schliessen

Filtern

 

Bibliotheken

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up t... Full description

Journal Title: Nature Genetics 2010, Vol.42(2), p.105
Main Author: Josée Dupuis
Other Authors: Claudia Langenberg , Inga Prokopenko , Richa Saxena , Nicole Soranzo , Anne U Jackson , Eleanor Wheeler , Nicole L Glazer , Nabila Bouatia-Naji , Anna L Gloyn , Cecilia M Lindgren , Reedik Mägi , Andrew P Morris , Joshua Randall , Toby Johnson , Paul Elliott , Denis Rybin , Gudmar Thorleifsson , Valgerdur Steinthorsdottir , Peter Henneman , Harald Grallert , Abbas Dehghan , Jouke Jan Hottenga , Christopher S Franklin , Pau Navarro , Kijoung Song , Anuj Goel , John R B Perry , Josephine M Egan , Taina Lajunen , Niels Grarup , Thomas Sparsø , Alex Doney , Benjamin F Voight , Heather M Stringham , Man Li , Stavroula Kanoni , Peter Shrader , Christine Cavalcanti-Proença , Meena Kumari , Lu Qi , Nicholas J Timpson , Christian Gieger , Carina Zabena , Ghislain Rocheleau , Erik Ingelsson , Ping An , Jeffrey O'Connell , Jian'An Luan , Amanda Elliott , Steven A Mccarroll , Felicity Payne , Rosa Maria Roccasecca , François Pattou , Praveen Sethupathy , Kristin Ardlie , Yavuz Ariyurek , Beverley Balkau , Philip Barter , John P Beilby , Yoav Ben-Shlomo , Rafn Benediktsson , Amanda J Bennett , Sven Bergmann , Murielle Bochud , Eric Boerwinkle , Amélie Bonnefond , Lori L Bonnycastle , Knut Borch-Johnsen , Yvonne Böttcher , Eric Brunner , Suzannah J Bumpstead , Guillaume Charpentier , Yii-Der Ida Chen , Peter Chines , Robert Clarke , Lachlan J M Coin , Matthew N Cooper , Marilyn Cornelis , Gabe Crawford , Laura Crisponi , Ian N M Day , Eco J C De Geus , Jerome Delplanque , Christian Dina , Michael R Erdos , Annette C Fedson , Antje Fischer-Rosinsky , Nita G Forouhi , Caroline S Fox , Rune Frants , Maria Grazia Franzosi , Pilar Galan , Mark O Goodarzi , Jürgen Graessler , Christopher J Groves , Scott Grundy , Rhian Gwilliam , Ulf Gyllensten , Samy Hadjadj , Göran Hallmans , Naomi Hammond , Xijing Han , Anna-Liisa Hartikainen , Neelam Hassanali , Caroline Hayward , Simon C Heath , Serge Hercberg , Christian Herder , Andrew A Hicks , David R Hillman , Aroon D Hingorani , Albert Hofman , Jennie Hui , Joe Hung , Bo Isomaa , Paul R V Johnson , Torben Jørgensen , Antti Jula , Marika Kaakinen , Jaakko Kaprio , Y Antero Kesaniemi , Mika Kivimaki , Beatrice Knight , Seppo Koskinen , Peter Kovacs , Kirsten Ohm Kyvik , G Mark Lathrop , Debbie A Lawlor , Olivier Le Bacquer , Cécile Lecoeur , Yun Li , Valeriya Lyssenko , Robert Mahley , Massimo Mangino , Alisa K Manning , María Teresa Martínez-Larrad , Jarred B Mcateer , Laura J Mcculloch , Ruth Mcpherson , Christa Meisinger , David Melzer , David Meyre , Braxton D Mitchell , Mario A Morken , Sutapa Mukherjee , Silvia Naitza , Narisu Narisu , Matthew J Neville , Ben A Oostra , Marco Orrù , Ruth Pakyz , Colin N A Palmer , Giuseppe Paolisso , Cristian Pattaro , Daniel Pearson , John F Peden , Nancy L Pedersen , Markus Perola , Andreas F H Pfeiffer , Irene Pichler , Ozren Polasek , Danielle Posthuma , Simon C Potter , Anneli Pouta , Michael A Province , Bruce M Psaty , Wolfgang Rathmann , Nigel W Rayner , Kenneth Rice , Samuli Ripatti , Fernando Rivadeneira , Michael Roden , Olov Rolandsson , Annelli Sandbaek , Manjinder Sandhu , Serena Sanna , Avan Aihie Sayer , Paul Scheet , Laura J Scott , Udo Seedorf , Stephen J Sharp , Beverley Shields , Gunnar Sigurðsson , Eric J G Sijbrands , Angela Silveira , Laila Simpson , Andrew Singleton , Nicholas L Smith , Ulla Sovio , Amy Swift , Holly Syddall , Ann-Christine Syvänen , Toshiko Tanaka , Barbara Thorand , Jean Tichet , Anke Tönjes , Tiinamaija Tuomi , André G Uitterlinden , Ko Willems Van Dijk , Mandy Van Hoek , Dhiraj Varma , Sophie Visvikis-Siest , Veronique Vitart , Nicole Vogelzangs , Gérard Waeber , Peter J Wagner , Andrew Walley , G Bragi Walters , Kim L Ward , Hugh Watkins , Michael N Weedon , Sarah H Wild , Gonneke Willemsen , Jaqueline C M Witteman , John W G Yarnell , Eleftheria Zeggini , Diana Zelenika , Björn Zethelius , Guangju Zhai , Jing Hua Zhao , M Carola Zillikens , Ingrid B Borecki , Ruth J F Loos , Pierre Meneton , Patrik K E Magnusson , David M Nathan , Gordon H Williams , Andrew T Hattersley , Kaisa Silander , Veikko Salomaa , George Davey Smith , Stefan R Bornstein , Peter Schwarz , Joachim Spranger , Fredrik Karpe , Alan R Shuldiner , Cyrus Cooper , George V Dedoussis , Manuel Serrano-Ríos , Andrew D Morris , Lars Lind , Lyle J Palmer , Frank B Hu , Paul W Franks , Shah Ebrahim , Michael Marmot , W H Linda Kao , James S Pankow , Michael J Sampson , Johanna Kuusisto , Markku Laakso , Torben Hansen , Oluf Pedersen , Peter Paul Pramstaller , H Erich Wichmann , Thomas Illig , Igor Rudan , Alan F Wright , Michael Stumvoll , Harry Campbell , James F Wilson
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: ISSN: 1061-4036 ; E-ISSN: 1546-1718 ; DOI: 10.1038/ng.520
Link: http://dx.doi.org/10.1038/ng.520
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: nature_a10.1038/ng.520
title: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
format: Article
creator:
  • Josée Dupuis
  • Claudia Langenberg
  • Inga Prokopenko
  • Richa Saxena
  • Nicole Soranzo
  • Anne U Jackson
  • Eleanor Wheeler
  • Nicole L Glazer
  • Nabila Bouatia-Naji
  • Anna L Gloyn
  • Cecilia M Lindgren
  • Reedik Mägi
  • Andrew P Morris
  • Joshua Randall
  • Toby Johnson
  • Paul Elliott
  • Denis Rybin
  • Gudmar Thorleifsson
  • Valgerdur Steinthorsdottir
  • Peter Henneman
  • Harald Grallert
  • Abbas Dehghan
  • Jouke Jan Hottenga
  • Christopher S Franklin
  • Pau Navarro
  • Kijoung Song
  • Anuj Goel
  • John R B Perry
  • Josephine M Egan
  • Taina Lajunen
  • Niels Grarup
  • Thomas Sparsø
  • Alex Doney
  • Benjamin F Voight
  • Heather M Stringham
  • Man Li
  • Stavroula Kanoni
  • Peter Shrader
  • Christine Cavalcanti-Proença
  • Meena Kumari
  • Lu Qi
  • Nicholas J Timpson
  • Christian Gieger
  • Carina Zabena
  • Ghislain Rocheleau
  • Erik Ingelsson
  • Ping An
  • Jeffrey O'Connell
  • Jian'An Luan
  • Amanda Elliott
  • Steven A Mccarroll
  • Felicity Payne
  • Rosa Maria Roccasecca
  • François Pattou
  • Praveen Sethupathy
  • Kristin Ardlie
  • Yavuz Ariyurek
  • Beverley Balkau
  • Philip Barter
  • John P Beilby
  • Yoav Ben-Shlomo
  • Rafn Benediktsson
  • Amanda J Bennett
  • Sven Bergmann
  • Murielle Bochud
  • Eric Boerwinkle
  • Amélie Bonnefond
  • Lori L Bonnycastle
  • Knut Borch-Johnsen
  • Yvonne Böttcher
  • Eric Brunner
  • Suzannah J Bumpstead
  • Guillaume Charpentier
  • Yii-Der Ida Chen
  • Peter Chines
  • Robert Clarke
  • Lachlan J M Coin
  • Matthew N Cooper
  • Marilyn Cornelis
  • Gabe Crawford
  • Laura Crisponi
  • Ian N M Day
  • Eco J C De Geus
  • Jerome Delplanque
  • Christian Dina
  • Michael R Erdos
  • Annette C Fedson
  • Antje Fischer-Rosinsky
  • Nita G Forouhi
  • Caroline S Fox
  • Rune Frants
  • Maria Grazia Franzosi
  • Pilar Galan
  • Mark O Goodarzi
  • Jürgen Graessler
  • Christopher J Groves
  • Scott Grundy
  • Rhian Gwilliam
  • Ulf Gyllensten
  • Samy Hadjadj
