-01