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Mudskipper genomes provide insights into the terrestrial adaptation of amphibious fishes

Mudskippers are amphibious fishes that have developed morphological and physiological adaptations to match their unique lifestyles. Here we perform whole-genome sequencing of four representative mudskippers to elucidate the molecular mechanisms underlying these adaptations. We discover an expansion... Full description

Journal Title: Nature Communications 2014, Vol.5
Main Author: Xinxin You
Other Authors: Chao Bian , Qijie Zan , Xun Xu , Xin Liu , Jieming Chen , Jintu Wang , Ying Qiu , Wujiao Li , Xinhui Zhang , Ying Sun , Shixi Chen , Wanshu Hong , Yuxiang Li , Shifeng Cheng , Guangyi Fan , Chengcheng Shi , Jie Liang , Y. Tom Tang , Chengye Yang , Zhiqiang Ruan , Jie Bai , Chao Peng , Qian Mu , Jun Lu , Mingjun Fan , Shuang Yang , Zhiyong Huang , Xuanting Jiang , Xiaodong Fang , Guojie Zhang , Yong Zhang , Gianluca Polgar , Hui Yu , Jia Li , Zhongjian Liu , Guoqiang Zhang , Vydianathan Ravi , Steven L. Coon , Jian Wang , Huanming Yang , Byrappa Venkatesh , Jun Wang , Qiong Shi
Format: Electronic Article Electronic Article
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ID: ISSN: 2041-1723 ; E-ISSN: 2041-1723 ; DOI: 10.1038/ncomms6594
Link: http://dx.doi.org/10.1038/ncomms6594
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recordid: nature_a10.1038/ncomms6594
title: Mudskipper genomes provide insights into the terrestrial adaptation of amphibious fishes
format: Article
creator:
  • Xinxin You
  • Chao Bian
  • Qijie Zan
  • Xun Xu
  • Xin Liu
  • Jieming Chen
  • Jintu Wang
  • Ying Qiu
  • Wujiao Li
  • Xinhui Zhang
  • Ying Sun
  • Shixi Chen
  • Wanshu Hong
  • Yuxiang Li
  • Shifeng Cheng
  • Guangyi Fan
  • Chengcheng Shi
  • Jie Liang
  • Y. Tom Tang
  • Chengye Yang
  • Zhiqiang Ruan
  • Jie Bai
  • Chao Peng
  • Qian Mu
  • Jun Lu
  • Mingjun Fan
  • Shuang Yang
  • Zhiyong Huang
  • Xuanting Jiang
  • Xiaodong Fang
  • Guojie Zhang
  • Yong Zhang
  • Gianluca Polgar
  • Hui Yu
  • Jia Li
  • Zhongjian Liu
  • Guoqiang Zhang
  • Vydianathan Ravi
  • Steven L. Coon
  • Jian Wang
  • Huanming Yang
  • Byrappa Venkatesh
  • Jun Wang
  • Qiong Shi
subjects:
  • Biology
ispartof: Nature Communications, 2014, Vol.5
description: Mudskippers are amphibious fishes that have developed morphological and physiological adaptations to match their unique lifestyles. Here we perform whole-genome sequencing of four representative mudskippers to elucidate the molecular mechanisms underlying these adaptations. We discover an expansion of innate immune system genes in the mudskippers that may provide defence against terrestrial pathogens. Several genes of the ammonia excretion pathway in the gills have experienced positive selection, suggesting their important roles in mudskippers' tolerance to environmental ammonia. Some vision-related genes are differentially lost or mutated, illustrating genomic changes associated with aerial vision. Transcriptomic analyses of mudskippers exposed to air highlight regulatory pathways that are up- or down-regulated in response to hypoxia. The present study provides a valuable resource for understanding the molecular mechanisms underlying water-to-land transition of vertebrates.
language:
source:
identifier: ISSN: 2041-1723 ; E-ISSN: 2041-1723 ; DOI: 10.1038/ncomms6594
fulltext: fulltext
issn:
  • 2041-1723
  • 20411723
url: Link


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titleMudskipper genomes provide insights into the terrestrial adaptation of amphibious fishes
creatorXinxin You ; Chao Bian ; Qijie Zan ; Xun Xu ; Xin Liu ; Jieming Chen ; Jintu Wang ; Ying Qiu ; Wujiao Li ; Xinhui Zhang ; Ying Sun ; Shixi Chen ; Wanshu Hong ; Yuxiang Li ; Shifeng Cheng ; Guangyi Fan ; Chengcheng Shi ; Jie Liang ; Y. Tom Tang ; Chengye Yang ; Zhiqiang Ruan ; Jie Bai ; Chao Peng ; Qian Mu ; Jun Lu ; Mingjun Fan ; Shuang Yang ; Zhiyong Huang ; Xuanting Jiang ; Xiaodong Fang ; Guojie Zhang ; Yong Zhang ; Gianluca Polgar ; Hui Yu ; Jia Li ; Zhongjian Liu ; Guoqiang Zhang ; Vydianathan Ravi ; Steven L. Coon ; Jian Wang ; Huanming Yang ; Byrappa Venkatesh ; Jun Wang ; Qiong Shi
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descriptionMudskippers are amphibious fishes that have developed morphological and physiological adaptations to match their unique lifestyles. Here we perform whole-genome sequencing of four representative mudskippers to elucidate the molecular mechanisms underlying these adaptations. We discover an expansion of innate immune system genes in the mudskippers that may provide defence against terrestrial pathogens. Several genes of the ammonia excretion pathway in the gills have experienced positive selection, suggesting their important roles in mudskippers' tolerance to environmental ammonia. Some vision-related genes are differentially lost or mutated, illustrating genomic changes associated with aerial vision. Transcriptomic analyses of mudskippers exposed to air highlight regulatory pathways that are up- or down-regulated in response to hypoxia. The present study provides a valuable resource for understanding the molecular mechanisms underlying water-to-land transition of vertebrates.
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titleMudskipper genomes provide insights into the terrestrial adaptation of amphibious fishes
authorXinxin You ; Chao Bian ; Qijie Zan ; Xun Xu ; Xin Liu ; Jieming Chen ; Jintu Wang ; Ying Qiu ; Wujiao Li ; Xinhui Zhang ; Ying Sun ; Shixi Chen ; Wanshu Hong ; Yuxiang Li ; Shifeng Cheng ; Guangyi Fan ; Chengcheng Shi ; Jie Liang ; Y. Tom Tang ; Chengye Yang ; Zhiqiang Ruan ; Jie Bai ; Chao Peng ; Qian Mu ; Jun Lu ; Mingjun Fan ; Shuang Yang ; Zhiyong Huang ; Xuanting Jiang ; Xiaodong Fang ; Guojie Zhang ; Yong Zhang ; Gianluca Polgar ; Hui Yu ; Jia Li ; Zhongjian Liu ; Guoqiang Zhang ; Vydianathan Ravi ; Steven L. Coon ; Jian Wang ; Huanming Yang ; Byrappa Venkatesh ; Jun Wang ; Qiong Shi
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11Shixi Chen
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14Shifeng Cheng
15Guangyi Fan
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17Jie Liang
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19Chengye Yang
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22Chao Peng
23Qian Mu
24Jun Lu
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28Xuanting Jiang
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doi10.1038/ncomms6594
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date2014-12-02