  • Göran Hallmans
  • Naomi Hammond
  • Xijing Han
  • Anna-Liisa Hartikainen
  • Neelam Hassanali
  • Caroline Hayward
  • Simon C Heath
  • Serge Hercberg
  • Christian Herder
  • Andrew A Hicks
  • David R Hillman
  • Aroon D Hingorani
  • Albert Hofman
  • Jennie Hui
  • Joe Hung
  • Bo Isomaa
  • Paul R V Johnson
  • Torben Jørgensen
  • Antti Jula
  • Marika Kaakinen
  • Jaakko Kaprio
  • Y Antero Kesaniemi
  • Mika Kivimaki
  • Beatrice Knight
  • Seppo Koskinen
  • Peter Kovacs
  • Kirsten Ohm Kyvik
  • G Mark Lathrop
  • Debbie A Lawlor
  • Olivier Le Bacquer
  • Cécile Lecoeur
  • Yun Li
  • Valeriya Lyssenko
  • Robert Mahley
  • Massimo Mangino
  • Alisa K Manning
  • María Teresa Martínez-Larrad
  • Jarred B Mcateer
  • Laura J Mcculloch
  • Ruth Mcpherson
  • Christa Meisinger
  • David Melzer
  • David Meyre
  • Braxton D Mitchell
  • Mario A Morken
  • Sutapa Mukherjee
  • Silvia Naitza
  • Narisu Narisu
  • Matthew J Neville
  • Ben A Oostra
  • Marco Orrù
  • Ruth Pakyz
  • Colin N A Palmer
  • Giuseppe Paolisso
  • Cristian Pattaro
  • Daniel Pearson
  • John F Peden
  • Nancy L Pedersen
  • Markus Perola
  • Andreas F H Pfeiffer
  • Irene Pichler
  • Ozren Polasek
  • Danielle Posthuma
  • Simon C Potter
  • Anneli Pouta
  • Michael A Province
  • Bruce M Psaty
  • Wolfgang Rathmann
  • Nigel W Rayner
  • Kenneth Rice
  • Samuli Ripatti
  • Fernando Rivadeneira
  • Michael Roden
  • Olov Rolandsson
  • Annelli Sandbaek
  • Manjinder Sandhu
  • Serena Sanna
  • Avan Aihie Sayer
  • Paul Scheet
  • Laura J Scott
  • Udo Seedorf
  • Stephen J Sharp
  • Beverley Shields
  • Gunnar Sigurðsson
  • Eric J G Sijbrands
  • Angela Silveira
  • Laila Simpson
  • Andrew Singleton
  • Nicholas L Smith
  • Ulla Sovio
  • Amy Swift
  • Holly Syddall
  • Ann-Christine Syvänen
  • Toshiko Tanaka
  • Barbara Thorand
  • Jean Tichet
  • Anke Tönjes
  • Tiinamaija Tuomi
  • André G Uitterlinden
  • Ko Willems Van Dijk
  • Mandy Van Hoek
  • Dhiraj Varma
  • Sophie Visvikis-Siest
  • Veronique Vitart
  • Nicole Vogelzangs
  • Gérard Waeber
  • Peter J Wagner
  • Andrew Walley
  • G Bragi Walters
  • Kim L Ward
  • Hugh Watkins
  • Michael N Weedon
  • Sarah H Wild
  • Gonneke Willemsen
  • Jaqueline C M Witteman
  • John W G Yarnell
  • Eleftheria Zeggini
  • Diana Zelenika
  • Björn Zethelius
  • Guangju Zhai
  • Jing Hua Zhao
  • M Carola Zillikens
  • Ingrid B Borecki
  • Ruth J F Loos
  • Pierre Meneton
  • Patrik K E Magnusson
  • David M Nathan
  • Gordon H Williams
  • Andrew T Hattersley
  • Kaisa Silander
  • Veikko Salomaa
  • George Davey Smith
  • Stefan R Bornstein
  • Peter Schwarz
  • Joachim Spranger
  • Fredrik Karpe
  • Alan R Shuldiner
  • Cyrus Cooper
  • George V Dedoussis
  • Manuel Serrano-Ríos
  • Andrew D Morris
  • Lars Lind
  • Lyle J Palmer
  • Frank B Hu
  • Paul W Franks
  • Shah Ebrahim
  • Michael Marmot
  • W H Linda Kao
  • James S Pankow
  • Michael J Sampson
  • Johanna Kuusisto
  • Markku Laakso
  • Torben Hansen
  • Oluf Pedersen
  • Peter Paul Pramstaller
  • H Erich Wichmann
  • Thomas Illig
  • Igor Rudan
  • Alan F Wright
  • Michael Stumvoll
  • Harry Campbell
  • James F Wilson
subjects:
  • Medical And Health Sciences
  • Medicin Och Hälsovetenskap
  • Medicine
  • Medicin
  • Medical And Health Sciences
  • Clinical Medicine
  • Endocrinology And Diabetes
  • Medicin Och Hälsovetenskap
  • Klinisk Medicin
  • Endokrinologi Och Diabetes
ispartof: Nature Genetics, 2010, Vol.42(2), p.105
description: Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.
