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Lysophosphatidic Acid Receptors 1 and 2 Play Roles in Regulation of Vascular Injury Responses but Not Blood Pressure

Phenotypic modulation of vascular smooth muscle cells (SMCs) is essential for the development of intimal hyperplasia. Lysophosphatidic acid (LPA) is a serum component that can promote phenotypic modulation of cultured SMCs, but an endogenous role for this bioactive lipid as a regulator of SMC functi... Full description

Journal Title: Circulation Research 2008, Vol.103(6), pp.662-670
Main Author: Panchatcharam, J., Manikandan
Other Authors: Miriyala, S., Sumitra , Yang, S., Fanmuyi , Rojas, S., Mauricio , End, S., Christopher , Vallant, S., Christopher , Dong, S., Anping , Lynch, S., Kevin , Chun, S., Jerold , Morris, S., Andrew , Smyth, S., Susan
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ID: ISSN: 0009-7330 ; DOI: 10.1161/CIRCRESAHA.108.180778
Link: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00003012-200809120-00017
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title: Lysophosphatidic Acid Receptors 1 and 2 Play Roles in Regulation of Vascular Injury Responses but Not Blood Pressure
format: Article
creator:
  • Panchatcharam, J., Manikandan
  • Miriyala, S., Sumitra
  • Yang, S., Fanmuyi
  • Rojas, S., Mauricio
  • End, S., Christopher
  • Vallant, S., Christopher
  • Dong, S., Anping
  • Lynch, S., Kevin
  • Chun, S., Jerold
  • Morris, S., Andrew
  • Smyth, S., Susan
subjects:
  • Medicine
ispartof: Circulation Research, 2008, Vol.103(6), pp.662-670
description: Phenotypic modulation of vascular smooth muscle cells (SMCs) is essential for the development of intimal hyperplasia. Lysophosphatidic acid (LPA) is a serum component that can promote phenotypic modulation of cultured SMCs, but an endogenous role for this bioactive lipid as a regulator of SMC function in vivo has not been established. Ligation injury of the carotid artery in mice increased levels in the vessel of both autotaxin, the lysophospholipase D enzyme responsible for generation of extracellular LPA, and 2 LPA responsive G protein–coupled receptors 1 (LPA1) and 2 (LPA2). LPA12 mice were partially protected from the development of injury-induced neointimal hyperplasia, whereas LPA1 mice developed larger neointimal lesions after injury. Growth in serum, LPA-induced extracellular signal-regulated protein kinase activation, and migration to LPA and serum were all attenuated in SMCs isolated from LPA12 mice. In contrast, LPA1 SMCs exhibited enhanced migration resulting from an upregulation of LPA3. However, despite their involvement in intimal hyperplasia, neither LPA1 nor LPA2 was required for dedifferentiation of SMCs following vascular injury or dedifferentiation of isolated SMCs in response to LPA or serum in vitro. Similarly, neither LPA1 nor LPA2 was required for LPA to elicit a transient increase in blood pressure following intravenous administration of LPA to mice. These results identify a role for LPA1 and LPA2 in regulating SMC migratory responses in the context of vascular injury but suggest that additional LPA receptor subtypes are required for other LPA-mediated effects in the vasculature.
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identifier: ISSN: 0009-7330 ; DOI: 10.1161/CIRCRESAHA.108.180778
fulltext: fulltext
issn:
  • 0009-7330
  • 00097330
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titleLysophosphatidic Acid Receptors 1 and 2 Play Roles in Regulation of Vascular Injury Responses but Not Blood Pressure
creatorPanchatcharam, J., Manikandan ; Miriyala, S., Sumitra ; Yang, S., Fanmuyi ; Rojas, S., Mauricio ; End, S., Christopher ; Vallant, S., Christopher ; Dong, S., Anping ; Lynch, S., Kevin ; Chun, S., Jerold ; Morris, S., Andrew ; Smyth, S., Susan
ispartofCirculation Research, 2008, Vol.103(6), pp.662-670
identifierISSN: 0009-7330 ; DOI: 10.1161/CIRCRESAHA.108.180778
descriptionPhenotypic modulation of vascular smooth muscle cells (SMCs) is essential for the development of intimal hyperplasia. Lysophosphatidic acid (LPA) is a serum component that can promote phenotypic modulation of cultured SMCs, but an endogenous role for this bioactive lipid as a regulator of SMC function in vivo has not been established. Ligation injury of the carotid artery in mice increased levels in the vessel of both autotaxin, the lysophospholipase D enzyme responsible for generation of extracellular LPA, and 2 LPA responsive G protein–coupled receptors 1 (LPA1) and 2 (LPA2). LPA12 mice were partially protected from the development of injury-induced neointimal hyperplasia, whereas LPA1 mice developed larger neointimal lesions after injury. Growth in serum, LPA-induced extracellular signal-regulated protein kinase activation, and migration to LPA and serum were all attenuated in SMCs isolated from LPA12 mice. In contrast, LPA1 SMCs exhibited enhanced migration resulting from an upregulation of LPA3. However, despite their involvement in intimal hyperplasia, neither LPA1 nor LPA2 was required for dedifferentiation of SMCs following vascular injury or dedifferentiation of isolated SMCs in response to LPA or serum in vitro. Similarly, neither LPA1 nor LPA2 was required for LPA to elicit a transient increase in blood pressure following intravenous administration of LPA to mice. These results identify a role for LPA1 and LPA2 in regulating SMC migratory responses in the context of vascular injury but suggest that additional LPA receptor subtypes are required for other LPA-mediated effects in the vasculature.
