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In vitro gastrointestinal digestion promotes the protective effect of blackberry extract against acrylamide-induced oxidative stress

Acrylamide (AA)-induced toxicity has been associated with accumulation of excessive reactive oxygen species. The present study was therefore undertaken to investigate the protective effect of blackberry digests produced after (BBD) in vitro gastrointestinal (GI) digestion against AA-induced oxidativ... Full description

Journal Title: Scientific Reports 2017, Vol.7
Main Author: Wei Chen
Other Authors: Hongming Su , Yang Xu , Chao Jin
Format: Electronic Article Electronic Article
Language:
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ID: ISSN: ; E-ISSN: 2045-2322 ; DOI: 10.1038/srep40514
Link: http://dx.doi.org/10.1038/srep40514
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recordid: nature_a10.1038/srep40514
title: In vitro gastrointestinal digestion promotes the protective effect of blackberry extract against acrylamide-induced oxidative stress
format: Article
creator:
  • Wei Chen
  • Hongming Su
  • Yang Xu
  • Chao Jin
subjects:
  • Acrylamide -- Toxicity
  • Digestion -- Drug Effects
  • Gastrointestinal Tract -- Physiology
  • Oxidative Stress -- Drug Effects
  • Plant Extracts -- Pharmacology
  • Rubus -- Chemistry
ispartof: Scientific Reports, 2017, Vol.7
description: Acrylamide (AA)-induced toxicity has been associated with accumulation of excessive reactive oxygen species. The present study was therefore undertaken to investigate the protective effect of blackberry digests produced after (BBD) in vitro gastrointestinal (GI) digestion against AA-induced oxidative damage. The results indicated that the BBD (0.5 mg/mL) pretreatment significantly suppressed AA-induced intracellular ROS generation (56.6 ± 2.9% of AA treatment), mitochondrial membrane potential (MMP) decrease (297 ± 18% of AA treatment) and glutathione (GSH) depletion (307 ± 23% of AA treatment), thereby ameliorating cytotoxicity. Furthermore, LC/MS/MS analysis identified eight phenolic compounds with high contents in BBD, including ellagic acid, ellagic acid pentoside, ellagic acid glucuronoside, methyl-ellagic acid pentoside, methyl-ellagic acid glucuronoside, cyanidin glucoside, gallic acid and galloyl esters, as primary active compounds responsible for antioxidant action. Collectively, our study uncovered that the protective effect of blackberry was reserved after gastrointestinal digestion in combating exogenous pollutant-induced oxidative stress.
language:
source:
identifier: ISSN: ; E-ISSN: 2045-2322 ; DOI: 10.1038/srep40514
fulltext: fulltext
issn:
  • 2045-2322
  • 20452322
url: Link


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titleIn vitro gastrointestinal digestion promotes the protective effect of blackberry extract against acrylamide-induced oxidative stress
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descriptionAcrylamide (AA)-induced toxicity has been associated with accumulation of excessive reactive oxygen species. The present study was therefore undertaken to investigate the protective effect of blackberry digests produced after (BBD) in vitro gastrointestinal (GI) digestion against AA-induced oxidative damage. The results indicated that the BBD (0.5 mg/mL) pretreatment significantly suppressed AA-induced intracellular ROS generation (56.6 ± 2.9% of AA treatment), mitochondrial membrane potential (MMP) decrease (297 ± 18% of AA treatment) and glutathione (GSH) depletion (307 ± 23% of AA treatment), thereby ameliorating cytotoxicity. Furthermore, LC/MS/MS analysis identified eight phenolic compounds with high contents in BBD, including ellagic acid, ellagic acid pentoside, ellagic acid glucuronoside, methyl-ellagic acid pentoside, methyl-ellagic acid glucuronoside, cyanidin glucoside, gallic acid and galloyl esters, as primary active compounds responsible for antioxidant action. Collectively, our study uncovered that the protective effect of blackberry was reserved after gastrointestinal digestion in combating exogenous pollutant-induced oxidative stress.
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