language:
source:
identifier: ISSN: 1061-4036 ; E-ISSN: 1546-1718 ; DOI: 10.1038/ng.520
fulltext: fulltext
issn:
  • 1061-4036
  • 10614036
  • 1546-1718
  • 15461718
url: Link


@attributes
ID1581004549
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1038/ng.520
sourceidnature_a
recordidTN_nature_a10.1038/ng.520
sourcesystemPC
pqid21328952
galeid218527314
display
typearticle
titleNew genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
creatorJosée Dupuis ; Claudia Langenberg ; Inga Prokopenko ; Richa Saxena ; Nicole Soranzo ; Anne U Jackson ; Eleanor Wheeler ; Nicole L Glazer ; Nabila Bouatia-Naji ; Anna L Gloyn ; Cecilia M Lindgren ; Reedik Mägi ; Andrew P Morris ; Joshua Randall ; Toby Johnson ; Paul Elliott ; Denis Rybin ; Gudmar Thorleifsson ; Valgerdur Steinthorsdottir ; Peter Henneman ; Harald Grallert ; Abbas Dehghan ; Jouke Jan Hottenga ; Christopher S Franklin ; Pau Navarro ; Kijoung Song ; Anuj Goel ; John R B Perry ; Josephine M Egan ; Taina Lajunen ; Niels Grarup ; Thomas Sparsø ; Alex Doney ; Benjamin F Voight ; Heather M Stringham ; Man Li ; Stavroula Kanoni ; Peter Shrader ; Christine Cavalcanti-Proença ; Meena Kumari ; Lu Qi ; Nicholas J Timpson ; Christian Gieger ; Carina Zabena ; Ghislain Rocheleau ; Erik Ingelsson ; Ping An ; Jeffrey O'Connell ; Jian'An Luan ; Amanda Elliott ; Steven A Mccarroll ; Felicity Payne ; Rosa Maria Roccasecca ; François Pattou ; Praveen Sethupathy ; Kristin Ardlie ; Yavuz Ariyurek ; Beverley Balkau ; Philip Barter ; John P Beilby ; Yoav Ben-Shlomo ; Rafn Benediktsson ; Amanda J Bennett ; Sven Bergmann ; Murielle Bochud ; Eric Boerwinkle ; Amélie Bonnefond ; Lori L Bonnycastle ; Knut Borch-Johnsen ; Yvonne Böttcher ; Eric Brunner ; Suzannah J Bumpstead ; Guillaume Charpentier ; Yii-Der Ida Chen ; Peter Chines ; Robert Clarke ; Lachlan J M Coin ; Matthew N Cooper ; Marilyn Cornelis ; Gabe Crawford ; Laura Crisponi ; Ian N M Day ; Eco J C De Geus ; Jerome Delplanque ; Christian Dina ; Michael R Erdos ; Annette C Fedson ; Antje Fischer-Rosinsky ; Nita G Forouhi ; Caroline S Fox ; Rune Frants ; Maria Grazia Franzosi ; Pilar Galan ; Mark O Goodarzi ; Jürgen Graessler ; Christopher J Groves ; Scott Grundy ; Rhian Gwilliam ; Ulf Gyllensten ; Samy Hadjadj ; Göran Hallmans ; Naomi Hammond ; Xijing Han ; Anna-Liisa Hartikainen ; Neelam Hassanali ; Caroline Hayward ; Simon C Heath ; Serge Hercberg ; Christian Herder ; Andrew A Hicks ; David R Hillman ; Aroon D Hingorani ; Albert Hofman ; Jennie Hui ; Joe Hung ; Bo Isomaa ; Paul R V Johnson ; Torben Jørgensen ; Antti Jula ; Marika Kaakinen ; Jaakko Kaprio ; Y Antero Kesaniemi ; Mika Kivimaki ; Beatrice Knight ; Seppo Koskinen ; Peter Kovacs ; Kirsten Ohm Kyvik ; G Mark Lathrop ; Debbie A Lawlor ; Olivier Le Bacquer ; Cécile Lecoeur ; Yun Li ; Valeriya Lyssenko ; Robert Mahley ; Massimo Mangino ; Alisa K Manning ; María Teresa Martínez-Larrad ; Jarred B Mcateer ; Laura J Mcculloch ; Ruth Mcpherson ; Christa Meisinger ; David Melzer ; David Meyre ; Braxton D Mitchell ; Mario A Morken ; Sutapa Mukherjee ; Silvia Naitza ; Narisu Narisu ; Matthew J Neville ; Ben A Oostra ; Marco Orrù ; Ruth Pakyz ; Colin N A Palmer ; Giuseppe Paolisso ; Cristian Pattaro ; Daniel Pearson ; John F Peden ; Nancy L Pedersen ; Markus Perola ; Andreas F H Pfeiffer ; Irene Pichler ; Ozren Polasek ; Danielle Posthuma ; Simon C Potter ; Anneli Pouta ; Michael A Province ; Bruce M Psaty ; Wolfgang Rathmann ; Nigel W Rayner ; Kenneth Rice ; Samuli Ripatti ; Fernando Rivadeneira ; Michael Roden ; Olov Rolandsson ; Annelli Sandbaek ; Manjinder Sandhu ; Serena Sanna ; Avan Aihie Sayer ; Paul Scheet ; Laura J Scott ; Udo Seedorf ; Stephen J Sharp ; Beverley Shields ; Gunnar Sigurðsson ; Eric