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titleLysophosphatidic Acid Receptors 1 and 2 Play Roles in Regulation of Vascular Injury Responses but Not Blood Pressure
descriptionPhenotypic modulation of vascular smooth muscle cells (SMCs) is essential for the development of intimal hyperplasia. Lysophosphatidic acid (LPA) is a serum component that can promote phenotypic modulation of cultured SMCs, but an endogenous role for this bioactive lipid as a regulator of SMC function in vivo has not been established. Ligation injury of the carotid artery in mice increased levels in the vessel of both autotaxin, the lysophospholipase D enzyme responsible for generation of extracellular LPA, and 2 LPA responsive G protein–coupled receptors 1 (LPA1) and 2 (LPA2). LPA12 mice were partially protected from the development of injury-induced neointimal hyperplasia, whereas LPA1 mice developed larger neointimal lesions after injury. Growth in serum, LPA-induced extracellular signal-regulated protein kinase activation, and migration to LPA and serum were all attenuated in SMCs isolated from LPA12 mice. In contrast, LPA1 SMCs exhibited enhanced migration resulting from an upregulation of LPA3. However, despite their involvement in intimal hyperplasia, neither LPA1 nor LPA2 was required for dedifferentiation of SMCs following vascular injury or dedifferentiation of isolated SMCs in response to LPA or serum in vitro. Similarly, neither LPA1 nor LPA2 was required for LPA to elicit a transient increase in blood pressure following intravenous administration of LPA to mice. These results identify a role for LPA1 and LPA2 in regulating SMC migratory responses in the context of vascular injury but suggest that additional LPA receptor subtypes are required for other LPA-mediated effects in the vasculature.
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abstractPhenotypic modulation of vascular smooth muscle cells (SMCs) is essential for the development of intimal hyperplasia. Lysophosphatidic acid (LPA) is a serum component that can promote phenotypic modulation of cultured SMCs, but an endogenous role for this bioactive lipid as a regulator of SMC function in vivo has not been established. Ligation injury of the carotid artery in mice increased levels in the vessel of both autotaxin, the lysophospholipase D enzyme responsible for generation of extracellular LPA, and 2 LPA responsive G protein–coupled receptors 1 (LPA1) and 2 (LPA2). LPA12 mice were partially protected from the development of injury-induced neointimal hyperplasia, whereas LPA1 mice developed larger neointimal lesions after injury. Growth in serum, LPA-induced extracellular signal-regulated protein kinase activation, and migration to LPA and serum were all attenuated in SMCs isolated from LPA12 mice. In contrast, LPA1 SMCs exhibited enhanced migration resulting from an upregulation of LPA3. However, despite their involvement in intimal hyperplasia, neither LPA1 nor LPA2 was required for dedifferentiation of SMCs following vascular injury or dedifferentiation of isolated SMCs in response to LPA or serum in vitro. Similarly, neither LPA1 nor LPA2 was required for LPA to elicit a transient increase in blood pressure following intravenous administration of LPA to mice. These results identify a role for LPA1 and LPA2 in regulating SMC migratory responses in the context of vascular injury but suggest that additional LPA receptor subtypes are required for other LPA-mediated effects in the vasculature.
pub© 2008 American Heart Association, Inc.
doi10.1161/CIRCRESAHA.108.180778
eissn15244571
date2008-09-12