J G Sijbrands ; Angela Silveira ; Laila Simpson ; Andrew Singleton ; Nicholas L Smith ; Ulla Sovio ; Amy Swift ; Holly Syddall ; Ann-Christine Syvänen ; Toshiko Tanaka ; Barbara Thorand ; Jean Tichet ; Anke Tönjes ; Tiinamaija Tuomi ; André G Uitterlinden ; Ko Willems Van Dijk ; Mandy Van Hoek ; Dhiraj Varma ; Sophie Visvikis-Siest ; Veronique Vitart ; Nicole Vogelzangs ; Gérard Waeber ; Peter J Wagner ; Andrew Walley ; G Bragi Walters ; Kim L Ward ; Hugh Watkins ; Michael N Weedon ; Sarah H Wild ; Gonneke Willemsen ; Jaqueline C M Witteman ; John W G Yarnell ; Eleftheria Zeggini ; Diana Zelenika ; Björn Zethelius ; Guangju Zhai ; Jing Hua Zhao ; M Carola Zillikens ; Ingrid B Borecki ; Ruth J F Loos ; Pierre Meneton ; Patrik K E Magnusson ; David M Nathan ; Gordon H Williams ; Andrew T Hattersley ; Kaisa Silander ; Veikko Salomaa ; George Davey Smith ; Stefan R Bornstein ; Peter Schwarz ; Joachim Spranger ; Fredrik Karpe ; Alan R Shuldiner ; Cyrus Cooper ; George V Dedoussis ; Manuel Serrano-Ríos ; Andrew D Morris ; Lars Lind ; Lyle J Palmer ; Frank B Hu ; Paul W Franks ; Shah Ebrahim ; Michael Marmot ; W H Linda Kao ; James S Pankow ; Michael J Sampson ; Johanna Kuusisto ; Markku Laakso ; Torben Hansen ; Oluf Pedersen ; Peter Paul Pramstaller ; H Erich Wichmann ; Thomas Illig ; Igor Rudan ; Alan F Wright ; Michael Stumvoll ; Harry Campbell ; James F Wilson
ispartofNature Genetics, 2010, Vol.42(2), p.105
identifier
source
subjectMedical And Health Sciences ; Medicin Och Hälsovetenskap ; Medicine ; Medicin ; Medical And Health Sciences ; Clinical Medicine ; Endocrinology And Diabetes ; Medicin Och Hälsovetenskap ; Klinisk Medicin ; Endokrinologi Och Diabetes;
descriptionLevels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.
version16
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://dx.doi.org/10.1038/ng.520$$EView_this_record_in_Nature
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Josée Dupuis
1Claudia Langenberg
2Inga Prokopenko
3Richa Saxena
4Nicole Soranzo
5Anne U Jackson
6Eleanor Wheeler
7Nicole L Glazer
8Nabila Bouatia-Naji
9Anna L Gloyn
10Cecilia M Lindgren
11Reedik Mägi
12Andrew P Morris
13Joshua Randall
14Toby Johnson
15Paul Elliott
16Denis Rybin
17Gudmar Thorleifsson
18Valgerdur Steinthorsdottir
19Peter Henneman
20Harald Grallert
21Abbas Dehghan
22Jouke Jan Hottenga
23Christopher S Franklin
24Pau Navarro
25Kijoung Song
26Anuj Goel
27John R B Perry
28Josephine M Egan
29Taina Lajunen
30Niels Grarup
31Thomas Sparsø
32Alex Doney
33Benjamin F Voight
34Heather M Stringham
35Man Li
36Stavroula Kanoni
37Peter Shrader
38Christine Cavalcanti-Proença
39Meena Kumari
40Lu Qi
41Nicholas J Timpson
42Christian Gieger
43Carina Zabena
44Ghislain Rocheleau
45Erik Ingelsson
46Ping An
47Jeffrey O'Connell
48Jian'An Luan
49Amanda Elliott
50Steven A Mccarroll
51Felicity Payne
52Rosa Maria Roccasecca
53François Pattou
54Praveen Sethupathy
55Kristin Ardlie
56Yavuz Ariyurek
57Beverley Balkau
58Philip Barter
59John P Beilby
60Yoav Ben-Shlomo
61Rafn Benediktsson
62Amanda J Bennett
63Sven Bergmann
64Murielle Bochud
65Eric Boerwinkle
66Amélie Bonnefond
67Lori L Bonnycastle
68Knut Borch-Johnsen
69Yvonne Böttcher
70Eric Brunner
71Suzannah J Bumpstead
72Guillaume Charpentier
73Yii-Der Ida Chen
74Peter Chines
75Robert Clarke
76Lachlan J M Coin
77Matthew N Cooper
78Marilyn Cornelis
79Gabe Crawford
80Laura Crisponi
81Ian N M Day
82Eco J C De Geus
83Jerome Delplanque
84Christian Dina
85Michael R Erdos
86Annette C Fedson
87Antje Fischer-Rosinsky
88Nita G Forouhi
89Caroline S Fox
90Rune Frants
91Maria Grazia Franzosi
92Pilar Galan
93Mark O Goodarzi
94Jürgen Graessler
95Christopher J Groves
96Scott Grundy
97Rhian Gwilliam
98Ulf Gyllensten
99Samy Hadjadj
100...
titleNew genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
general
0Nature Publishing Group
110.1038/ng.520
2nature.com (Nature Publishing Group)
sourceidnature_a
recordidnature_a10.1038/ng.520
issn
01061-4036
110614036
21546-1718
315461718
rsrctypearticle
creationdate2010
searchscopenature_a
scopenature_a
lsr30VSR-Enriched:[galeid, pqid, subject, eissn, description, pages]
sort
titleNew genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
authorJosée Dupuis ; Claudia Langenberg ; Inga Prokopenko ; Richa Saxena ; Nicole Soranzo ; Anne U Jackson ; Eleanor Wheeler ; Nicole L Glazer ; Nabila Bouatia-Naji ; Anna L Gloyn ; Cecilia M Lindgren ; Reedik Mägi ; Andrew P Morris ; Joshua Randall ; Toby Johnson ; Paul Elliott ; Denis Rybin ; Gudmar Thorleifsson ; Valgerdur Steinthorsdottir ; Peter Henneman ; Harald Grallert ; Abbas Dehghan ; Jouke Jan Hottenga ; Christopher S Franklin ; Pau Navarro ; Kijoung Song ; Anuj Goel ; John R B Perry ; Josephine M Egan ; Taina Lajunen ; Niels Grarup ; Thomas Sparsø ; Alex Doney ; Benjamin F Voight ; Heather M Stringham ; Man Li ; Stavroula Kanoni ; Peter Shrader ; Christine Cavalcanti-Proença ; Meena Kumari ; Lu Qi ; Nicholas J Timpson ; Christian Gieger ; Carina Zabena ; Ghislain Rocheleau ; Erik Ingelsson ; Ping An ; Jeffrey O'Connell ; Jian'An Luan ; Amanda Elliott ; Steven A Mccarroll ; Felicity Payne ; Rosa Maria Roccasecca ; François Pattou ; Praveen Sethupathy ; Kristin Ardlie ; Yavuz Ariyurek ; Beverley Balkau ; Philip Barter ; John P Beilby ; Yoav Ben-Shlomo ; Rafn Benediktsson ; Amanda J Bennett ; Sven Bergmann ; Murielle Bochud ; Eric Boerwinkle ; Amélie Bonnefond ; Lori L Bonnycastle ; Knut Borch-Johnsen ; Yvonne Böttcher ; Eric Brunner ; Suzannah J Bumpstead ; Guillaume Charpentier ; Yii-Der Ida Chen ; Peter Chines ; Robert Clarke ; Lachlan J M Coin ; Matthew N Cooper ; Marilyn Cornelis ; Gabe Crawford ; Laura Crisponi ; Ian N M Day ; Eco J C De Geus ; Jerome Delplanque ; Christian Dina ; Michael R Erdos ; Annette C Fedson ; Antje Fischer-Rosinsky ; Nita G Forouhi ; Caroline S Fox ; Rune Frants ; Maria Grazia Franzosi ; Pilar Galan ; Mark O Goodarzi ; Jürgen Graessler ; Christopher J Groves ; Scott Grundy ; Rhian Gwilliam ; Ulf Gyllensten ; Samy Hadjadj ; Göran Hallmans ; Naomi Hammond ; Xijing Han ; Anna-Liisa Hartikainen ; Neelam Hassanali ; Caroline Hayward ; Simon C Heath ; Serge Hercberg ; Christian Herder ; Andrew A Hicks ; David R Hillman ; Aroon D Hingorani ; Albert Hofman ; Jennie Hui ; Joe Hung ; Bo Isomaa ; Paul R V Johnson ; Torben Jørgensen ; Antti Jula ; Marika Kaakinen ; Jaakko Kaprio ; Y Antero Kesaniemi ; Mika Kivimaki ; Beatrice Knight ; Seppo Koskinen ; Peter Kovacs ; Kirsten Ohm Kyvik ; G Mark Lathrop ; Debbie A Lawlor ; Olivier Le Bacquer ; Cécile Lecoeur ; Yun Li ; Valeriya Lyssenko ; Robert Mahley ; Massimo Mangino ; Alisa K Manning ; María Teresa Martínez-Larrad ; Jarred B Mcateer ; Laura J Mcculloch ; Ruth Mcpherson ; Christa Meisinger ; David Melzer ; David Meyre ; Braxton D Mitchell ; Mario A Morken ; Sutapa Mukherjee ; Silvia Naitza ; Narisu Narisu ; Matthew J Neville ; Ben A Oostra ; Marco Orrù ; Ruth Pakyz ; Colin N A Palmer ; Giuseppe Paolisso ; Cristian Pattaro ; Daniel Pearson ; John F Peden ; Nancy L Pedersen ; Markus Perola ; Andreas F H Pfeiffer ; Irene Pichler ; Ozren Polasek ; Danielle Posthuma ; Simon C Potter ; Anneli Pouta ; Michael A Province ; Bruce M Psaty ; Wolfgang Rathmann ; Nigel W Rayner ; Kenneth Rice ; Samuli Ripatti ; Fernando Rivadeneira ; Michael Roden ; Olov Rolandsson ; Annelli Sandbaek ; Manjinder Sandhu ; Serena Sanna ; Avan Aihie Sayer ; Paul Scheet ; Laura J Scott ; Udo Seedorf ; Stephen J Sharp ; Beverley Shields ; Gunnar Sigurðsson ; Eric J G Sijbrands ; Angela Silveira ; Laila Simpson ; Andrew Singleton ; Nicholas L Smith ; Ulla Sovio ; Amy Swift ; Holly Syddall ; Ann-Christine Syvänen ; Toshiko Tanaka ; Barbara Thorand ; Jean Tichet ; Anke Tönjes ; Tiinamaija Tuomi ; André G Uitterlinden ; Ko Willems Van Dijk ; Mandy Van Hoek ; Dhiraj Varma ; Sophie Visvikis-Siest ; Veronique Vitart ; Nicole Vogelzangs ; Gérard Waeber ; Peter J Wagner ; Andrew Walley ; G Bragi Walters ; Kim L Ward ; Hugh Watkins ; Michael N Weedon ; Sarah H Wild ; Gonneke Willemsen ; Jaqueline C M Witteman ; John W G Yarnell ; Eleftheria Zeggini ; Diana Zelenika ; Björn Zethelius ; Guangju Zhai ; Jing Hua Zhao ; M Carola Zillikens ; Ingrid B Borecki ; Ruth J F Loos ; Pierre Meneton ; Patrik K E Magnusson ; David M Nathan ; Gordon H Williams ; Andrew T Hattersley ; Kaisa Silander ; Veikko Salomaa ; George Davey Smith ; Stefan R Bornstein ; Peter Schwarz ; Joachim Spranger ; Fredrik Karpe ; Alan R Shuldiner ; Cyrus Cooper ; George V Dedoussis ; Manuel Serrano-Ríos ; Andrew D Morris ; Lars Lind ; Lyle J Palmer ; Frank B Hu ; Paul W Franks ; Shah Ebrahim ; Michael Marmot ; W H Linda Kao ; James S Pankow ; Michael J Sampson ; Johanna Kuusisto ; Markku Laakso ; Torben Hansen ; Oluf Pedersen ; Peter Paul Pramstaller ; H Erich Wichmann ; Thomas Illig ; Igor Rudan ; Alan F Wright ; Michael Stumvoll ; Harry Campbell ; James F Wilson
creationdate20100117
facets
frbrgroupid8825123900440290581
frbrtype5
creationdate2010
collectionnature.com (Nature Publishing Group)
prefilterarticles
rsrctypearticles
creatorcontrib
0Josée Dupuis
1Claudia Langenberg
2Inga Prokopenko
3Richa Saxena
4Nicole Soranzo
5Anne U Jackson
6Eleanor Wheeler
7Nicole L Glazer
8Nabila Bouatia-Naji
9Anna L Gloyn
10Cecilia M Lindgren
11Reedik Mägi
12Andrew P Morris
13Joshua Randall
14Toby Johnson
15Paul Elliott
16Denis Rybin
17Gudmar Thorleifsson
18Valgerdur Steinthorsdottir
19Peter Henneman
20Harald Grallert
21Abbas Dehghan
22Jouke Jan Hottenga
23Christopher S Franklin
24Pau Navarro
25Kijoung Song
26Anuj Goel
27John R B Perry
28Josephine M Egan
29Taina Lajunen
30Niels Grarup
31Thomas Sparsø
32Alex Doney
33Benjamin F Voight
34Heather M Stringham
35Man Li
36Stavroula Kanoni
37Peter Shrader
38Christine Cavalcanti-Proença
39Meena Kumari
40Lu Qi
41Nicholas J Timpson
42Christian Gieger
43Carina Zabena
44Ghislain Rocheleau
45Erik Ingelsson
46Ping An
47Jeffrey O'Connell
48Jian'An Luan
49Amanda Elliott
50Steven A Mccarroll
51Felicity Payne
52Rosa Maria Roccasecca
53François Pattou
54Praveen Sethupathy
55Kristin Ardlie
56Yavuz Ariyurek
57Beverley Balkau
58Philip Barter
59John P Beilby
60Yoav Ben-Shlomo
61Rafn Benediktsson
62Amanda J Bennett
63Sven Bergmann
64Murielle Bochud
65Eric Boerwinkle
66Amélie Bonnefond
67Lori L Bonnycastle
68Knut Borch-Johnsen
69Yvonne Böttcher
70Eric Brunner
71Suzannah J Bumpstead
72Guillaume Charpentier
73Yii-Der Ida Chen
74Peter Chines
75Robert Clarke
76Lachlan J M Coin
77Matthew N Cooper
78Marilyn Cornelis
79Gabe Crawford
80Laura Crisponi
81Ian N M Day
82Eco J C De Geus
83Jerome Delplanque
84Christian Dina
85Michael R Erdos
86Annette C Fedson
87Antje Fischer-Rosinsky
88Nita G Forouhi
89Caroline S Fox
90Rune Frants
91Maria Grazia Franzosi
92Pilar Galan
93Mark O Goodarzi
94Jürgen Graessler
95Christopher J Groves
96Scott Grundy
97Rhian Gwilliam
98Ulf Gyllensten
99Samy Hadjadj
100...
jtitleNature Genetics
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Josée Dupuis
1Claudia Langenberg
2Inga Prokopenko
3Richa Saxena
4Nicole Soranzo
5Anne U Jackson
6Eleanor Wheeler
7Nicole L Glazer
8Nabila Bouatia-Naji
9Anna L Gloyn
10Cecilia M Lindgren
11Reedik Mägi
12Andrew P Morris
13Joshua Randall
14Toby Johnson
15Paul Elliott
16Denis Rybin
17Gudmar Thorleifsson
18Valgerdur Steinthorsdottir
19Peter Henneman
20Harald Grallert
21Abbas Dehghan
22Jouke Jan Hottenga
23Christopher S Franklin
24Pau Navarro
25Kijoung Song
26Anuj Goel
27John R B Perry
28Josephine M Egan
29Taina Lajunen
30Niels Grarup
31Thomas Sparsø
32Alex Doney
33Benjamin F Voight
34Heather M Stringham
35Man Li
36Stavroula Kanoni
37Peter Shrader
38Christine Cavalcanti-Proença
39Meena Kumari
40Lu Qi
41Nicholas J Timpson
42Christian Gieger
43Carina Zabena
44Ghislain Rocheleau
45Erik Ingelsson
46Ping An
47Jeffrey O'Connell
48Jian'An Luan
49Amanda Elliott
50Steven A Mccarroll
51Felicity Payne
52Rosa Maria Roccasecca
53François Pattou
54Praveen Sethupathy
55Kristin Ardlie
56Yavuz Ariyurek
57Beverley Balkau
58Philip Barter
59John P Beilby
60Yoav Ben-Shlomo
61Rafn Benediktsson
62Amanda J Bennett
63Sven Bergmann
64Murielle Bochud
65Eric Boerwinkle
66Amélie Bonnefond
67Lori L Bonnycastle
68Knut Borch-Johnsen
69Yvonne Böttcher
70Eric Brunner
71Suzannah J Bumpstead
72Guillaume Charpentier
73Yii-Der Ida Chen
74Peter Chines
75Robert Clarke
76Lachlan J M Coin
77Matthew N Cooper
78Marilyn Cornelis
79Gabe Crawford
80Laura Crisponi
81Ian N M Day
82Eco J C De Geus
83Jerome Delplanque
84Christian Dina
85Michael R Erdos
86Annette C Fedson
87Antje Fischer-Rosinsky
88Nita G Forouhi
89Caroline S Fox
90Rune Frants
91Maria Grazia Franzosi
92Pilar Galan
93Mark O Goodarzi
94Jürgen Graessler
95Christopher J Groves
96Scott Grundy
97Rhian Gwilliam
98Ulf Gyllensten
99Samy Hadjadj
100...
atitleNew genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
jtitleNature Genetics
risdate20100117
volume42
issue2
spage105
issn1061-4036
genrearticle
ristypeJOUR
pubNature Publishing Group
doi10.1038/ng.520
pages105-116
eissn15461718
date2010-01-17